| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Goettl VM et al. | Motoric behavior in aged rats treated with GM1. | 2001 | Brain Res. | pmid:11430865 |
| Pickl WF et al. | Lipid rafts and pseudotyping. | 2001 | J. Virol. | pmid:11435598 |
| Valdes-Gonzalez T et al. | Neuropeptides interact with glycolipid receptors: a surface plasmon resonance study. | 2001 | Peptides | pmid:11445240 |
| Aman AT et al. | A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11447291 |
| Yuan C and Johnston LJ | Atomic force microscopy studies of ganglioside GM1 domains in phosphatidylcholine and phosphatidylcholine/cholesterol bilayers. | 2001 | Biophys. J. | pmid:11463647 |
| Zaprianova E et al. | Serum ganglioside patterns in multiple sclerosis. | 2001 | Neurochem. Res. | pmid:11478747 |
| Rodighiero C et al. | A cholera toxin B-subunit variant that binds ganglioside G(M1) but fails to induce toxicity. | 2001 | J. Biol. Chem. | pmid:11479294 |
| Horibata Y et al. | Transglycosylation and reverse hydrolysis reactions of endoglycoceramidase from the jellyfish, Cyanea nozakii. | 2001 | J. Biochem. | pmid:11481044 |
| McNamara N et al. | ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11481474 |
| Sueyoshi N et al. | Apoptosis of Neuro2a cells induced by lysosphingolipids with naturally occurring stereochemical configurations. | 2001 | J. Lipid Res. | pmid:11483620 |
| Zuolo ML et al. | Identification of GM3 as a marker of therapy-resistant periradicular lesions. | 2001 | J Endod | pmid:11491632 |
| Gómez-Móuton C et al. | Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11493690 |
| Pierini LM and Maxfield FR | Flotillas of lipid rafts fore and aft. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11504934 |
| Metelmann W et al. | Gangliosides from human granulocytes: a nano-ESI QTOF mass spectrometry fucosylation study of low abundance species in complex mixtures. | 2001 | J. Am. Soc. Mass Spectrom. | pmid:11506229 |
| Carrer DC and Maggio B | Transduction to self-assembly of molecular geometry and local interactions in mixtures of ceramides and ganglioside GM1. | 2001 | Biochim. Biophys. Acta | pmid:11513807 |
| Tohyama J et al. | Psychosine is as potent an inducer of cell death as C6-ceramide in cultured fibroblasts and in MOCH-1 cells. | 2001 | Neurochem. Res. | pmid:11519726 |
| Osofsky MR et al. | Does exogenous GM1 ganglioside enhance the effects of electrical stimulation in ameliorating degeneration after neonatal deafness? | 2001 | Hear. Res. | pmid:11520632 |
| Marmor MD and Julius M | Role for lipid rafts in regulating interleukin-2 receptor signaling. | 2001 | Blood | pmid:11520799 |
| Kuhara T et al. | Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. | 2000 | Nutr Cancer | pmid:11525597 |
| Ortiz N et al. | IgM monoclonal antibody against terminal moiety of GM2, GalNAc-GD1a and GalNAc-GM1b from a pure motor chronic demyelinating polyneuropathy patient: effects on neurotransmitter release. | 2001 | J. Neuroimmunol. | pmid:11525808 |