MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Bartels T et al. | N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation. | 2014 | PLoS ONE | pmid:25075858 |
Basu I and Mukhopadhyay C | Insights into binding of cholera toxin to GM1 containing membrane. | 2014 | Langmuir | pmid:25425333 |
Ueno H et al. | Comparison between the aggregation of human and rodent amyloid β-proteins in GM1 ganglioside clusters. | 2014 | Biochemistry | pmid:25399921 |
Takatori S et al. | Microscopic methods to observe the distribution of lipids in the cellular membrane. | 2014 | Biochemistry | pmid:24460209 |
Hsieh CL et al. | Tracking single particles on supported lipid membranes: multimobility diffusion and nanoscopic confinement. | 2014 | J Phys Chem B | pmid:24433014 |
Magini A et al. | Methods to discriminate the distribution of acidic glycohydrolases between the endosomal-lysosomal systems and the plasma membrane. | 2014 | Meth. Enzymol. | pmid:24359946 |
Bisel B et al. | GM1 and GM2 gangliosides: recent developments. | 2014 | Biomol Concepts | pmid:25372744 |
Kim W et al. | Dietary fish oil and DHA down-regulate antigen-activated CD4+ T-cells while promoting the formation of liquid-ordered mesodomains. | 2014 | Br. J. Nutr. | pmid:23962659 |
Spillane KM et al. | High-speed single-particle tracking of GM1 in model membranes reveals anomalous diffusion due to interleaflet coupling and molecular pinning. | 2014 | Nano Lett. | pmid:25133992 |
Khatun UL and Mukhopadhyay C | Interaction of bee venom toxin melittin with ganglioside GM1 bicelle. | 2013 Oct-Nov | Biophys. Chem. | pmid:23850803 |
Hirai M et al. | Change of dynamics of raft-model membrane induced by amyloid-β protein binding. | 2013 | Eur Phys J E Soft Matter | pmid:23852578 |
Rondelli V et al. | Neutrons for rafts, rafts for neutrons. | 2013 | Eur Phys J E Soft Matter | pmid:23852579 |
Yang R et al. | Monosialoanglioside improves memory deficits and relieves oxidative stress in the hippocampus of rat model of Alzheimer's disease. | 2013 | Neurol. Sci. | pmid:23229411 |
Nomura M et al. | 13-Cis retinoic acid can enhance the antitumor activity of non-replicating Sendai virus particle against neuroblastoma. | 2013 | Cancer Sci. | pmid:23134437 |
Liu Q et al. | Specific interaction of postsynaptic densities with membrane rafts isolated from synaptic plasma membranes. | 2013 | J. Neurogenet. | pmid:23527882 |
Kreutz F et al. | Alterations of membrane lipids and in gene expression of ganglioside metabolism in different brain structures in a mouse model of mucopolysaccharidosis type I (MPS I). | 2013 | Gene | pmid:23774686 |
Mahmood I et al. | Influence of lipid composition on the structural stability of g-protein coupled receptor. | 2013 | Chem. Pharm. Bull. | pmid:23546002 |
Konishi M et al. | Extending the glucosyl ceramide cassette approach: application in the total synthesis of ganglioside GalNAc-GM1b. | 2013 | Molecules | pmid:24335571 |
Bisel B et al. | Decoupling polarization of the Golgi apparatus and GM1 in the plasma membrane. | 2013 | PLoS ONE | pmid:24312472 |
Manna M and Mukhopadhyay C | Binding, conformational transition and dimerization of amyloid-β peptide on GM1-containing ternary membrane: insights from molecular dynamics simulation. | 2013 | PLoS ONE | pmid:23951128 |
Zhong L et al. | NSOM/QD-based visualization of GM1 serving as platforms for TCR/CD3 mediated T-cell activation. | 2013 | Biomed Res Int | pmid:24288672 |
Szklarczyk OM et al. | Receptor concentration and diffusivity control multivalent binding of Sv40 to membrane bilayers. | 2013 | PLoS Comput. Biol. | pmid:24244125 |
Cox CJ et al. | Brain human monoclonal autoantibody from sydenham chorea targets dopaminergic neurons in transgenic mice and signals dopamine D2 receptor: implications in human disease. | 2013 | J. Immunol. | pmid:24184556 |
Rios FJ et al. | Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts. | 2013 | PLoS ONE | pmid:24130805 |
Rong X et al. | Ganglioside GM1 reduces white matter damage in neonatal rats. | 2013 | Acta Neurobiol Exp (Wars) | pmid:24129486 |
Moeller S et al. | Lack of association between autism and anti-GM1 ganglioside antibody. | 2013 | Neurology | pmid:24068789 |
Pellistri F et al. | Different ataxin-3 amyloid aggregates induce intracellular Ca(2+) deregulation by different mechanisms in cerebellar granule cells. | 2013 | Biochim. Biophys. Acta | pmid:24035922 |
Saslowsky DE et al. | Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain. | 2013 | J. Biol. Chem. | pmid:23884419 |
Itokazu Y et al. | Effects of amyloid β-peptides and gangliosides on mouse neural stem cells. | 2013 | Neurochem. Res. | pmid:23851714 |
Armendariz KP and Dunn RC | Ganglioside influence on phospholipid films investigated with single molecule fluorescence measurements. | 2013 | J Phys Chem B | pmid:23745772 |
Gustafsson T et al. | Direct interaction between cholera toxin and dendritic cells is required for oral adjuvant activity. | 2013 | Eur. J. Immunol. | pmid:23649516 |
Triantafilou M et al. | Synergic activation of toll-like receptor (TLR) 2/6 and 9 in response to Ureaplasma parvum & urealyticum in human amniotic epithelial cells. | 2013 | PLoS ONE | pmid:23593431 |
Rivera FP et al. | Bovine lactoferrin decreases cholera-toxin-induced intestinal fluid accumulation in mice by ganglioside interaction. | 2013 | PLoS ONE | pmid:23580005 |
Lauria I et al. | GLTP mediated non-vesicular GM1 transport between native membranes. | 2013 | PLoS ONE | pmid:23555818 |
Calamai M and Pavone FS | Partitioning and confinement of GM1 ganglioside induced by amyloid aggregates. | 2013 | FEBS Lett. | pmid:23523632 |
Hamorsky KT et al. | Rapid and scalable plant-based production of a cholera toxin B subunit variant to aid in mass vaccination against cholera outbreaks. | 2013 | PLoS Negl Trop Dis | pmid:23505583 |
Zhu Y et al. | Ganglioside-monosialic acid (GM1) prevents oxaliplatin-induced peripheral neurotoxicity in patients with gastrointestinal tumors. | 2013 | World J Surg Oncol | pmid:23351188 |
Benktander J et al. | The repertoire of glycosphingolipids recognized by Vibrio cholerae. | 2013 | PLoS ONE | pmid:23349777 |
Schneider JS et al. | A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients. | 2013 | J. Neurol. Sci. | pmid:23199590 |
Li X et al. | TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice. | 2013 | J. Mol. Med. | pmid:23108456 |
Sezgin E et al. | Photoconversion of bodipy-labeled lipid analogues. | 2013 | Chembiochem | pmid:23512865 |
Lozano MM et al. | Colocalization of the ganglioside G(M1) and cholesterol detected by secondary ion mass spectrometry. | 2013 | J. Am. Chem. Soc. | pmid:23514537 |
Kuwabara S and Yuki N | Axonal Guillain-Barré syndrome: concepts and controversies. | 2013 | Lancet Neurol | pmid:24229616 |
Sasahara K et al. | Effects of membrane interaction and aggregation of amyloid β-peptide on lipid mobility and membrane domain structure. | 2013 | Phys Chem Chem Phys | pmid:23515399 |
Wakerley BR et al. | Atypical Bickerstaff brainstem encephalitis: ataxic hypersomnolence without ophthalmoplegia. | 2013 | J. Neurol. Neurosurg. Psychiatry | pmid:23564757 |
Van Blerkom J and Caltrider K | Sperm attachment and penetration competence in the human oocyte: a possible aetiology of fertilization failure involving the organization of oolemmal lipid raft microdomains influenced by the ΔΨm of subplasmalemmal mitochondria. | 2013 | Reprod. Biomed. Online | pmid:24157131 |
Okawa S et al. | Tolosa-hunt syndrome associated with cytomegalovirus infection. | 2013 | Intern. Med. | pmid:23676602 |
Ogawa G et al. | An antibody to the GM1/GalNAc-GD1a complex correlates with development of pure motor Guillain-Barré syndrome with reversible conduction failure. | 2013 | J. Neuroimmunol. | pmid:23000056 |
Kreutz F et al. | Alterations on Naâº,Kâº-ATPase and acetylcholinesterase activities induced by amyloid-β peptide in rat brain and GM1 ganglioside neuroprotective action. | 2013 | Neurochem. Res. | pmid:24013887 |
Galban-Horcajo F et al. | Antibodies to heteromeric glycolipid complexes in multifocal motor neuropathy. | 2013 | Eur. J. Neurol. | pmid:22727042 |
Mattarella M et al. | Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. | 2013 | Org. Biomol. Chem. | pmid:23736158 |
Garcia-Hartjes J et al. | Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix[5]arene. | 2013 | Org. Biomol. Chem. | pmid:23689250 |
Hoshino T et al. | Binding and aggregation mechanism of amyloid β-peptides onto the GM1 ganglioside-containing lipid membrane. | 2013 | J Phys Chem B | pmid:23688073 |
Willjes G et al. | Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity. | 2013 | Biochemistry | pmid:23647335 |
Poggi A et al. | Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells. | 2013 | PLoS ONE | pmid:23667543 |
Yamamoto N et al. | Propofol and thiopental suppress amyloid fibril formation and GM1 ganglioside expression through the γ-aminobutyric acid A receptor. | 2013 | Anesthesiology | pmid:23422796 |
Verhelst R et al. | E. coli heat labile toxin (LT) inactivation by specific polyphenols is aggregation dependent. | 2013 | Vet. Microbiol. | pmid:23391440 |
Matsubara T et al. | Density of GM1 in nanoclusters is a critical factor in the formation of a spherical assembly of amyloid β-protein on synaptic plasma membranes. | 2013 | Langmuir | pmid:23294326 |
Dobos J et al. | Sex-dependent liver colonization of human melanoma in SCID mice--role of host defense mechanisms. | 2013 | Clin. Exp. Metastasis | pmid:23203681 |
Kuwahara M et al. | Clinical features of CIDP with LM1-associated antibodies. | 2013 | J. Neurol. Neurosurg. Psychiatry | pmid:23138763 |
Cheng Q et al. | Fuzheng Huayu inhibits carbon tetrachloride-induced liver fibrosis in mice through activating hepatic NK cells. | 2013 | J Ethnopharmacol | pmid:23127651 |
Hosoya S et al. | Innate immune responses involving natural killer and natural killer T cells promote liver regeneration after partial hepatectomy in mice. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23086918 |
Lammertse DP | Clinical trials in spinal cord injury: lessons learned on the path to translation. The 2011 International Spinal Cord Society Sir Ludwig Guttmann Lecture. | 2013 | Spinal Cord | pmid:23165505 |
Vlam L et al. | Immune pathogenesis and treatment of multifocal motor neuropathy. | 2013 | J. Clin. Immunol. | pmid:22941513 |
Yamaguchi T et al. | Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins. | 2013 | Chem. Commun. (Camb.) | pmid:23296043 |
Buschiazzo J et al. | Cholesterol depletion disorganizes oocyte membrane rafts altering mouse fertilization. | 2013 | PLoS ONE | pmid:23638166 |
Rockett BD et al. | Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function. | 2012 | J. Lipid Res. | pmid:22315394 |
Pryor S et al. | NGF causes TrkA to specifically attract microtubules to lipid rafts. | 2012 | PLoS ONE | pmid:22496904 |
Å tefl M et al. | Dynamics and size of cross-linking-induced lipid nanodomains in model membranes. | 2012 | Biophys. J. | pmid:22824274 |
Wu CS et al. | Cancer-associated carbohydrate antigens as potential biomarkers for hepatocellular carcinoma. | 2012 | PLoS ONE | pmid:22808038 |
Gitz E et al. | Improved platelet survival after cold storage by prevention of glycoprotein Ibα clustering in lipid rafts. | 2012 | Haematologica | pmid:22733027 |
Rogers TJ et al. | Role of lipid rafts and flagellin in invasion of colonic epithelial cells by Shiga-toxigenic Escherichia coli O113:H21. | 2012 | Infect. Immun. | pmid:22689816 |
Puryear WB et al. | HIV-1 incorporation of host-cell-derived glycosphingolipid GM3 allows for capture by mature dendritic cells. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22529395 |
Sezgin E et al. | Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes. | 2012 | Biochim. Biophys. Acta | pmid:22450237 |
Essaka DC et al. | Single cell ganglioside catabolism in primary cerebellar neurons and glia. | 2012 | Neurochem. Res. | pmid:22407243 |
Viljetić B et al. | Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes. | 2012 | Biochim. Biophys. Acta | pmid:22206893 |
Di Pardo A et al. | Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22331905 |
Sekiguchi Y et al. | Antiganglioside antibodies are associated with axonal Guillain-Barré syndrome: a Japanese-Italian collaborative study. | 2012 | J. Neurol. Neurosurg. Psychiatry | pmid:22010183 |
Olvera-Gomez I et al. | Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22308317 |
Fewou SN et al. | Anti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy. | 2012 | J. Clin. Invest. | pmid:22307327 |
Evangelisti E et al. | Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers. | 2012 | J. Cell. Sci. | pmid:22344258 |
Staneva G et al. | Segregative clustering of Lo and Ld membrane microdomains induced by local pH gradients in GM1-containing giant vesicles: a lipid model for cellular polarization. | 2012 | Langmuir | pmid:23121205 |
Schengrund CL et al. | Cholesterol, GM1, and autism. | 2012 | Neurochem. Res. | pmid:22252726 |
Fukunaga S et al. | GM1 cluster mediates formation of toxic Aβ fibrils by providing hydrophobic environments. | 2012 | Biochemistry | pmid:23009396 |
Li H et al. | Expression of tyrosine kinase receptors in cultured dorsal root ganglion neurons in the presence of monosialoganglioside and skeletal muscle cells. | 2012 | J. Muscle Res. Cell. Motil. | pmid:22968393 |
Zhang Y et al. | Protein-glycosphingolipid interactions revealed using catch-and-release mass spectrometry. | 2012 | Anal. Chem. | pmid:22920193 |
Lee KY | Anti-GQ1b-negative Miller Fisher syndrome after Campylobacter jejuni enteritis. | 2012 | Pediatr. Neurol. | pmid:22883289 |
Moyano AL et al. | Novel antibodies reacting with two neighboring gangliosides are induced in rabbits immunized with bovine brain gangliosides. | 2012 | Glycobiology | pmid:22843673 |
Breimer ME et al. | Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human individual. | 2012 | Glycobiology | pmid:22833314 |
Khatun UL et al. | Modulation of the neurotensin solution structure in the presence of ganglioside GM1 bicelle. | 2012 | Biophys. Chem. | pmid:22824320 |
Del Favero E et al. | Transient step-like kinetics of enzyme reaction on fragmented-condensed substrates. | 2012 | J Phys Chem B | pmid:22809280 |
Li L et al. | Spatiotemporally controlled and multifactor involved assay of neuronal compartment regeneration after chemical injury in an integrated microfluidics. | 2012 | Anal. Chem. | pmid:22793989 |
Yamamoto N et al. | Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes. | 2012 | J. Neurochem. | pmid:22260232 |
Peng W | Intravenous immunoglobulin treatment on anti-GM1 antibodies associated neuropathies inhibits cholera toxin and galectin-1 binding to ganglioside GM1. | 2012 | Immunol. Lett. | pmid:22289946 |
Kopitz J et al. | Ganglioside GM1/galectin-dependent growth regulation in human neuroblastoma cells: special properties of bivalent galectin-4 and significance of linker length for ligand selection. | 2012 | Neurochem. Res. | pmid:22234579 |
Tsai YF et al. | The total synthesis of a ganglioside Hp-s1 analogue possessing neuritogenic activity by chemoselective activation glycosylation. | 2012 | Org. Biomol. Chem. | pmid:22179062 |
Tellier S et al. | [Guillain-Barré syndrome in a child with normal tendon reflexes]. | 2012 | Arch Pediatr | pmid:22154102 |
Jiang S et al. | A proteomics approach to the cell-surface interactome using the enzyme-mediated activation of radical sources reaction. | 2012 | Proteomics | pmid:22106087 |
Bucciantini M et al. | Toxic effects of amyloid fibrils on cell membranes: the importance of ganglioside GM1. | 2012 | FASEB J. | pmid:22071505 |
Kawakami S et al. | A-waves in Guillain-Barré syndrome: correlation with electrophysiological subtypes and antiganglioside antibodies. | 2012 | Clin Neurophysiol | pmid:22055840 |