MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Qiu JX et al. | Structure-function studies of an anti-asialo GM1 antibody obtained from a phage display library. | 1999 | J. Neuroimmunol. | pmid:10408972 |
Ryu BR et al. | Attenuation of cortical neuronal apoptosis by gangliosides. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10411596 |
Fukumoto H et al. | Effect of a chimeric anti-ganglioside GM2 antibody on ganglioside GM2-expressing human solid tumors in vivo. | 1999 | Int. J. Cancer | pmid:10417777 |
Sawada N et al. | Ganglioside GD1 alpha analogues as high-affinity ligands for myelin-associated glycoprotein (MAG). | 1999 | Carbohydr. Res. | pmid:10420586 |
Möbius W et al. | Intracellular distribution of a biotin-labeled ganglioside, GM1, by immunoelectron microscopy after endocytosis in fibroblasts. | 1999 | J. Histochem. Cytochem. | pmid:10424884 |
Goettl VM et al. | GM1 ganglioside restores dopaminergic neurochemical and morphological markers in aged rats. | 1999 | Neuroscience | pmid:10426539 |
Ravichandra B and Joshi PG | Regulation of transmembrane signaling by ganglioside GM1: interaction of anti-GM1 with Neuro2a cells. | 1999 | J. Neurochem. | pmid:10428051 |
Kozireski-Chuback D et al. | Axonogenesis in neuro-2a cells correlates with GM1 upregulation in the nuclear and plasma membranes. | 1999 | J. Neurosci. Res. | pmid:10440904 |
Odaka M et al. | Antibodies to GD1alpha and to GQ1beta in Guillain-Barré syndrome and the related disorders. | 1999 | J. Neurol. Sci. | pmid:10450797 |
Matsubara T et al. | Selection of ganglioside GM1-binding peptides by using a phage library. | 1999 | FEBS Lett. | pmid:10456319 |