| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bao R et al. | Atomic force microscopy study of ganglioside GM1 concentration effect on lateral phase separation of sphingomyelin/dioleoylphosphatidylcholine/cholesterol bilayers. | 2011 | J Phys Chem B | pmid:21526782 |
| Bond MR et al. | Metabolism of diazirine-modified N-acetylmannosamine analogues to photo-cross-linking sialosides. | 2011 | Bioconjug. Chem. | pmid:21838313 |
| Zhang J and Zhou X | Novel 3-dimensional dendrimer platform for glycolipid microarray. | 2011 | Biosens Bioelectron | pmid:21820887 |
| Suzuki T et al. | Association of membrane rafts and postsynaptic density: proteomics, biochemical, and ultrastructural analyses. | 2011 | J. Neurochem. | pmid:21797867 |
| Lim ST et al. | Exogenous gangliosides increase the release of brain-derived neurotrophic factor. | 2011 | Neuropharmacology | pmid:20971126 |
| Gayen A et al. | NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles. | 2011 | Biochim. Biophys. Acta | pmid:20937248 |
| Satoh H et al. | Rapid detection of GM1 ganglioside in cerebrospinal fluid in dogs with GM1 gangliosidosis using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. | 2011 | J. Vet. Diagn. Invest. | pmid:22362802 |
| Xu X et al. | A human IgM signals axon outgrowth: coupling lipid raft to microtubules. | 2011 | J. Neurochem. | pmid:21824142 |
| Kanie O et al. | Multi-stage mass spectrometric information obtained by deconvolution of energy-resolved spectra acquired by triple-quadrupole mass spectrometry. | 2011 | Rapid Commun. Mass Spectrom. | pmid:21594937 |
| Tran HA et al. | Multifunctional multivalency: a focused library of polymeric cholera toxin antagonists. | 2011 | Org. Biomol. Chem. | pmid:21451844 |
| Cutrullis RA et al. | Immunomodulatory and anti-fibrotic effects of ganglioside therapy on the cardiac chronic form of experimental Trypanosoma cruzi infection. | 2011 | Int. Immunopharmacol. | pmid:21371583 |
| Lardone RD et al. | Anti-GM1 IgG antibodies in Guillain-Barré syndrome: fine specificity is associated with disease severity. | 2010 | J. Neurol. Neurosurg. Psychiatry | pmid:19965859 |
| Becker PM et al. | Inhibition of binding of the AB5-type enterotoxins LT-I and cholera toxin to ganglioside GM1 by galactose-rich dietary components. | 2010 | Foodborne Pathog. Dis. | pmid:19919285 |
| Zarei M et al. | Separation and identification of GM1b pathway Neu5Ac- and Neu5Gc gangliosides by on-line nanoHPLC-QToF MS and tandem MS: toward glycolipidomics screening of animal cell lines. | 2010 | Glycobiology | pmid:19797321 |
| Mao Y et al. | Surface-induced phase separation of a sphingomyelin/cholesterol/ganglioside GM1-planar bilayer on mica surfaces and microdomain molecular conformation that accelerates Abeta oligomerization. | 2010 | Biochim. Biophys. Acta | pmid:20226163 |
| Heiser C et al. | [Open rhinophonia in adults: a rare manifestation of cranial polyneuritis]. | 2010 | HNO | pmid:19774355 |
| Avrova NF et al. | Protective and antioxidative effects of GM1 ganglioside in PC12 cells exposed to hydrogen peroxide are mediated by Trk tyrosine kinase. | 2010 | Neurochem. Res. | pmid:19621257 |
| Wang L et al. | Co-administration of monosialoganglioside and skeletal muscle cells on dorsal root ganglion neuronal phenotypes in vitro. | 2010 | Cell. Mol. Neurobiol. | pmid:19582569 |
| Jones R et al. | Tracking diffusion of GM1 gangliosides and zona pellucida binding molecules in sperm plasma membranes following cholesterol efflux. | 2010 | Dev. Biol. | pmid:20060391 |
| Petr T et al. | Histochemical detection of GM1 ganglioside using cholera toxin-B subunit. Evaluation of critical factors optimal for in situ detection with special emphasis to acetone pre-extraction. | 2010 | Eur J Histochem | pmid:20558344 |
| Yahi N et al. | How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's beta amyloid peptide (Abeta1-40). | 2010 | PLoS ONE | pmid:20140095 |
| MartÃn-MartÃn AI et al. | Cholesterol, ganglioside GM1 and class A scavenger receptor contribute to infection by Brucella ovis and Brucella canis in murine macrophages. | 2010 | Microbes Infect. | pmid:20083220 |
| Hac-Wydro K and Dynarowicz-Åatka P | The relationship between the concentration of ganglioside GM1 and antitumor activity of edelfosine--the Langmuir monolayer study. | 2010 | Colloids Surf B Biointerfaces | pmid:20692132 |
| Tanaka S et al. | Protective effects of exogenous GM-1 ganglioside on acoustic injury of the mouse cochlea. | 2010 | Neurosci. Lett. | pmid:20219629 |
| Yuki N | Human gangliosides and bacterial lipo-oligosaccharides in the development of autoimmune neuropathies. | 2010 | Methods Mol. Biol. | pmid:19882120 |
| Fifadara NH et al. | Interaction between activated chemokine receptor 1 and FcepsilonRI at membrane rafts promotes communication and F-actin-rich cytoneme extensions between mast cells. | 2010 | Int. Immunol. | pmid:20173038 |
| Harris JR and Milton NG | Cholesterol in Alzheimer's disease and other amyloidogenic disorders. | 2010 | Subcell. Biochem. | pmid:20213540 |
| Zrimi J et al. | Cholera toxin B subunits assemble into pentamers--proposition of a fly-casting mechanism. | 2010 | PLoS ONE | pmid:21203571 |
| Schroeder F et al. | Caveolin, sterol carrier protein-2, membrane cholesterol-rich microdomains and intracellular cholesterol trafficking. | 2010 | Subcell. Biochem. | pmid:20213548 |
| Carton I et al. | Dynamic modulation of the glycosphingolipid content in supported lipid bilayers by glycolipid transfer protein. | 2010 | Biophys. J. | pmid:21044592 |
| Saslowsky DE et al. | Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2. | 2010 | J. Clin. Invest. | pmid:21041954 |
| Corbeil D et al. | Prominin-1: a distinct cholesterol-binding membrane protein and the organisation of the apical plasma membrane of epithelial cells. | 2010 | Subcell. Biochem. | pmid:20213552 |
| Gavella M et al. | Modulation of ROS production in human leukocytes by ganglioside micelles. | 2010 | Braz. J. Med. Biol. Res. | pmid:20878014 |
| Mikhalyov I et al. | Designed fluorescent probes reveal interactions between amyloid-beta(1-40) peptides and GM1 gangliosides in micelles and lipid vesicles. | 2010 | Biophys. J. | pmid:20816063 |
| Kopitz J et al. | How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane. | 2010 | IUBMB Life | pmid:20665623 |
| Dong L et al. | Increased expression of ganglioside GM1 in peripheral CD4+ T cells correlates soluble form of CD30 in Systemic Lupus Erythematosus patients. | 2010 | J. Biomed. Biotechnol. | pmid:20625494 |
| Togayachi A et al. | Lack of lacto/neolacto-glycolipids enhances the formation of glycolipid-enriched microdomains, facilitating B cell activation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20547865 |
| Zhang JZ et al. | Monosialotetrahexosy-1 ganglioside attenuates diabetes-enhanced brain damage after transient forebrain ischemia and suppresses phosphorylation of ERK1/2 in the rat brain. | 2010 | Brain Res. | pmid:20546707 |
| Mudrak B and Kuehn MJ | Heat-labile enterotoxin: beyond G(m1) binding. | 2010 | Toxins (Basel) | pmid:22069646 |
| van der Pol WL et al. | Intravenous immunoglobulin treatment in multifocal motor neuropathy. | 2010 | J. Clin. Immunol. | pmid:20405181 |
| Nobre TM et al. | The specificity of frutalin lectin using biomembrane models. | 2010 | Biochim. Biophys. Acta | pmid:20353752 |
| Ang CW et al. | Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11. | 2010 | PLoS ONE | pmid:20339556 |
| van Zanten TS et al. | Direct mapping of nanoscale compositional connectivity on intact cell membranes. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20713733 |
| Yanagisawa M et al. | Cytotoxic effects of G(M1) ganglioside and amyloid β-peptide on mouse embryonic neural stem cells. | 2010 | ASN Neuro | pmid:20305711 |
| Maglione V et al. | Impaired ganglioside metabolism in Huntington's disease and neuroprotective role of GM1. | 2010 | J. Neurosci. | pmid:20237277 |
| Hall LJ et al. | NK cells influence both innate and adaptive immune responses after mucosal immunization with antigen and mucosal adjuvant. | 2010 | J. Immunol. | pmid:20220095 |
| Chebukati JN et al. | Bis(monoacylglycero)phosphate and ganglioside GM1 spontaneously form small homogeneous vesicles at specific concentrations. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20206128 |
| Mailloux AW et al. | NK depletion results in increased CCL22 secretion and Treg levels in Lewis lung carcinoma via the accumulation of CCL22-secreting CD11b+CD11c+ cells. | 2010 | Int. J. Cancer | pmid:20198623 |
| Wernick NL et al. | Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. | 2010 | Toxins (Basel) | pmid:22069586 |
| Soo JC et al. | Surface immobilized cholera toxin B subunit (CTB) facilitates vesicle docking, trafficking and exocytosis. | 2010 | Integr Biol (Camb) | pmid:20535419 |
| Cole AA et al. | Co-segregation of AMPA receptors with G(M1) ganglioside in synaptosomal membrane subfractions. | 2010 | Biochem. J. | pmid:20148761 |
| Yamamoto N et al. | Insulin inhibits Abeta fibrillogenesis through a decrease of the GM1 ganglioside-rich microdomain in neuronal membranes. | 2010 | J. Neurochem. | pmid:20132476 |
| Yagi-Utsumi M et al. | NMR characterization of the interactions between lyso-GM1 aqueous micelles and amyloid beta. | 2010 | FEBS Lett. | pmid:20074569 |
| Demarco ML et al. | Presentation of membrane-anchored glycosphingolipids determined from molecular dynamics simulations and NMR paramagnetic relaxation rate enhancement. | 2010 | J. Am. Chem. Soc. | pmid:20058858 |
| Qi R et al. | The mechanism of polyplex internalization into cells: testing the GM1/caveolin-1 lipid raft mediated endocytosis pathway. | 2010 | Mol. Pharm. | pmid:20025295 |
| Mahfoud R et al. | A major fraction of glycosphingolipids in model and cellular cholesterol-containing membranes is undetectable by their binding proteins. | 2010 | J. Biol. Chem. | pmid:20716521 |
| Silveira e Souza AM et al. | Gangliosides are important for the preservation of the structure and organization of RBL-2H3 mast cells. | 2010 | J. Histochem. Cytochem. | pmid:19786609 |
| Ledeen RW and Wu G | In search of a solution to the sphinx-like riddle of GM1. | 2010 | Neurochem. Res. | pmid:21076871 |
| Naruse M et al. | Acrosome reaction-related steroidal saponin, Co-ARIS, from the starfish induces structural changes in microdomains. | 2010 | Dev. Biol. | pmid:20816679 |
| Carton I et al. | Label-free detection of clustering of membrane-bound proteins. | 2010 | Anal. Chem. | pmid:21028837 |
| Awad A et al. | Acute motor axonal neuropathy in association with Sjögren syndrome. | 2010 | Muscle Nerve | pmid:20976785 |
| Piepers S et al. | IVIg inhibits classical pathway activity and anti-GM1 IgM-mediated complement deposition in MMN. | 2010 | J. Neuroimmunol. | pmid:20920831 |
| Mrówczyńska L et al. | Echinophilic proteins stomatin, sorcin, and synexin locate outside gangliosideM1 (GM1) patches in the erythrocyte membrane. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20858460 |
| O'Ferrall EK et al. | Demyelinating symmetric motor polyneuropathy with high titers of anti-GM1 antibodies. | 2010 | Muscle Nerve | pmid:20730877 |
| Ueda A et al. | Anti-GM1 antibodies affect the integrity of lipid rafts. | 2010 | Mol. Cell. Neurosci. | pmid:20659560 |
| Yuyama K and Yanagisawa K | Sphingomyelin accumulation provides a favorable milieu for GM1 ganglioside-induced assembly of amyloid beta-protein. | 2010 | Neurosci. Lett. | pmid:20599476 |
| Nakayasu K et al. | [Case of Fisher syndrome with ocular flutter]. | 2010 | Nippon Ganka Gakkai Zasshi | pmid:20593660 |
| Pestronk A et al. | Motor neuropathies and serum IgM binding to NS6S heparin disaccharide or GM1 ganglioside. | 2010 | J. Neurol. Neurosurg. Psychiatry | pmid:20581137 |
| Tomita M et al. | Pyramidal tract involvement in Guillain-Barré syndrome associated with anti-GM1 antibody. | 2010 | J. Neurol. Neurosurg. Psychiatry | pmid:20460598 |
| Eckert GP et al. | Lipid membranes and beta-amyloid: a harmful connection. | 2010 | Curr. Protein Pept. Sci. | pmid:20423299 |
| Zhang M et al. | Association study between an outbreak of Guillain-Barre syndrome in Jilin, China, and preceding Campylobacter jejuni infection. | 2010 | Foodborne Pathog. Dis. | pmid:20455754 |
| Marcon RM et al. | Potentializing the effects of GM1 by hyperbaric oxygen therapy in acute experimental spinal cord lesion in rats. | 2010 | Spinal Cord | pmid:20421874 |
| Sutedja NA et al. | Increased frequency of HLA-DRB1*15 in patients with multifocal motor neuropathy. | 2010 | Neurology | pmid:20211906 |
| Schneider JS et al. | GM1 ganglioside in Parkinson's disease: Results of a five year open study. | 2010 | J. Neurol. Sci. | pmid:20206941 |
| Loc NH et al. | Tissue culture and expression of Escherichia coli heat-labile enterotoxin B subunit in transgenic Peperomia pellucida. | 2010 | Protein Expr. Purif. | pmid:20176109 |
| Huang F et al. | GM1 and nerve growth factor modulate mitochondrial membrane potential and neurofilament light mRNA expression in cultured dorsal root ganglion and spinal cord neurons during excitotoxic glutamate exposure. | 2010 | J Clin Neurosci | pmid:20171893 |
| Di Pasquale E et al. | Altered ion channel formation by the Parkinson's-disease-linked E46K mutant of alpha-synuclein is corrected by GM3 but not by GM1 gangliosides. | 2010 | J. Mol. Biol. | pmid:20114052 |
| McCombe PA and Csurhes PA | T cells from patients with Guillain-Barré syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1. | 2010 | J Clin Neurosci | pmid:20093028 |
| Valdomero A et al. | GM1 ganglioside enhances the rewarding properties of cocaine in rats. | 2010 | Eur. J. Pharmacol. | pmid:20044989 |
| Cheshev P et al. | Synthesis and affinity evaluation of a small library of bidentate cholera toxin ligands: towards nonhydrolyzable ganglioside mimics. | 2010 | Chemistry | pmid:20039344 |
| Ewers H et al. | GM1 structure determines SV40-induced membrane invagination and infection. | 2010 | Nat. Cell Biol. | pmid:20023649 |
| Sachl R et al. | A comparative study on ganglioside micelles using electronic energy transfer, fluorescence correlation spectroscopy and light scattering techniques. | 2009 | Phys Chem Chem Phys | pmid:19458836 |
| Chen CG et al. | Amplification of immune responses against a DNA-delivered idiotypic lymphoma antigen by fusion to the B subunit of E. coli heat labile toxin. | 2009 | Vaccine | pmid:19450635 |
| Mikhalyov I et al. | Fluorescent BODIPY-labelled GM1 gangliosides designed for exploring lipid membrane properties and specific membrane-target interactions. | 2009 | Chem. Phys. Lipids | pmid:19428361 |
| Bunyakul N et al. | Cholera toxin subunit B detection in microfluidic devices. | 2009 | Anal Bioanal Chem | pmid:18777170 |
| Nixon B et al. | Composition and significance of detergent resistant membranes in mouse spermatozoa. | 2009 | J. Cell. Physiol. | pmid:18726997 |
| Kim YS et al. | Expression and assembly of cholera toxin B subunit (CTB) in transgenic carrot (Daucus carota L.). | 2009 | Mol. Biotechnol. | pmid:18642102 |
| Lü HZ and Li BQ | Effect of HMG-CoA reductase inhibitors on activation of human gammadeltaT cells induced by Mycobacterium tuberculosis antigens. | 2009 | Immunopharmacol Immunotoxicol | pmid:19555197 |
| Komori T et al. | Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates. | 2009 | Carbohydr. Res. | pmid:19560125 |
| Zhang H et al. | Ganglioside GM1 binding the N-terminus of amyloid precursor protein. | 2009 | Neurobiol. Aging | pmid:18077059 |
| Ayalew S et al. | Intranasal vaccination of calves with Mannheimia haemolytica chimeric protein containing the major surface epitope of outer membrane lipoprotein PlpE, the neutralizing epitope of leukotoxin, and cholera toxin subunit B. | 2009 | Vet. Immunol. Immunopathol. | pmid:19581005 |
| Takimoto K et al. | Storage of gangliosides GM2 and fucosyl GM1 in the kidney of MCC strain of mastomys (Praomys coucha). | 2009 | J. Biochem. | pmid:19556222 |
| Van Slambrouck S et al. | AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression. | 2009 | Int. J. Oncol. | pmid:19724904 |
| Bodhankar S et al. | NK cells interfere with the generation of resistance against mycoplasma respiratory infection following nasal-pulmonary immunization. | 2009 | J. Immunol. | pmid:19625649 |
| Hong S et al. | The role of ganglioside GM1 in cellular internalization mechanisms of poly(amidoamine) dendrimers. | 2009 | Bioconjug. Chem. | pmid:19583240 |
| Nagorny P et al. | On the emerging role of chemistry in the fashioning of biologics: synthesis of a bidomainal fucosyl GM1-based vaccine for the treatment of small cell lung cancer. | 2009 | J. Org. Chem. | pmid:19555091 |
| Wu G et al. | Sodium-calcium exchanger complexed with GM1 ganglioside in nuclear membrane transfers calcium from nucleoplasm to endoplasmic reticulum. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19541636 |
| Biraboneye AC et al. | Potential neuroprotective drugs in cerebral ischemia: new saturated and polyunsaturated lipids coupled to hydrophilic moieties: synthesis and biological activity. | 2009 | J. Med. Chem. | pmid:19537799 |
| Kovács T et al. | The density of GM1-enriched lipid rafts correlates inversely with the efficiency of transfection mediated by cationic liposomes. | 2009 | Cytometry A | pmid:19526485 |
| Park JY et al. | On the mechanism of internalization of alpha-synuclein into microglia: roles of ganglioside GM1 and lipid raft. | 2009 | J. Neurochem. | pmid:19457104 |