| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Crain SM and Shen KF | GM1 ganglioside-induced modulation of opioid receptor-mediated functions. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668346 |
| Müthing J et al. | Glycosphingolipids of skeletal muscle: I. Subcellular distribution of neutral glycosphingolipids and gangliosides in rabbit skeletal muscle. | 1998 | Carbohydr. Res. | pmid:9658569 |
| Cox NR et al. | Thymic alterations in feline GM1 gangliosidosis. | 1998 | Vet. Immunol. Immunopathol. | pmid:9656423 |
| Sack DA et al. | Microtiter assay for detecting Campylobacter spp. and Helicobacter pylori with surface gangliosides which bind cholera toxin. | 1998 | J. Clin. Microbiol. | pmid:9650959 |
| Marchesini S et al. | Ganglioside GM2 is substrate for a sialidase in MDCK cells. | 1998 | FEBS Lett. | pmid:9645488 |
| Hirai M and Takizawa T | Intensive extrusion and occlusion of water in ganglioside micelles with thermal reversibility. | 1998 | Biophys. J. | pmid:9635755 |
| Schneider JS et al. | Parkinson's disease: improved function with GM1 ganglioside treatment in a randomized placebo-controlled study. | 1998 | Neurology | pmid:9633704 |
| Orthaber D and Glatter O | Time and temperature dependent aggregation behaviour of the ganglioside GM1 in aqueous solution. | 1998 | Chem. Phys. Lipids | pmid:9631537 |
| Odaka M et al. | N-glycolylneuraminic acid-containing GM1 is a new molecule for serum antibody in Guillain-Barré syndrome. | 1998 | Ann. Neurol. | pmid:9629854 |
| Mukerjee S et al. | Characterization of human IgG1 monoclonal antibody against gangliosides expressed on tumor cells. | 1998 | Hybridoma | pmid:9627053 |
| Zhou J et al. | Gangliosides enhance apoptosis of thymocytes. | 1998 | Cell. Immunol. | pmid:9606992 |
| Schweizer F et al. | Interaction between the pili of Pseudomonas aeruginosa PAK and its carbohydrate receptor beta-D-GalNAc(1-->4)beta-D-Gal analogs. | 1998 | Can. J. Microbiol. | pmid:9606914 |
| Vénien-Bryan C et al. | Characterization of the growth of 2D protein crystals on a lipid monolayer by ellipsometry and rigidity measurements coupled to electron microscopy. | 1998 | Biophys. J. | pmid:9591688 |
| Marks N et al. | Activation of caspase-3 and apoptosis in cerebellar granule cells. | 1998 | J. Neurosci. Res. | pmid:9590441 |
| Harder T et al. | Lipid domain structure of the plasma membrane revealed by patching of membrane components. | 1998 | J. Cell Biol. | pmid:9585412 |
| Wolf AA et al. | Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia. | 1998 | J. Cell Biol. | pmid:9585411 |
| Ilangumaran S et al. | CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes. | 1998 | Blood | pmid:9573028 |
| Wang M et al. | Natural killer cell depletion fails to influence initial CD4 T cell commitment in vivo in exogenous antigen-stimulated cytokine and antibody responses. | 1998 | J. Immunol. | pmid:9570522 |
| Pohl P et al. | Membrane fusion mediated by ricin and viscumin. | 1998 | Biochim. Biophys. Acta | pmid:9565651 |
| Yanagisawa K and Ihara Y | GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain. | Neurobiol. Aging | pmid:9562471 |