| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu ZX et al. | NK cells cause liver injury and facilitate the induction of T cell-mediated immunity to a viral liver infection. | 2000 | J. Immunol. | pmid:10843705 |
| Hazes B et al. | Crystal structure of Pseudomonas aeruginosa PAK pilin suggests a main-chain-dominated mode of receptor binding. | 2000 | J. Mol. Biol. | pmid:10843854 |
| Badizadegan K et al. | Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1). | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10859219 |
| Lenne PF et al. | Synchrotron radiation diffraction from two-dimensional protein crystals at the air/water interface. | 2000 | Biophys. J. | pmid:10866975 |
| Milewicz C et al. | Membrane expression of Thy-1,2 and GM1 ganglioside on differentiating T lymphocytes. | 1976 | J. Immunol. | pmid:1086862 |
| Galisteo M et al. | Hepatotoxicity of tacrine: occurrence of membrane fluidity alterations without involvement of lipid peroxidation. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10871308 |
| Sautter J et al. | Systemic treatment with GM1 ganglioside improves survival and function of cryopreserved embryonic midbrain grafted to the 6-hydroxydopamine-lesioned rat striatum. | 2000 | Exp. Neurol. | pmid:10877922 |
| Chen XP et al. | Ganglioside control over IL-4 priming and cytokine production in activated T cells. | 2000 | Cytokine | pmid:10880242 |
| Pestronk A | Testing for serum IgM binding to GM1 ganglioside in clinical practice. | 2000 | Neurology | pmid:10881275 |
| Kosanke SD et al. | Clinical and biochemical abnormalities in porcine GM2-gangliosidosis. | 1978 | Vet. Pathol. | pmid:108843 |
| Le Forestier N and Bouche P | [Motor conduction block]. | 2000 | Rev. Neurol. (Paris) | pmid:10891806 |
| Rampersaud AA et al. | Gangliosides and growth factor receptor regulation. | 1999 | Biochem. Soc. Trans. | pmid:10917613 |
| Zhang D et al. | [Effect of ganglioside GM1 on the metabolism of Alzheimer amyloid beta-protein precursor]. | 1998 | Zhonghua Yi Xue Za Zhi | pmid:10923524 |
| Linton D et al. | Phase variation of a beta-1,3 galactosyltransferase involved in generation of the ganglioside GM1-like lipo-oligosaccharide of Campylobacter jejuni. | 2000 | Mol. Microbiol. | pmid:10931344 |
| Sefrioui H et al. | Graft-versus-leukemia effect in minor antigen mismatched chimeras given delayed donor leucocyte infusion: immunoregulatory aspects and role of donor T and ASGM1-positive cells. | 2000 | Transplantation | pmid:10933162 |
| Song X et al. | Flow cytometry-based biosensor for detection of multivalent proteins. | 2000 | Anal. Biochem. | pmid:10933853 |
| Wilkening G et al. | Degradation of membrane-bound ganglioside GM1. Stimulation by bis(monoacylglycero)phosphate and the activator proteins SAP-B and GM2-AP. | 2000 | J. Biol. Chem. | pmid:10942779 |
| Seidl EC | Promising pharmacological agents in the management of acute spinal cord injury. | 2000 | Pharm Pract Manag Q | pmid:10947539 |
| Kanda T et al. | Anti-GM1 antibody facilitates leakage in an in vitro blood-nerve barrier model. | 2000 | Neurology | pmid:10953200 |
| Fang Y et al. | Endogenous GM1 ganglioside of the plasma membrane promotes neuritogenesis by two mechanisms. | 2000 | Neurochem. Res. | pmid:10959489 |