| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamamoto N et al. | Propofol and thiopental suppress amyloid fibril formation and GM1 ganglioside expression through the γ-aminobutyric acid A receptor. | 2013 | Anesthesiology | pmid:23422796 |
| Sato S et al. | A Self-Assembled Spherical Complex Displaying a Gangliosidic Glycan Cluster Capable of Interacting with Amyloidogenic Proteins. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:26015171 |
| Geisler FH et al. | Past and current clinical studies with GM-1 ganglioside in acute spinal cord injury. | 1993 | Ann Emerg Med | pmid:8503523 |
| Caudie C et al. | [Antiganglioside autoantibody profiles in Guillain-Barré syndrome]. | Ann. Biol. Clin. (Paris) | pmid:12368145 | |
| Caudie C et al. | [Measurement of antiganglioside autoantibodies by immunodot-blot assay: clinical importance in peripheral neuropathies]. | Ann. Biol. Clin. (Paris) | pmid:10518060 | |
| Swallow DM et al. | The role of lysosomal sialidase and beta-galactosidase in processing the complex carbohydrate chains on lysosomal enzymes and possibly other glycoproteins. | 1984 | Ann. Hum. Genet. | pmid:6431895 |
| Rösner H | Significance of gangliosides in neuronal differentiation of neuroblastoma cells and neurite growth in tissue culture. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668353 |
| Freed WJ et al. | Embryonic substantia nigra grafts. Factors controlling behavioral efficacy and reinnervation of the host striatum. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3474960 |
| Wallace JI et al. | T-cell ratios: sperm and asialo GM1 antibody levels in New York City prostitutes. | 1984 | Ann. N. Y. Acad. Sci. | pmid:6242009 |
| Yuki N and Miyatake T | Guillain-Barré syndrome and Fisher's syndrome following Campylobacter jejuni infection. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668366 |
| Baumann N et al. | Antiglycolipid antibodies in motor neuropathies. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668365 |
| Rothblat DS and Schneider JS | Effects of GM1 ganglioside treatment on dopamine innervation of the striatum of MPTP-treated mice. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668361 |
| Ferrari G and Greene LA | Promotion of neuronal survival by GM1 ganglioside. Phenomenology and mechanism of action. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668360 |
| Saito M et al. | The semisynthetic glycosphingolipid LIGA20 potently protects neurons against apoptosis. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668359 |
| Dreyfus H et al. | Gangliosides and neurotrophic growth factors in the retina. Molecular interactions and applications as neuroprotective agents. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668358 |
| Ando S et al. | Gangliosides and sialylcholesterol as modulators of synaptic functions. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668357 |
| Hadjiconstantinou M and Neff NH | GM1 and the aged brain. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668356 |
| Ledeen RW et al. | The role of GM1 and other gangliosides in neuronal differentiation. Overview and new finding. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668350 |
| Wu G et al. | The role of GM1 ganglioside in regulating excitatory opioid effects. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668347 |
| Crain SM and Shen KF | GM1 ganglioside-induced modulation of opioid receptor-mediated functions. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668346 |