MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Frontczak-Baniewicz M et al. | Beneficial effects of GM1 ganglioside on photochemically-induced microvascular injury in cerebral cortex and hypophysis in rat. | 2000 | Exp. Toxicol. Pathol. | pmid:10965984 |
Go T | Partial oculomotor nerve palsy associated with elevated anti-galactocerebroside and anti-GM1 antibodies. | 2000 | J. Pediatr. | pmid:10969272 |
Goettl VM et al. | Retinal cholinergic and dopaminergic deficits of aged rats are improved following treatment with GM1 ganglioside. | 2000 | Brain Res. | pmid:10980236 |
Shamshiev A et al. | The alphabeta T cell response to self-glycolipids shows a novel mechanism of CD1b loading and a requirement for complex oligosaccharides. | 2000 | Immunity | pmid:10981968 |
Montero EF et al. | Kidney and small intestine morphologic aspects following systemic use of gangliosides. | 2000 | Transplant. Proc. | pmid:10995967 |
Bernardi A et al. | Second generation mimics of ganglioside GM1 as artificial receptors for cholera toxin: replacement of the sialic acid moiety. | 2000 | Bioorg. Med. Chem. Lett. | pmid:11012028 |
Oliveira AL and Langone F | GM-1 ganglioside treatment reduces motoneuron death after ventral root avulsion in adult rats. | 2000 | Neurosci. Lett. | pmid:11027851 |
pmid:11034355 | ||||
Avrova NF et al. | The use of antioxidants to prevent glutamate-induced derangement of calcium ion metabolism in rat cerebral cortex synaptosomes. | 2000 Sep-Oct | Neurosci. Behav. Physiol. | pmid:11037144 |
van Ginkel FW et al. | Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues. | 2000 | J. Immunol. | pmid:11045998 |
Radhakrishnan A et al. | Condensed complexes, rafts, and the chemical activity of cholesterol in membranes. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11050164 |
Yuan C and Johnston LJ | Distribution of ganglioside GM1 in L-alpha-dipalmitoylphosphatidylcholine/cholesterol monolayers: a model for lipid rafts. | 2000 | Biophys. J. | pmid:11053150 |
Baumann N | Specificity of antiglycolipid antibodies. | 2000 | Clin Rev Allergy Immunol | pmid:11064824 |
Portoukalian J | Immunogenicity of glycolipids. | 2000 | Clin Rev Allergy Immunol | pmid:11064828 |
Silv RH et al. | Effects of neonatal ganglioside GM1 administration on memory in adult and old rats. | 2000 | Pharmacol. Toxicol. | pmid:11068852 |
Emoto M et al. | Participation of leukocyte function-associated antigen-1 and NK cells in the homing of thymic CD8+NKT cells to the liver. | 2000 | Eur. J. Immunol. | pmid:11069089 |
Ishikawa D and Taki T | Thin-layer chromatography immunostaining. | 2000 | Meth. Enzymol. | pmid:11070869 |
MacKenzie CR and Hirama T | Quantitative analyses of binding affinity and specificity for glycolipid receptors by surface plasmon resonance. | 2000 | Meth. Enzymol. | pmid:11070874 |
Lingwood CA et al. | Analysis of interactions between glycosphingolipids and microbial toxins. | 2000 | Meth. Enzymol. | pmid:11070894 |
Schwarzmann G et al. | Using biotinylated gangliosides to study their distribution and traffic in cells by immunoelectron microscopy. | 2000 | Meth. Enzymol. | pmid:11070901 |