Ganglioside GI

Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GI?

Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ganglioside GI

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Gaucher Disease D005776 13 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GI

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GI?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Ganglioside GI?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ganglioside GI?

Related references are published most in these journals:

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What genes are associated with Ganglioside GI?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ganglioside GI?

Knock-out

Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).

Transgenic Model

Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).

Disease model

Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ganglioside GI

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Authors Title Published Journal PubMed Link
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Marty P et al. Fortuitous Diagnosis of Preexisting Neuropathy During Ultrasound-Guided Regional Anesthesia Performance: A Case Report. 2017 A A Case Rep pmid:28368901
Matsuzaki K How do membranes initiate Alzheimer's Disease? Formation of toxic amyloid fibrils by the amyloid β-protein on ganglioside clusters. 2014 Acc. Chem. Res. pmid:25029558
Hung JT et al. Design, Synthesis, and Biological Evaluation of Ganglioside Hp-s1 Analogues Varying at Glucosyl Moiety. 2016 ACS Chem Neurosci pmid:27276519
Chang JC and Rosenthal SJ Visualization of lipid raft membrane compartmentalization in living RN46A neuronal cells using single quantum dot tracking. 2012 ACS Chem Neurosci pmid:23077717
Huang M et al. GM1-Modified Lipoprotein-like Nanoparticle: Multifunctional Nanoplatform for the Combination Therapy of Alzheimer's Disease. 2015 ACS Nano pmid:26440073
Wittenberg NJ et al. Facile assembly of micro- and nanoarrays for sensing with natural cell membranes. 2011 ACS Nano pmid:21842844
Masserini M et al. Glycolipid-protein interaction in the mechanism of signal transduction: studies with a photoactivable ganglioside analogue. 1998 Acta Biochim. Pol. pmid:9821870
Trandaburu I et al. The immunohistochemical localization of the glycosphingolipid asialo-GM1 in the intestine of weaned piglets. 2011 Acta Histochem. pmid:19740529
Werka T et al. Partial lesion of dorsal hippocampal afferents and GM1-ganglioside treatment effects on the two-way avoidance in rats. 1988 Acta Neurobiol Exp (Wars) pmid:3407451
Skup M et al. Analysis of the time course of GM1 ganglioside effect on changes in choline acetyltransferase activity in partially denervated rat hippocampus. 1987 Acta Neurobiol Exp (Wars) pmid:3445796
Jegliński W et al. Difluoromethylornithine counteracts lesion-induced astrogliosis in rat hippocampus: enhancement of inhibitory effect by combined treatment with GM1 ganglioside. 1996 Acta Neurobiol Exp (Wars) pmid:8768305
Rong X et al. Ganglioside GM1 reduces white matter damage in neonatal rats. 2013 Acta Neurobiol Exp (Wars) pmid:24129486
Lazarewicz JW et al. Effects of MK-801 and ganglioside GM1 on postischemic prostanoid release and hippocampal lesion in gerbil brain. 1994 Acta Neurobiol Exp (Wars) pmid:7887181
Skup M and Gradkowska M Early changes in ornithine decarboxylase activity in a partially denervated hippocampus of rats untreated and treated with GM1 ganglioside. 1990 Acta Neurobiol Exp (Wars) pmid:2130667
Geisler FH et al. GM1 gangliosides in the treatment of spinal cord injury: report of preliminary data analysis. 1990 Acta Neurobiol Exp (Wars) pmid:2130666
Lipartiti M et al. Monosialoganglioside effects following cerebral ischemia: relationship with anti-neuronotoxic and pro-neuronotrophic effects. 1990 Acta Neurobiol Exp (Wars) pmid:2130663
Casamenti F et al. Lesions of the nucleus basalis magnocellularis in the rat: morphological, biochemical and behavioral reparative effect of nerve growth factor and ganglioside GM1. 1990 Acta Neurobiol Exp (Wars) pmid:2130662
Cuello AC et al. Evidence for nerve growth factor-ganglioside interaction in forebrain cholinergic neurons. 1990 Acta Neurobiol Exp (Wars) pmid:2130661
Stein DG Some functional consequences of chronic GM1 ganglioside administration in brain damaged rats. 1990 Acta Neurobiol Exp (Wars) pmid:2130658
Voumvourakis C et al. Serum anti-GM1 and anti-GD1a antibodies in patients with motor neuron disease. 1992 Acta Neurol. Scand. pmid:1481647
Zappia M et al. Anti-GM1 ganglioside antibodies in Parkinson's disease. 2002 Acta Neurol. Scand. pmid:12067330
Uyama E et al. Type 3 GM1 gangliosidosis: characteristic MRI findings correlated with dystonia. 1992 Acta Neurol. Scand. pmid:1336295
Koga M et al. Antecedent symptoms in Guillain-Barré syndrome: an important indicator for clinical and serological subgroups. 2001 Acta Neurol. Scand. pmid:11328202
Annunziata P et al. Association of polyclonal anti-GM1 IgM and anti-neurofilament antibodies with CSF oligoclonal bands in a young with amyotrophic lateral sclerosis. 1995 Acta Neurol. Scand. pmid:8610492
Niebroj-Dobosz I et al. Anti-neural antibodies in serum and cerebrospinal fluid of amyotrophic lateral sclerosis (ALS) patients. 1999 Acta Neurol. Scand. pmid:10694928
Svennerholm L et al. Parenteral administration of GM1 ganglioside to presenile Alzheimer patients. 1990 Acta Neurol. Scand. pmid:2330815
Sindern E et al. Serum antibodies to GM1 and GM3-gangliosides in systemic lupus erythematosus with chronic inflammatory demyelinating polyradiculoneuropathy. 1991 Acta Neurol. Scand. pmid:1887763
Coyle JT et al. Development of central neurotransmitter-specified neuronal systems: implications for pediatric neuro-psychiatric disorders. 1984 Acta Neurol. Scand. pmid:6147947
Svennerholm L Gangliosides and nerve growth factors in Alzheimer's disease. 1990 Acta Neurol. Scand., Suppl. pmid:2220320
Kirkeby S Cholera toxin B subunit-binding and ganglioside GM1 immuno-expression are not necessarily correlated in human salivary glands. 2014 Acta Odontol. Scand. pmid:24655314
Lekman A et al. Gangliosides in children with autism. 1995 Acta Paediatr. pmid:7549298
Varkila K et al. Asialo GM1+ NK cells have opposite roles in the activation of alloreactive cytotoxic T lymphocyte (CTL) response in vitro and in vivo. 1987 Acta Pathol Microbiol Immunol Scand C pmid:3499751
Liu JR et al. Monosialoganglioside protected ischemic rat hippocampal slices through stabilizing expression of N-methyl-D-aspartate receptor subunit. 2004 Acta Pharmacol. Sin. pmid:15169623
Janson AM et al. GM1 ganglioside protects against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of nigrostriatal dopamine neurons in the black mouse. 1988 Acta Physiol. Scand. pmid:3265839
Agnati LF et al. Effects of lesions and ganglioside GM1 treatment on striatal polyamine levels and nigral DA neurons. A role of putrescine in the neurotropic activity of gangliosides. 1985 Acta Physiol. Scand. pmid:2864781
Cimino M et al. Differential effect of ganglioside GM1 on rat brain phosphoproteins: potentiation and inhibition of protein phosphorylation regulated by calcium/calmodulin and calcium/phospholipid-dependent protein kinases. 1987 Acta Physiol. Scand. pmid:3604718
Agnati LF et al. Effects of ganglioside GM1 treatment on striatal glucose metabolism, blood flow, and protein phosphorylation of the rat. 1985 Acta Physiol. Scand. pmid:2996304
Toffano G et al. Effect of GM1 ganglioside treatment on the recovery of dopaminergic nigro-striatal neurons after different types of lesion. 1984 Acta Physiol. Scand. pmid:6151339
Fuxe K et al. On the cellular localization and distribution of the ganglioside GM1 in the rat brain as revealed by immunofluorescence histochemistry of cholera toxin binding sites. 1989 Acta Physiol. Scand. pmid:2690577
Agnati LF et al. Gangliosides increase the survival of lesioned nigral dopamine neurons and favour the recovery of dopaminergic synaptic function in striatum of rats by collateral sprouting. 1983 Acta Physiol. Scand. pmid:6141701
Agnati LF et al. Selective modulation of 3H-spiperone labeled 5-HT receptors by subchronic treatment with the ganglioside GM1 in the rat. 1983 Acta Physiol. Scand. pmid:6869038
Cossy Isasi S et al. GM1 ganglioside induced myocardial restoration and survival of mice with experimental Chagas' disease. 1999 Acta Trop. pmid:10546847
Cohen R et al. Lipid Regulation of Acrosome Exocytosis. 2016 Adv Anat Embryol Cell Biol pmid:27194352
Luckham PF Manipulating forces between surfaces: applications in colloid science and biophysics. 2004 Adv Colloid Interface Sci pmid:15571661
Liu D et al. An In Situ Gelling Drug Delivery System for Improved Recovery after Spinal Cord Injury. 2016 Adv Healthc Mater pmid:27113454
Kato K Structural glycomic approaches to molecular recognition events on cell surfaces. 2012 Adv. Exp. Med. Biol. pmid:22695835
Yu RK et al. Pathological roles of ganglioside mimicry in Guillain-Barré syndrome and related neuropathies. 2011 Adv. Exp. Med. Biol. pmid:21618117
Chieco-Bianchi L et al. CD4 modulation and inhibition of HIV-1 infectivity induced by monosialoganglioside GM1 in vitro. 1989 AIDS pmid:2478163
Seddiki N et al. Membrane glycolipids and human immunodeficiency virus infection of primary macrophages. 1996 AIDS Res. Hum. Retroviruses pmid:8744580
Chen SY et al. The membrane disordering effect of ethanol on neural crest cells in vitro and the protective role of GM1 ganglioside. Alcohol pmid:8949954
Stout JG et al. Ethanol disordering of GM1-enriched short-sleep synaptosomal plasma membranes. Alcohol pmid:7818801
Laev H et al. Cortical cell plasma membrane alterations after in vitro alcohol exposure: prevention by GM1 ganglioside. Alcohol pmid:8814655
Wallis CJ et al. GM1 ganglioside reduces ethanol intoxication and the development of ethanol dependence. Alcohol pmid:8590622
Cadete-Leite A et al. Effects of GM1 ganglioside upon neuronal degeneration during withdrawal from alcohol. Alcohol pmid:1781918
Stout JG et al. Characterization of a GM1-dependent surface interaction for alcohol with DPPC membranes. Alcohol pmid:7639951
Brandão F et al. GM1 and piracetam do not revert the alcohol-induced depletion of cholinergic fibers in the hippocampal formation of the rat. 1999 Alcohol pmid:10487390
Ullman MD et al. Effect of exogenous GM1 on ethanol sensitivity in selectively bred mouse lines. 1997 Alcohol. Clin. Exp. Res. pmid:9194921
Ullman MD et al. Surface exposure of synaptosomal gangliosides from long-sleep and short-sleep mice. 1992 Alcohol. Clin. Exp. Res. pmid:1443421
Ullman MD et al. Gangliosides of long sleep and short sleep mouse cerebellum and hippocampus and cerebellar and whole brain synaptosomal plasma membranes. 1987 Alcohol. Clin. Exp. Res. pmid:3296834
Saito M et al. Effects of gangliosides on ethanol-induced neurodegeneration in the developing mouse brain. 2007 Alcohol. Clin. Exp. Res. pmid:17374046
Laev H et al. In utero ethanol exposure retards growth and alters morphology of cortical cultures: GM1 reverses effects. 1995 Alcohol. Clin. Exp. Res. pmid:8561295
Slomiany BL et al. GM1 ganglioside protection against ethanol-induced gastric mucosal injury. 1991 Alcohol. Clin. Exp. Res. pmid:2058795
Hoffman PL et al. Attenuation of glutamate-induced neurotoxicity in chronically ethanol-exposed cerebellar granule cells by NMDA receptor antagonists and ganglioside GM1. 1995 Alcohol. Clin. Exp. Res. pmid:7573799
Hungund BL et al. Ganglioside GM1 reduces fetal alcohol effects in rat pups exposed to ethanol in utero. 1994 Alcohol. Clin. Exp. Res. pmid:7847614
Saito M et al. Alcohol reduces GM1 ganglioside content in the serum of inbred mouse strains. 2004 Alcohol. Clin. Exp. Res. pmid:15252298
Basavarajappa BS et al. Activation of arachidonic acid-specific phospholipase A2 in human neuroblastoma cells after chronic alcohol exposure: prevention by GM1 ganglioside. 1997 Alcohol. Clin. Exp. Res. pmid:9347079
Liu L et al. Alterations in cholesterol and ganglioside GM1 content of lipid rafts in platelets from patients with Alzheimer disease. Alzheimer Dis Assoc Disord pmid:24759545
Hatzifilippou E et al. Antibodies against GM1 in demented patients. Am J Alzheimers Dis Other Demen pmid:18509104
Hatzifilippou E et al. Antibodies against gangliosides in patients with dementia. 2014 Am J Alzheimers Dis Other Demen pmid:24838532
Hu H et al. Factors affecting the prognosis of patients with delayed encephalopathy after acute carbon monoxide poisoning. 2011 Am J Emerg Med pmid:20825794
Warner TG et al. Prenatal diagnosis of GM1 gangliosidosis by detection of galactosyl-oligosaccharides in amniotic fluid with high-performance liquid chromatography. 1983 Am. J. Hum. Genet. pmid:6412544
Gravel RA et al. Infantile sialidosis: a phenocopy of type 1 GM1 gangliosidosis distinguished by genetic complementation and urinary oligosaccharides. 1979 Am. J. Hum. Genet. pmid:117700
Nishimoto J et al. GM1-gangliosidosis (genetic beta-galactosidase deficiency): identification of four mutations in different clinical phenotypes among Japanese patients. 1991 Am. J. Hum. Genet. pmid:1909089
Yoshida K et al. Human beta-galactosidase gene mutations in GM1-gangliosidosis: a common mutation among Japanese adult/chronic cases. 1991 Am. J. Hum. Genet. pmid:1907800
Murnane RD et al. Prenatal lesions in an ovine fetus with GM1 gangliosidosis. 1991 Am. J. Med. Genet. pmid:1907804
Witkin SS et al. Antibodies to the neutral glycolipid asialo ganglio-N-tetraosylceramide: association with gynecologic cancers. 1985 Am. J. Obstet. Gynecol. pmid:3976767
Lipscomb MF et al. Role of natural killer cells in resistance to Cryptococcus neoformans infections in mice. 1987 Am. J. Pathol. pmid:3618730
Russelakis-Carneiro M et al. Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts. 2004 Am. J. Pathol. pmid:15509552
Alroy J et al. Canine GM1-gangliosidosis. A clinical, morphologic, histochemical, and biochemical comparison of two different models. 1992 Am. J. Pathol. pmid:1546746
Yang L et al. Bone marrow-derived mesenchymal stem cells differentiate to hepatic myofibroblasts by transforming growth factor-β1 via sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis. 2012 Am. J. Pathol. pmid:22609227
Young LH et al. In vivo expression of perforin by natural killer cells during a viral infection. Studies on uveitis produced by herpes simplex virus type I. 1990 Am. J. Pathol. pmid:2190470
Chu SH et al. Age and cortisone alter host responsiveness to cholera toxin in the developing gut. 1989 Am. J. Physiol. pmid:2536237
Hoch BS and Levine SD Cholera toxin enhances adenylate cyclase-dependent transport in toad urinary bladder. 1987 Am. J. Physiol. pmid:2436487
Lencer WI et al. Signal transduction by cholera toxin: processing in vesicular compartments does not require acidification. 1995 Am. J. Physiol. pmid:7485507
Hyun CS and Kimmich GA Interaction of cholera toxin and Escherichia coli enterotoxin with isolated intestinal epithelial cells. 1984 Am. J. Physiol. pmid:6095676
Lencer WI et al. Interaction of cholera toxin with cloned human goblet cells in monolayer culture. 1990 Am. J. Physiol. pmid:2154122
Hosoya S et al. Innate immune responses involving natural killer and natural killer T cells promote liver regeneration after partial hepatectomy in mice. 2013 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:23086918
Badizadegan K et al. Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1). 2000 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:10859219