| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Inada T et al. | Vaccines using dendritic cells, differentiated with propofol, enhance antitumor immunity in mice. | 2009 | Immunopharmacol Immunotoxicol | pmid:19951075 |
| Furian AF et al. | Nitric oxide and potassium channels mediate GM1 ganglioside-induced vasorelaxation. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19894035 |
| Isa P et al. | Dissecting the role of integrin subunits alpha 2 and beta 3 in rotavirus cell entry by RNA silencing. | 2009 | Virus Res. | pmid:19635510 |
| Peters I et al. | The interaction of beta-amyloid protein with cellular membranes stimulates its own production. | 2009 | Biochim. Biophys. Acta | pmid:19366591 |
| Ogawa G et al. | Antibodies to ganglioside complexes consisting of asialo-GM1 and GQ1b or GT1a in Fisher and Guillain-Barré syndromes. | 2009 | J. Neuroimmunol. | pmid:19631994 |
| Oikawa N et al. | Gangliosides determine the amyloid pathology of Alzheimer's disease. | 2009 | Neuroreport | pmid:19590389 |
| Sachl R et al. | A comparative study on ganglioside micelles using electronic energy transfer, fluorescence correlation spectroscopy and light scattering techniques. | 2009 | Phys Chem Chem Phys | pmid:19458836 |
| Chen CG et al. | Amplification of immune responses against a DNA-delivered idiotypic lymphoma antigen by fusion to the B subunit of E. coli heat labile toxin. | 2009 | Vaccine | pmid:19450635 |
| Mikhalyov I et al. | Fluorescent BODIPY-labelled GM1 gangliosides designed for exploring lipid membrane properties and specific membrane-target interactions. | 2009 | Chem. Phys. Lipids | pmid:19428361 |
| Gong Z et al. | Cloning, expression, purification and characterization of the cholera toxin B subunit and triple glutamic acid decarboxylase epitopes fusion protein in Escherichia coli. | 2009 | Protein Expr. Purif. | pmid:19364533 |
| Nobile-Orazio E | Antigenic determinants in IgM paraprotein-related neuropathies. | 2009 | Clin Lymphoma Myeloma | pmid:19362989 |
| Taïeb N et al. | The first extracellular domain of the tumour stem cell marker CD133 contains an antigenic ganglioside-binding motif. | 2009 | Cancer Lett. | pmid:19216024 |
| Young JW et al. | Acute inflammatory encephalomyelitis following Campylobacter enteritis associated with high titre antiganglioside GM1 IgG antibodies. | 2009 | J Clin Neurosci | pmid:19200732 |
| Kalra V et al. | Childhood acute transverse myelitis: clinical profile, outcome, and association with antiganglioside antibodies. | 2009 | J. Child Neurol. | pmid:19196873 |
| Huang F et al. | The neuroprotective effects of NGF combined with GM1 on injured spinal cord neurons in vitro. | 2009 | Brain Res. Bull. | pmid:19133317 |
| Lievens I et al. | [Multifocal motor neuropathy: a retrospective study of sensory nerve conduction velocities in long-term follow-up of 21 patients]. | 2009 | Rev. Neurol. (Paris) | pmid:19118851 |
| Bach HG et al. | The behavioral and immunological effect of GM-1 ganglioside on nerve root regeneration following C5 nerve root avulsion in a rat model. | 2009 | J Reconstr Microsurg | pmid:18925552 |
| Valentino P et al. | Anti-GM1 antibodies are not associated with cerebral atrophy in patients with multiple sclerosis. | 2009 | Mult. Scler. | pmid:18845652 |
| Bunyakul N et al. | Cholera toxin subunit B detection in microfluidic devices. | 2009 | Anal Bioanal Chem | pmid:18777170 |
| Nixon B et al. | Composition and significance of detergent resistant membranes in mouse spermatozoa. | 2009 | J. Cell. Physiol. | pmid:18726997 |
| Kim YS et al. | Expression and assembly of cholera toxin B subunit (CTB) in transgenic carrot (Daucus carota L.). | 2009 | Mol. Biotechnol. | pmid:18642102 |
| Wu HP et al. | Gold nanoparticles as assisted matrices for the detection of biomolecules in a high-salt solution through laser desorption/ionization mass spectrometry. | 2009 | J. Am. Soc. Mass Spectrom. | pmid:19211262 |
| Lü HZ and Li BQ | Effect of HMG-CoA reductase inhibitors on activation of human gammadeltaT cells induced by Mycobacterium tuberculosis antigens. | 2009 | Immunopharmacol Immunotoxicol | pmid:19555197 |
| Petro KA and Schengrund CL | Membrane raft disruption promotes axonogenesis in n2a neuroblastoma cells. | 2009 | Neurochem. Res. | pmid:18307034 |
| Knorr R et al. | Endocytosis of MHC molecules by distinct membrane rafts. | 2009 | J. Cell. Sci. | pmid:19383725 |
| Jedlovszky P et al. | GM1 ganglioside embedded in a hydrated DOPC membrane: a molecular dynamics simulation study. | 2009 | J Phys Chem B | pmid:19275209 |
| Komori T et al. | Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates. | 2009 | Carbohydr. Res. | pmid:19560125 |
| Zhang H et al. | Ganglioside GM1 binding the N-terminus of amyloid precursor protein. | 2009 | Neurobiol. Aging | pmid:18077059 |
| Ayalew S et al. | Intranasal vaccination of calves with Mannheimia haemolytica chimeric protein containing the major surface epitope of outer membrane lipoprotein PlpE, the neutralizing epitope of leukotoxin, and cholera toxin subunit B. | 2009 | Vet. Immunol. Immunopathol. | pmid:19581005 |
| Nordenfelt P et al. | Different requirements for early and late phases of azurophilic granule-phagosome fusion. | 2009 | Traffic | pmid:19804565 |
| Takimoto K et al. | Storage of gangliosides GM2 and fucosyl GM1 in the kidney of MCC strain of mastomys (Praomys coucha). | 2009 | J. Biochem. | pmid:19556222 |
| Sano R et al. | GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis. | 2009 | Mol. Cell | pmid:19917257 |
| Wang Q et al. | [Effects of ganglioside 1 and nerve growth factor on the proliferation of neural stem cells in vitro]. | 2009 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:19849946 |
| Kawano MA et al. | Calcium bridge triggers capsid disassembly in the cell entry process of simian virus 40. | 2009 | J. Biol. Chem. | pmid:19822519 |
| Iglesias-Bartolomé R et al. | Differential endocytic trafficking of neuropathy-associated antibodies to GM1 ganglioside and cholera toxin in epithelial and neural cells. | 2009 | Biochim. Biophys. Acta | pmid:19800863 |
| Van Slambrouck S et al. | AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression. | 2009 | Int. J. Oncol. | pmid:19724904 |
| Bodhankar S et al. | NK cells interfere with the generation of resistance against mycoplasma respiratory infection following nasal-pulmonary immunization. | 2009 | J. Immunol. | pmid:19625649 |
| Biraboneye AC et al. | Potential neuroprotective drugs in cerebral ischemia: new saturated and polyunsaturated lipids coupled to hydrophilic moieties: synthesis and biological activity. | 2009 | J. Med. Chem. | pmid:19537799 |
| Lin IH et al. | Ordering transitions in micrometer-thick films of nematic liquid crystals driven by self-assembly of ganglioside GM1. | 2009 | J Colloid Interface Sci | pmid:19428021 |
| Kato-Motozaki Y et al. | Polyethylene glycol interferon alpha-2b-induced immune-mediated polyradiculoneuropathy. | 2009 | Intern. Med. | pmid:19336961 |
| Lin Y et al. | Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer. | 2009 | Reproduction | pmid:19321657 |
| Wang J et al. | Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis. | 2009 | J. Immunol. | pmid:19299701 |
| Greenshields KN et al. | The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice. | 2009 | J. Clin. Invest. | pmid:19221437 |
| Girouard J et al. | Compartmentalization of proteins in epididymosomes coordinates the association of epididymal proteins with the different functional structures of bovine spermatozoa. | 2009 | Biol. Reprod. | pmid:19164173 |
| Bergström M et al. | Cholera toxin inhibitors studied with high-performance liquid affinity chromatography: a robust method to evaluate receptor-ligand interactions. | 2009 | Chem Biol Drug Des | pmid:19152642 |
| Ichikawa N et al. | Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth. | 2009 | J. Cell. Sci. | pmid:19118221 |
| Selvaraj V et al. | Mechanisms underlying the micron-scale segregation of sterols and GM1 in live mammalian sperm. | 2009 | J. Cell. Physiol. | pmid:19012288 |
| Nakazawa Y et al. | The interaction of amyloid Abeta(1-40) with lipid bilayers and ganglioside as studied by 31P solid-state NMR. | 2009 | Chem. Phys. Lipids | pmid:19138679 |
| Asano A et al. | Biochemical characterization of membrane fractions in murine sperm: identification of three distinct sub-types of membrane rafts. | 2009 | J. Cell. Physiol. | pmid:19006178 |
| Kuehnle K et al. | Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice. | 2009 | Neurochem. Res. | pmid:19115107 |