| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lai BQ et al. | Cholera Toxin B Subunit Shows Transneuronal Tracing after Injection in an Injured Sciatic Nerve. | 2015 | PLoS ONE | pmid:26640949 |
| Schneider JS et al. | Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson's Disease. | 2015 | PLoS ONE | pmid:26629687 |
| Basu I et al. | Insights into the behavioral difference of water in the presence of GM1. | 2015 | FEBS Lett. | pmid:26611347 |
| Guan F et al. | Ganglioside-magnetosome complex formation enhances uptake of gangliosides by cells. | 2015 | Int J Nanomedicine | pmid:26609230 |
| Wands AM et al. | Fucosylation and protein glycosylation create functional receptors for cholera toxin. | 2015 | Elife | pmid:26512888 |
| Hirano-Sakamaki W et al. | Alzheimer's disease is associated with disordered localization of ganglioside GM1 molecular species in the human dentate gyrus. | 2015 | FEBS Lett. | pmid:26484596 |
| Victorino F et al. | Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody. | 2015 | J. Immunol. | pmid:26453755 |
| Williams TL et al. | Europium as an inhibitor of Amyloid-β(1-42) induced membrane permeation. | 2015 | FEBS Lett. | pmid:26450778 |
| Schneider JS et al. | GM1 ganglioside in Parkinson's disease: Pilot study of effects on dopamine transporter binding. | 2015 | J. Neurol. Sci. | pmid:26099170 |
| Caughlin S et al. | Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity and Stroke. | 2015 | PLoS ONE | pmid:26086081 |
| Ling ZM et al. | Evaluation of Avulsion-Induced Neuropathology in Rat Spinal Cords with 18F-FDG Micro-PET/CT. | 2015 | PLoS ONE | pmid:26010770 |
| Leonhard V et al. | Biochemical characterization of the interactions between doxorubicin and lipidic GM1 micelles with or without paclitaxel loading. | 2015 | Int J Nanomedicine | pmid:26005348 |
| Vandermeersch S et al. | Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V. | 2015 | Molecules | pmid:25913930 |
| Takagishi T et al. | Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane. | 2015 | PLoS ONE | pmid:25910247 |
| Koga M et al. | Complex of GM1- and GD1a-like lipo-oligosaccharide mimics GM1b, inducing anti-GM1b antibodies. | 2015 | PLoS ONE | pmid:25867522 |
| Moens PD et al. | Modes of diffusion of cholera toxin bound to GM1 on live cell membrane by image mean square displacement analysis. | 2015 | Biophys. J. | pmid:25809257 |
| Baldauf KJ et al. | Cholera toxin B: one subunit with many pharmaceutical applications. | 2015 | Toxins (Basel) | pmid:25802972 |
| Osteikoetxea X et al. | Improved characterization of EV preparations based on protein to lipid ratio and lipid properties. | 2015 | PLoS ONE | pmid:25798862 |
| Hata R et al. | Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice. | 2015 | Sci Rep | pmid:25765541 |
| De Chatterjee A et al. | The assembly of GM1 glycolipid- and cholesterol-enriched raft-like membrane microdomains is important for giardial encystation. | 2015 | Infect. Immun. | pmid:25733521 |
| Liang B et al. | Label-free detection and identification of protein ligands captured by receptors in a polymerized planar lipid bilayer using MALDI-TOF MS. | 2015 | Anal Bioanal Chem | pmid:25694144 |
| Song RB and Lou WH | Monosialotetrahexosylganglioside Inhibits the Expression of p-CREB and NR2B in the Auditory Cortex in Rats with Salicylate-Induced Tinnitus. | 2015 | Clin. Lab. | pmid:26554229 |
| Okabayashi S et al. | Diabetes mellitus accelerates Aβ pathology in brain accompanied by enhanced GAβ generation in nonhuman primates. | 2015 | PLoS ONE | pmid:25675436 |
| Leonhard V et al. | Biochemical characterization of GM1 micelles-Amphotericin B interaction. | 2015 | Curr Drug Deliv | pmid:25772153 |
| Zakharova IO et al. | Role of Protein Kinase Akt Activation in Protective Effect of Ganglioside GM1 on PC12 Cells Exposed to H2O2. | 2015 | Bull. Exp. Biol. Med. | pmid:26459480 |
| Hamorsky KT et al. | N-glycosylation of cholera toxin B subunit in Nicotiana benthamiana: impacts on host stress response, production yield and vaccine potential. | 2015 | Sci Rep | pmid:25614217 |
| Chakrabarti A and Patra M | Differential interactions of two local anesthetics with phospholipid membrane and nonerythroid spectrin: Localization in presence of cholesterol and ganglioside, GM1. | 2015 | Biochim. Biophys. Acta | pmid:25482358 |
| Grey M et al. | Acceleration of α-synuclein aggregation by exosomes. | 2015 | J. Biol. Chem. | pmid:25425650 |
| Margheri F et al. | Differential uPAR recruitment in caveolar-lipid rafts by GM1 and GM3 gangliosides regulates endothelial progenitor cells angiogenesis. | 2015 | J. Cell. Mol. Med. | pmid:25313007 |
| Å achl R et al. | On multivalent receptor activity of GM1 in cholesterol containing membranes. | 2015 | Biochim. Biophys. Acta | pmid:25101973 |
| Sato S et al. | A Self-Assembled Spherical Complex Displaying a Gangliosidic Glycan Cluster Capable of Interacting with Amyloidogenic Proteins. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:26015171 |
| Zhang J et al. | The Possible Damaged Mechanism and the Preventive Effect of Monosialotetrahexosylganglioside in a Rat Model of Cerebral Ischemia-Reperfusion Injury. | 2015 | J Stroke Cerebrovasc Dis | pmid:25934141 |
| Yagi-Utsumi M and Kato K | Structural and dynamic views of GM1 ganglioside. | 2015 | Glycoconj. J. | pmid:25931034 |
| Sasahara K et al. | Uptake of raft components into amyloid β-peptide aggregates and membrane damage. | 2015 | Anal. Biochem. | pmid:25908557 |
| Yanagisawa K | GM1 ganglioside and Alzheimer's disease. | 2015 | Glycoconj. J. | pmid:25903682 |
| Maeda Y et al. | Effects of cyclodextrins on GM1-gangliosides in fibroblasts from GM1-gangliosidosis patients. | 2015 | J. Pharm. Pharmacol. | pmid:25851126 |
| Togawa J et al. | Similarities of serum anti-ganglioside antibodies in first and third episodes of recurrent Guillain-Barre syndrome: case report. | 2015 | J. Neurol. | pmid:25845761 |
| Koike Y et al. | [A case of progressive encephalomyelitis with rigidity and myoclonus associated with anti-GAD, anti-glycine receptor and anti-GM1 antibodies]. | 2015 | Rinsho Shinkeigaku | pmid:25746075 |
| Hurlbert RJ et al. | Pharmacological therapy for acute spinal cord injury. | 2015 | Neurosurgery | pmid:25692371 |
| Yamamoto N et al. | Midazolam inhibits the formation of amyloid fibrils and GM1 ganglioside-rich microdomains in presynaptic membranes through the gamma-aminobutyric acid A receptor. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25600806 |
| Fujimura M and Usuki F | Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: in vitro and in vivo effects of TrkA pathway activators. | 2015 | Toxicol. Appl. Pharmacol. | pmid:25545984 |
| Matheou CJ et al. | Cu²⺠accentuates distinct misfolding of Aβâ‚â‚‹â‚„â‚€ and Aβâ‚â‚‹â‚„â‚‚ peptides, and potentiates membrane disruption. | 2015 | Biochem. J. | pmid:25471541 |
| Fukuda Y et al. | Neurotropin promotes NGF signaling through interaction of GM1 ganglioside with Trk neurotrophin receptor in PC12 cells. | 2015 | Brain Res. | pmid:25454796 |
| Valdomero A et al. | Exogenous GM1 ganglioside increases accumbal BDNF levels in rats. | 2015 | Behav. Brain Res. | pmid:25453740 |
| Hadaczek P et al. | GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model. | 2015 | Exp. Neurol. | pmid:25448159 |
| Nikolaeva S et al. | GM1 and GD1a gangliosides modulate toxic and inflammatory effects of E. coli lipopolysaccharide by preventing TLR4 translocation into lipid rafts. | 2015 | Biochim. Biophys. Acta | pmid:25499607 |
| Benedetti L et al. | Meningoencephalitis-like onset of post-infectious AQP4-IgG-positive optic neuritis complicated by GM1-IgG-positive acute polyneuropathy. | 2015 | Mult. Scler. | pmid:24557856 |
| Bian L et al. | Isolation and purification of monosialotetrahexosylgangliosides from pig brain by extraction and liquid chromatography. | 2015 | Biomed. Chromatogr. | pmid:25845558 |
| Mitsui Y et al. | A multicentre prospective study of Guillain-Barré syndrome in Japan: a focus on the incidence of subtypes. | 2015 | J. Neurol. Neurosurg. Psychiatry | pmid:24273220 |
| Majewski J et al. | X-ray reflectivity and grazing incidence diffraction studies of interaction between human adhesion/growth-regulatory galectin-1 and DPPE-GM1 lipid monolayer at an air/water interface. | 2015 | Biochemistry Mosc. | pmid:26542007 |
| Cuddy LK et al. | Regulation of the high-affinity choline transporter activity and trafficking by its association with cholesterol-rich lipid rafts. | 2014 | J. Neurochem. | pmid:24127780 |
| Zheng Y et al. | Efficient biotransformation of polysialogangliosides for preparation of GM1 by Cellulosimicrobium sp. 21. | 2014 | Molecules | pmid:25299818 |
| Yamamoto N et al. | Leptin inhibits amyloid β-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway. | 2014 | J. Neurochem. | pmid:25039425 |
| Monnier J and Zabel BA | Anti-asialo GM1 NK cell depleting antibody does not alter the development of bleomycin induced pulmonary fibrosis. | 2014 | PLoS ONE | pmid:24922516 |
| Clausen MP et al. | Simultaneous multi-species tracking in live cells with quantum dot conjugates. | 2014 | PLoS ONE | pmid:24892555 |
| Romero MM et al. | Outbreaks of Mycobacterium tuberculosis MDR strains differentially induce neutrophil respiratory burst involving lipid rafts, p38 MAPK and Syk. | 2014 | BMC Infect. Dis. | pmid:24886274 |
| Botto L et al. | Role of lipid rafts and GM1 in the segregation and processing of prion protein. | 2014 | PLoS ONE | pmid:24859148 |
| Wittenberg NJ et al. | Formation of biomembrane microarrays with a squeegee-based assembly method. | 2014 | J Vis Exp | pmid:24837169 |
| Puff N et al. | Lo/Ld phase coexistence modulation induced by GM1. | 2014 | Biochim. Biophys. Acta | pmid:24835016 |
| Newburn EN et al. | GM1 ganglioside enhances Ret signaling in striatum. | 2014 | J. Neurochem. | pmid:24821093 |
| Harschnitz O et al. | MMN: from immunological cross-talk to conduction block. | 2014 | J. Clin. Immunol. | pmid:24728842 |
| Hong S et al. | Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes. | 2014 | Neuron | pmid:24685176 |
| Liu Y et al. | Anti-diabetic effects of CTB-APSL fusion protein in type 2 diabetic mice. | 2014 | Mar Drugs | pmid:24633252 |
| Romero I et al. | T lymphocytes restrain spontaneous metastases in permanent dormancy. | 2014 | Cancer Res. | pmid:24531750 |
| Cohen R et al. | Lipid modulation of calcium flux through CaV2.3 regulates acrosome exocytosis and fertilization. | 2014 | Dev. Cell | pmid:24525187 |
| Itokazu Y et al. | Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24500283 |
| Zeng Y and Tarbell JM | The adaptive remodeling of endothelial glycocalyx in response to fluid shear stress. | 2014 | PLoS ONE | pmid:24465988 |
| McDonald G et al. | Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients. | 2014 | J. Clin. Invest. | pmid:24463447 |
| Lei L et al. | The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation. | 2014 | Biomaterials | pmid:24397990 |
| Lundius EG et al. | GPR37 protein trafficking to the plasma membrane regulated by prosaposin and GM1 gangliosides promotes cell viability. | 2014 | J. Biol. Chem. | pmid:24371137 |
| te Welscher YM et al. | Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1. | 2014 | J Control Release | pmid:24370893 |
| Xu R et al. | The possible mechanism of Parkinson's disease progressive damage and the preventive effect of GM1 in the rat model induced by 6-hydroxydopamine. | 2014 | Brain Res. | pmid:25285892 |
| Notturno F et al. | Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy. | 2014 | J. Neuroimmunol. | pmid:25283719 |
| Zakharova IO et al. | GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity. | 2014 | Neurochem. Res. | pmid:25216715 |
| Khatun UL et al. | Capability of ganglioside GM1 in modulating interactions, structure, location and dynamics of peptides/proteins: biophysical approaches: interaction of ganglioside GM1 with peptides/proteins. | 2014 | Glycoconj. J. | pmid:25178424 |
| Ishikawa N et al. | A pediatric case of peripheral polyneuropathy with IgM anti-GM1 antibody associated with A group a beta-hemolytic Streptococcus infection. | 2014 | Pediatr. Neurol. | pmid:25160552 |
| Matsuzaki K | How do membranes initiate Alzheimer's Disease? Formation of toxic amyloid fibrils by the amyloid β-protein on ganglioside clusters. | 2014 | Acc. Chem. Res. | pmid:25029558 |
| Miura Y et al. | Autoantibodies to GM1 and GQ1bα are not biological markers of Alzheimer's disease. | 2014 | J. Alzheimers Dis. | pmid:25024341 |
| Da P et al. | Surface plasmon resonance enhanced real-time photoelectrochemical protein sensing by gold nanoparticle-decorated TiOâ‚‚ nanowires. | 2014 | Anal. Chem. | pmid:24915128 |
| Yuki N et al. | GD1b-specific antibodies may bind to complex of GQ1b and GM1, causing ataxia. | 2014 | J. Neurol. | pmid:24859332 |
| Yuki N et al. | Lower motor neuron syndrome associated with IgG anti-GM1 antibodies revisited. | 2014 | J. Neuroimmunol. | pmid:24841627 |
| Hatzifilippou E et al. | Antibodies against gangliosides in patients with dementia. | 2014 | Am J Alzheimers Dis Other Demen | pmid:24838532 |
| Tsuchida T et al. | The development of humanized liver with Rag1 knockout rats. | 2014 | Transplant. Proc. | pmid:24815157 |
| Franssen H | The node of Ranvier in multifocal motor neuropathy. | 2014 | J. Clin. Immunol. | pmid:24801202 |
| Sha S et al. | Deficits in cognitive function and hippocampal plasticity in GM2/GD2 synthase knockout mice. | 2014 | Hippocampus | pmid:24765676 |
| Koski CL | Treatment of multifocal motor neuropathy with intravenous immunoglobulin. | 2014 | J. Clin. Immunol. | pmid:24699885 |
| Andrisani A et al. | Effect of various commercial buffers on sperm viability and capacitation. | 2014 | Syst Biol Reprod Med | pmid:24673547 |
| Kirkeby S | Cholera toxin B subunit-binding and ganglioside GM1 immuno-expression are not necessarily correlated in human salivary glands. | 2014 | Acta Odontol. Scand. | pmid:24655314 |
| Domingue JC and Rao MC | CFTR and GM1 "gangl-ing" up to heal thy wound. Focus on "Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair". | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24627559 |
| Schulte W et al. | A Langmuir monolayer study of the action of phospholipase A2 on model phospholipid and mixed phospholipid-GM1 ganglioside membranes. | 2014 | Colloids Surf B Biointerfaces | pmid:24524938 |
| Takatori S et al. | Microscopic methods to observe the distribution of lipids in the cellular membrane. | 2014 | Biochemistry | pmid:24460209 |
| Morgan ML et al. | Anti-asialo-GM1 and GD1a variant of Miller Fisher variant of Guillain-Barré Syndrome. | 2014 | J Neuroophthalmol | pmid:25062498 |
| Novák J et al. | GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis. | 2014 | Mol. Immunol. | pmid:24231767 |
| Margheri G et al. | The β-subunit of cholera toxin has a high affinity for ganglioside GM1 embedded into solid supported lipid membranes with a lipid raft-like composition. | 2014 | Lipids | pmid:24122042 |
| Willison HJ et al. | Antibodies to GM1: galactocerebroside complexes in multifocal motor neuropathy: it takes two to tango. | 2014 | J. Neurol. Neurosurg. Psychiatry | pmid:24006050 |
| Nobile-Orazio E et al. | Sensitivity and predictive value of anti-GM1/galactocerebroside IgM antibodies in multifocal motor neuropathy. | 2014 | J. Neurol. Neurosurg. Psychiatry | pmid:23907602 |
| Hotta S et al. | Neurophysiological and immunohistochemical studies of IgG anti-GM1 monoclonal antibody on neuromuscular transmission: effects in rat neuromuscular junctions. | 2014 | Neurol. Sci. | pmid:23820959 |
| Shrestha D et al. | CD1d favors MHC neighborhood, GM1 ganglioside proximity and low detergent sensitive membrane regions on the surface of B lymphocytes. | 2014 | Biochim. Biophys. Acta | pmid:24482817 |
| Kang S et al. | Altered levels of α-synuclein and sphingolipids in Batten disease lymphoblast cells. | 2014 | Gene | pmid:24534465 |
| Petr T et al. | The effect of heme oxygenase on ganglioside redistribution within hepatocytes in experimental estrogen-induced cholestasis. | 2014 | Physiol Res | pmid:24564601 |