| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Raghavan SA et al. | GM1-ganglioside beta-galactosidase in leukocytes and cultured fibroblasts. | 1977 | Clin. Chim. Acta | pmid:411612 |
| Kurczynski TW et al. | Lactosylceramidases in canine globoid cell leukodystrophy. | 1977 | J. Neurochem. | pmid:886322 |
| Duffard RO et al. | Ganglioside composition and biosynthesis in cultred cells derived from CNS. | 1977 | J. Neurochem. | pmid:406360 |
| Ng SS and Dain JA | Sialyltransferases in rat brain: reaction kinetics, product analyses, and multiplicities of enzyme species. | 1977 | J. Neurochem. | pmid:74403 |
| Peters SP et al. | Isolation of heat-stable glucocerebrosidase activators from the spleens of three variants of Gaucher's disease. | 1977 | Arch. Biochem. Biophys. | pmid:907355 |
| Ogino T et al. | Atypical GM1 ganglioside accumulation in a case of juvenile amaurotic idiocy. | 1977 | Clin. Chim. Acta | pmid:884852 |
| Yusuf HK et al. | Effect of development on the gangliosides of human brain. | 1977 | J. Neurochem. | pmid:874491 |
| Tonegawa Y and Hakomori SI | "Ganglioprotein and globoprotein": the glycoproteins reacting with anti-ganglioside and anti-globoside antibodies and the ganglioprotein change associated with transformation. | 1977 | Biochem. Biophys. Res. Commun. | pmid:194594 |
| Tanaka H and Suzuki K | Lactosylceramidase assays for diagnosis of globoid cell leukodystrophy and GM1-gangliosidosis. | 1977 | Clin. Chim. Acta | pmid:403037 |
| Suzuki Y et al. | Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver. | 1977 | Arch. Neurol. | pmid:402903 |
| Murray JA et al. | Ocular lesions in cats with GM1-gangliosidosis with visceral involvement. | 1977 | J Small Anim Pract | pmid:404469 |
| van Heyningen S | Activity of covalently cross-linked cholera toxin with the adenylate cyclase of intact and lysed pigeon erythrocytes. | 1977 | Biochem. J. | pmid:606247 |
| Miller AL et al. | Purified human liver acid beta-D-galactosidases possessing activity towards G(M1)-ganglioside and lactosylceramide. | 1977 | Biochem. J. | pmid:411490 |
| Hansson HA et al. | Ultrastructural localization of cell membrane GM1 ganglioside by cholera toxin. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:269432 |
| Ginsburg CM and Long CG | GM1 gangliosidosis type 1 in twins. | 1977 | J. Med. Genet. | pmid:404410 |
| Purpura DP and Baker HJ | Meganeurites and other aberrant processes of neurons in feline GM1-gangliosidosis: a Golgi study. | 1978 | Brain Res. | pmid:415798 |
| Purpura DP et al. | Fine structure of meganeurites and secondary growth processes in feline GM1-gangliosidosis. | 1978 | Brain Res. | pmid:415797 |
| Stein KE et al. | Glycolipid markers of murine lymphocyte subpopulations. | 1978 | J. Immunol. | pmid:304463 |
| Frost RG et al. | Characterization of purified human liver acid beta-D-galactosidases A2 and A3. | 1978 | Biochem. J. | pmid:104712 |
| Pacuszka T et al. | A sensitive method for the detection of GM1-ganglioside in rat adipocyte preparations based on its interaction with choleragen. | 1978 | J. Biol. Chem. | pmid:670180 |