| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Van Slambrouck S et al. | Carbohydrate-to-carbohydrate interactions between α2,3-linked sialic acids on α2 integrin subunits and asialo-GM1 underlie the bone metastatic behaviour of LNCAP-derivative C4-2B prostate cancer cells. | 2014 | Biosci. Rep. | pmid:25137483 |
| Bartels T et al. | N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation. | 2014 | PLoS ONE | pmid:25075858 |
| Basu I and Mukhopadhyay C | Insights into binding of cholera toxin to GM1 containing membrane. | 2014 | Langmuir | pmid:25425333 |
| Ueno H et al. | Comparison between the aggregation of human and rodent amyloid β-proteins in GM1 ganglioside clusters. | 2014 | Biochemistry | pmid:25399921 |
| Hsieh CL et al. | Tracking single particles on supported lipid membranes: multimobility diffusion and nanoscopic confinement. | 2014 | J Phys Chem B | pmid:24433014 |
| Magini A et al. | Methods to discriminate the distribution of acidic glycohydrolases between the endosomal-lysosomal systems and the plasma membrane. | 2014 | Meth. Enzymol. | pmid:24359946 |
| Bisel B et al. | GM1 and GM2 gangliosides: recent developments. | 2014 | Biomol Concepts | pmid:25372744 |
| Kim W et al. | Dietary fish oil and DHA down-regulate antigen-activated CD4+ T-cells while promoting the formation of liquid-ordered mesodomains. | 2014 | Br. J. Nutr. | pmid:23962659 |
| Spillane KM et al. | High-speed single-particle tracking of GM1 in model membranes reveals anomalous diffusion due to interleaflet coupling and molecular pinning. | 2014 | Nano Lett. | pmid:25133992 |
| Khatun UL and Mukhopadhyay C | Interaction of bee venom toxin melittin with ganglioside GM1 bicelle. | 2013 Oct-Nov | Biophys. Chem. | pmid:23850803 |
| Hirai M et al. | Change of dynamics of raft-model membrane induced by amyloid-β protein binding. | 2013 | Eur Phys J E Soft Matter | pmid:23852578 |
| Rondelli V et al. | Neutrons for rafts, rafts for neutrons. | 2013 | Eur Phys J E Soft Matter | pmid:23852579 |
| Nomura M et al. | 13-Cis retinoic acid can enhance the antitumor activity of non-replicating Sendai virus particle against neuroblastoma. | 2013 | Cancer Sci. | pmid:23134437 |
| Liu Q et al. | Specific interaction of postsynaptic densities with membrane rafts isolated from synaptic plasma membranes. | 2013 | J. Neurogenet. | pmid:23527882 |
| Kreutz F et al. | Alterations of membrane lipids and in gene expression of ganglioside metabolism in different brain structures in a mouse model of mucopolysaccharidosis type I (MPS I). | 2013 | Gene | pmid:23774686 |
| Mahmood I et al. | Influence of lipid composition on the structural stability of g-protein coupled receptor. | 2013 | Chem. Pharm. Bull. | pmid:23546002 |
| Konishi M et al. | Extending the glucosyl ceramide cassette approach: application in the total synthesis of ganglioside GalNAc-GM1b. | 2013 | Molecules | pmid:24335571 |
| Bisel B et al. | Decoupling polarization of the Golgi apparatus and GM1 in the plasma membrane. | 2013 | PLoS ONE | pmid:24312472 |
| Saslowsky DE et al. | Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain. | 2013 | J. Biol. Chem. | pmid:23884419 |
| Itokazu Y et al. | Effects of amyloid β-peptides and gangliosides on mouse neural stem cells. | 2013 | Neurochem. Res. | pmid:23851714 |
| Armendariz KP and Dunn RC | Ganglioside influence on phospholipid films investigated with single molecule fluorescence measurements. | 2013 | J Phys Chem B | pmid:23745772 |
| Gustafsson T et al. | Direct interaction between cholera toxin and dendritic cells is required for oral adjuvant activity. | 2013 | Eur. J. Immunol. | pmid:23649516 |
| Triantafilou M et al. | Synergic activation of toll-like receptor (TLR) 2/6 and 9 in response to Ureaplasma parvum & urealyticum in human amniotic epithelial cells. | 2013 | PLoS ONE | pmid:23593431 |
| Rivera FP et al. | Bovine lactoferrin decreases cholera-toxin-induced intestinal fluid accumulation in mice by ganglioside interaction. | 2013 | PLoS ONE | pmid:23580005 |
| Lauria I et al. | GLTP mediated non-vesicular GM1 transport between native membranes. | 2013 | PLoS ONE | pmid:23555818 |
| Calamai M and Pavone FS | Partitioning and confinement of GM1 ganglioside induced by amyloid aggregates. | 2013 | FEBS Lett. | pmid:23523632 |
| Hamorsky KT et al. | Rapid and scalable plant-based production of a cholera toxin B subunit variant to aid in mass vaccination against cholera outbreaks. | 2013 | PLoS Negl Trop Dis | pmid:23505583 |
| Zhu Y et al. | Ganglioside-monosialic acid (GM1) prevents oxaliplatin-induced peripheral neurotoxicity in patients with gastrointestinal tumors. | 2013 | World J Surg Oncol | pmid:23351188 |
| Benktander J et al. | The repertoire of glycosphingolipids recognized by Vibrio cholerae. | 2013 | PLoS ONE | pmid:23349777 |
| Schneider JS et al. | A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients. | 2013 | J. Neurol. Sci. | pmid:23199590 |
| Sezgin E et al. | Photoconversion of bodipy-labeled lipid analogues. | 2013 | Chembiochem | pmid:23512865 |
| Lozano MM et al. | Colocalization of the ganglioside G(M1) and cholesterol detected by secondary ion mass spectrometry. | 2013 | J. Am. Chem. Soc. | pmid:23514537 |
| Kuwabara S and Yuki N | Axonal Guillain-Barré syndrome: concepts and controversies. | 2013 | Lancet Neurol | pmid:24229616 |
| Sasahara K et al. | Effects of membrane interaction and aggregation of amyloid β-peptide on lipid mobility and membrane domain structure. | 2013 | Phys Chem Chem Phys | pmid:23515399 |
| Wakerley BR et al. | Atypical Bickerstaff brainstem encephalitis: ataxic hypersomnolence without ophthalmoplegia. | 2013 | J. Neurol. Neurosurg. Psychiatry | pmid:23564757 |
| Van Blerkom J and Caltrider K | Sperm attachment and penetration competence in the human oocyte: a possible aetiology of fertilization failure involving the organization of oolemmal lipid raft microdomains influenced by the ΔΨm of subplasmalemmal mitochondria. | 2013 | Reprod. Biomed. Online | pmid:24157131 |
| Okawa S et al. | Tolosa-hunt syndrome associated with cytomegalovirus infection. | 2013 | Intern. Med. | pmid:23676602 |
| Ogawa G et al. | An antibody to the GM1/GalNAc-GD1a complex correlates with development of pure motor Guillain-Barré syndrome with reversible conduction failure. | 2013 | J. Neuroimmunol. | pmid:23000056 |
| Kreutz F et al. | Alterations on Naâº,Kâº-ATPase and acetylcholinesterase activities induced by amyloid-β peptide in rat brain and GM1 ganglioside neuroprotective action. | 2013 | Neurochem. Res. | pmid:24013887 |
| Galban-Horcajo F et al. | Antibodies to heteromeric glycolipid complexes in multifocal motor neuropathy. | 2013 | Eur. J. Neurol. | pmid:22727042 |
| Mattarella M et al. | Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. | 2013 | Org. Biomol. Chem. | pmid:23736158 |
| Garcia-Hartjes J et al. | Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix[5]arene. | 2013 | Org. Biomol. Chem. | pmid:23689250 |
| Hoshino T et al. | Binding and aggregation mechanism of amyloid β-peptides onto the GM1 ganglioside-containing lipid membrane. | 2013 | J Phys Chem B | pmid:23688073 |
| Willjes G et al. | Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity. | 2013 | Biochemistry | pmid:23647335 |
| Poggi A et al. | Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells. | 2013 | PLoS ONE | pmid:23667543 |
| Yamamoto N et al. | Propofol and thiopental suppress amyloid fibril formation and GM1 ganglioside expression through the γ-aminobutyric acid A receptor. | 2013 | Anesthesiology | pmid:23422796 |
| Cheng Q et al. | Fuzheng Huayu inhibits carbon tetrachloride-induced liver fibrosis in mice through activating hepatic NK cells. | 2013 | J Ethnopharmacol | pmid:23127651 |
| Hosoya S et al. | Innate immune responses involving natural killer and natural killer T cells promote liver regeneration after partial hepatectomy in mice. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23086918 |
| Vlam L et al. | Immune pathogenesis and treatment of multifocal motor neuropathy. | 2013 | J. Clin. Immunol. | pmid:22941513 |
| Buschiazzo J et al. | Cholesterol depletion disorganizes oocyte membrane rafts altering mouse fertilization. | 2013 | PLoS ONE | pmid:23638166 |