Ganglioside GI

Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GI?

Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ganglioside GI

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Gaucher Disease D005776 13 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GI

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GI?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Ganglioside GI?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ganglioside GI?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ganglioside GI?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ganglioside GI?

Knock-out

Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).

Transgenic Model

Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).

Disease model

Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ganglioside GI

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Authors Title Published Journal PubMed Link
McKallip R et al. Tumor gangliosides inhibit the tumor-specific immune response. 1999 J. Immunol. pmid:10490967
Zhang D et al. Analysis of receptor for Vibrio cholerae El tor hemolysin with a monoclonal antibody that recognizes glycophorin B of human erythrocyte membrane. 1999 Infect. Immun. pmid:10496913
Gori AH et al. Mediation of attachment of Burkholderia pseudomallei to human pharyngeal epithelial cells by the asialoganglioside GM1-GM2 receptor complex. 1999 Am. J. Trop. Med. Hyg. pmid:10497993
Zervas M and Walkley SU Ferret pyramidal cell dendritogenesis: changes in morphology and ganglioside expression during cortical development. 1999 J. Comp. Neurol. pmid:10502250
Guo CT et al. Ganglioside GM(1a) on the cell surface is involved in the infection by human rotavirus KUN and MO strains. 1999 J. Biochem. pmid:10502675
Eto Y et al. Neurochemical abnormality in I-cell disease: chemical analysis and a possible importance of beta-galactosidase deficiency. 1979 J. Neurochem. pmid:105085
Cavallini L et al. Ganglioside GM1 protection from apoptosis of rat heart fibroblasts. 1999 Arch. Biochem. Biophys. pmid:10510273
Simons M et al. Exogenous administration of gangliosides displaces GPI-anchored proteins from lipid microdomains in living cells. 1999 Mol. Biol. Cell pmid:10512859
Caudie C et al. [Measurement of antiganglioside autoantibodies by immunodot-blot assay: clinical importance in peripheral neuropathies]. Ann. Biol. Clin. (Paris) pmid:10518060
Hyuga S et al. Suppression by ganglioside GD1A of migration capability, adhesion to vitronectin and metastatic potential of highly metastatic FBJ-LL cells. 1999 Int. J. Cancer pmid:10521808