MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yamazaki Y et al. | Fucoganglioside alpha-fucosyl(alpha-galactosyl)-GM1: a novel member of lipid membrane microdomain components involved in PC12 cell neuritogenesis. | 2007 | Biochem. J. | pmid:17608628 |
Barbat C et al. | p56lck, LFA-1 and PI3K but not SHP-2 interact with GM1- or GM3-enriched microdomains in a CD4-p56lck association-dependent manner. | 2007 | Biochem. J. | pmid:17123354 |
Ghidoni R et al. | Incorporation and metabolism of exogenous GM1 ganglioside in rat liver. | 1986 | Biochem. J. | pmid:3800874 |
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Gatt S et al. | Effect of bile salts on the hydrolysis of gangliosides, glycoproteins and neuraminyl-lactose by the neuraminidase of Clostridium perfringens. | 1981 | Biochem. J. | pmid:6272704 |
Critchley DR et al. | Characterization of the cholera toxin receptor on Balb/c 3T3 cells as a ganglioside similar to, or identical with, ganglioside GM1. No evidence for galactoproteins with receptor activity. | 1982 | Biochem. J. | pmid:7052064 |
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Cheetham PS | An explanation for variations in the clinical and biochemical symptoms of lysosomal-enzyme deficiency diseases such as GM1 gangliosidosis [proceedings]. | 1979 | Biochem. Soc. Trans. | pmid:116891 |
Marcello A et al. | E. coli heat-labile enterotoxin B subunit as a carrier for delivery of a peptide with anti-HSV activity. | 1992 | Biochem. Soc. Trans. | pmid:1336736 |
Athanassopoulou N et al. | Cholera toxin and GM1: a model membrane study with IAsys. | 1999 | Biochem. Soc. Trans. | pmid:10093760 |
Rampersaud AA et al. | Gangliosides and growth factor receptor regulation. | 1999 | Biochem. Soc. Trans. | pmid:10917613 |
Cai XE and Yang J | The binding potential between the cholera toxin B-oligomer and its receptor. | 2003 | Biochemistry | pmid:12680755 |
Luria A et al. | Detergent-free domain isolated from Xenopus egg plasma membrane with properties similar to those of detergent-resistant membranes. | 2002 | Biochemistry | pmid:12403620 |
McCann JA et al. | Conformational changes in cholera toxin B subunit-ganglioside GM1 complexes are elicited by environmental pH and evoke changes in membrane structure. | 1997 | Biochemistry | pmid:9230049 |
Kakio A et al. | Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid. | 2002 | Biochemistry | pmid:12044171 |
Lauer S et al. | Analysis of cholera toxin-ganglioside interactions by flow cytometry. | 2002 | Biochemistry | pmid:11827518 |
Thomaier M et al. | High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs. | 2016 | Biochemistry | pmid:27933798 |
Sherwood AL et al. | An amino acid region at the N-terminus of rat hepatoma alpha1-->2 fucosyltransferase modulates enzyme activity and interaction with lipids: strong preference for glycosphingolipids containing terminal Galbeta1-->3GalNAc-structures. | 2001 | Biochemistry | pmid:11341836 |
Suh JY et al. | Backbone dynamics of receptor binding and antigenic regions of a Pseudomonas aeruginosa pilin monomer. | 2001 | Biochemistry | pmid:11300779 |
Basu SS et al. | Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line. | 1996 | Biochemistry | pmid:8611500 |
Ferraretto A et al. | Lipid domains in the membrane: thermotropic properties of sphingomyelin vesicles containing GM1 ganglioside and cholesterol. | 1997 | Biochemistry | pmid:9230056 |
Ueno H et al. | Comparison between the aggregation of human and rodent amyloid β-proteins in GM1 ganglioside clusters. | 2014 | Biochemistry | pmid:25399921 |
Takatori S et al. | Microscopic methods to observe the distribution of lipids in the cellular membrane. | 2014 | Biochemistry | pmid:24460209 |
Willjes G et al. | Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity. | 2013 | Biochemistry | pmid:23647335 |
Chandrasekaran EV et al. | Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides. | 2011 | Biochemistry | pmid:21913655 |
Miyazaki Y et al. | Interaction of antimicrobial peptide magainin 2 with gangliosides as a target for human cell binding. | 2012 | Biochemistry | pmid:23194027 |
Fukunaga S et al. | GM1 cluster mediates formation of toxic Aβ fibrils by providing hydrophobic environments. | 2012 | Biochemistry | pmid:23009396 |
Minke WE et al. | Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonists. | 1999 | Biochemistry | pmid:10231518 |
Matsuzaki K and Horikiri C | Interactions of amyloid beta-peptide (1-40) with ganglioside-containing membranes. | 1999 | Biochemistry | pmid:10194329 |
Chi EY et al. | Ganglioside G(M1)-mediated amyloid-beta fibrillogenesis and membrane disruption. | 2007 | Biochemistry | pmid:17256880 |
Ikeda K et al. | Mechanism of amyloid β-protein aggregation mediated by GM1 ganglioside clusters. | 2011 | Biochemistry | pmid:21682276 |
Bou Khalil M et al. | FTIR study of the monosialoganglioside GM1 in perdeuterated dimyristoylglycerophosphocholine (DMPCd54) multilamellar bilayers: spectroscopic evidence of a significant interaction between Ca2+ ions and the sialic acid moiety of GM1. | 2000 | Biochemistry | pmid:10715118 |
Siebert HC et al. | Unique conformer selection of human growth-regulatory lectin galectin-1 for ganglioside GM1 versus bacterial toxins. | 2003 | Biochemistry | pmid:14674750 |
Panasiewicz M et al. | Structure of the ceramide moiety of GM1 ganglioside determines its occurrence in different detergent-resistant membrane domains in HL-60 cells. | 2003 | Biochemistry | pmid:12767245 |
Martinez Z et al. | GM1 specifically interacts with alpha-synuclein and inhibits fibrillation. | 2007 | Biochemistry | pmid:17253773 |
Khan TK et al. | Binding of NAP-22, a calmodulin-binding neuronal protein, to raft-like domains in model membranes. | 2003 | Biochemistry | pmid:12718518 |
Golovanova NK et al. | Sialidase activity in normal and atherosclerotic human aortic intima. | 2002 | Biochemistry Mosc. | pmid:12495418 |
Majewski J et al. | X-ray reflectivity and grazing incidence diffraction studies of interaction between human adhesion/growth-regulatory galectin-1 and DPPE-GM1 lipid monolayer at an air/water interface. | 2015 | Biochemistry Mosc. | pmid:26542007 |
Allen TM and Hansen C | Pharmacokinetics of stealth versus conventional liposomes: effect of dose. | 1991 | Biochim. Biophys. Acta | pmid:1911826 |
Simbulan CM et al. | Sulfate- and sialic acid-containing glycolipids inhibit DNA polymerase alpha activity. | 1994 | Biochim. Biophys. Acta | pmid:8142486 |