MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chao L and Daniel S | Measuring the partitioning kinetics of membrane biomolecules using patterned two-phase coexistant lipid bilayers. | 2011 | J. Am. Chem. Soc. | pmid:21848257 |
Buschiazzo J et al. | Nongenomic steroid- and ceramide-induced maturation in amphibian oocytes involves functional caveolae-like microdomains associated with a cytoskeletal environment. | 2011 | Biol. Reprod. | pmid:21653896 |
Arthur JR et al. | Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain. | 2011 | J. Lipid Res. | pmid:21508255 |
Dhanushkodi A and McDonald MP | Intracranial V. cholerae sialidase protects against excitotoxic neurodegeneration. | 2011 | PLoS ONE | pmid:22195039 |
Sanghera N et al. | Deciphering the molecular details for the binding of the prion protein to main ganglioside GM1 of neuronal membranes. | 2011 | Chem. Biol. | pmid:22118676 |
Nishijima T et al. | Antiretroviral therapy for treatment-naïve chronic HIV-1 infection with an axonal variant of Guillain-Barré syndrome positive for anti-ganglioside antibody: a case report. | 2011 | Intern. Med. | pmid:22001481 |
Chandrasekaran EV et al. | Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides. | 2011 | Biochemistry | pmid:21913655 |
Mace TA et al. | Differentiation of CD8+ T cells into effector cells is enhanced by physiological range hyperthermia. | 2011 | J. Leukoc. Biol. | pmid:21873456 |
Wittenberg NJ et al. | Facile assembly of micro- and nanoarrays for sensing with natural cell membranes. | 2011 | ACS Nano | pmid:21842844 |
Staneva G et al. | Making a tool of an artifact: the application of photoinduced Lo domains in giant unilamellar vesicles to the study of Lo/Ld phase spinodal decomposition and its modulation by the ganglioside GM1. | 2011 | Langmuir | pmid:22026409 |
Chubinskiy-Nadezhdin VI et al. | Cholesterol depletion-induced inhibition of stretch-activated channels is mediated via actin rearrangement. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21798240 |
Huang SH et al. | Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3). | 2011 | J. Biol. Chem. | pmid:21693704 |
Zhang YP et al. | GM1 improves neurofascin155 association with lipid rafts and prevents rat brain myelin injury after hypoxia-ischemia. | 2011 | Braz. J. Med. Biol. Res. | pmid:21670940 |
Mostafa GA and Al-Ayadhi LY | Increased serum levels of anti-ganglioside M1 auto-antibodies in autistic children: relation to the disease severity. | 2011 | J Neuroinflammation | pmid:21513576 |
Chatterjee D and Chaudhuri K | Association of cholera toxin with Vibrio cholerae outer membrane vesicles which are internalized by human intestinal epithelial cells. | 2011 | FEBS Lett. | pmid:21510946 |
Bax M et al. | Campylobacter jejuni lipooligosaccharides modulate dendritic cell-mediated T cell polarization in a sialic acid linkage-dependent manner. | 2011 | Infect. Immun. | pmid:21502591 |
Nishikado H et al. | NK cell-depleting anti-asialo GM1 antibody exhibits a lethal off-target effect on basophils in vivo. | 2011 | J. Immunol. | pmid:21490162 |
Kabaso D et al. | Temperature and cholera toxin B are factors that influence formation of membrane nanotubes in RT4 and T24 urothelial cancer cell lines. | 2011 | Int J Nanomedicine | pmid:21468353 |
Waheed MT et al. | Plastid expression of a double-pentameric vaccine candidate containing human papillomavirus-16 L1 antigen fused with LTB as adjuvant: transplastomic plants show pleiotropic phenotypes. | 2011 | Plant Biotechnol. J. | pmid:21447051 |
Baksh MM et al. | Label-free quantification of membrane-ligand interactions using backscattering interferometry. | 2011 | Nat. Biotechnol. | pmid:21399645 |
Lü HZ et al. | Formation and aggregation of lipid rafts in γδ T cells following stimulation with Mycobacterium tuberculosis antigens. | 2011 | Tohoku J. Exp. Med. | pmid:21372520 |
Yang W et al. | NKT cell exacerbation of liver metastases arising from melanomas transplanted into either the eyes or spleens of mice. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:21330669 |
Lemkul JA and Bevan DR | Lipid composition influences the release of Alzheimer's amyloid β-peptide from membranes. | 2011 | Protein Sci. | pmid:21692120 |
Kaittanis C et al. | Identification of molecular-mimicry-based ligands for cholera diagnostics using magnetic relaxation. | 2011 | Bioconjug. Chem. | pmid:21226491 |
Del Favero E et al. | Nanoscale structural response of ganglioside-containing aggregates to the interaction with sialidase. | 2011 | J. Neurochem. | pmid:21214561 |
Honke K and Kotani N | The enzyme-mediated activation of radical source reaction: a new approach to identify partners of a given molecule in membrane microdomains. | 2011 | J. Neurochem. | pmid:21214558 |
Borch J et al. | Nanodisc-based co-immunoprecipitation for mass spectrometric identification of membrane-interacting proteins. | 2011 | Mol. Cell Proteomics | pmid:21532009 |
Riva N et al. | Chronic motor axonal neuropathy. | 2011 | J. Peripher. Nerv. Syst. | pmid:22176149 |
Kawamura N et al. | Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients. | 2011 | J. Neuroimmunol. | pmid:21996079 |
Trandaburu I et al. | The immunohistochemical localization of the glycosphingolipid asialo-GM1 in the intestine of weaned piglets. | 2011 | Acta Histochem. | pmid:19740529 |
Jeong SH et al. | Nystagmus and ataxia associated with antiganglioside antibodies. | 2011 | J Neuroophthalmol | pmid:21918476 |
Cecchi C et al. | Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aβ42 aggregate toxicity. | 2011 | J. Alzheimers Dis. | pmid:21876252 |
Li D et al. | Critical studies on binding-based RT-PCR detection of infectious Noroviruses. | 2011 | J. Virol. Methods | pmid:21843552 |
Rufini S et al. | The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles. | 2011 | Biochem. Pharmacol. | pmid:21820419 |
Pukin AV et al. | Detection of antibodies in neuropathy patients by synthetic GM1 mimics. | 2011 | Glycobiology | pmid:21798866 |
Taylor M et al. | Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptide. | 2011 | Nanomedicine | pmid:21722618 |
Bereczki E et al. | Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells. | 2011 | Nanomedicine | pmid:21703989 |
Ikeda K et al. | Mechanism of amyloid β-protein aggregation mediated by GM1 ganglioside clusters. | 2011 | Biochemistry | pmid:21682276 |
Galassi G | Demyelinating symmetric motor polyneuropathy with high anti-GM1 antibody titer: do we need to split? | 2011 | Muscle Nerve | pmid:21660986 |
Yu RK et al. | Pathological roles of ganglioside mimicry in Guillain-Barré syndrome and related neuropathies. | 2011 | Adv. Exp. Med. Biol. | pmid:21618117 |
Zhang J et al. | Efficient conversion from polysialogangliosides to monosialotetrahexosylganglioside using Oerskovia xanthineolytica YZ-2. | 2011 | Bioprocess Biosyst Eng | pmid:21153421 |
Nilsson EC et al. | The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. | 2011 | Nat. Med. | pmid:21151139 |
Kuwabara S et al. | Neuromuscular transmission is not impaired in axonal Guillain--Barré syndrome. | 2011 | J. Neurol. Neurosurg. Psychiatry | pmid:21071752 |
Corley SC and Albert AD | Assessment of bovine rod outer segment disk membrane heterogeneity utilizing flow cytometry. | 2011 | Exp. Eye Res. | pmid:21055402 |
Sato B et al. | Lipid rafts enriched in monosialylGb5Cer carrying the stage-specific embryonic antigen-4 epitope are involved in development of mouse preimplantation embryos at cleavage stage. | 2011 | BMC Dev. Biol. | pmid:21489308 |
Hu H et al. | Factors affecting the prognosis of patients with delayed encephalopathy after acute carbon monoxide poisoning. | 2011 | Am J Emerg Med | pmid:20825794 |
Bolean M et al. | Thermodynamic properties and characterization of proteoliposomes rich in microdomains carrying alkaline phosphatase. | 2011 | Biophys. Chem. | pmid:21676530 |
Kook KH et al. | Altered ganglioside expression modulates the pathogenic mechanism of thyroid-associated ophthalmopathy by increase in hyaluronic acid. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:20811057 |
Habarta A et al. | Increased immunogenicity to LipL32 of Leptospira interrogans when expressed as a fusion protein with the cholera toxin B subunit. | 2011 | Curr. Microbiol. | pmid:20721666 |
Yuki N et al. | IVIG blocks complement deposition mediated by anti-GM1 antibodies in multifocal motor neuropathy. | 2011 | J. Neurol. Neurosurg. Psychiatry | pmid:20667861 |