MeSH term | MeSH ID | Detail |
---|---|---|
Gaucher Disease | D005776 | 13 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Gaucher Disease | D005776 | 13 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Kanfer JN et al. | Lipolytic action of cholera toxin on fat cells. Re-examination of the concept implicating GM1 ganglioside as the native membrane receptor. | 1976 | J. Biol. Chem. | pmid:1002701 |
Kikkawa H et al. | Role of sialylglycoconjugate(s) in the initial phase of metastasis of liver-metastatic RAW117 lymphoma cells. | 1998 | Jpn. J. Cancer Res. | pmid:10081491 |
Xia GL et al. | Characteristics of B lymphocyte and natural killer cell xenotolerance in a concordant hamster-to-athymic rat cardiac xenotransplantation model. | Transplant. Proc. | pmid:10083409 | |
Rushfeldt C et al. | Early events of hepatic metastasis formation in mice: role of Kupffer and NK-cells in natural and interferon-gamma-stimulated defense. | 1999 | J. Surg. Res. | pmid:10090831 |
Tong HH et al. | Effect of lacto-N-neotetraose, asialoganglioside-GM1 and neuraminidase on adherence of otitis media-associated serotypes of Streptococcus pneumoniae to chinchilla tracheal epithelium. | 1999 | Microb. Pathog. | pmid:10090858 |
Athanassopoulou N et al. | Cholera toxin and GM1: a model membrane study with IAsys. | 1999 | Biochem. Soc. Trans. | pmid:10093760 |
Bolot G et al. | Occurrence of monosialosyl pentahexaosylceramide GalNAc-GM1 as specific tumor-associated ganglioside of human head and neck squamous cell carcinomas. | 1999 | Cancer Lett. | pmid:10096424 |
Williams NA et al. | Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic. | 1999 | Immunol. Today | pmid:10098329 |
MacPhee I and Barker PA | Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation. | 1999 | J. Neurochem. | pmid:10098845 |
Choo YK | Distribution of gangliosides, GM1 and GM3, in the rat oviduct. | 1999 | Mol. Cells | pmid:10102572 |
Palermo-Neto J et al. | Kinetic analysis of GM1 effects on haloperidol-induced dopaminergic supersensitivity. | 1999 | Gen. Pharmacol. | pmid:10188630 |
Nachamkin I et al. | Ganglioside GM1 mimicry in Campylobacter strains from sporadic infections in the United States. | 1999 | J. Infect. Dis. | pmid:10191221 |
Matsuzaki K and Horikiri C | Interactions of amyloid beta-peptide (1-40) with ganglioside-containing membranes. | 1999 | Biochemistry | pmid:10194329 |
Koga M et al. | Antiganglioside antibody in patients with Guillain-Barré syndrome who show bulbar palsy as an initial symptom. | 1999 | J. Neurol. Neurosurg. Psychiatry | pmid:10201426 |
Heckmann JG et al. | Acute motor axonal neuropathy associated with IgM anti-GM1 following Mycoplasma pneumoniae infection. | 1999 | Eur. Neurol. | pmid:10202255 |
Goettl VM et al. | Decreased neuropeptide content in the spinal cord of aged rats: the effect of GM1 ganglioside. | 1999 | Neuroreport | pmid:10208581 |
Fujiwara S et al. | Purification and characterization of a novel protein produced by Bifidobacterium longum SBT2928 that inhibits the binding of enterotoxigenic Escherichia coli Pb176 (CFA/II) to gangliotetraosylceramide. | 1999 | J. Appl. Microbiol. | pmid:10212407 |
Mori M et al. | Haemophilus influenzae has a GM1 ganglioside-like structure and elicits Guillain-Barré syndrome. | 1999 | Neurology | pmid:10214761 |
Schwerer B et al. | Distinct immunoglobulin class and immunoglobulin G subclass patterns against ganglioside GQ1b in Miller Fisher syndrome following different types of infection. | 1999 | Infect. Immun. | pmid:10225903 |
Minke WE et al. | Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonists. | 1999 | Biochemistry | pmid:10231518 |
Davies J et al. | Reduction in the adherence of Pseudomonas aeruginosa to native cystic fibrosis epithelium with anti-asialoGM1 antibody and neuraminidase inhibition. | 1999 | Eur. Respir. J. | pmid:10232427 |
Dozier CE et al. | Diaphragmatic paralysis with monoclonal gammopathy and antiganglioside GM1 antibodies. | 1999 | Neurology | pmid:10331712 |
Kemp SF and Stoolmiller AC | Biosynthesis of glycosphingolipids in cultured mouse neuroblastoma cells. Precursor-product relationships among sialoglycosphingolipids. | 1976 | J. Biol. Chem. | pmid:1033935 |
Minke WE et al. | The role of waters in docking strategies with incremental flexibility for carbohydrate derivatives: heat-labile enterotoxin, a multivalent test case. | 1999 | J. Med. Chem. | pmid:10346930 |
Glasier MM et al. | GM1 produces attenuation of short-term memory deficits in Hebb-Williams maze performance after unilateral entorhinal cortex lesions. | 1999 | Physiol. Behav. | pmid:10357433 |
Volpe CM et al. | AsGM1+ NK cells prevent metastasis of invading LD-MCA-38 tumor cells in the nude mouse. | 1999 | J. Surg. Res. | pmid:10357913 |
Shamshiev A et al. | Self glycolipids as T-cell autoantigens. | 1999 | Eur. J. Immunol. | pmid:10359121 |
Hao Q et al. | Anti-GalNAc-GD1a antibody-associated Guillain-Barré syndrome with a predominantly distal weakness without cranial nerve impairment and sensory disturbance. | 1999 | Ann. Neurol. | pmid:10360768 |
Stewart IJ and Peel S | Effect of serum on mouse granulated metrial gland cell cytotoxicity. | 1999 | Am. J. Reprod. Immunol. | pmid:10374706 |
Görtzen A et al. | Schmidt-Lanterman's incisures--the principal target of autoimmune attack in demyelinating Guillain-Barré syndrome? | 1999 | J. Neuroimmunol. | pmid:10376936 |
Comolli JC et al. | Pili binding to asialo-GM1 on epithelial cells can mediate cytotoxicity or bacterial internalization by Pseudomonas aeruginosa. | 1999 | Infect. Immun. | pmid:10377092 |
Prendergast MM et al. | Human monoclonal immunoglobulin M antibodies to ganglioside GM1 show diverse cross-reactivities with lipopolysaccharides of Campylobacter jejuni strains associated with Guillain-Barré syndrome. | 1999 | Infect. Immun. | pmid:10377164 |
Lanne B et al. | Binding of cholera toxin B-subunits to derivatives of the natural ganglioside receptor, GM1. | 1999 | J. Biochem. | pmid:10393343 |
Galván EM et al. | Participation of ABH glycoconjugates in the secretory response to Escherichia coli heat-labile toxin in rabbit intestine. | 1999 | J. Infect. Dis. | pmid:10395858 |
Lencer WI et al. | Membrane traffic and the cellular uptake of cholera toxin. | 1999 | Biochim. Biophys. Acta | pmid:10395933 |
Slevin M et al. | Physiological concentrations of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells. | 1999 | Int. J. Cancer | pmid:10399959 |
Yuki N et al. | Autoantibodies to GM1b and GalNAc-GD1a: relationship to Campylobacter jejuni infection and acute motor axonal neuropathy in China. | 1999 | J. Neurol. Sci. | pmid:10402024 |
Kuwabara S et al. | Hyperreflexia in Guillain-Barré syndrome: relation with acute motor axonal neuropathy and anti-GM1 antibody. | 1999 | J. Neurol. Neurosurg. Psychiatry | pmid:10406985 |
Kozireski-Chuback D et al. | Developmental appearance of nuclear GM1 in neurons of the central and peripheral nervous systems. | 1999 | Brain Res. Dev. Brain Res. | pmid:10407137 |
Qiu JX et al. | Structure-function studies of an anti-asialo GM1 antibody obtained from a phage display library. | 1999 | J. Neuroimmunol. | pmid:10408972 |
Ryu BR et al. | Attenuation of cortical neuronal apoptosis by gangliosides. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10411596 |
Fukumoto H et al. | Effect of a chimeric anti-ganglioside GM2 antibody on ganglioside GM2-expressing human solid tumors in vivo. | 1999 | Int. J. Cancer | pmid:10417777 |
Sawada N et al. | Ganglioside GD1 alpha analogues as high-affinity ligands for myelin-associated glycoprotein (MAG). | 1999 | Carbohydr. Res. | pmid:10420586 |
Möbius W et al. | Intracellular distribution of a biotin-labeled ganglioside, GM1, by immunoelectron microscopy after endocytosis in fibroblasts. | 1999 | J. Histochem. Cytochem. | pmid:10424884 |
Goettl VM et al. | GM1 ganglioside restores dopaminergic neurochemical and morphological markers in aged rats. | 1999 | Neuroscience | pmid:10426539 |
Ravichandra B and Joshi PG | Regulation of transmembrane signaling by ganglioside GM1: interaction of anti-GM1 with Neuro2a cells. | 1999 | J. Neurochem. | pmid:10428051 |
Kozireski-Chuback D et al. | Axonogenesis in neuro-2a cells correlates with GM1 upregulation in the nuclear and plasma membranes. | 1999 | J. Neurosci. Res. | pmid:10440904 |
Odaka M et al. | Antibodies to GD1alpha and to GQ1beta in Guillain-Barré syndrome and the related disorders. | 1999 | J. Neurol. Sci. | pmid:10450797 |
Matsubara T et al. | Selection of ganglioside GM1-binding peptides by using a phage library. | 1999 | FEBS Lett. | pmid:10456319 |
Patel M and Isaäcson M | The effect of iron on the toxigenicity of Vibrio cholerae. | 1999 | Am. J. Trop. Med. Hyg. | pmid:10466965 |
Nakagawa T et al. | Preparation of fluorescence-labeled GM1 and sphingomyelin by the reverse hydrolysis reaction of sphingolipid ceramide N-deacylase as substrates for assay of sphingolipid-degrading enzymes and for detection of sphingolipid-binding proteins. | 1999 | J. Biochem. | pmid:10467178 |
Frost RG et al. | Characterization of purified human liver acid beta-D-galactosidases A2 and A3. | 1978 | Biochem. J. | pmid:104712 |
Nowroozi N et al. | High levels of GM(1)-ganglioside and GM(1)-ganglioside beta-galactosidase in the parotid gland: a new model for secretory mechanisms of the parotid gland. | 1999 | Otolaryngol. Clin. North Am. | pmid:10477786 |
Hashimoto H | Peripheral neuropathies in lupus patients with anti-GM1 antibodies. | 1999 | Intern. Med. | pmid:10480297 |
Matsuki Y et al. | Systemic lupus erythematosus demonstrating serum anti-GM1 antibody, with sudden onset of drop foot as the initial presentation. | 1999 | Intern. Med. | pmid:10480305 |
Shogomori H et al. | Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons. | 1999 | FEBS Lett. | pmid:10481046 |
Saito M et al. | Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neurons. | 1999 | Neurochem. Res. | pmid:10485581 |
Wang Y et al. | Antagonistic effect of ganglioside GM1 and GM3 on the activity and conformation of sarcoplasmic reticulum Ca(2+)-ATPase. | 1999 | FEBS Lett. | pmid:10486582 |
Brandão F et al. | GM1 and piracetam do not revert the alcohol-induced depletion of cholinergic fibers in the hippocampal formation of the rat. | 1999 | Alcohol | pmid:10487390 |
McKallip R et al. | Tumor gangliosides inhibit the tumor-specific immune response. | 1999 | J. Immunol. | pmid:10490967 |
Zhang D et al. | Analysis of receptor for Vibrio cholerae El tor hemolysin with a monoclonal antibody that recognizes glycophorin B of human erythrocyte membrane. | 1999 | Infect. Immun. | pmid:10496913 |
Gori AH et al. | Mediation of attachment of Burkholderia pseudomallei to human pharyngeal epithelial cells by the asialoganglioside GM1-GM2 receptor complex. | 1999 | Am. J. Trop. Med. Hyg. | pmid:10497993 |
Zervas M and Walkley SU | Ferret pyramidal cell dendritogenesis: changes in morphology and ganglioside expression during cortical development. | 1999 | J. Comp. Neurol. | pmid:10502250 |
Guo CT et al. | Ganglioside GM(1a) on the cell surface is involved in the infection by human rotavirus KUN and MO strains. | 1999 | J. Biochem. | pmid:10502675 |
Eto Y et al. | Neurochemical abnormality in I-cell disease: chemical analysis and a possible importance of beta-galactosidase deficiency. | 1979 | J. Neurochem. | pmid:105085 |
Cavallini L et al. | Ganglioside GM1 protection from apoptosis of rat heart fibroblasts. | 1999 | Arch. Biochem. Biophys. | pmid:10510273 |
Simons M et al. | Exogenous administration of gangliosides displaces GPI-anchored proteins from lipid microdomains in living cells. | 1999 | Mol. Biol. Cell | pmid:10512859 |
Caudie C et al. | [Measurement of antiganglioside autoantibodies by immunodot-blot assay: clinical importance in peripheral neuropathies]. | Ann. Biol. Clin. (Paris) | pmid:10518060 | |
Hyuga S et al. | Suppression by ganglioside GD1A of migration capability, adhesion to vitronectin and metastatic potential of highly metastatic FBJ-LL cells. | 1999 | Int. J. Cancer | pmid:10521808 |
Yuki N et al. | Acute motor axonal neuropathy and acute motor-sensory axonal neuropathy share a common immunological profile. | 1999 | J. Neurol. Sci. | pmid:10526194 |
Zuberbier T et al. | Alterations in ganglioside expression during the differentiation of human mast cells. | 1999 | Exp. Dermatol. | pmid:10536964 |
Dickler MN et al. | Immunogenicity of a fucosyl-GM1-keyhole limpet hemocyanin conjugate vaccine in patients with small cell lung cancer. | 1999 | Clin. Cancer Res. | pmid:10537341 |
Niimura Y et al. | The major acidic glycolipids from the kidney of the Pacific salmon (Oncorhynchus keta): characterization of a novel ganglioside, fucosyl-N-acetylgalactosaminyl-GM1. | 1999 | J. Biochem. | pmid:10544292 |
Finsterer J and Derfler K | Immunoadsorption in multifocal motor neuropathy. | 1999 | J. Immunother. | pmid:10546160 |
Cossy Isasi S et al. | GM1 ganglioside induced myocardial restoration and survival of mice with experimental Chagas' disease. | 1999 | Acta Trop. | pmid:10546847 |
Lian T et al. | Formulation of HIV-envelope protein with lipid vesicles expressing ganglioside GM1 associated to cholera toxin B enhances mucosal immune responses. | 1999 | Vaccine | pmid:10547418 |
Russell-Jones GJ et al. | Lectin-mediated transport of nanoparticles across Caco-2 and OK cells. | 1999 | Int J Pharm | pmid:10547456 |
Lang ML et al. | Gamma-chain dependent recruitment of tyrosine kinases to membrane rafts by the human IgA receptor Fc alpha R. | 1999 | J. Immunol. | pmid:10553064 |
Minke WE et al. | Using a galactose library for exploration of a novel hydrophobic pocket in the receptor binding site of the Escherichia coli heat-labile enterotoxin. | 1999 | J. Biol. Chem. | pmid:10559230 |
Bierfreund U et al. | Sphingolipid hydrolases and activator proteins. | 2000 | Meth. Enzymol. | pmid:10563332 |
Knoll F et al. | Sphingolipid photoaffinity labels. | 2000 | Meth. Enzymol. | pmid:10563350 |
Siagoside. GM1, Sygen. | 1999 | Drugs R D | pmid:10565981 | |
Cox NR et al. | Alterations in the growth hormone/insulin-like growth factor I pathways in feline GM1 gangliosidosis. | 1999 | Endocrinology | pmid:10579334 |
Cheng PC et al. | A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. | 1999 | J. Exp. Med. | pmid:10587346 |
Möbius W et al. | Gangliosides are transported from the plasma membrane to intralysosomal membranes as revealed by immuno-electron microscopy. | 1999 | Biosci. Rep. | pmid:10589996 |
Mauri L et al. | A procedure for the preparation of GM3 ganglioside from GM1-lactone. | 1999 | Glycoconj. J. | pmid:10596894 |
Holloway RG and Feasby TE | To test or not to test? That is the question. | 1999 | Neurology | pmid:10599756 |
Ang CW et al. | Rapidly progressive, predominantly motor Guillain-Barré syndrome with anti-GalNAc-GD1a antibodies. | 1999 | Neurology | pmid:10599792 |
Carpo M et al. | Marginally improved detection of GM1 antibodies by Covalink ELISA in multifocal motor neuropathy. | 1999 | Neurology | pmid:10599811 |
Haque S et al. | Protection against lethal toxoplasmosis in mice by an avirulent strain of Toxoplasma gondii: stimulation of IFN-gamma and TNF-alpha response. | 1999 | Exp. Parasitol. | pmid:10600449 |
Trambley J et al. | Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection. | 1999 | J. Clin. Invest. | pmid:10606625 |
Matà S et al. | Multiple sclerosis is associated with enhanced B cell responses to the ganglioside GD1a. | 1999 | Mult. Scler. | pmid:10618693 |
Chiaramonte MG et al. | CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. | 2000 | J. Immunol. | pmid:10623847 |
Neisser A et al. | Ganglioside-induced antiganglioside antibodies from a neuropathy patient cross-react with lipopolysaccharides of Campylobacter jejuni associated with Guillain-Barré syndrome. | 2000 | J. Neuroimmunol. | pmid:10626671 |
Tanigawa M et al. | Natural killer cells prevent direct anterior-to-posterior spread of herpes simplex virus type 1 in the eye. | 2000 | Invest. Ophthalmol. Vis. Sci. | pmid:10634612 |
Dillon SR et al. | Annexin V binds to viable B cells and colocalizes with a marker of lipid rafts upon B cell receptor activation. | 2000 | J. Immunol. | pmid:10640746 |
Fresta M and Puglisi G | Reduction of maturation phenomenon in cerebral ischemia with CDP-choline-loaded liposomes. | 1999 | Pharm. Res. | pmid:10644072 |
Kuwabara S et al. | Isolated absence of F waves and proximal axonal dysfunction in Guillain-Barré syndrome with antiganglioside antibodies. | 2000 | J. Neurol. Neurosurg. Psychiatry | pmid:10644786 |
Seidl EC | Promising pharmacological agents in the management of acute spinal cord injury. | 1999 | Crit Care Nurs Q | pmid:10646442 |