MeSH term | MeSH ID | Detail |
---|---|---|
Gaucher Disease | D005776 | 13 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Gaucher Disease | D005776 | 13 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Jonas S et al. | Does effect of a neuroprotective agent on volume of experimental animal cerebral infarct predict effect of the agent on clinical outcome in human stroke? | 1997 | Ann. N. Y. Acad. Sci. | pmid:9369994 |
Ledeen RW et al. | Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected]. | 2012 | Ann. N. Y. Acad. Sci. | pmid:22524425 |
Hynds DL et al. | GM1 does not affect PDGF-BB-stimulated [3H] thymidine incorporation or neuritogenesis in SH-SY5Y cells treated with phosphorothioate oligonucleotides antisense to PDGF-A. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668381 |
Ferrari G et al. | GM1, like IGF-I and GDNF, prevents neuronal apoptosis. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668378 |
Farooqui T and Yates AJ | Effect of GM1 on TrkA dimerization. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668377 |
Akporiaye ET et al. | Effect of beta-carotene on cytotoxic activity and receptor expression of tumor-specific lymphocytes. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8129307 |
Hadden RD et al. | Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group. | 1998 | Ann. Neurol. | pmid:9818934 |
Bech E et al. | Association of IgM type anti-GM1 antibodies and muscle strength in chronic acquired demyelinating polyneuropathy. | 1998 | Ann. Neurol. | pmid:9450770 |
Vriesendorp FJ et al. | Serum antibodies to GM1, GD1b, peripheral nerve myelin, and Campylobacter jejuni in patients with Guillain-Barré syndrome and controls: correlation and prognosis. | 1993 | Ann. Neurol. | pmid:8338337 |
Singer HS et al. | Neurotransmitter chemistry in feline GM1 gangliosidosis: a model for human ganglioside storage disease. | 1982 | Ann. Neurol. | pmid:6126152 |
Pestronk A et al. | Patterns of serum IgM antibodies to GM1 and GD1a gangliosides in amyotrophic lateral sclerosis. | 1989 | Ann. Neurol. | pmid:2913936 |
Kobayashi T and Suzuki K | Chronic GM1 gangliosidosis presenting as dystonia: II. Biochemical studies. | 1981 | Ann. Neurol. | pmid:6791575 |
Goldman JE et al. | Chronic GM1 gangliosidosis presenting as dystonia: I. Clinical and pathological features. | 1981 | Ann. Neurol. | pmid:6791574 |
Farrell DF and MacMartin MP | GM1 gangliosidosis: enzymatic variation in a single family. | 1981 | Ann. Neurol. | pmid:6784663 |
Farrell DF and Ochs U | GM1 gangliosidosis: phenotypic variation in a single family. | 1981 | Ann. Neurol. | pmid:6784662 |
Nardelli E et al. | Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1b. | 1988 | Ann. Neurol. | pmid:3389760 |
Mullin BR et al. | Interaction of multiple sclerosis serum with liposomes containing ganglioside GM1. | 1980 | Ann. Neurol. | pmid:7436364 |
Treatment of Guillain-Barré syndrome with high-dose immune globulins combined with methylprednisolone: a pilot study. The Dutch Guillain-Barré Study Group. | 1994 | Ann. Neurol. | pmid:8210234 | |
Hafer-Macko C et al. | Acute motor axonal neuropathy: an antibody-mediated attack on axolemma. | 1996 | Ann. Neurol. | pmid:8871584 |
Yuki N et al. | Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside. | 2001 | Ann. Neurol. | pmid:11409422 |
Sheikh KA and Griffin JW | Variants of the Guillain Barré syndrome: progress toward fulfilling "Koch's postulates". | 2001 | Ann. Neurol. | pmid:11409419 |
Harschnitz O et al. | Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model. | 2016 | Ann. Neurol. | pmid:27130524 |
Singer HS et al. | Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease. | 1987 | Ann. Neurol. | pmid:3035998 |
Jacobs BC et al. | Campylobacter jejuni infections and anti-GM1 antibodies in Guillain-Barré syndrome. | 1996 | Ann. Neurol. | pmid:8773599 |
Santoro M et al. | Experimental conduction block induced by serum from a patient with anti-GM1 antibodies. | 1992 | Ann. Neurol. | pmid:1586139 |
Malik U et al. | Intravenous gamma-globulin inhibits binding of anti-GM1 to its target antigen. | 1996 | Ann. Neurol. | pmid:8572660 |
Rees JH et al. | Anti-ganglioside GM1 antibodies in Guillain-Barré syndrome and their relationship to Campylobacter jejuni infection. | 1995 | Ann. Neurol. | pmid:7486873 |
Steck A and Kuntzer T | Diagnosis of amyotrophic lateral sclerosis. | 1991 | Ann. Neurol. | pmid:1897916 |
Yuki N et al. | Clinical features and response to treatment in Guillain-Barré syndrome associated with antibodies to GM1b ganglioside. | 2000 | Ann. Neurol. | pmid:10716250 |
Oomes PG et al. | Anti-GM1 IgG antibodies and Campylobacter bacteria in Guillain-Barré syndrome: evidence of molecular mimicry. | 1995 | Ann. Neurol. | pmid:7654064 |
Pestronk A et al. | A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. | 1988 | Ann. Neurol. | pmid:2843079 |
Roberts M et al. | Multifocal motor neuropathy human sera block distal motor nerve conduction in mice. | 1995 | Ann. Neurol. | pmid:7611713 |
Kornberg AJ and Pestronk A | Chronic motor neuropathies: diagnosis, therapy, and pathogenesis. | 1995 | Ann. Neurol. | pmid:8968216 |
Takigawa T et al. | Antibodies against GM1 ganglioside affect K+ and Na+ currents in isolated rat myelinated nerve fibers. | 1995 | Ann. Neurol. | pmid:7717679 |
Hao Q et al. | Anti-GalNAc-GD1a antibody-associated Guillain-Barré syndrome with a predominantly distal weakness without cranial nerve impairment and sensory disturbance. | 1999 | Ann. Neurol. | pmid:10360768 |
Santoro M et al. | IgM deposits at nodes of Ranvier in a patient with amyotrophic lateral sclerosis, anti-GM1 antibodies, and multifocal motor conduction block. | 1990 | Ann. Neurol. | pmid:2132741 |
Ala TA and Frey WH | The clinical correlates of high-titer IgG anti-GM1 antibodies. | 1994 | Ann. Neurol. | pmid:8080261 |
Salazar-Grueso EF et al. | Polyclonal IgM anti-GM1 ganglioside antibody in patients with motor neuron disease and variants. | 1990 | Ann. Neurol. | pmid:2113790 |
Kastner A et al. | Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP-intoxicated monkeys: effect of levodopa and GM1 ganglioside therapy. | 1994 | Ann. Neurol. | pmid:7914399 |
Pestronk A et al. | Lower motor neuron syndromes defined by patterns of weakness, nerve conduction abnormalities, and high titers of antiglycolipid antibodies. | 1990 | Ann. Neurol. | pmid:2327739 |
Wirguin I et al. | Monoclonal IgM antibodies to GM1 and asialo-GM1 in chronic neuropathies cross-react with Campylobacter jejuni lipopolysaccharides. | 1994 | Ann. Neurol. | pmid:8210226 |
Sheikh KA et al. | An anti-ganglioside antibody-secreting hybridoma induces neuropathy in mice. | 2004 | Ann. Neurol. | pmid:15293275 |
Marcus DM | Measurement and clinical importance of antibodies to glycosphingolipids. | 1990 | Ann. Neurol. | pmid:2194428 |
Latov N | Neuropathy and anti-GM1 antibodies. | 1990 | Ann. Neurol. | pmid:2194425 |
Kuwabara S et al. | IgG anti-GM1 antibody is associated with reversible conduction failure and axonal degeneration in Guillain-Barré syndrome. | 1998 | Ann. Neurol. | pmid:9708542 |
Willison HJ et al. | Cloning of human anti-GM1 antibodies from motor neuropathy patients. | 1994 | Ann. Neurol. | pmid:8154875 |
Meyer MA et al. | Structural similarities between ganglioside GM1 and antigens of the P2 phenotype. | 1989 | Ann. Neurol. | pmid:2817846 |
Kornberg AJ et al. | The clinical correlates of high-titer IgG anti-GM1 antibodies. | 1994 | Ann. Neurol. | pmid:8109905 |
Susuki K et al. | Acute motor axonal neuropathy rabbit model: immune attack on nerve root axons. | 2003 | Ann. Neurol. | pmid:12953272 |
Shy ME et al. | Antibodies to GM1 and GD1b in patients with motor neuron disease without plasma cell dyscrasia. | 1989 | Ann. Neurol. | pmid:2505666 |
Odaka M et al. | N-glycolylneuraminic acid-containing GM1 is a new molecule for serum antibody in Guillain-Barré syndrome. | 1998 | Ann. Neurol. | pmid:9629854 |
Moss J and Vaughan M | Activation of adenylate cyclase by choleragen. | 1979 | Annu. Rev. Biochem. | pmid:224804 |
Lucki NC and Sewer MB | Nuclear sphingolipid metabolism. | 2012 | Annu. Rev. Physiol. | pmid:21888508 |
Chatterjee A and Chowdhury R | Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. | 2008 | Antimicrob. Agents Chemother. | pmid:17954701 |
Basse PH et al. | Enumeration of organ-associated natural killer cells in mice: application of a new stereological method. | 1992 | APMIS | pmid:1562313 |
Kang TJ et al. | Enhanced expression of B-subunit of Escherichia coli heat-labile enterotoxin in tobacco by optimization of coding sequence. | 2004 | Appl. Biochem. Biotechnol. | pmid:15304769 |
Liljeqvist S et al. | Surface display of the cholera toxin B subunit on Staphylococcus xylosus and Staphylococcus carnosus. | 1997 | Appl. Environ. Microbiol. | pmid:9212399 |
Tellier S et al. | [Guillain-Barré syndrome in a child with normal tendon reflexes]. | 2012 | Arch Pediatr | pmid:22154102 |
Davies AL et al. | Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury. | 2007 | Arch Phys Med Rehabil | pmid:17964877 |
Naoi M and Yagi K | Effects of phospholipids on substrate specificity of beta-galactosidase purified from Aspergillus oryzae. | 1982 | Arch. Biochem. Biophys. | pmid:6807206 |
Hiraiwa M et al. | The effect of carbohydrate removal on stability and activity of saposin B. | 1993 | Arch. Biochem. Biophys. | pmid:8099782 |
Cavallini L et al. | Ganglioside GM1 protection from apoptosis of rat heart fibroblasts. | 1999 | Arch. Biochem. Biophys. | pmid:10510273 |
Krivan HC et al. | Pseudomonas aeruginosa and Pseudomonas cepacia isolated from cystic fibrosis patients bind specifically to gangliotetraosylceramide (asialo GM1) and gangliotriaosylceramide (asialo GM2). | 1988 | Arch. Biochem. Biophys. | pmid:3124753 |
Vogel A et al. | Identity of the activator proteins for the enzymatic hydrolysis of sulfatide, ganglioside GM1, and globotriaosylceramide. | 1987 | Arch. Biochem. Biophys. | pmid:3426245 |
Peters SP et al. | Isolation of heat-stable glucocerebrosidase activators from the spleens of three variants of Gaucher's disease. | 1977 | Arch. Biochem. Biophys. | pmid:907355 |
Yamamoto K et al. | Destruction of cholera toxin receptor on HeLa cell membrane using microbial endoglycoceramidase. | 1996 | Arch. Biochem. Biophys. | pmid:8638937 |
Zeng FY and Gabius HJ | Carbohydrate-binding specificity of calcyclin and its expression in human tissues and leukemic cells. | 1991 | Arch. Biochem. Biophys. | pmid:1716875 |
Saito M and Sugiyama K | A distinct ganglioside composition of rat pancreatic islets. | 2000 | Arch. Biochem. Biophys. | pmid:10775425 |
Ong RL and Yu RK | 1H-NMR assignments of GM1-oligosaccharide in deuterated water at 500 MHz by two-dimensional spin-echo J-correlated spectroscopy. | 1986 | Arch. Biochem. Biophys. | pmid:3004355 |
Maggio B et al. | Molecular parameters and conformation of globoside and asialo-GM1. | 1985 | Arch. Biochem. Biophys. | pmid:4026313 |
Inui K and Wenger DA | Biochemical, immunological, and structural studies on a sphingolipid activator protein (SAP-1). | 1984 | Arch. Biochem. Biophys. | pmid:6435528 |
Lunblad A et al. | Characterization of a penta-and an octasaccharide from urine of a patient with juvenile GM1-gangliosidosis. | 1978 | Arch. Biochem. Biophys. | pmid:98112 |
Schessl J et al. | Prospective study on anti-ganglioside antibodies in childhood Guillain-Barré syndrome. | 2007 | Arch. Dis. Child. | pmid:16920757 |
Campbell AW et al. | Neural autoantibodies and neurophysiologic abnormalities in patients exposed to molds in water-damaged buildings. | 2003 | Arch. Environ. Health | pmid:15259425 |
Hadfield MG et al. | Pathologic findings in mucopolysaccharidosis type IIIB (Sanfilippo's sydnrome B). | 1980 | Arch. Neurol. | pmid:6775621 |
Suzuki Y et al. | Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver. | 1977 | Arch. Neurol. | pmid:402903 |
Fishman PS et al. | Antibodies to the ganglioside GD1b in a patient with motor neuron disease and thyroid adenoma. | 1991 | Arch. Neurol. | pmid:1953407 |
Bieber FR et al. | Pathologic findings in fetal GM1 gangliosidosis. | 1986 | Arch. Neurol. | pmid:3089200 |
Pestronk A | Immunosuppressive treatment of motor neuron syndromes. | 1995 | Arch. Neurol. | pmid:7726976 |
Ala T et al. | GM-1 treatment of Alzheimer's disease. A pilot study of safety and efficacy. | 1990 | Arch. Neurol. | pmid:2222246 |
Tan E et al. | Immunosuppressive treatment of motor neuron syndromes. Attempts to distinguish a treatable disorder. | 1994 | Arch. Neurol. | pmid:8304845 |
Nowroozi N et al. | High beta-galactosidase and ganglioside GM1 levels in the human parotid gland. | 2001 | Arch. Otolaryngol. Head Neck Surg. | pmid:11701079 |
Jin S et al. | Lysosomal targeting and trafficking of acid sphingomyelinase to lipid raft platforms in coronary endothelial cells. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18772496 |
Yanagisawa M et al. | Cytotoxic effects of G(M1) ganglioside and amyloid β-peptide on mouse embryonic neural stem cells. | 2010 | ASN Neuro | pmid:20305711 |
Zhang X et al. | Abnormal lipid rafts related ganglioside expression and signaling in T lymphocytes in immune thrombocytopenia patients. | 2016 | Autoimmunity | pmid:26287565 |
Ni YF et al. | GM1 ganglioside reverses the cognitive deficits induced by MK801 in mice. | 2016 | Behav Pharmacol | pmid:26960162 |
Dunbar GL et al. | Comparison of GM1 ganglioside, AGF2, and D-amphetamine as treatments for spatial reversal and place learning deficits following lesions of the neostriatum. | 1993 | Behav. Brain Res. | pmid:8504013 |
Fong TG et al. | GM1 ganglioside improves spatial learning and memory of aged rats. | 1997 | Behav. Brain Res. | pmid:9105576 |
Petrosini L | Behavioural recovery from unilateral vestibular lesion is facilitated by GM1 ganglioside treatment. | 1987 | Behav. Brain Res. | pmid:3566906 |
Zieliński K et al. | Effects of partial lesion of dorsal hippocampal afferent and GM1 ganglioside treatment on conditioned emotional response and hippocampal afferent markers in rats. | 1993 | Behav. Brain Res. | pmid:8329129 |
Valdomero A et al. | Exogenous GM1 ganglioside increases accumbal BDNF levels in rats. | 2015 | Behav. Brain Res. | pmid:25453740 |
Sahyoun N et al. | Skeletal association of the cholera toxin receptor in rat erythrocytes. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7198441 |
Chatterjee C and Mukhopadhyay C | Melittin-GM1 interaction: a model for a side-by-side complex. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11906200 |
Mertz JA et al. | Fluorescence analysis of galactose, lactose, and fucose interaction with the cholera toxin B subunit. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806604 |
Tomasi M et al. | Comparison of water exposed area of cholera toxin when free in solution and bound to liposomes containing the ganglioside GM1. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4026857 |
Chubinskiy-Nadezhdin VI et al. | Cholesterol depletion-induced inhibition of stretch-activated channels is mediated via actin rearrangement. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21798240 |
Gabius S et al. | Carrier-immobilized derivatized lysoganglioside GM1 is a ligand for specific binding sites in various human tumor cell types and peripheral blood lymphocytes and monocytes. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2350347 |
Houri JJ et al. | The metabolic processing of glycosphingolipids in HT-29 cells is differentiation-dependent. | 1994 | Biochem. Biophys. Res. Commun. | pmid:8048973 |
Kosugi S et al. | Biological effect of anti-fucosyl GM1 ganglioside antibody on cyclic adenosine 3',5'-monophosphate production in FRTL5 rat thyroid cells. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2882753 |
Chatterjee C and Mukhopadhyay C | Conformational alteration of bradykinin in presence of GM1 micelle. | 2004 | Biochem. Biophys. Res. Commun. | pmid:14985092 |