Ganglioside GI

Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GI?

Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ganglioside GI

MeSH term MeSH ID Detail
Gaucher Disease D005776 13 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Brain Ischemia D002545 89 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GI

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GI?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Ganglioside GI?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ganglioside GI?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Ganglioside GI?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ganglioside GI?

Knock-out

Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).

Transgenic Model

Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).

Disease model

Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Ganglioside GI

Download all related citations
Per page 10 20 50 100 | Total 3081
Authors Title Published Journal PubMed Link
Davis S et al. The monosialosyl ganglioside GM-1 reduces the vagolytic efficacy of delta2-opioid receptor stimulation. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16815987
Jin ZQ et al. Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12003800
Li J et al. Signaling intermediates required for NF-kappa B activation and IL-8 expression in CF bronchial epithelial cells. 2003 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:12388360
Tao W et al. Cardiovascular dysfunction caused by cecal ligation and puncture is attenuated in CD8 knockout mice treated with anti-asialoGM1. 2005 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:15845883
Tao W and Sherwood ER Beta2-microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis. 2004 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:14630624
Itokazu Y et al. Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair. 2014 Am. J. Physiol., Cell Physiol. pmid:24500283
Domingue JC and Rao MC CFTR and GM1 "gangl-ing" up to heal thy wound. Focus on "Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair". 2014 Am. J. Physiol., Cell Physiol. pmid:24627559
Badizadegan K et al. Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton. 2004 Am. J. Physiol., Cell Physiol. pmid:15294854
Chaouat G et al. Immune suppression and Th1/Th2 balance in pregnancy revisited: a (very) personal tribute to Tom Wegmann. 1997 Am. J. Reprod. Immunol. pmid:9228297
Stewart IJ and Peel S Effect of serum on mouse granulated metrial gland cell cytotoxicity. 1999 Am. J. Reprod. Immunol. pmid:10374706
Arck PC et al. Stress-triggered abortion: inhibition of protective suppression and promotion of tumor necrosis factor-alpha (TNF-alpha) release as a mechanism triggering resorptions in mice. 1995 Am. J. Reprod. Immunol. pmid:7619237
Saba S et al. Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways. 2002 Am. J. Respir. Cell Mol. Biol. pmid:12397015
McNamara N et al. AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2. 2006 Am. J. Respir. Cell Mol. Biol. pmid:16439799
Bryan R et al. Overproduction of the CFTR R domain leads to increased levels of asialoGM1 and increased Pseudomonas aeruginosa binding by epithelial cells. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9698599
Muir A et al. Toll-like receptors in normal and cystic fibrosis airway epithelial cells. 2004 Am. J. Respir. Cell Mol. Biol. pmid:14656745
Sherwood ER et al. Beta 2 microglobulin knockout mice are resistant to lethal intraabdominal sepsis. 2003 Am. J. Respir. Crit. Care Med. pmid:12626348
Kuhlmann FM et al. Blood Group O-Dependent Cellular Responses to Cholera Toxin: Parallel Clinical and Epidemiological Links to Severe Cholera. 2016 Am. J. Trop. Med. Hyg. pmid:27162272
Gori AH et al. Mediation of attachment of Burkholderia pseudomallei to human pharyngeal epithelial cells by the asialoganglioside GM1-GM2 receptor complex. 1999 Am. J. Trop. Med. Hyg. pmid:10497993
Patel M and Isaäcson M The effect of iron on the toxigenicity of Vibrio cholerae. 1999 Am. J. Trop. Med. Hyg. pmid:10466965
Avila JL et al. Increase in asialoganglioside- and monosialoganglioside-reactive antibodies in chronic Chagas' disease patients. 1998 Am. J. Trop. Med. Hyg. pmid:9546415
Suchyta MR et al. The role of natural killer cells in histoplasmosis. 1988 Am. Rev. Respir. Dis. pmid:3202412
Bunyakul N et al. Cholera toxin subunit B detection in microfluidic devices. 2009 Anal Bioanal Chem pmid:18777170
Liang B et al. Label-free detection and identification of protein ligands captured by receptors in a polymerized planar lipid bilayer using MALDI-TOF MS. 2015 Anal Bioanal Chem pmid:25694144
Abd-Elhadi S et al. Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA. 2016 Anal Bioanal Chem pmid:27624766
Ogura K et al. Peroxidase-amplified assay of sialidase activity toward gangliosides. 1992 Anal. Biochem. pmid:1595901
Wu GS and Ledeen R Quantification of gangliotetraose gangliosides with cholera toxin. 1988 Anal. Biochem. pmid:3189815
Müthing J and Mühlradt PF Detection of gangliosides of the GM1b type on high-performance thin-layer chromatography plates by immunostaining after neuraminidase treatment. 1988 Anal. Biochem. pmid:3263817
Panasiewicz M et al. Preparation of Alexa Fluor 350-conjugated nonradioactive or 3H-labeled GM1 ganglioside derivatives with different ceramides. 2009 Anal. Biochem. pmid:18983810
Magnani JL et al. Detection of gangliosides that bind cholera toxin: direct binding of 125I-labeled toxin to thin-layer chromatograms. 1980 Anal. Biochem. pmid:7224165
Urbanowski JC et al. A colorimetric procedure for measuring the enzymatic hydrolysis of terminal galactose from GM ganglioside. 1980 Anal. Biochem. pmid:6779665
Mattoo RL and Roseman S Quantitative determination of sialic acid in the monosialoganglioside, GM1, by the thiobarbituric acid method. 1997 Anal. Biochem. pmid:9056179
PÃ¥hlsson P and Nilsson B Fast atom bombardment-mass spectrometry of glycosphingolipids extracted from thin-layer chromatography plates. 1988 Anal. Biochem. pmid:3364706
Yeung KK et al. A fluorometric method for monitoring the enzymic hydrolysis of terminal galactose from GM1-ganglioside. 1979 Anal. Biochem. pmid:223469
Uwiera RE et al. Effect of covalent modification on the binding of cholera toxin B subunit to ileal brush border surfaces. 1992 Anal. Biochem. pmid:1443521
Edwards KA and March JC GM(1)-functionalized liposomes in a microtiter plate assay for cholera toxin in Vibrio cholerae culture samples. 2007 Anal. Biochem. pmid:17603995
Song X et al. Flow cytometry-based biosensor for detection of multivalent proteins. 2000 Anal. Biochem. pmid:10933853
Song X et al. Detection of multivalent interactions through two-tiered energy transfer. 2001 Anal. Biochem. pmid:11262166
Miyoshi I et al. A solid-phase enzyme-linked assay for ceramide glycanase using GM1 and a novel beta-galactosidase inhibitor. 1996 Anal. Biochem. pmid:8660520
Sasahara K et al. Uptake of raft components into amyloid β-peptide aggregates and membrane damage. 2015 Anal. Biochem. pmid:25908557
Schwarz A et al. Isolation of gangliosides by cloud-point extraction with a nonionic detergent. 1997 Anal. Biochem. pmid:9417780
Panasiewicz M et al. HPLC-based procedure for the preparation of carbene-generating photoreactive GM3 and GM1 ganglioside derivatives radioiodinated to high specific radioactivity with chloramine T as an oxidant. 2005 Anal. Biochem. pmid:15840512
Saito M et al. In situ immunological determination of basic carbohydrate structures of gangliosides on thin-layer plates. 1985 Anal. Biochem. pmid:4037308
Rodriguez PE and Cumar FA Gangliosides noncovalently bound to DEAE-Sephadex: application to purification of anti-ganglioside antibodies. 1990 Anal. Biochem. pmid:2221368
Leskawa KC et al. A simplified procedure for the preparation of tritiated GM1 ganglioside and other glycosphingolipids. 1984 Anal. Biochem. pmid:6486403
Wiesner DA and Sweeley CC Microscale analysis of glycosphingolipids by methanolysis, peracetylation, and gas chromatography. 1994 Anal. Biochem. pmid:8203762
Isobe R et al. Negative ion fast atom bombardment mass spectrometry for native gangliosides using a neutral matrix. 1989 Anal. Biochem. pmid:2729549
Zhang Y et al. Protein-glycosphingolipid interactions revealed using catch-and-release mass spectrometry. 2012 Anal. Chem. pmid:22920193
Jönsson P et al. Accumulation and separation of membrane-bound proteins using hydrodynamic forces. 2011 Anal. Chem. pmid:21155531
Boardman AK et al. Interface of an array of five capillaries with an array of one-nanoliter wells for high-resolution electrophoretic analysis as an approach to high-throughput chemical cytometry. 2008 Anal. Chem. pmid:18717573
Shi J et al. Multiplexing ligand-receptor binding measurements by chemically patterning microfluidic channels. 2008 Anal. Chem. pmid:18570383