MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fabani MM et al. | Study of in vitro stability of liposomes and in vivo antibody response to antigen associated with liposomes containing GM1 after oral and subcutaneous immunization. | J Liposome Res | pmid:12604034 | |
Maysinger D et al. | Microencapsulated monosialoganglioside GM1: physical properties and in vivo effects. | J Microencapsul | pmid:2715912 | |
Barnes IC et al. | Hepatic beta galactosidase and feline GMI gangliosidosis. | Neuropathol. Appl. Neurobiol. | pmid:6799849 | |
Selvaraj V et al. | GM1 dynamics as a marker for membrane changes associated with the process of capacitation in murine and bovine spermatozoa. | J. Androl. | pmid:17377143 | |
Yamashita K et al. | Interleukin-18 inhibits lodging and subsequent growth of human multiple myeloma cells in the bone marrow. | Oncol. Rep. | pmid:12375027 | |
Karpiak SE et al. | Gangliosides (GM1 and AGF2) reduce mortality due to ischemia: protection of membrane function. | Stroke | pmid:3027926 | |
Tanaka K et al. | Effect of the ganglioside GM1, on cerebral metabolism, microcirculation, recovery kinetics of ECoG and histology, during the recovery period following focal ischemia in cats. | Stroke | pmid:3810717 | |
Hatzifilippou E et al. | Antibodies against GM1 in demented patients. | Am J Alzheimers Dis Other Demen | pmid:18509104 | |
Baumgartner WA et al. | Pathophysiology of cerebral injury and future management. | J Card Surg | pmid:9271760 | |
pmid:6103241 | ||||
Kholodenko IV et al. | Ganglioside GM1-binding sites in interleukin-4: a photoaffinity labeling study. | Dokl. Biochem. Biophys. | pmid:18429602 | |
Touraine JL et al. | Improved engraftment and chimerism by anti-NK cell treatment in allogeneic transplantation of hematopoietic stem cells. | Transplant. Proc. | pmid:9123496 | |
Mikami M et al. | Characteristic alteration in the concentration of IV 3NeuAc alpha-nLc4Cer in the villi of human placenta during the gestational period. | Placenta | pmid:8248034 | |
Gavella M et al. | Trisialoganglioside GT1b prevents increase in sperm membrane molecular ordering induced by in vitro lipid peroxidation. | J. Androl. | pmid:16291967 | |
pmid:2420639 | ||||
Basta I et al. | [Antibodies to ganglioside GM1 and Campylobacter jejuni in patients with Guillain-Barré syndrome]. | Srp Arh Celok Lek | pmid:16206698 | |
pmid:8738233 | ||||
Boggs JM et al. | Immune lysis of lipid vesicles containing myelin basic protein or glycolipid antigens by multiple sclerosis and normal sera. | J. Neurol. Sci. | pmid:6085112 | |
Chen SY et al. | The membrane disordering effect of ethanol on neural crest cells in vitro and the protective role of GM1 ganglioside. | Alcohol | pmid:8949954 | |
pmid:4009116 | ||||
Polyzos A et al. | Biofunctionalized surfactant mesophases as polyvalent inhibitors of cholera toxin. | Bioconjug. Chem. | pmid:17715991 | |
Marushchak D et al. | Self-aggregation--an intrinsic property of G(M1) in lipid bilayers. | Mol. Membr. Biol. | pmid:17453417 | |
Yanagisawa K and Ihara Y | GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain. | Neurobiol. Aging | pmid:9562471 | |
Augustinsson LE et al. | Intracerebroventricular administration of GM1 ganglioside to presenile Alzheimer patients. | Dement Geriatr Cogn Disord | pmid:8997549 | |
Röckendorf N et al. | Synthesis of a fluorescent ganglioside GM1 derivative and screening of a synthetic peptide library for GM1 binding sequence motifs. | Bioconjug. Chem. | pmid:17323913 | |
Mutoh T et al. | Unglycosylated Trk protein does not co-localize nor associate with ganglioside GM1 in stable clone of PC12 cells overexpressing Trk (PCtrk cells). | Glycoconj. J. | pmid:11201795 | |
Fantini J et al. | Glycosphingolipid (GSL) microdomains as attachment platforms for host pathogens and their toxins on intestinal epithelial cells: activation of signal transduction pathways and perturbations of intestinal absorption and secretion. | Glycoconj. J. | pmid:11201788 | |
BadÃa Picazo MC et al. | [Hyperreflexia in a patient with Guillain Barre syndrome]. | Rev Neurol | pmid:15098195 | |
Stout JG et al. | Ethanol disordering of GM1-enriched short-sleep synaptosomal plasma membranes. | Alcohol | pmid:7818801 | |
Kirschner G et al. | Competitive binding assay for quantitative determination of GM1 ganglioside in plasma and cerebrospinal fluid. | J Pharm Biomed Anal | pmid:1391096 | |
Brezicka T and Einbeigi Z | Supra-additive cytotoxic effects of a combination of cytostatic drugs and antibody-induced complement activation on tumor cells in vitro. | Tumour Biol. | pmid:11125282 | |
Laev H et al. | Cortical cell plasma membrane alterations after in vitro alcohol exposure: prevention by GM1 ganglioside. | Alcohol | pmid:8814655 | |
Valsecchi M et al. | Rat cerebellar granule cells in culture associate and metabolize differently exogenous GM1 ganglioside molecular species containing a C18 or C20 long chain base. | Chem. Phys. Lipids | pmid:1505063 | |
Izumi T et al. | Normal developmental profiles of CSF gangliotetraose-series gangliosides from neonatal period to adolescence. | Pediatr. Neurol. | pmid:8216543 | |
Izumi T et al. | Low levels of CSF gangliotetraose-series gangliosides in West syndrome: implication of brain maturation disturbance. | Pediatr. Neurol. | pmid:8216542 | |
Ledeen RW and Wu G | GM1 ganglioside: another nuclear lipid that modulates nuclear calcium. GM1 potentiates the nuclear sodium-calcium exchanger. | Can. J. Physiol. Pharmacol. | pmid:16902585 | |
Richardson JM et al. | Solution dynamics of the oligosaccharide moiety of ganglioside GM1: comparison of solution conformations with the bound state conformation in association with cholera toxin B-pentamer. | J. Mol. Recognit. | pmid:9052976 | |
Fong TG et al. | GM1 and NGF synergism on choline acetyltransferase and choline uptake in aged brain. | Neurobiol. Aging | pmid:8622782 | |
Suzuki Y | Beta-galactosidase deficiency: an approach to chaperone therapy. | J. Inherit. Metab. Dis. | pmid:16763919 | |
Guan C et al. | Expression of cholera toxin B subunit-lumbrokinase in edible sunflower seeds-the use of transmucosal carrier to enhance its fusion protein's effect on protection of rats and mice against thrombosis. | Biotechnol. Prog. | pmid:25080206 | |
Wallis CJ et al. | GM1 ganglioside reduces ethanol intoxication and the development of ethanol dependence. | Alcohol | pmid:8590622 | |
Cadete-Leite A et al. | Effects of GM1 ganglioside upon neuronal degeneration during withdrawal from alcohol. | Alcohol | pmid:1781918 | |
Morrison WJ et al. | Ganglioside (GM1)-treated T cells shed CD4. | Immunopharmacology | pmid:1761402 | |
Caudie C et al. | [Antiganglioside autoantibody profiles in Guillain-Barré syndrome]. | Ann. Biol. Clin. (Paris) | pmid:12368145 | |
Liu L et al. | Alterations in cholesterol and ganglioside GM1 content of lipid rafts in platelets from patients with Alzheimer disease. | Alzheimer Dis Assoc Disord | pmid:24759545 | |
pmid:7358687 | ||||
Morrison WJ et al. | Transmembrane signalling associated with ganglioside-induced CD4 modulation. | Immunopharmacology | pmid:2176187 | |
Peel S and Adam E | The killing of rat placental cells by rat and mouse granulated metrial gland cells in vitro. | Placenta | pmid:1871073 | |
Ricci LC et al. | Erythrocyte receptors for cholera and heat-labile enterotoxins of Escherichia coli. | Res. Microbiol. | pmid:2559437 | |
Stout JG et al. | Characterization of a GM1-dependent surface interaction for alcohol with DPPC membranes. | Alcohol | pmid:7639951 | |
Hao C et al. | Interaction between ganglioside G(M1) and diosgenin in langmuir monolayers at the air/water interface. | Scanning | pmid:23553978 | |
Bassi S et al. | Monosialoganglioside therapy in stroke. | Stroke | pmid:3901426 | |
pmid: | ||||
Cencioni MT et al. | T cell response in acute motor axonal neuropathy. | Int J Immunopathol Pharmacol | pmid:20074468 | |
Izumi T et al. | Abnormality of cerebral gangliosides in Fukuyama type congenital muscular dystrophy. | Brain Dev. | pmid:7762760 | |
pmid:1680104 | ||||
Sergeeva SS et al. | Antibodies against gangliosides GM1 of patients with multiple sclerosis alter the response of neurons to synaptic activation. | Dokl. Biol. Sci. | pmid:15717608 | |
Dawson RM | Characterization of the binding of cholera toxin to ganglioside GM1 immobilized onto microtitre plates. | J Appl Toxicol | pmid:15669043 | |
Sommer BR et al. | Changes in tardive dyskinesia symptoms in elderly patients treated with ganglioside GM1 or placebo. | J Geriatr Psychiatry Neurol | pmid:7826493 | |
Xia GL et al. | Characteristics of B lymphocyte and natural killer cell xenotolerance in a concordant hamster-to-athymic rat cardiac xenotransplantation model. | Transplant. Proc. | pmid:10083409 | |
pmid:11113142 | ||||
Simma B et al. | [GM1 gangliosidosis and dilated cardiomyopathy]. | Klin Padiatr | pmid:2113151 | |
pmid:11034355 | ||||
Arai M and Kusunoki S | [A case of multifocal motor neuropathy with IgM lambda anti-GM1 antibody and IgM kappa paraprotein reacting exclusively with GM2]. | Rinsho Shinkeigaku | pmid:19348179 | |
pmid:2306612 | ||||
Caudie C et al. | [Measurement of antiganglioside autoantibodies by immunodot-blot assay: clinical importance in peripheral neuropathies]. | Ann. Biol. Clin. (Paris) | pmid:10518060 | |
pmid:2527208 | ||||
Mitchell JS et al. | Clustering T-cell GM1 lipid rafts increases cellular resistance to shear on fibronectin through changes in integrin affinity and cytoskeletal dynamics. | Immunol. Cell Biol. | pmid:19139760 | |
Olivier V et al. | Influence of targeting ligand flexibility on receptor binding of particulate drug delivery systems. | Bioconjug. Chem. | pmid:14624636 | |
Shell LG et al. | Neuronal-visceral GM1 gangliosidosis in Portuguese water dogs. | J. Vet. Intern. Med. | pmid:2494322 | |
pmid:18573324 | ||||
Sadeghlar F et al. | Physiological relevance of sphingolipid activator proteins in cultured human fibroblasts. | Biochimie | pmid:12770782 | |
Revesz T et al. | Differential expression of cell surface binding sites for cholera toxin in acute and chronic leukaemias. | 1976 | Br. J. Haematol. | pmid:791345 |
Milewicz C et al. | Membrane expression of Thy-1,2 and GM1 ganglioside on differentiating T lymphocytes. | 1976 | J. Immunol. | pmid:1086862 |
Read DH et al. | Neuronal-visceral GM1 gangliosidosis in a dog with beta-galactosidase deficiency. | 1976 | Science | pmid:824730 |
Kemp SF and Stoolmiller AC | Biosynthesis of glycosphingolipids in cultured mouse neuroblastoma cells. Precursor-product relationships among sialoglycosphingolipids. | 1976 | J. Biol. Chem. | pmid:1033935 |
Kanfer JN et al. | Lipolytic action of cholera toxin on fat cells. Re-examination of the concept implicating GM1 ganglioside as the native membrane receptor. | 1976 | J. Biol. Chem. | pmid:1002701 |
Moss J et al. | Choleragen-mediated release of trapped glucose from liposomes containing ganglioside GM1. | 1976 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1068459 |
Raghavan SA et al. | GM1-ganglioside beta-galactosidase in leukocytes and cultured fibroblasts. | 1977 | Clin. Chim. Acta | pmid:411612 |
Kurczynski TW et al. | Lactosylceramidases in canine globoid cell leukodystrophy. | 1977 | J. Neurochem. | pmid:886322 |
Esselman WJ and Miller HC | Modulation of B cell responses by glycolipid released from antigen-stimulated T cells. | 1977 | J. Immunol. | pmid:334979 |
Duffard RO et al. | Ganglioside composition and biosynthesis in cultred cells derived from CNS. | 1977 | J. Neurochem. | pmid:406360 |
Ng SS and Dain JA | Sialyltransferases in rat brain: reaction kinetics, product analyses, and multiplicities of enzyme species. | 1977 | J. Neurochem. | pmid:74403 |
Peters SP et al. | Isolation of heat-stable glucocerebrosidase activators from the spleens of three variants of Gaucher's disease. | 1977 | Arch. Biochem. Biophys. | pmid:907355 |
Ogino T et al. | Atypical GM1 ganglioside accumulation in a case of juvenile amaurotic idiocy. | 1977 | Clin. Chim. Acta | pmid:884852 |
Yusuf HK et al. | Effect of development on the gangliosides of human brain. | 1977 | J. Neurochem. | pmid:874491 |
Tonegawa Y and Hakomori SI | "Ganglioprotein and globoprotein": the glycoproteins reacting with anti-ganglioside and anti-globoside antibodies and the ganglioprotein change associated with transformation. | 1977 | Biochem. Biophys. Res. Commun. | pmid:194594 |
Tanaka H and Suzuki K | Lactosylceramidase assays for diagnosis of globoid cell leukodystrophy and GM1-gangliosidosis. | 1977 | Clin. Chim. Acta | pmid:403037 |
Suzuki Y et al. | Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver. | 1977 | Arch. Neurol. | pmid:402903 |
Murray JA et al. | Ocular lesions in cats with GM1-gangliosidosis with visceral involvement. | 1977 | J Small Anim Pract | pmid:404469 |
van Heyningen S | Activity of covalently cross-linked cholera toxin with the adenylate cyclase of intact and lysed pigeon erythrocytes. | 1977 | Biochem. J. | pmid:606247 |
Miller AL et al. | Purified human liver acid beta-D-galactosidases possessing activity towards G(M1)-ganglioside and lactosylceramide. | 1977 | Biochem. J. | pmid:411490 |
Hansson HA et al. | Ultrastructural localization of cell membrane GM1 ganglioside by cholera toxin. | 1977 | Proc. Natl. Acad. Sci. U.S.A. | pmid:269432 |
Ginsburg CM and Long CG | GM1 gangliosidosis type 1 in twins. | 1977 | J. Med. Genet. | pmid:404410 |
Moss J et al. | Effect of the A and B protomers of choleragen on release of trapped glucose from liposomes containing or lacking ganglioside GM1. | 1977 | J. Biol. Chem. | pmid:833153 |
Frost RG et al. | Characterization of purified human liver acid beta-D-galactosidases A2 and A3. | 1978 | Biochem. J. | pmid:104712 |
Pacuszka T et al. | A sensitive method for the detection of GM1-ganglioside in rat adipocyte preparations based on its interaction with choleragen. | 1978 | J. Biol. Chem. | pmid:670180 |
De Cicco D and Greaves MF | Independent mobility of cholera toxin binding sites and Thy-1 alloantigen on mouse thymocytes. | 1978 | Immunology | pmid:79545 |
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Sugano K et al. | Susceptibility of ganglioside GM1 to a new bacterial neuraminidase. | 1978 | FEBS Lett. | pmid:658424 |