| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:6103241 | ||||
| pmid:2420639 | ||||
| pmid:8738233 | ||||
| pmid:4009116 | ||||
| pmid:7358687 | ||||
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| pmid:1680104 | ||||
| pmid:11113142 | ||||
| pmid:11034355 | ||||
| pmid:2306612 | ||||
| pmid:2527208 | ||||
| pmid:18573324 | ||||
| Marty P et al. | Fortuitous Diagnosis of Preexisting Neuropathy During Ultrasound-Guided Regional Anesthesia Performance: A Case Report. | 2017 | A A Case Rep | pmid:28368901 |
| Matsuzaki K | How do membranes initiate Alzheimer's Disease? Formation of toxic amyloid fibrils by the amyloid β-protein on ganglioside clusters. | 2014 | Acc. Chem. Res. | pmid:25029558 |
| Hung JT et al. | Design, Synthesis, and Biological Evaluation of Ganglioside Hp-s1 Analogues Varying at Glucosyl Moiety. | 2016 | ACS Chem Neurosci | pmid:27276519 |
| Chang JC and Rosenthal SJ | Visualization of lipid raft membrane compartmentalization in living RN46A neuronal cells using single quantum dot tracking. | 2012 | ACS Chem Neurosci | pmid:23077717 |
| Huang M et al. | GM1-Modified Lipoprotein-like Nanoparticle: Multifunctional Nanoplatform for the Combination Therapy of Alzheimer's Disease. | 2015 | ACS Nano | pmid:26440073 |
| Wittenberg NJ et al. | Facile assembly of micro- and nanoarrays for sensing with natural cell membranes. | 2011 | ACS Nano | pmid:21842844 |
| Masserini M et al. | Glycolipid-protein interaction in the mechanism of signal transduction: studies with a photoactivable ganglioside analogue. | 1998 | Acta Biochim. Pol. | pmid:9821870 |
| Trandaburu I et al. | The immunohistochemical localization of the glycosphingolipid asialo-GM1 in the intestine of weaned piglets. | 2011 | Acta Histochem. | pmid:19740529 |
| Werka T et al. | Partial lesion of dorsal hippocampal afferents and GM1-ganglioside treatment effects on the two-way avoidance in rats. | 1988 | Acta Neurobiol Exp (Wars) | pmid:3407451 |
| Skup M et al. | Analysis of the time course of GM1 ganglioside effect on changes in choline acetyltransferase activity in partially denervated rat hippocampus. | 1987 | Acta Neurobiol Exp (Wars) | pmid:3445796 |
| Jegliński W et al. | Difluoromethylornithine counteracts lesion-induced astrogliosis in rat hippocampus: enhancement of inhibitory effect by combined treatment with GM1 ganglioside. | 1996 | Acta Neurobiol Exp (Wars) | pmid:8768305 |
| Rong X et al. | Ganglioside GM1 reduces white matter damage in neonatal rats. | 2013 | Acta Neurobiol Exp (Wars) | pmid:24129486 |
| Lazarewicz JW et al. | Effects of MK-801 and ganglioside GM1 on postischemic prostanoid release and hippocampal lesion in gerbil brain. | 1994 | Acta Neurobiol Exp (Wars) | pmid:7887181 |
| Skup M and Gradkowska M | Early changes in ornithine decarboxylase activity in a partially denervated hippocampus of rats untreated and treated with GM1 ganglioside. | 1990 | Acta Neurobiol Exp (Wars) | pmid:2130667 |
| Geisler FH et al. | GM1 gangliosides in the treatment of spinal cord injury: report of preliminary data analysis. | 1990 | Acta Neurobiol Exp (Wars) | pmid:2130666 |
| Lipartiti M et al. | Monosialoganglioside effects following cerebral ischemia: relationship with anti-neuronotoxic and pro-neuronotrophic effects. | 1990 | Acta Neurobiol Exp (Wars) | pmid:2130663 |
| Casamenti F et al. | Lesions of the nucleus basalis magnocellularis in the rat: morphological, biochemical and behavioral reparative effect of nerve growth factor and ganglioside GM1. | 1990 | Acta Neurobiol Exp (Wars) | pmid:2130662 |
| Cuello AC et al. | Evidence for nerve growth factor-ganglioside interaction in forebrain cholinergic neurons. | 1990 | Acta Neurobiol Exp (Wars) | pmid:2130661 |
| Stein DG | Some functional consequences of chronic GM1 ganglioside administration in brain damaged rats. | 1990 | Acta Neurobiol Exp (Wars) | pmid:2130658 |
| Voumvourakis C et al. | Serum anti-GM1 and anti-GD1a antibodies in patients with motor neuron disease. | 1992 | Acta Neurol. Scand. | pmid:1481647 |
| Zappia M et al. | Anti-GM1 ganglioside antibodies in Parkinson's disease. | 2002 | Acta Neurol. Scand. | pmid:12067330 |
| Uyama E et al. | Type 3 GM1 gangliosidosis: characteristic MRI findings correlated with dystonia. | 1992 | Acta Neurol. Scand. | pmid:1336295 |
| Koga M et al. | Antecedent symptoms in Guillain-Barré syndrome: an important indicator for clinical and serological subgroups. | 2001 | Acta Neurol. Scand. | pmid:11328202 |
| Annunziata P et al. | Association of polyclonal anti-GM1 IgM and anti-neurofilament antibodies with CSF oligoclonal bands in a young with amyotrophic lateral sclerosis. | 1995 | Acta Neurol. Scand. | pmid:8610492 |
| Niebroj-Dobosz I et al. | Anti-neural antibodies in serum and cerebrospinal fluid of amyotrophic lateral sclerosis (ALS) patients. | 1999 | Acta Neurol. Scand. | pmid:10694928 |
| Svennerholm L et al. | Parenteral administration of GM1 ganglioside to presenile Alzheimer patients. | 1990 | Acta Neurol. Scand. | pmid:2330815 |
| Sindern E et al. | Serum antibodies to GM1 and GM3-gangliosides in systemic lupus erythematosus with chronic inflammatory demyelinating polyradiculoneuropathy. | 1991 | Acta Neurol. Scand. | pmid:1887763 |
| Coyle JT et al. | Development of central neurotransmitter-specified neuronal systems: implications for pediatric neuro-psychiatric disorders. | 1984 | Acta Neurol. Scand. | pmid:6147947 |
| Svennerholm L | Gangliosides and nerve growth factors in Alzheimer's disease. | 1990 | Acta Neurol. Scand., Suppl. | pmid:2220320 |
| Kirkeby S | Cholera toxin B subunit-binding and ganglioside GM1 immuno-expression are not necessarily correlated in human salivary glands. | 2014 | Acta Odontol. Scand. | pmid:24655314 |
| Lekman A et al. | Gangliosides in children with autism. | 1995 | Acta Paediatr. | pmid:7549298 |
| Varkila K et al. | Asialo GM1+ NK cells have opposite roles in the activation of alloreactive cytotoxic T lymphocyte (CTL) response in vitro and in vivo. | 1987 | Acta Pathol Microbiol Immunol Scand C | pmid:3499751 |
| Liu JR et al. | Monosialoganglioside protected ischemic rat hippocampal slices through stabilizing expression of N-methyl-D-aspartate receptor subunit. | 2004 | Acta Pharmacol. Sin. | pmid:15169623 |
| Janson AM et al. | GM1 ganglioside protects against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of nigrostriatal dopamine neurons in the black mouse. | 1988 | Acta Physiol. Scand. | pmid:3265839 |
| Agnati LF et al. | Effects of lesions and ganglioside GM1 treatment on striatal polyamine levels and nigral DA neurons. A role of putrescine in the neurotropic activity of gangliosides. | 1985 | Acta Physiol. Scand. | pmid:2864781 |
| Toffano G et al. | Effect of GM1 ganglioside treatment on the recovery of dopaminergic nigro-striatal neurons after different types of lesion. | 1984 | Acta Physiol. Scand. | pmid:6151339 |
| Fuxe K et al. | On the cellular localization and distribution of the ganglioside GM1 in the rat brain as revealed by immunofluorescence histochemistry of cholera toxin binding sites. | 1989 | Acta Physiol. Scand. | pmid:2690577 |
| Agnati LF et al. | Selective modulation of 3H-spiperone labeled 5-HT receptors by subchronic treatment with the ganglioside GM1 in the rat. | 1983 | Acta Physiol. Scand. | pmid:6869038 |