| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang D et al. | [Effect of ganglioside GM1 on the metabolism of Alzheimer amyloid beta-protein precursor]. | 1998 | Zhonghua Yi Xue Za Zhi | pmid:10923524 |
| Xiang SL et al. | [Immunopathological evidence of terminal residues containing sialic acid in Campylobacter jejuni lipopolysaccharide as the critical antigen to induce peripheral neuropathy]. | 2005 | Zhonghua Er Ke Za Zhi | pmid:16191299 |
| Shu XM et al. | [Comparative study on the role of parent Campylobacter jejuni and galE mutant in inducing experimental peripheral nerve damage]. | 2005 | Zhonghua Er Ke Za Zhi | pmid:15924714 |
| Wang Q et al. | [Effects of ganglioside 1 and nerve growth factor on the proliferation of neural stem cells in vitro]. | 2009 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:19849946 |
| Shapiro K et al. | GM1 ganglioside concentration in the cerebrospinal fluid of hydrocephalic infants and children. | 1981 | Z Kinderchir | pmid:7331550 |
| Chen D et al. | NK-cell-dependent acute xenograft rejection in the mouse heart-to-rat model. | 2006 | Xenotransplantation | pmid:16925664 |
| Zhu Y et al. | Ganglioside-monosialic acid (GM1) prevents oxaliplatin-induced peripheral neurotoxicity in patients with gastrointestinal tumors. | 2013 | World J Surg Oncol | pmid:23351188 |
| Werner PC | New drugs for improving injury outcome in spinal cord injuries. | 1997 | West. J. Med. | pmid:9168687 |
| Isa P et al. | Dissecting the role of integrin subunits alpha 2 and beta 3 in rotavirus cell entry by RNA silencing. | 2009 | Virus Res. | pmid:19635510 |
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| Jeffree CE et al. | Distribution of the attachment (G) glycoprotein and GM1 within the envelope of mature respiratory syncytial virus filaments revealed using field emission scanning electron microscopy. | 2003 | Virology | pmid:12642099 |
| Triantafilou K and Triantafilou M | Lipid-raft-dependent Coxsackievirus B4 internalization and rapid targeting to the Golgi. | 2004 | Virology | pmid:15262490 |
| White LL and Smith RA | D variant of encephalomyocarditis virus (EMCV-D)-induced diabetes following natural killer cell depletion in diabetes-resistant male C57BL/6J mice. | 1990 | Viral Immunol. | pmid:2153386 |
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| Kosanke SD et al. | Clinical and biochemical abnormalities in porcine GM2-gangliosidosis. | 1978 | Vet. Pathol. | pmid:108843 |
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| Lian T et al. | Formulation of HIV-envelope protein with lipid vesicles expressing ganglioside GM1 associated to cholera toxin B enhances mucosal immune responses. | 1999 | Vaccine | pmid:10547418 |
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| Brezicka T and Einbeigi Z | Supra-additive cytotoxic effects of a combination of cytostatic drugs and antibody-induced complement activation on tumor cells in vitro. | Tumour Biol. | pmid:11125282 | |
| Crain SM and Shen KF | Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions. | 1998 | Trends Pharmacol. Sci. | pmid:9786023 |
| Hazlett LD | Bacterial lipopolysaccharide binding to host receptors. | 1996 | Trends Microbiol. | pmid:8950808 |
| Harwood JL | Understanding liposomal properties to aid their clinical usage. | 1992 | Trends Biochem. Sci. | pmid:1502719 |
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| Waer M et al. | Protective role of asialo GM1+, NK1.1- cells in the occurrence of graft-versus-host disease after total lymphoid irradiation. | 1993 | Transplantation | pmid:8212193 |
| Beck BN et al. | Display of the neutral glycolipid ganglio-n-tetraosylceramide (asialo GM1) on cells of the natural killer and T lineages. | 1982 | Transplantation | pmid:6977214 |
| Lin Y et al. | Contribution of activated macrophages to the process of delayed xenograft rejection. | 1997 | Transplantation | pmid:9422401 |
| Ghayur T et al. | Prevention of murine graft-versus-host disease by inducing and eliminating ASGM1+ cells of donor origin. | 1988 | Transplantation | pmid:3347937 |
| Sykes M and Abraham VS | The mechanism of IL-2-mediated protection against GVHD in mice. II. Protection occurs independently of NK/LAK cells. | 1992 | Transplantation | pmid:1533968 |
| Lacerda JF et al. | Administration of rabbit anti-asialo GM1 antiserum facilitates the development of human Epstein-Barr virus-induced lymphoproliferations in xenografted C.B-17 scid/scid mice. | 1996 | Transplantation | pmid:8610366 |
| Sefrioui H et al. | Graft-versus-leukemia effect in minor antigen mismatched chimeras given delayed donor leucocyte infusion: immunoregulatory aspects and role of donor T and ASGM1-positive cells. | 2000 | Transplantation | pmid:10933162 |
| Arii S et al. | Pathogenic role of Kupffer cell activation in the reperfusion injury of cold-preserved liver. | 1994 | Transplantation | pmid:7974713 |
| Ferrara JL et al. | Evidence that anti-asialo GM1 in vivo improves engraftment of T cell-depleted bone marrow in hybrid recipients. | 1990 | Transplantation | pmid:2301005 |
| Adair J et al. | Inflammatory polyneuropathy after heart transplantation. Its association with antibodies to asialo-GM1 and sulfatide. | 1993 | Transplantation | pmid:8305086 |
| Cipriano D et al. | Protection of mice against acute lethal graft-versus-host disease by treatment with anti-asialo GM1 antibody. Alopecia dermatitis in long-term survivors. | 1989 | Transplantation | pmid:2718249 |
| Touraine JL et al. | Improved engraftment and chimerism by anti-NK cell treatment in allogeneic transplantation of hematopoietic stem cells. | Transplant. Proc. | pmid:9123496 | |
| Chargui J et al. | Inhibition of NK cell activity induces improvement and stable chimerism after allogeneic transplantation. | 2000 | Transplant. Proc. | pmid:11120245 |
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| Xia GL et al. | Characteristics of B lymphocyte and natural killer cell xenotolerance in a concordant hamster-to-athymic rat cardiac xenotransplantation model. | Transplant. Proc. | pmid:10083409 | |
| Montero EF et al. | Kidney and small intestine morphologic aspects following systemic use of gangliosides. | 2000 | Transplant. Proc. | pmid:10995967 |