| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Kanfer JN et al. | Lipolytic action of cholera toxin on fat cells. Re-examination of the concept implicating GM1 ganglioside as the native membrane receptor. | 1976 | J. Biol. Chem. | pmid:1002701 |
| Kikkawa H et al. | Role of sialylglycoconjugate(s) in the initial phase of metastasis of liver-metastatic RAW117 lymphoma cells. | 1998 | Jpn. J. Cancer Res. | pmid:10081491 |
| Xia GL et al. | Characteristics of B lymphocyte and natural killer cell xenotolerance in a concordant hamster-to-athymic rat cardiac xenotransplantation model. | Transplant. Proc. | pmid:10083409 | |
| Rushfeldt C et al. | Early events of hepatic metastasis formation in mice: role of Kupffer and NK-cells in natural and interferon-gamma-stimulated defense. | 1999 | J. Surg. Res. | pmid:10090831 |
| Tong HH et al. | Effect of lacto-N-neotetraose, asialoganglioside-GM1 and neuraminidase on adherence of otitis media-associated serotypes of Streptococcus pneumoniae to chinchilla tracheal epithelium. | 1999 | Microb. Pathog. | pmid:10090858 |
| Athanassopoulou N et al. | Cholera toxin and GM1: a model membrane study with IAsys. | 1999 | Biochem. Soc. Trans. | pmid:10093760 |
| Bolot G et al. | Occurrence of monosialosyl pentahexaosylceramide GalNAc-GM1 as specific tumor-associated ganglioside of human head and neck squamous cell carcinomas. | 1999 | Cancer Lett. | pmid:10096424 |
| Williams NA et al. | Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic. | 1999 | Immunol. Today | pmid:10098329 |
| MacPhee I and Barker PA | Extended ceramide exposure activates the trkA receptor by increasing receptor homodimer formation. | 1999 | J. Neurochem. | pmid:10098845 |
| Choo YK | Distribution of gangliosides, GM1 and GM3, in the rat oviduct. | 1999 | Mol. Cells | pmid:10102572 |
| Palermo-Neto J et al. | Kinetic analysis of GM1 effects on haloperidol-induced dopaminergic supersensitivity. | 1999 | Gen. Pharmacol. | pmid:10188630 |
| Nachamkin I et al. | Ganglioside GM1 mimicry in Campylobacter strains from sporadic infections in the United States. | 1999 | J. Infect. Dis. | pmid:10191221 |
| Matsuzaki K and Horikiri C | Interactions of amyloid beta-peptide (1-40) with ganglioside-containing membranes. | 1999 | Biochemistry | pmid:10194329 |
| Koga M et al. | Antiganglioside antibody in patients with Guillain-Barré syndrome who show bulbar palsy as an initial symptom. | 1999 | J. Neurol. Neurosurg. Psychiatry | pmid:10201426 |
| Heckmann JG et al. | Acute motor axonal neuropathy associated with IgM anti-GM1 following Mycoplasma pneumoniae infection. | 1999 | Eur. Neurol. | pmid:10202255 |
| Goettl VM et al. | Decreased neuropeptide content in the spinal cord of aged rats: the effect of GM1 ganglioside. | 1999 | Neuroreport | pmid:10208581 |
| Fujiwara S et al. | Purification and characterization of a novel protein produced by Bifidobacterium longum SBT2928 that inhibits the binding of enterotoxigenic Escherichia coli Pb176 (CFA/II) to gangliotetraosylceramide. | 1999 | J. Appl. Microbiol. | pmid:10212407 |
| Mori M et al. | Haemophilus influenzae has a GM1 ganglioside-like structure and elicits Guillain-Barré syndrome. | 1999 | Neurology | pmid:10214761 |
| Schwerer B et al. | Distinct immunoglobulin class and immunoglobulin G subclass patterns against ganglioside GQ1b in Miller Fisher syndrome following different types of infection. | 1999 | Infect. Immun. | pmid:10225903 |
| Minke WE et al. | Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonists. | 1999 | Biochemistry | pmid:10231518 |
| Davies J et al. | Reduction in the adherence of Pseudomonas aeruginosa to native cystic fibrosis epithelium with anti-asialoGM1 antibody and neuraminidase inhibition. | 1999 | Eur. Respir. J. | pmid:10232427 |
| Dozier CE et al. | Diaphragmatic paralysis with monoclonal gammopathy and antiganglioside GM1 antibodies. | 1999 | Neurology | pmid:10331712 |
| Kemp SF and Stoolmiller AC | Biosynthesis of glycosphingolipids in cultured mouse neuroblastoma cells. Precursor-product relationships among sialoglycosphingolipids. | 1976 | J. Biol. Chem. | pmid:1033935 |
| Minke WE et al. | The role of waters in docking strategies with incremental flexibility for carbohydrate derivatives: heat-labile enterotoxin, a multivalent test case. | 1999 | J. Med. Chem. | pmid:10346930 |
| Glasier MM et al. | GM1 produces attenuation of short-term memory deficits in Hebb-Williams maze performance after unilateral entorhinal cortex lesions. | 1999 | Physiol. Behav. | pmid:10357433 |
| Volpe CM et al. | AsGM1+ NK cells prevent metastasis of invading LD-MCA-38 tumor cells in the nude mouse. | 1999 | J. Surg. Res. | pmid:10357913 |
| Shamshiev A et al. | Self glycolipids as T-cell autoantigens. | 1999 | Eur. J. Immunol. | pmid:10359121 |
| Hao Q et al. | Anti-GalNAc-GD1a antibody-associated Guillain-Barré syndrome with a predominantly distal weakness without cranial nerve impairment and sensory disturbance. | 1999 | Ann. Neurol. | pmid:10360768 |
| Stewart IJ and Peel S | Effect of serum on mouse granulated metrial gland cell cytotoxicity. | 1999 | Am. J. Reprod. Immunol. | pmid:10374706 |
| Görtzen A et al. | Schmidt-Lanterman's incisures--the principal target of autoimmune attack in demyelinating Guillain-Barré syndrome? | 1999 | J. Neuroimmunol. | pmid:10376936 |
| Comolli JC et al. | Pili binding to asialo-GM1 on epithelial cells can mediate cytotoxicity or bacterial internalization by Pseudomonas aeruginosa. | 1999 | Infect. Immun. | pmid:10377092 |
| Prendergast MM et al. | Human monoclonal immunoglobulin M antibodies to ganglioside GM1 show diverse cross-reactivities with lipopolysaccharides of Campylobacter jejuni strains associated with Guillain-Barré syndrome. | 1999 | Infect. Immun. | pmid:10377164 |
| Lanne B et al. | Binding of cholera toxin B-subunits to derivatives of the natural ganglioside receptor, GM1. | 1999 | J. Biochem. | pmid:10393343 |
| Galván EM et al. | Participation of ABH glycoconjugates in the secretory response to Escherichia coli heat-labile toxin in rabbit intestine. | 1999 | J. Infect. Dis. | pmid:10395858 |
| Lencer WI et al. | Membrane traffic and the cellular uptake of cholera toxin. | 1999 | Biochim. Biophys. Acta | pmid:10395933 |
| Slevin M et al. | Physiological concentrations of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells. | 1999 | Int. J. Cancer | pmid:10399959 |
| Yuki N et al. | Autoantibodies to GM1b and GalNAc-GD1a: relationship to Campylobacter jejuni infection and acute motor axonal neuropathy in China. | 1999 | J. Neurol. Sci. | pmid:10402024 |
| Kuwabara S et al. | Hyperreflexia in Guillain-Barré syndrome: relation with acute motor axonal neuropathy and anti-GM1 antibody. | 1999 | J. Neurol. Neurosurg. Psychiatry | pmid:10406985 |
| Kozireski-Chuback D et al. | Developmental appearance of nuclear GM1 in neurons of the central and peripheral nervous systems. | 1999 | Brain Res. Dev. Brain Res. | pmid:10407137 |
| Qiu JX et al. | Structure-function studies of an anti-asialo GM1 antibody obtained from a phage display library. | 1999 | J. Neuroimmunol. | pmid:10408972 |
| Ryu BR et al. | Attenuation of cortical neuronal apoptosis by gangliosides. | 1999 | J. Pharmacol. Exp. Ther. | pmid:10411596 |
| Fukumoto H et al. | Effect of a chimeric anti-ganglioside GM2 antibody on ganglioside GM2-expressing human solid tumors in vivo. | 1999 | Int. J. Cancer | pmid:10417777 |
| Sawada N et al. | Ganglioside GD1 alpha analogues as high-affinity ligands for myelin-associated glycoprotein (MAG). | 1999 | Carbohydr. Res. | pmid:10420586 |
| Möbius W et al. | Intracellular distribution of a biotin-labeled ganglioside, GM1, by immunoelectron microscopy after endocytosis in fibroblasts. | 1999 | J. Histochem. Cytochem. | pmid:10424884 |
| Goettl VM et al. | GM1 ganglioside restores dopaminergic neurochemical and morphological markers in aged rats. | 1999 | Neuroscience | pmid:10426539 |
| Ravichandra B and Joshi PG | Regulation of transmembrane signaling by ganglioside GM1: interaction of anti-GM1 with Neuro2a cells. | 1999 | J. Neurochem. | pmid:10428051 |
| Kozireski-Chuback D et al. | Axonogenesis in neuro-2a cells correlates with GM1 upregulation in the nuclear and plasma membranes. | 1999 | J. Neurosci. Res. | pmid:10440904 |
| Odaka M et al. | Antibodies to GD1alpha and to GQ1beta in Guillain-Barré syndrome and the related disorders. | 1999 | J. Neurol. Sci. | pmid:10450797 |
| Matsubara T et al. | Selection of ganglioside GM1-binding peptides by using a phage library. | 1999 | FEBS Lett. | pmid:10456319 |