| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fredman P et al. | Expression of the GM1-species, [NeuN]-GM1, in a case of human glioma. | 1999 | Neurochem. Res. | pmid:9972875 |
| Tzeng SF et al. | Myelin basic protein and myelin basic protein peptides induce the proliferation of Schwann cells via ganglioside GM1 and the FGF receptor. | 1999 | Neurochem. Res. | pmid:9972872 |
| Ariga T and Yu RK | GM1 inhibits amyloid beta-protein-induced cytokine release. | 1999 | Neurochem. Res. | pmid:9972868 |
| Fujioka N et al. | Interleukin-18 protects mice against acute herpes simplex virus type 1 infection. | 1999 | J. Virol. | pmid:9971824 |
| Vincent A | Antiganglioside antibodies in peripheral neuropathies. | 1998 | J. Clin. Pathol. | pmid:9930063 |
| Viola A et al. | T lymphocyte costimulation mediated by reorganization of membrane microdomains. | 1999 | Science | pmid:9924026 |
| Kozireski-Chuback D et al. | Upregulation of nuclear GM1 accompanies axon-like, but not dendrite-like, outgrowth in NG108-15 cells. | 1999 | J. Neurosci. Res. | pmid:9890439 |
| Matà S et al. | Anti-GM1, anti-central myelin proteins, and anti-cardiolipin autoantibodies during plasma-exchange in Guillain-Barré syndrome (GBS). | 1998 | J Clin Apher | pmid:9886794 |
| Murphy WJ et al. | CD40 stimulation promotes human secondary immunoglobulin responses in HuPBL-SCID chimeras. | 1999 | Clin. Immunol. | pmid:9884349 |
| Ishikawa D et al. | GD1alpha-replica peptides functionally mimic GD1alpha, an adhesion molecule of metastatic tumor cells, and suppress the tumor metastasis. | 1998 | FEBS Lett. | pmid:9877157 |
| Schengrund CL and Kovác P | A simple, nonenzymatic method for desialylating polysialylated ganglio-N-tetraose series gangliosides to produce GM1. | 1999 | J. Lipid Res. | pmid:9869662 |
| Weiss MD et al. | Molecular mimicry in chronic inflammatory demyelinating polyneuropathy and melanoma. | 1998 | Neurology | pmid:9855537 |
| Kuwabara S et al. | Two patterns of clinical recovery in Guillain-Barré syndrome with IgG anti-GM1 antibody. | 1998 | Neurology | pmid:9855518 |
| Tagawa Y et al. | Antiganglioside antibodies in various episodes in a patient with recurrent Guillain-Barré syndrome. | 1998 | J. Neurol. Neurosurg. Psychiatry | pmid:9854989 |
| Pestronk A | Multifocal motor neuropathy: diagnosis and treatment. | 1998 | Neurology | pmid:9851726 |
| Slos P et al. | Production of cholera toxin B subunit in Lactobacillus. | 1998 | FEMS Microbiol. Lett. | pmid:9851032 |
| Pitto M et al. | Influence of endogenous GM1 ganglioside on TrkB activity, in cultured neurons. | 1998 | FEBS Lett. | pmid:9849885 |
| Zhou J et al. | Evaluation of GM1 ganglioside-mediated apoptosis in feline thymocytes. | 1998 | Vet. Immunol. Immunopathol. | pmid:9847018 |
| Laouini D et al. | Antibodies to human myelin proteins and gangliosides in patients with acute neuroparalytic accidents induced by brain-derived rabies vaccine. | 1998 | J. Neuroimmunol. | pmid:9846820 |
| Page G et al. | Membrane carbohydrate conjugates desialylation does not alter [3H]-dopamine uptake in rat striatal slices. | 1998 | Neurosci. Lett. | pmid:9832192 |
| Tseng CT and Rank RG | Role of NK cells in early host response to chlamydial genital infection. | 1998 | Infect. Immun. | pmid:9826367 |
| Schneider JS et al. | Differential recovery of sensorimotor function in GM1 ganglioside-treated vs. spontaneously recovered MPTP-treated cats: partial striatal dopaminergic reinnervation vs. neurochemical compensation. | 1998 | Brain Res. | pmid:9824674 |
| Masserini M et al. | Glycolipid-protein interaction in the mechanism of signal transduction: studies with a photoactivable ganglioside analogue. | 1998 | Acta Biochim. Pol. | pmid:9821870 |
| Hadden RD et al. | Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group. | 1998 | Ann. Neurol. | pmid:9818934 |
| Panni MK et al. | Ganglioside GM1 potentiates NGF action on axotomised medial septal cholinergic neurons. | 1998 | Brain Res. | pmid:9813248 |
| Lunblad A et al. | Characterization of a penta-and an octasaccharide from urine of a patient with juvenile GM1-gangliosidosis. | 1978 | Arch. Biochem. Biophys. | pmid:98112 |
| Watarai S et al. | Antibody response in the intestinal tract of mice orally immunized with antigen associated with liposomes. | 1998 | J. Vet. Med. Sci. | pmid:9795911 |
| Chong H et al. | Expression of B7 co-stimulatory molecules by B16 melanoma results in a natural killer cell-dependent local anti-tumour response, but induces T-cell-dependent systemic immunity only against B7-expressing tumours. | 1998 | Br. J. Cancer | pmid:9792148 |
| Crain SM and Shen KF | Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions. | 1998 | Trends Pharmacol. Sci. | pmid:9786023 |
| Thompson JP and Schengrund CL | Inhibition of the adherence of cholera toxin and the heat-labile enterotoxin of Escherichia coli to cell-surface GM1 by oligosaccharide-derivatized dendrimers. | 1998 | Biochem. Pharmacol. | pmid:9783728 |
| Taoka Y and Okajima K | Spinal cord injury in the rat. | 1998 | Prog. Neurobiol. | pmid:9770243 |
| de Haan L et al. | Role of GM1 binding in the mucosal immunogenicity and adjuvant activity of the Escherichia coli heat-labile enterotoxin and its B subunit. | 1998 | Immunology | pmid:9767427 |
| Nordin V et al. | Gangliosides in cerebrospinal fluid in children with autism spectrum disorders. | 1998 | Dev Med Child Neurol | pmid:9766735 |
| Plesneva SA et al. | Adenylate cyclase system of the rat striatum: regulatory properties and the effects of gangliosides. | 1998 Jul-Aug | Neurosci. Behav. Physiol. | pmid:9762710 |
| Ilangumaran S and Hoessli DC | Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane. | 1998 | Biochem. J. | pmid:9761744 |
| Merritt EA et al. | The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site. | 1998 | J. Mol. Biol. | pmid:9753553 |
| Mukai T et al. | Haemagglutination and glycolipid-binding activities of Lactobacillus reuteri. | 1998 | Lett. Appl. Microbiol. | pmid:9750315 |
| Montixi C et al. | Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. | 1998 | EMBO J. | pmid:9736612 |
| Palaniyar N et al. | Surfactant protein A (SP-A) forms a novel supraquaternary structure in the form of fibers. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9735345 |
| Nedelkoska L and Benjamins JA | Binding of cholera toxin B subunit: a surface marker for murine microglia but not oligodendrocytes or astrocytes. | 1998 | J. Neurosci. Res. | pmid:9726431 |
| Tang YP et al. | Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments. | 1998 | J. Neurosci. Res. | pmid:9726430 |
| Ma JJ et al. | HLA and T-cell receptor gene polymorphisms in Guillain-Barré syndrome. | 1998 | Neurology | pmid:9710006 |
| Kuwabara S et al. | IgG anti-GM1 antibody is associated with reversible conduction failure and axonal degeneration in Guillain-Barré syndrome. | 1998 | Ann. Neurol. | pmid:9708542 |
| Tseng EE et al. | Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest. | 1998 | Surgery | pmid:9706152 |
| Bryan R et al. | Overproduction of the CFTR R domain leads to increased levels of asialoGM1 and increased Pseudomonas aeruginosa binding by epithelial cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9698599 |
| Avrova NF et al. | Inhibition of glutamate-induced intensification of free radical reactions by gangliosides: possible role in their protective effect in rat cerebellar granule cells and brain synaptosomes. | 1998 | Neurochem. Res. | pmid:9690736 |
| de Haan L et al. | The role of ADP-ribosylation and G(M1)-binding activity in the mucosal immunogenicity and adjuvanticity of the Escherichia coli heat-labile enterotoxin and Vibrio cholerae cholera toxin. | 1998 | Immunol. Cell Biol. | pmid:9682971 |
| Hirai K et al. | Immunoadsorption therapy in Guillain-Barré syndrome. | 1998 | Pediatr. Neurol. | pmid:9682887 |
| Krifuks O et al. | The down-modulation of CD4 induced by the GM1 ganglioside is regulated by phosphatases and kinases: evidence from enzyme inhibitors and anti-CD45 antibodies. | 1998 | Cell. Immunol. | pmid:9682003 |
| Kitov PI et al. | The synthesis of 16-mercaptohexadecanyl glycosides for biosensor applications. | 1998 | Carbohydr. Res. | pmid:9675372 |