| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fabani MM et al. | Study of in vitro stability of liposomes and in vivo antibody response to antigen associated with liposomes containing GM1 after oral and subcutaneous immunization. | J Liposome Res | pmid:12604034 | |
| Maysinger D et al. | Microencapsulated monosialoganglioside GM1: physical properties and in vivo effects. | J Microencapsul | pmid:2715912 | |
| Barnes IC et al. | Hepatic beta galactosidase and feline GMI gangliosidosis. | Neuropathol. Appl. Neurobiol. | pmid:6799849 | |
| Selvaraj V et al. | GM1 dynamics as a marker for membrane changes associated with the process of capacitation in murine and bovine spermatozoa. | J. Androl. | pmid:17377143 | |
| Tanaka K et al. | Effect of the ganglioside GM1, on cerebral metabolism, microcirculation, recovery kinetics of ECoG and histology, during the recovery period following focal ischemia in cats. | Stroke | pmid:3810717 | |
| Hatzifilippou E et al. | Antibodies against GM1 in demented patients. | Am J Alzheimers Dis Other Demen | pmid:18509104 | |
| Baumgartner WA et al. | Pathophysiology of cerebral injury and future management. | J Card Surg | pmid:9271760 | |
| Kholodenko IV et al. | Ganglioside GM1-binding sites in interleukin-4: a photoaffinity labeling study. | Dokl. Biochem. Biophys. | pmid:18429602 | |
| Touraine JL et al. | Improved engraftment and chimerism by anti-NK cell treatment in allogeneic transplantation of hematopoietic stem cells. | Transplant. Proc. | pmid:9123496 | |
| Mikami M et al. | Characteristic alteration in the concentration of IV 3NeuAc alpha-nLc4Cer in the villi of human placenta during the gestational period. | Placenta | pmid:8248034 | |
| Gavella M et al. | Trisialoganglioside GT1b prevents increase in sperm membrane molecular ordering induced by in vitro lipid peroxidation. | J. Androl. | pmid:16291967 | |
| pmid:2420639 | ||||
| Basta I et al. | [Antibodies to ganglioside GM1 and Campylobacter jejuni in patients with Guillain-Barré syndrome]. | Srp Arh Celok Lek | pmid:16206698 | |
| pmid:8738233 | ||||
| Chen SY et al. | The membrane disordering effect of ethanol on neural crest cells in vitro and the protective role of GM1 ganglioside. | Alcohol | pmid:8949954 | |
| pmid:4009116 | ||||
| Polyzos A et al. | Biofunctionalized surfactant mesophases as polyvalent inhibitors of cholera toxin. | Bioconjug. Chem. | pmid:17715991 | |
| Augustinsson LE et al. | Intracerebroventricular administration of GM1 ganglioside to presenile Alzheimer patients. | Dement Geriatr Cogn Disord | pmid:8997549 | |
| Röckendorf N et al. | Synthesis of a fluorescent ganglioside GM1 derivative and screening of a synthetic peptide library for GM1 binding sequence motifs. | Bioconjug. Chem. | pmid:17323913 | |
| Mutoh T et al. | Unglycosylated Trk protein does not co-localize nor associate with ganglioside GM1 in stable clone of PC12 cells overexpressing Trk (PCtrk cells). | Glycoconj. J. | pmid:11201795 | |
| Fantini J et al. | Glycosphingolipid (GSL) microdomains as attachment platforms for host pathogens and their toxins on intestinal epithelial cells: activation of signal transduction pathways and perturbations of intestinal absorption and secretion. | Glycoconj. J. | pmid:11201788 | |
| BadÃa Picazo MC et al. | [Hyperreflexia in a patient with Guillain Barre syndrome]. | Rev Neurol | pmid:15098195 | |
| Stout JG et al. | Ethanol disordering of GM1-enriched short-sleep synaptosomal plasma membranes. | Alcohol | pmid:7818801 | |
| Kirschner G et al. | Competitive binding assay for quantitative determination of GM1 ganglioside in plasma and cerebrospinal fluid. | J Pharm Biomed Anal | pmid:1391096 | |
| Laev H et al. | Cortical cell plasma membrane alterations after in vitro alcohol exposure: prevention by GM1 ganglioside. | Alcohol | pmid:8814655 | |
| Ledeen RW and Wu G | GM1 ganglioside: another nuclear lipid that modulates nuclear calcium. GM1 potentiates the nuclear sodium-calcium exchanger. | Can. J. Physiol. Pharmacol. | pmid:16902585 | |
| Suzuki Y | Beta-galactosidase deficiency: an approach to chaperone therapy. | J. Inherit. Metab. Dis. | pmid:16763919 | |
| Guan C et al. | Expression of cholera toxin B subunit-lumbrokinase in edible sunflower seeds-the use of transmucosal carrier to enhance its fusion protein's effect on protection of rats and mice against thrombosis. | Biotechnol. Prog. | pmid:25080206 | |
| Cadete-Leite A et al. | Effects of GM1 ganglioside upon neuronal degeneration during withdrawal from alcohol. | Alcohol | pmid:1781918 | |
| Morrison WJ et al. | Ganglioside (GM1)-treated T cells shed CD4. | Immunopharmacology | pmid:1761402 | |
| Liu L et al. | Alterations in cholesterol and ganglioside GM1 content of lipid rafts in platelets from patients with Alzheimer disease. | Alzheimer Dis Assoc Disord | pmid:24759545 | |
| pmid:7358687 | ||||
| Peel S and Adam E | The killing of rat placental cells by rat and mouse granulated metrial gland cells in vitro. | Placenta | pmid:1871073 | |
| Ricci LC et al. | Erythrocyte receptors for cholera and heat-labile enterotoxins of Escherichia coli. | Res. Microbiol. | pmid:2559437 | |
| Stout JG et al. | Characterization of a GM1-dependent surface interaction for alcohol with DPPC membranes. | Alcohol | pmid:7639951 | |
| Hao C et al. | Interaction between ganglioside G(M1) and diosgenin in langmuir monolayers at the air/water interface. | Scanning | pmid:23553978 | |
| Bassi S et al. | Monosialoganglioside therapy in stroke. | Stroke | pmid:3901426 | |
| pmid: | ||||
| Cencioni MT et al. | T cell response in acute motor axonal neuropathy. | Int J Immunopathol Pharmacol | pmid:20074468 | |
| Sommer BR et al. | Changes in tardive dyskinesia symptoms in elderly patients treated with ganglioside GM1 or placebo. | J Geriatr Psychiatry Neurol | pmid:7826493 | |
| Xia GL et al. | Characteristics of B lymphocyte and natural killer cell xenotolerance in a concordant hamster-to-athymic rat cardiac xenotransplantation model. | Transplant. Proc. | pmid:10083409 | |
| pmid:11113142 | ||||
| Arai M and Kusunoki S | [A case of multifocal motor neuropathy with IgM lambda anti-GM1 antibody and IgM kappa paraprotein reacting exclusively with GM2]. | Rinsho Shinkeigaku | pmid:19348179 | |
| pmid:2306612 | ||||
| Caudie C et al. | [Measurement of antiganglioside autoantibodies by immunodot-blot assay: clinical importance in peripheral neuropathies]. | Ann. Biol. Clin. (Paris) | pmid:10518060 | |
| pmid:2527208 | ||||
| Mitchell JS et al. | Clustering T-cell GM1 lipid rafts increases cellular resistance to shear on fibronectin through changes in integrin affinity and cytoskeletal dynamics. | Immunol. Cell Biol. | pmid:19139760 | |
| Shell LG et al. | Neuronal-visceral GM1 gangliosidosis in Portuguese water dogs. | J. Vet. Intern. Med. | pmid:2494322 | |
| pmid:18573324 | ||||
| Sadeghlar F et al. | Physiological relevance of sphingolipid activator proteins in cultured human fibroblasts. | Biochimie | pmid:12770782 |