| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vahed M et al. | Analysis of Physicochemical Interaction of Aβ with a GM1 Ganglioside-Containing Lipid Membrane. | 2018 | J Phys Chem B | pmid:29536735 |
| Islam Z et al. | FAS promoter polymorphisms and serum sFas level are associated with increased risk of nerve damage in Bangladeshi patients with Guillain-Barré syndrome. | 2018 | PLoS ONE | pmid:29432441 |
| Rodi PM et al. | Direct visualization of the lateral structure of giant vesicles composed of pseudo-binary mixtures of sulfatide, asialo-GM1 and GM1 with POPC. | 2018 | Biochim. Biophys. Acta | pmid:29106974 |
| Anuforo OUU et al. | Natural killer cells play an essential role in resolution of antigen-induced inflammation in mice. | 2018 | Mol. Immunol. | pmid:29112834 |
| Komura N et al. | Syntheses of Fluorescent Gangliosides for the Studies of Raft Domains. | 2017 | Meth. Enzymol. | pmid:28935104 |
| Watanabe H et al. | Lipid raft dynamics linked to sperm competency for fertilization in mice. | 2017 | Genes Cells | pmid:28425215 |
| Simón L et al. | Manchette-acrosome disorders during spermiogenesis and low efficiency of seminiferous tubules in hypercholesterolemic rabbit model. | 2017 | PLoS ONE | pmid:28241054 |
| Chiricozzi E et al. | Role of the GM1 ganglioside oligosaccharide portion in the TrkA-dependent neurite sprouting in neuroblastoma cells. | 2017 | J. Neurochem. | pmid:28796418 |
| Zhang Y et al. | Enhanced soluble production of cholera toxin B subunit in Escherichia coli by co-expression of SKP chaperones. | 2017 | Protein Expr. Purif. | pmid:28673733 |
| Ceccarelli A et al. | New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains. | 2017 | Biochim. Biophys. Acta | pmid:28499815 |
| Rondelli V et al. | Building a biomimetic membrane for neutron reflectivity investigation: Complexity, asymmetry and contrast. | 2017 | Biophys. Chem. | pmid:28499578 |
| Cebecauer M et al. | Impact of GM1 on Membrane-Mediated Aggregation/Oligomerization of β-Amyloid: Unifying View. | 2017 | Biophys. J. | pmid:28410623 |
| Zou D et al. | Penetration of blood-brain barrier and antitumor activity and nerve repair in glioma by doxorubicin-loaded monosialoganglioside micelles system. | 2017 | Int J Nanomedicine | pmid:28744122 |
| Su D et al. | Monosialotetrahexosy-1 ganglioside attenuates diabetes-associated cerebral ischemia/reperfusion injury through suppression of the endoplasmic reticulum stress-induced apoptosis. | 2017 | J Clin Neurosci | pmid:28392211 |
| Marty P et al. | Fortuitous Diagnosis of Preexisting Neuropathy During Ultrasound-Guided Regional Anesthesia Performance: A Case Report. | 2017 | A A Case Rep | pmid:28368901 |
| Han TH et al. | Transient Isolated Lower Bulbar Palsy With Elevated Serum Anti-GM1 and Anti-GD1b Antibodies During Aripiprazole Treatment. | 2017 | Pediatr. Neurol. | pmid:28341090 |
| Wang Y et al. | IgG-degrading enzyme of Streptococcus pyogenes (IdeS) prevents disease progression and facilitates improvement in a rabbit model of Guillain-Barré syndrome. | 2017 | Exp. Neurol. | pmid:28214515 |
| Han YB et al. | Structural Insights into the Broad Substrate Specificity of a Novel Endoglycoceramidase I Belonging to a New Subfamily of GH5 Glycosidases. | 2017 | J. Biol. Chem. | pmid:28179425 |
| Manna M et al. | Long-chain GM1 gangliosides alter transmembrane domain registration through interdigitation. | 2017 | Biochim. Biophys. Acta | pmid:28143757 |
| Patra M et al. | Localization and dynamics of the anticarcinogenic curcumin with GM1 and other miceller assemblies. | 2017 | Glycoconj. J. | pmid:27866299 |
| Iwamori M et al. | Enhanced fucosylation of GA1 in the digestive tracts of X-ray-irradiated mice. | 2017 | Glycoconj. J. | pmid:27858203 |
| Das PK et al. | Aqueous RAFT Synthesis of Glycopolymers for Determination of Saccharide Structure and Concentration Effects on Amyloid β Aggregation. | 2017 | Biomacromolecules | pmid:28893064 |
| Dai R et al. | Enhanced Autophagy Contributes to Protective Effects of GM1 Ganglioside Against Aβ1-42-Induced Neurotoxicity and Cognitive Deficits. | 2017 | Neurochem. Res. | pmid:28497346 |
| Kasahara R et al. | The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes. | 2017 | Neuroscience | pmid:27815022 |
| Cardona C et al. | Localization patterns of the ganglioside G in human sperm are indicative of male fertility and independent of traditional semen measures. | 2017 | Mol. Reprod. Dev. | pmid:28418610 |
| Rajamanickam GD et al. | Content of testis-specific isoform of Na/K-ATPase (ATP1A4) is increased during bovine sperm capacitation through translation in mitochondrial ribosomes. | 2017 | Cell Tissue Res. | pmid:27807702 |
| Chung TW et al. | The function of cancer-shed gangliosides in macrophage phenotype: involvement with angiogenesis. | 2017 | Oncotarget | pmid:28032600 |
| Tang B et al. | An in vivo study of hypoxia-inducible factor-1α signaling in ginsenoside Rg1-mediated brain repair after hypoxia/ischemia brain injury. | 2017 | Pediatr. Res. | pmid:27632778 |
| Brocca P et al. | Water response to ganglioside GM1 surface remodelling. | 2017 | Biochim. Biophys. Acta | pmid:27155581 |
| Suzuki KGN et al. | Development of new ganglioside probes and unraveling of raft domain structure by single-molecule imaging. | 2017 | Biochim. Biophys. Acta | pmid:28734966 |
| Ruggiero FM et al. | Membrane binding, endocytic trafficking and intracellular fate of high-affinity antibodies to gangliosides GD1a and GM1. | 2017 | Biochim. Biophys. Acta | pmid:27806911 |
| Patel DS et al. | Influence of Ganglioside GM1 Concentration on Lipid Clustering and Membrane Properties and Curvature. | 2016 | Biophys. J. | pmid:27806280 |
| Takehara M et al. | Clostridium perfringens α-Toxin Impairs Lipid Raft Integrity in Neutrophils. | 2016 | Biol. Pharm. Bull. | pmid:27725448 |
| Przybylska-FeluÅ› M et al. | Concentrations of antiganglioside M1 antibodies, neuron-specific enolase, and interleukin 10 as potential markers of autonomic nervous system impairment in celiac disease. | 2016 | Pol. Arch. Med. Wewn. | pmid:27545437 |
| Drolez A et al. | ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier. | 2016 | Int J Mol Sci | pmid:27529215 |
| Marcon RM et al. | Effects of ganglioside G(M1) and erythropoietin on spinal cord lesions in rats: functional and histological evaluations. | 2016 | Clinics (Sao Paulo) | pmid:27438570 |
| Bragiel AM et al. | Mechanisms Underlying Activation of αâ‚-Adrenergic Receptor-Induced Trafficking of AQP5 in Rat Parotid Acinar Cells under Isotonic or Hypotonic Conditions. | 2016 | Int J Mol Sci | pmid:27367668 |
| Kuhlmann FM et al. | Blood Group O-Dependent Cellular Responses to Cholera Toxin: Parallel Clinical and Epidemiological Links to Severe Cholera. | 2016 | Am. J. Trop. Med. Hyg. | pmid:27162272 |
| Yeh SC et al. | Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27143722 |
| Worstell NC et al. | Binding Cooperativity Matters: A GM1-Like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array. | 2016 | PLoS ONE | pmid:27070150 |
| Kohyama M et al. | In situ detection of GM1 and GM2 gangliosides using immunohistochemical and immunofluorescent techniques for auxiliary diagnosis of canine and feline gangliosidoses. | 2016 | BMC Vet. Res. | pmid:27036194 |
| Luo Y et al. | Interaction between Simian Virus 40 Major Capsid Protein VP1 and Cell Surface Ganglioside GM1 Triggers Vacuole Formation. | 2016 | MBio | pmid:27006465 |
| Thomaier M et al. | High-Affinity Binding of Monomeric but Not Oligomeric Amyloid-β to Ganglioside GM1 Containing Nanodiscs. | 2016 | Biochemistry | pmid:27933798 |
| Yu RK et al. | Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial cells in vitro. | 2016 | Glycobiology | pmid:26405107 |
| He B et al. | Dynamic bio-adhesion of polymer nanoparticles on MDCK epithelial cells and its impact on bio-membranes, endocytosis and paracytosis. | 2016 | Nanoscale | pmid:26932537 |
| Blaum BS et al. | Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations. | 2016 | Glycobiology | pmid:26715202 |
| Zhang X et al. | Abnormal lipid rafts related ganglioside expression and signaling in T lymphocytes in immune thrombocytopenia patients. | 2016 | Autoimmunity | pmid:26287565 |
| Nicastro MC et al. | Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains. | 2016 | Biophys. Chem. | pmid:26259785 |
| Fricke N and Dimova R | GM1 Softens POPC Membranes and Induces the Formation of Micron-Sized Domains. | 2016 | Biophys. J. | pmid:27806275 |
| Prasanna X et al. | The ganglioside GM1 interacts with the serotonin1A receptor via the sphingolipid binding domain. | 2016 | Biochim. Biophys. Acta | pmid:27552916 |