| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ryu YS et al. | Continuity of Monolayer-Bilayer Junctions for Localization of Lipid Raft Microdomains in Model Membranes. | 2016 | Sci Rep | pmid:27230411 |
| Patel DS et al. | Influence of Ganglioside GM1 Concentration on Lipid Clustering and Membrane Properties and Curvature. | 2016 | Biophys. J. | pmid:27806280 |
| Leri M et al. | Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2-microglobulin. | 2016 | J. Cell. Mol. Med. | pmid:26990223 |
| Madhavan TP et al. | Binding of CFA/I Pili of Enterotoxigenic Escherichia coli to Asialo-GM1 Is Mediated by the Minor Pilin CfaE. | 2016 | Infect. Immun. | pmid:26975993 |
| Friedrich RP et al. | Novel nanoparticulate drug delivery systems. | 2016 | Nanomedicine (Lond) | pmid:26911384 |
| Zhao L et al. | Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells. | 2016 | Virology | pmid:26901486 |
| Eich C et al. | Changes in membrane sphingolipid composition modulate dynamics and adhesion of integrin nanoclusters. | 2016 | Sci Rep | pmid:26869100 |
| Kim JW et al. | Ganglioside GD1a promotes oocyte maturation, furthers preimplantation development, and increases blastocyst quality in pigs. | 2016 | J. Reprod. Dev. | pmid:26860251 |
| Lardone RD et al. | Individual Restriction Of Fine Specificity Variability In Anti-GM1 IgG Antibodies Associated With Guillain-Barré Syndrome. | 2016 | Sci Rep | pmid:26818965 |
| Li L et al. | Protection against Experimental Stroke by Ganglioside GM1 Is Associated with the Inhibition of Autophagy. | 2016 | PLoS ONE | pmid:26751695 |
| Calamai M et al. | Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Aβ1-42 oligomers. | 2016 | Biochim. Biophys. Acta | pmid:26656159 |
| Wu G et al. | Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca²⺠influx. | 2016 | J. Neurochem. | pmid:26526326 |
| Tsai YT et al. | GM1 Ganglioside is Involved in Epigenetic Activation Loci of Neuronal Cells. | 2016 | Neurochem. Res. | pmid:26498762 |
| Sridhar A et al. | Multi-scale molecular dynamics study of cholera pentamer binding to a GM1-phospholipid membrane. | 2016 | J. Mol. Graph. Model. | pmid:27474868 |
| Ando K et al. | Nanometric Gap Structure with a Fluid Lipid Bilayer for the Selective Transport and Detection of Biological Molecules. | 2016 | Langmuir | pmid:27427950 |
| Oropesa-Nuñez R et al. | Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy. | 2016 | Oncotarget | pmid:27391440 |
| Hung JT et al. | Design, Synthesis, and Biological Evaluation of Ganglioside Hp-s1 Analogues Varying at Glucosyl Moiety. | 2016 | ACS Chem Neurosci | pmid:27276519 |
| Liao B et al. | Alternating ptosis associated with asialo-GM1 and GD1b antibodies. | 2016 | Int. J. Neurosci. | pmid:26710925 |
| Cohen R et al. | Lipid Regulation of Acrosome Exocytosis. | 2016 | Adv Anat Embryol Cell Biol | pmid:27194352 |
| Lee D et al. | Unilateral isolated oculomotor nerve palsy with antibodies to GM1 ganglioside. | 2016 | Neurol. Sci. | pmid:27166708 |
| Harschnitz O et al. | Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model. | 2016 | Ann. Neurol. | pmid:27130524 |
| Liu D et al. | An In Situ Gelling Drug Delivery System for Improved Recovery after Spinal Cord Injury. | 2016 | Adv Healthc Mater | pmid:27113454 |
| Kasimov MR et al. | Similar oxysterols may lead to opposite effects on synaptic transmission: Olesoxime versus 5α-cholestan-3-one at the frog neuromuscular junction. | 2016 | Biochim. Biophys. Acta | pmid:27102612 |
| Bhuiyan RH et al. | Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes. | 2016 | Glycobiology | pmid:27102283 |
| Ni YF et al. | GM1 ganglioside reverses the cognitive deficits induced by MK801 in mice. | 2016 | Behav Pharmacol | pmid:26960162 |
| Haroon MM et al. | A designed recombinant fusion protein for targeted delivery of siRNA to the mouse brain. | 2016 | J Control Release | pmid:26948382 |
| He B et al. | Dynamic bio-adhesion of polymer nanoparticles on MDCK epithelial cells and its impact on bio-membranes, endocytosis and paracytosis. | 2016 | Nanoscale | pmid:26932537 |
| Blaum BS et al. | Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations. | 2016 | Glycobiology | pmid:26715202 |
| Zhang X et al. | Abnormal lipid rafts related ganglioside expression and signaling in T lymphocytes in immune thrombocytopenia patients. | 2016 | Autoimmunity | pmid:26287565 |
| Nicastro MC et al. | Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains. | 2016 | Biophys. Chem. | pmid:26259785 |
| Abd-Elhadi S et al. | Total α-synuclein levels in human blood cells, CSF, and saliva determined by a lipid-ELISA. | 2016 | Anal Bioanal Chem | pmid:27624766 |
| Aureli M et al. | GM1 Ganglioside: Past Studies and Future Potential. | 2016 | Mol. Neurobiol. | pmid:25762012 |
| Ba XH | Therapeutic effects of GM1 on Parkinson's disease in rats and its mechanism. | 2016 | Int. J. Neurosci. | pmid:25495991 |
| Evangelisti E et al. | Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases. | 2016 | Sci Rep | pmid:27619987 |
| Yagi-Utsumi M and Dobson CM | Conformational Effects of the A21G Flemish Mutation on the Aggregation of Amyloid β Peptide. | 2015 | Biol. Pharm. Bull. | pmid:26424029 |
| Shinchi H et al. | Visual Detection of Human Antibodies Using Sugar Chain-Immobilized Fluorescent Nanoparticles: Application as a Point of Care Diagnostic Tool for Guillain-Barré Syndrome. | 2015 | PLoS ONE | pmid:26378448 |
| Sasaki N et al. | Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells. | 2015 | J. Biol. Chem. | pmid:26338710 |
| Vlam L et al. | Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy. | 2015 | J. Neuroimmunol. | pmid:26298317 |
| Nan C et al. | Monosialoteterahexosyl ganglioside induces the differentiation of human umbilical cord-derived mesenchymal stem cells into neuron-like cells. | 2015 | Int. J. Mol. Med. | pmid:26259830 |
| Takahashi R and Yuki N | Streptococcal IdeS: therapeutic potential for Guillain-Barré syndrome. | 2015 | Sci Rep | pmid:26194472 |
| Huang FT et al. | A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production. | 2015 | J. Lipid Res. | pmid:26130766 |
| Basu I and Mukhopadhyay C | In silico phase separation in the presence of GM1 in ternary and quaternary lipid bilayers. | 2015 | Phys Chem Chem Phys | pmid:26067631 |
| Ledeen RW and Wu G | The multi-tasked life of GM1 ganglioside, a true factotum of nature. | 2015 | Trends Biochem. Sci. | pmid:26024958 |
| Phongsisay V et al. | Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors. | 2015 | Mol. Immunol. | pmid:26021803 |
| Sato S et al. | A Self-Assembled Spherical Complex Displaying a Gangliosidic Glycan Cluster Capable of Interacting with Amyloidogenic Proteins. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:26015171 |
| Zhang J et al. | The Possible Damaged Mechanism and the Preventive Effect of Monosialotetrahexosylganglioside in a Rat Model of Cerebral Ischemia-Reperfusion Injury. | 2015 | J Stroke Cerebrovasc Dis | pmid:25934141 |
| Yagi-Utsumi M and Kato K | Structural and dynamic views of GM1 ganglioside. | 2015 | Glycoconj. J. | pmid:25931034 |
| Sasahara K et al. | Uptake of raft components into amyloid β-peptide aggregates and membrane damage. | 2015 | Anal. Biochem. | pmid:25908557 |
| Yanagisawa K | GM1 ganglioside and Alzheimer's disease. | 2015 | Glycoconj. J. | pmid:25903682 |
| Maeda Y et al. | Effects of cyclodextrins on GM1-gangliosides in fibroblasts from GM1-gangliosidosis patients. | 2015 | J. Pharm. Pharmacol. | pmid:25851126 |