| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Slifka MK et al. | NK markers are expressed on a high percentage of virus-specific CD8+ and CD4+ T cells. | 2000 | J. Immunol. | pmid:10657652 |
| Pincelli MM et al. | Cholesterol-induced alterations of the packing properties of gangliosides: an EPR study. | 2000 | Chem. Phys. Lipids | pmid:10669311 |
| Beniac DR et al. | Cryoelectron microscopy of protein-lipid complexes of human myelin basic protein charge isomers differing in degree of citrullination. | 2000 | J. Struct. Biol. | pmid:10675299 |
| Crain SM and Shen K | Enhanced analgesic potency and reduced tolerance of morphine in 129/SvEv mice: evidence for a deficiency in GM1 ganglioside-regulated excitatory opioid receptor functions. | 2000 | Brain Res. | pmid:10677630 |
| Takikawa M et al. | Suppression of GD1alpha ganglioside-mediated tumor metastasis by liposomalized WHW-peptide. | 2000 | FEBS Lett. | pmid:10682865 |
| Moss J et al. | Choleragen-mediated release of trapped glucose from liposomes containing ganglioside GM1. | 1976 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1068459 |
| Maxzúd MK and Maccioni HJ | Glucosylceramide synthesized in vitro from endogenous ceramide is uncoupled from synthesis of lactosylceramide in Golgi membranes from chicken embryo neural retina cells. | 2000 | Neurochem. Res. | pmid:10685614 |
| Aydin M et al. | Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats. | 2000 | Cell Biochem. Funct. | pmid:10686582 |
| Okamoto M et al. | Cytokine-inducing activity and antitumor effect of a liposome-incorporated interferon-gamma-inducing molecule derived from OK-432, a streptococcal preparation. | 2000 | J. Immunother. | pmid:10687142 |
| Navarrete Santos A et al. | Aminopeptidase N/CD13 is associated with raft membrane microdomains in monocytes. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10694491 |
| Niebroj-Dobosz I et al. | Anti-neural antibodies in serum and cerebrospinal fluid of amyotrophic lateral sclerosis (ALS) patients. | 1999 | Acta Neurol. Scand. | pmid:10694928 |
| Qiu JX and Marcus DM | Use of peptide ligands to analyze the fine specificity of antibodies against asialo GM1. | 1999 | J. Neuroimmunol. | pmid:10695716 |
| Hughes RA et al. | Pathogenesis of Guillain-Barré syndrome. | 1999 | J. Neuroimmunol. | pmid:10695718 |
| Kiechl S et al. | Sensory predominant neuropathy with GM, antibodies, conduction blocks, and orbital pseudotumour. | 2000 | J. Neurol. Neurosurg. Psychiatr. | pmid:10702043 |
| Guelman LR et al. | GM1 ganglioside treatment protects against long-term neurotoxic effects of neonatal X-irradiation on cerebellar cortex cytoarchitecture and motor function. | 2000 | Brain Res. | pmid:10708681 |
| Goettl VM et al. | GM1 ganglioside restores abnormal responses to acute thermal and mechanical stimuli in aged rats. | 2000 | Brain Res. | pmid:10708690 |
| Ang CW et al. | Campylobacter jejuni lipopolysaccharides from Guillain-Barré syndrome patients induce IgG anti-GM1 antibodies in rabbits. | 2000 | J. Neuroimmunol. | pmid:10713352 |
| Bou Khalil M et al. | FTIR study of the monosialoganglioside GM1 in perdeuterated dimyristoylglycerophosphocholine (DMPCd54) multilamellar bilayers: spectroscopic evidence of a significant interaction between Ca2+ ions and the sialic acid moiety of GM1. | 2000 | Biochemistry | pmid:10715118 |
| Yuki N et al. | Clinical features and response to treatment in Guillain-Barré syndrome associated with antibodies to GM1b ganglioside. | 2000 | Ann. Neurol. | pmid:10716250 |
| Takigawa T et al. | The sera from GM1 ganglioside antibody positive patients with Guillain-Barré syndrome or chronic inflammatory demyelinating polyneuropathy blocks Na+ currents in rat single myelinated nerve fibers. | 2000 | Intern. Med. | pmid:10732828 |
| Lopez PH et al. | Normal human plasma contains antibodies that specifically block neuropathy-associated human anti-GM1 IgG-antibodies. | 2000 | J. Neuroimmunol. | pmid:10742560 |
| Yoshino H et al. | IgG antiganglioside antibodies in Guillain-Barré syndrome with bulbar palsy. | 2000 | J. Neuroimmunol. | pmid:10742563 |
| Palestini P et al. | Tubulin anchoring to glycolipid-enriched, detergent-resistant domains of the neuronal plasma membrane. | 2000 | J. Biol. Chem. | pmid:10744673 |
| Ang CW et al. | Cross-reactive antibodies against GM2 and CMV-infected fibroblasts in Guillain-Barré syndrome. | 2000 | Neurology | pmid:10751257 |
| Kanda T et al. | Glycosphingolipid antibodies and blood-nerve barrier in autoimmune demyelinative neuropathy. | 2000 | Neurology | pmid:10751258 |
| Pope-Coleman A et al. | Effects of GM1 ganglioside treatment on pre- and postsynaptic dopaminergic markers in the striatum of parkinsonian monkeys. | 2000 | Synapse | pmid:10767059 |
| Saito M and Sugiyama K | A distinct ganglioside composition of rat pancreatic islets. | 2000 | Arch. Biochem. Biophys. | pmid:10775425 |
| Rottenberg ME et al. | Regulation and role of IFN-gamma in the innate resistance to infection with Chlamydia pneumoniae. | 2000 | J. Immunol. | pmid:10779789 |
| Kenworthy AK et al. | High-resolution FRET microscopy of cholera toxin B-subunit and GPI-anchored proteins in cell plasma membranes. | 2000 | Mol. Biol. Cell | pmid:10793141 |
| Azulay JP et al. | [Lower motor neuron disease and signs of dysimmunity]. | 2000 | Rev. Neurol. (Paris) | pmid:10795014 |
| Candelise L and Ciccone A | Gangliosides for acute ischaemic stroke. | 2000 | Cochrane Database Syst Rev | pmid:10796297 |
| Molander M et al. | Immunostaining of ganglioside GD1b, GD3 and GM1 in rat cerebellum: cellular layer and cell type specific associations. | 2000 | J. Neurosci. Res. | pmid:10797556 |
| Bhattacharya SK and Danishefsky SJ | A total synthesis of the methyl glycoside of ganglioside GM(1). | 2000 | J. Org. Chem. | pmid:10813908 |
| Brodsky VY et al. | Ganglioside-mediated metabolic synchronization of protein synthesis activity in cultured hepatocytes. | 2000 | Cell Biol. Int. | pmid:10816322 |
| Galbete JL et al. | Cholesterol decreases secretion of the secreted form of amyloid precursor protein by interfering with glycosylation in the protein secretory pathway. | 2000 | Biochem. J. | pmid:10816423 |
| Picking WD | The use of fluorescence resonance energy transfer to detect conformational changes in protein toxins. | 2000 | Methods Mol. Biol. | pmid:10820720 |
| Odaka M et al. | Antibodies to GM1(NeuGc) in Guillain-Barré syndrome after ganglioside therapy. | 2000 | J. Neurol. Sci. | pmid:10831769 |
| Kornberg AJ | Anti-GM1 ganglioside antibodies: their role in the diagnosis and pathogenesis of immune-mediated motor neuropathies. | 2000 | J Clin Neurosci | pmid:10833614 |
| McCombe PA et al. | Results of testing for anti-GM1 antibodies. | 2000 | J Clin Neurosci | pmid:10833617 |
| Colella R et al. | GM1 enhances the association of neuron-specific MAP2 with actin in MAP2-transfected 3T3 cells. | 2000 | Brain Res. Dev. Brain Res. | pmid:10837887 |
| Liu ZX et al. | NK cells cause liver injury and facilitate the induction of T cell-mediated immunity to a viral liver infection. | 2000 | J. Immunol. | pmid:10843705 |
| Hazes B et al. | Crystal structure of Pseudomonas aeruginosa PAK pilin suggests a main-chain-dominated mode of receptor binding. | 2000 | J. Mol. Biol. | pmid:10843854 |
| Badizadegan K et al. | Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1). | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10859219 |
| Lenne PF et al. | Synchrotron radiation diffraction from two-dimensional protein crystals at the air/water interface. | 2000 | Biophys. J. | pmid:10866975 |
| Milewicz C et al. | Membrane expression of Thy-1,2 and GM1 ganglioside on differentiating T lymphocytes. | 1976 | J. Immunol. | pmid:1086862 |
| Galisteo M et al. | Hepatotoxicity of tacrine: occurrence of membrane fluidity alterations without involvement of lipid peroxidation. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10871308 |
| Sautter J et al. | Systemic treatment with GM1 ganglioside improves survival and function of cryopreserved embryonic midbrain grafted to the 6-hydroxydopamine-lesioned rat striatum. | 2000 | Exp. Neurol. | pmid:10877922 |
| Chen XP et al. | Ganglioside control over IL-4 priming and cytokine production in activated T cells. | 2000 | Cytokine | pmid:10880242 |
| Pestronk A | Testing for serum IgM binding to GM1 ganglioside in clinical practice. | 2000 | Neurology | pmid:10881275 |
| Kosanke SD et al. | Clinical and biochemical abnormalities in porcine GM2-gangliosidosis. | 1978 | Vet. Pathol. | pmid:108843 |