| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lai BQ et al. | Cholera Toxin B Subunit Shows Transneuronal Tracing after Injection in an Injured Sciatic Nerve. | 2015 | PLoS ONE | pmid:26640949 |
| Schneider JS et al. | Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson's Disease. | 2015 | PLoS ONE | pmid:26629687 |
| Basu I et al. | Insights into the behavioral difference of water in the presence of GM1. | 2015 | FEBS Lett. | pmid:26611347 |
| Yagi-Utsumi M and Dobson CM | Conformational Effects of the A21G Flemish Mutation on the Aggregation of Amyloid β Peptide. | 2015 | Biol. Pharm. Bull. | pmid:26424029 |
| Shinchi H et al. | Visual Detection of Human Antibodies Using Sugar Chain-Immobilized Fluorescent Nanoparticles: Application as a Point of Care Diagnostic Tool for Guillain-Barré Syndrome. | 2015 | PLoS ONE | pmid:26378448 |
| Sasaki N et al. | Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells. | 2015 | J. Biol. Chem. | pmid:26338710 |
| Vlam L et al. | Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy. | 2015 | J. Neuroimmunol. | pmid:26298317 |
| Nan C et al. | Monosialoteterahexosyl ganglioside induces the differentiation of human umbilical cord-derived mesenchymal stem cells into neuron-like cells. | 2015 | Int. J. Mol. Med. | pmid:26259830 |
| Takahashi R and Yuki N | Streptococcal IdeS: therapeutic potential for Guillain-Barré syndrome. | 2015 | Sci Rep | pmid:26194472 |
| Huang FT et al. | A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production. | 2015 | J. Lipid Res. | pmid:26130766 |
| Heredia V et al. | Interfacial stabilization of the antitumoral drug Paclitaxel in monolayers of GM1 and GD1a gangliosides. | 2015 | Biochim. Biophys. Acta | pmid:26119566 |
| Schneider JS et al. | GM1 ganglioside in Parkinson's disease: Pilot study of effects on dopamine transporter binding. | 2015 | J. Neurol. Sci. | pmid:26099170 |
| Caughlin S et al. | Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Aβ Toxicity and Stroke. | 2015 | PLoS ONE | pmid:26086081 |
| Ling ZM et al. | Evaluation of Avulsion-Induced Neuropathology in Rat Spinal Cords with 18F-FDG Micro-PET/CT. | 2015 | PLoS ONE | pmid:26010770 |
| Leonhard V et al. | Biochemical characterization of the interactions between doxorubicin and lipidic GM1 micelles with or without paclitaxel loading. | 2015 | Int J Nanomedicine | pmid:26005348 |
| Vandermeersch S et al. | Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V. | 2015 | Molecules | pmid:25913930 |
| Takagishi T et al. | Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane. | 2015 | PLoS ONE | pmid:25910247 |
| Koga M et al. | Complex of GM1- and GD1a-like lipo-oligosaccharide mimics GM1b, inducing anti-GM1b antibodies. | 2015 | PLoS ONE | pmid:25867522 |
| Moens PD et al. | Modes of diffusion of cholera toxin bound to GM1 on live cell membrane by image mean square displacement analysis. | 2015 | Biophys. J. | pmid:25809257 |
| Baldauf KJ et al. | Cholera toxin B: one subunit with many pharmaceutical applications. | 2015 | Toxins (Basel) | pmid:25802972 |
| Osteikoetxea X et al. | Improved characterization of EV preparations based on protein to lipid ratio and lipid properties. | 2015 | PLoS ONE | pmid:25798862 |
| Hata R et al. | Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice. | 2015 | Sci Rep | pmid:25765541 |
| De Chatterjee A et al. | The assembly of GM1 glycolipid- and cholesterol-enriched raft-like membrane microdomains is important for giardial encystation. | 2015 | Infect. Immun. | pmid:25733521 |
| Liang B et al. | Label-free detection and identification of protein ligands captured by receptors in a polymerized planar lipid bilayer using MALDI-TOF MS. | 2015 | Anal Bioanal Chem | pmid:25694144 |
| Okabayashi S et al. | Diabetes mellitus accelerates Aβ pathology in brain accompanied by enhanced GAβ generation in nonhuman primates. | 2015 | PLoS ONE | pmid:25675436 |
| Leonhard V et al. | Biochemical characterization of GM1 micelles-Amphotericin B interaction. | 2015 | Curr Drug Deliv | pmid:25772153 |
| Hamorsky KT et al. | N-glycosylation of cholera toxin B subunit in Nicotiana benthamiana: impacts on host stress response, production yield and vaccine potential. | 2015 | Sci Rep | pmid:25614217 |
| Hu Z et al. | Raman spectroscopy for detecting supported planar lipid bilayers composed of ganglioside-GM1/sphingomyelin/cholesterol in the presence of amyloid-β. | 2015 | Phys Chem Chem Phys | pmid:26256454 |
| Sun H et al. | Nanodomain Formation of Ganglioside GM1 in Lipid Membrane: Effects of Cholera Toxin-Mediated Cross-Linking. | 2015 | Langmuir | pmid:26250646 |
| Basu I and Mukhopadhyay C | In silico phase separation in the presence of GM1 in ternary and quaternary lipid bilayers. | 2015 | Phys Chem Chem Phys | pmid:26067631 |
| Ledeen RW and Wu G | The multi-tasked life of GM1 ganglioside, a true factotum of nature. | 2015 | Trends Biochem. Sci. | pmid:26024958 |
| Phongsisay V et al. | Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors. | 2015 | Mol. Immunol. | pmid:26021803 |
| Sato S et al. | A Self-Assembled Spherical Complex Displaying a Gangliosidic Glycan Cluster Capable of Interacting with Amyloidogenic Proteins. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:26015171 |
| Zhang J et al. | The Possible Damaged Mechanism and the Preventive Effect of Monosialotetrahexosylganglioside in a Rat Model of Cerebral Ischemia-Reperfusion Injury. | 2015 | J Stroke Cerebrovasc Dis | pmid:25934141 |
| Yagi-Utsumi M and Kato K | Structural and dynamic views of GM1 ganglioside. | 2015 | Glycoconj. J. | pmid:25931034 |
| Sasahara K et al. | Uptake of raft components into amyloid β-peptide aggregates and membrane damage. | 2015 | Anal. Biochem. | pmid:25908557 |
| Yanagisawa K | GM1 ganglioside and Alzheimer's disease. | 2015 | Glycoconj. J. | pmid:25903682 |
| Maeda Y et al. | Effects of cyclodextrins on GM1-gangliosides in fibroblasts from GM1-gangliosidosis patients. | 2015 | J. Pharm. Pharmacol. | pmid:25851126 |
| Togawa J et al. | Similarities of serum anti-ganglioside antibodies in first and third episodes of recurrent Guillain-Barre syndrome: case report. | 2015 | J. Neurol. | pmid:25845761 |
| Koike Y et al. | [A case of progressive encephalomyelitis with rigidity and myoclonus associated with anti-GAD, anti-glycine receptor and anti-GM1 antibodies]. | 2015 | Rinsho Shinkeigaku | pmid:25746075 |
| Hurlbert RJ et al. | Pharmacological therapy for acute spinal cord injury. | 2015 | Neurosurgery | pmid:25692371 |
| Yamamoto N et al. | Midazolam inhibits the formation of amyloid fibrils and GM1 ganglioside-rich microdomains in presynaptic membranes through the gamma-aminobutyric acid A receptor. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25600806 |
| Fujimura M and Usuki F | Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: in vitro and in vivo effects of TrkA pathway activators. | 2015 | Toxicol. Appl. Pharmacol. | pmid:25545984 |
| Matheou CJ et al. | Cu²⺠accentuates distinct misfolding of Aβâ‚â‚‹â‚„â‚€ and Aβâ‚â‚‹â‚„â‚‚ peptides, and potentiates membrane disruption. | 2015 | Biochem. J. | pmid:25471541 |
| Fukuda Y et al. | Neurotropin promotes NGF signaling through interaction of GM1 ganglioside with Trk neurotrophin receptor in PC12 cells. | 2015 | Brain Res. | pmid:25454796 |
| Valdomero A et al. | Exogenous GM1 ganglioside increases accumbal BDNF levels in rats. | 2015 | Behav. Brain Res. | pmid:25453740 |
| Nikolaeva S et al. | GM1 and GD1a gangliosides modulate toxic and inflammatory effects of E. coli lipopolysaccharide by preventing TLR4 translocation into lipid rafts. | 2015 | Biochim. Biophys. Acta | pmid:25499607 |
| Cats EA et al. | Clonality of anti-GM1 IgM antibodies in multifocal motor neuropathy and the Guillain-Barré syndrome. | 2015 | J. Neurol. Neurosurg. Psychiatry | pmid:25157033 |
| Benedetti L et al. | Meningoencephalitis-like onset of post-infectious AQP4-IgG-positive optic neuritis complicated by GM1-IgG-positive acute polyneuropathy. | 2015 | Mult. Scler. | pmid:24557856 |
| Bian L et al. | Isolation and purification of monosialotetrahexosylgangliosides from pig brain by extraction and liquid chromatography. | 2015 | Biomed. Chromatogr. | pmid:25845558 |