Ganglioside GI

Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GI?

Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Ganglioside GI

MeSH term MeSH ID Detail
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Gaucher Disease D005776 13 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GI

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GI?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Ganglioside GI?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ganglioside GI?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Ganglioside GI?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ganglioside GI?

Knock-out

Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).

Transgenic Model

Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).

Disease model

Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Ganglioside GI

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Authors Title Published Journal PubMed Link
Harris JR and Milton NG Cholesterol in Alzheimer's disease and other amyloidogenic disorders. 2010 Subcell. Biochem. pmid:20213540
Schroeder F et al. Caveolin, sterol carrier protein-2, membrane cholesterol-rich microdomains and intracellular cholesterol trafficking. 2010 Subcell. Biochem. pmid:20213548
Tseng EE et al. Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest. 1998 Surgery pmid:9706152
Fass B and Stein DG Effects of fimbria-fornix transection and ganglioside treatments on histochemical staining for glucose-6-phosphate dehydrogenase in the lateral septum. 1987 Synapse pmid:3505365
Pope-Coleman A et al. Effects of GM1 ganglioside treatment on pre- and postsynaptic dopaminergic markers in the striatum of parkinsonian monkeys. 2000 Synapse pmid:10767059
Andrisani A et al. Effect of various commercial buffers on sperm viability and capacitation. 2014 Syst Biol Reprod Med pmid:24673547
Kudoh T The abnormalities of beta-galactosidase in GM1-gangliosidoses. 1978 Tohoku J. Exp. Med. pmid:27879
Kudo T et al. Production of a human monoclonal antibody to a synthetic peptide by active in vivo immunization using a SCID mouse grafted with human lymphocytes. 1993 Tohoku J. Exp. Med. pmid:7514315
Lü HZ et al. Formation and aggregation of lipid rafts in γδ T cells following stimulation with Mycobacterium tuberculosis antigens. 2011 Tohoku J. Exp. Med. pmid:21372520
Kambe M et al. Induction of natural killer (NK) activity in mice by injection of chromomycin A3. 1991 Tohoku J. Exp. Med. pmid:1909057