MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Görtzen A et al. | Schmidt-Lanterman's incisures--the principal target of autoimmune attack in demyelinating Guillain-Barré syndrome? | 1999 | J. Neuroimmunol. | pmid:10376936 |
Comolli JC et al. | Pili binding to asialo-GM1 on epithelial cells can mediate cytotoxicity or bacterial internalization by Pseudomonas aeruginosa. | 1999 | Infect. Immun. | pmid:10377092 |
Prendergast MM et al. | Human monoclonal immunoglobulin M antibodies to ganglioside GM1 show diverse cross-reactivities with lipopolysaccharides of Campylobacter jejuni strains associated with Guillain-Barré syndrome. | 1999 | Infect. Immun. | pmid:10377164 |
Lanne B et al. | Binding of cholera toxin B-subunits to derivatives of the natural ganglioside receptor, GM1. | 1999 | J. Biochem. | pmid:10393343 |
Galván EM et al. | Participation of ABH glycoconjugates in the secretory response to Escherichia coli heat-labile toxin in rabbit intestine. | 1999 | J. Infect. Dis. | pmid:10395858 |
Lencer WI et al. | Membrane traffic and the cellular uptake of cholera toxin. | 1999 | Biochim. Biophys. Acta | pmid:10395933 |
Slevin M et al. | Physiological concentrations of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells. | 1999 | Int. J. Cancer | pmid:10399959 |
Yuki N et al. | Autoantibodies to GM1b and GalNAc-GD1a: relationship to Campylobacter jejuni infection and acute motor axonal neuropathy in China. | 1999 | J. Neurol. Sci. | pmid:10402024 |
Kuwabara S et al. | Hyperreflexia in Guillain-Barré syndrome: relation with acute motor axonal neuropathy and anti-GM1 antibody. | 1999 | J. Neurol. Neurosurg. Psychiatry | pmid:10406985 |
Kozireski-Chuback D et al. | Developmental appearance of nuclear GM1 in neurons of the central and peripheral nervous systems. | 1999 | Brain Res. Dev. Brain Res. | pmid:10407137 |