| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
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|---|---|---|---|---|
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| Yamamoto N et al. | Propofol and thiopental suppress amyloid fibril formation and GM1 ganglioside expression through the γ-aminobutyric acid A receptor. | 2013 | Anesthesiology | pmid:23422796 |
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| Freed WJ et al. | Embryonic substantia nigra grafts. Factors controlling behavioral efficacy and reinnervation of the host striatum. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3474960 |
| Ledeen RW et al. | Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected]. | 2012 | Ann. N. Y. Acad. Sci. | pmid:22524425 |
| Vital MB et al. | Monosialoganglioside increased the in vivo affinity of D2 receptors for apomorphine in supersensitive rats. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668390 |
| Silva RH et al. | Effects of neonatal GM1 administration on the discriminative avoidance behavior of adult rats. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668388 |
| Rampersaud AA et al. | GM1 activates the MAP kinase cascade through a novel wortmannin-sensitive step upstream from c-Raf. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668387 |
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| McGee SW et al. | Expression of recombinant beta-platelet-derived growth-factor receptor in Sf9 insect cells as a model to study receptor-ganglioside interactions. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668383 |
| Lainetti RD et al. | Ganglioside GM1 potentiates the stimulatory effect of nerve growth factor on peripheral nerve regeneration in vivo. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668382 |
| Hynds DL et al. | GM1 does not affect PDGF-BB-stimulated [3H] thymidine incorporation or neuritogenesis in SH-SY5Y cells treated with phosphorothioate oligonucleotides antisense to PDGF-A. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668381 |
| Ferrari G et al. | GM1, like IGF-I and GDNF, prevents neuronal apoptosis. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668378 |
| Farooqui T and Yates AJ | Effect of GM1 on TrkA dimerization. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668377 |
| Duchemin AM et al. | Induction of Trk phosphorylation in rat brain by GM1 ganglioside. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668376 |
| Bellot RG et al. | Effects of monosialoganglioside GM1 on scopolamine-induced amnesia. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668374 |
| Ariga T and Yu RK | GM1 ganglioside inhibits amyloid beta-protein induced-cytokine release. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668373 |
| Alter M | GM1 ganglioside for acute ischemic stroke. Trial design issues. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668372 |
| Baumgartner WA et al. | The role of the monosialoganglioside, GM1 as a neuroprotectant in an experimental model of cardiopulmonary bypass and hypothermic circulatory arrest. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668371 |
| Schneider JS | GM1 ganglioside in the treatment of Parkinson's disease. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668369 |
| Gatterbauer B et al. | Antiglycosphingolipid immune responses in neurology. The Vienna experience with isotypes, subclasses, and disease. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668368 |
| Yuki N and Miyatake T | Guillain-Barré syndrome and Fisher's syndrome following Campylobacter jejuni infection. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668366 |
| Baumann N et al. | Antiglycolipid antibodies in motor neuropathies. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668365 |
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| Ferrari G and Greene LA | Promotion of neuronal survival by GM1 ganglioside. Phenomenology and mechanism of action. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668360 |
| Saito M et al. | The semisynthetic glycosphingolipid LIGA20 potently protects neurons against apoptosis. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668359 |
| Akporiaye ET et al. | Effect of beta-carotene on cytotoxic activity and receptor expression of tumor-specific lymphocytes. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8129307 |
| Wu G et al. | The role of GM1 ganglioside in regulating excitatory opioid effects. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668347 |
| Crain SM and Shen KF | GM1 ganglioside-induced modulation of opioid receptor-mediated functions. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9668346 |