| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bartels T et al. | N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation. | 2014 | PLoS ONE | pmid:25075858 |
| Yamamoto N et al. | Leptin inhibits amyloid β-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway. | 2014 | J. Neurochem. | pmid:25039425 |
| Monnier J and Zabel BA | Anti-asialo GM1 NK cell depleting antibody does not alter the development of bleomycin induced pulmonary fibrosis. | 2014 | PLoS ONE | pmid:24922516 |
| Clausen MP et al. | Simultaneous multi-species tracking in live cells with quantum dot conjugates. | 2014 | PLoS ONE | pmid:24892555 |
| Romero MM et al. | Outbreaks of Mycobacterium tuberculosis MDR strains differentially induce neutrophil respiratory burst involving lipid rafts, p38 MAPK and Syk. | 2014 | BMC Infect. Dis. | pmid:24886274 |
| Botto L et al. | Role of lipid rafts and GM1 in the segregation and processing of prion protein. | 2014 | PLoS ONE | pmid:24859148 |
| Wittenberg NJ et al. | Formation of biomembrane microarrays with a squeegee-based assembly method. | 2014 | J Vis Exp | pmid:24837169 |
| Puff N et al. | Lo/Ld phase coexistence modulation induced by GM1. | 2014 | Biochim. Biophys. Acta | pmid:24835016 |
| Newburn EN et al. | GM1 ganglioside enhances Ret signaling in striatum. | 2014 | J. Neurochem. | pmid:24821093 |
| Harschnitz O et al. | MMN: from immunological cross-talk to conduction block. | 2014 | J. Clin. Immunol. | pmid:24728842 |
| Hong S et al. | Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes. | 2014 | Neuron | pmid:24685176 |
| Liu Y et al. | Anti-diabetic effects of CTB-APSL fusion protein in type 2 diabetic mice. | 2014 | Mar Drugs | pmid:24633252 |
| Romero I et al. | T lymphocytes restrain spontaneous metastases in permanent dormancy. | 2014 | Cancer Res. | pmid:24531750 |
| Cohen R et al. | Lipid modulation of calcium flux through CaV2.3 regulates acrosome exocytosis and fertilization. | 2014 | Dev. Cell | pmid:24525187 |
| Itokazu Y et al. | Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24500283 |
| Zeng Y and Tarbell JM | The adaptive remodeling of endothelial glycocalyx in response to fluid shear stress. | 2014 | PLoS ONE | pmid:24465988 |
| McDonald G et al. | Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients. | 2014 | J. Clin. Invest. | pmid:24463447 |
| Lei L et al. | The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation. | 2014 | Biomaterials | pmid:24397990 |
| Lundius EG et al. | GPR37 protein trafficking to the plasma membrane regulated by prosaposin and GM1 gangliosides promotes cell viability. | 2014 | J. Biol. Chem. | pmid:24371137 |
| te Welscher YM et al. | Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1. | 2014 | J Control Release | pmid:24370893 |
| Basu I and Mukhopadhyay C | Insights into binding of cholera toxin to GM1 containing membrane. | 2014 | Langmuir | pmid:25425333 |
| Ueno H et al. | Comparison between the aggregation of human and rodent amyloid β-proteins in GM1 ganglioside clusters. | 2014 | Biochemistry | pmid:25399921 |
| Xu R et al. | The possible mechanism of Parkinson's disease progressive damage and the preventive effect of GM1 in the rat model induced by 6-hydroxydopamine. | 2014 | Brain Res. | pmid:25285892 |
| Ishikawa N et al. | A pediatric case of peripheral polyneuropathy with IgM anti-GM1 antibody associated with A group a beta-hemolytic Streptococcus infection. | 2014 | Pediatr. Neurol. | pmid:25160552 |
| Matsuzaki K | How do membranes initiate Alzheimer's Disease? Formation of toxic amyloid fibrils by the amyloid β-protein on ganglioside clusters. | 2014 | Acc. Chem. Res. | pmid:25029558 |
| Miura Y et al. | Autoantibodies to GM1 and GQ1bα are not biological markers of Alzheimer's disease. | 2014 | J. Alzheimers Dis. | pmid:25024341 |
| Da P et al. | Surface plasmon resonance enhanced real-time photoelectrochemical protein sensing by gold nanoparticle-decorated TiOâ‚‚ nanowires. | 2014 | Anal. Chem. | pmid:24915128 |
| Yuki N et al. | GD1b-specific antibodies may bind to complex of GQ1b and GM1, causing ataxia. | 2014 | J. Neurol. | pmid:24859332 |
| Yuki N et al. | Lower motor neuron syndrome associated with IgG anti-GM1 antibodies revisited. | 2014 | J. Neuroimmunol. | pmid:24841627 |
| Hatzifilippou E et al. | Antibodies against gangliosides in patients with dementia. | 2014 | Am J Alzheimers Dis Other Demen | pmid:24838532 |
| Tsuchida T et al. | The development of humanized liver with Rag1 knockout rats. | 2014 | Transplant. Proc. | pmid:24815157 |
| Franssen H | The node of Ranvier in multifocal motor neuropathy. | 2014 | J. Clin. Immunol. | pmid:24801202 |
| Sha S et al. | Deficits in cognitive function and hippocampal plasticity in GM2/GD2 synthase knockout mice. | 2014 | Hippocampus | pmid:24765676 |
| Koski CL | Treatment of multifocal motor neuropathy with intravenous immunoglobulin. | 2014 | J. Clin. Immunol. | pmid:24699885 |
| Andrisani A et al. | Effect of various commercial buffers on sperm viability and capacitation. | 2014 | Syst Biol Reprod Med | pmid:24673547 |
| Kirkeby S | Cholera toxin B subunit-binding and ganglioside GM1 immuno-expression are not necessarily correlated in human salivary glands. | 2014 | Acta Odontol. Scand. | pmid:24655314 |
| Domingue JC and Rao MC | CFTR and GM1 "gangl-ing" up to heal thy wound. Focus on "Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair". | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24627559 |
| Schulte W et al. | A Langmuir monolayer study of the action of phospholipase A2 on model phospholipid and mixed phospholipid-GM1 ganglioside membranes. | 2014 | Colloids Surf B Biointerfaces | pmid:24524938 |
| Takatori S et al. | Microscopic methods to observe the distribution of lipids in the cellular membrane. | 2014 | Biochemistry | pmid:24460209 |
| Hsieh CL et al. | Tracking single particles on supported lipid membranes: multimobility diffusion and nanoscopic confinement. | 2014 | J Phys Chem B | pmid:24433014 |
| Morgan ML et al. | Anti-asialo-GM1 and GD1a variant of Miller Fisher variant of Guillain-Barré Syndrome. | 2014 | J Neuroophthalmol | pmid:25062498 |
| Magini A et al. | Methods to discriminate the distribution of acidic glycohydrolases between the endosomal-lysosomal systems and the plasma membrane. | 2014 | Meth. Enzymol. | pmid:24359946 |
| Willison HJ et al. | Antibodies to GM1: galactocerebroside complexes in multifocal motor neuropathy: it takes two to tango. | 2014 | J. Neurol. Neurosurg. Psychiatry | pmid:24006050 |
| Nobile-Orazio E et al. | Sensitivity and predictive value of anti-GM1/galactocerebroside IgM antibodies in multifocal motor neuropathy. | 2014 | J. Neurol. Neurosurg. Psychiatry | pmid:23907602 |
| Hotta S et al. | Neurophysiological and immunohistochemical studies of IgG anti-GM1 monoclonal antibody on neuromuscular transmission: effects in rat neuromuscular junctions. | 2014 | Neurol. Sci. | pmid:23820959 |
| Bisel B et al. | GM1 and GM2 gangliosides: recent developments. | 2014 | Biomol Concepts | pmid:25372744 |
| Shrestha D et al. | CD1d favors MHC neighborhood, GM1 ganglioside proximity and low detergent sensitive membrane regions on the surface of B lymphocytes. | 2014 | Biochim. Biophys. Acta | pmid:24482817 |
| Kang S et al. | Altered levels of α-synuclein and sphingolipids in Batten disease lymphoblast cells. | 2014 | Gene | pmid:24534465 |
| Kim W et al. | Dietary fish oil and DHA down-regulate antigen-activated CD4+ T-cells while promoting the formation of liquid-ordered mesodomains. | 2014 | Br. J. Nutr. | pmid:23962659 |
| Petr T et al. | The effect of heme oxygenase on ganglioside redistribution within hepatocytes in experimental estrogen-induced cholestasis. | 2014 | Physiol Res | pmid:24564601 |