MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Ganglioside GI
MeSH term | MeSH ID | Detail |
---|---|---|
Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
Brain Ischemia | D002545 | 89 associated lipids |
Cystic Fibrosis | D003550 | 65 associated lipids |
Gaucher Disease | D005776 | 13 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Cohen R et al. | Lipid modulation of calcium flux through CaV2.3 regulates acrosome exocytosis and fertilization. | 2014 | Dev. Cell | pmid:24525187 |
Itokazu Y et al. | Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24500283 |
Zeng Y and Tarbell JM | The adaptive remodeling of endothelial glycocalyx in response to fluid shear stress. | 2014 | PLoS ONE | pmid:24465988 |
McDonald G et al. | Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients. | 2014 | J. Clin. Invest. | pmid:24463447 |
Lei L et al. | The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation. | 2014 | Biomaterials | pmid:24397990 |
Franssen H | The node of Ranvier in multifocal motor neuropathy. | 2014 | J. Clin. Immunol. | pmid:24801202 |
Sha S et al. | Deficits in cognitive function and hippocampal plasticity in GM2/GD2 synthase knockout mice. | 2014 | Hippocampus | pmid:24765676 |
Koski CL | Treatment of multifocal motor neuropathy with intravenous immunoglobulin. | 2014 | J. Clin. Immunol. | pmid:24699885 |
Andrisani A et al. | Effect of various commercial buffers on sperm viability and capacitation. | 2014 | Syst Biol Reprod Med | pmid:24673547 |
Khatun UL and Mukhopadhyay C | Interaction of bee venom toxin melittin with ganglioside GM1 bicelle. | 2013 Oct-Nov | Biophys. Chem. | pmid:23850803 |
Hirai M et al. | Change of dynamics of raft-model membrane induced by amyloid-β protein binding. | 2013 | Eur Phys J E Soft Matter | pmid:23852578 |
Rondelli V et al. | Neutrons for rafts, rafts for neutrons. | 2013 | Eur Phys J E Soft Matter | pmid:23852579 |
Yang R et al. | Monosialoanglioside improves memory deficits and relieves oxidative stress in the hippocampus of rat model of Alzheimer's disease. | 2013 | Neurol. Sci. | pmid:23229411 |
Nomura M et al. | 13-Cis retinoic acid can enhance the antitumor activity of non-replicating Sendai virus particle against neuroblastoma. | 2013 | Cancer Sci. | pmid:23134437 |
Kreutz F et al. | Alterations of membrane lipids and in gene expression of ganglioside metabolism in different brain structures in a mouse model of mucopolysaccharidosis type I (MPS I). | 2013 | Gene | pmid:23774686 |
Konishi M et al. | Extending the glucosyl ceramide cassette approach: application in the total synthesis of ganglioside GalNAc-GM1b. | 2013 | Molecules | pmid:24335571 |
Bisel B et al. | Decoupling polarization of the Golgi apparatus and GM1 in the plasma membrane. | 2013 | PLoS ONE | pmid:24312472 |
Manna M and Mukhopadhyay C | Binding, conformational transition and dimerization of amyloid-β peptide on GM1-containing ternary membrane: insights from molecular dynamics simulation. | 2013 | PLoS ONE | pmid:23951128 |
Zhong L et al. | NSOM/QD-based visualization of GM1 serving as platforms for TCR/CD3 mediated T-cell activation. | 2013 | Biomed Res Int | pmid:24288672 |
Szklarczyk OM et al. | Receptor concentration and diffusivity control multivalent binding of Sv40 to membrane bilayers. | 2013 | PLoS Comput. Biol. | pmid:24244125 |
Cox CJ et al. | Brain human monoclonal autoantibody from sydenham chorea targets dopaminergic neurons in transgenic mice and signals dopamine D2 receptor: implications in human disease. | 2013 | J. Immunol. | pmid:24184556 |
Rios FJ et al. | Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts. | 2013 | PLoS ONE | pmid:24130805 |
Rong X et al. | Ganglioside GM1 reduces white matter damage in neonatal rats. | 2013 | Acta Neurobiol Exp (Wars) | pmid:24129486 |
Moeller S et al. | Lack of association between autism and anti-GM1 ganglioside antibody. | 2013 | Neurology | pmid:24068789 |
Pellistri F et al. | Different ataxin-3 amyloid aggregates induce intracellular Ca(2+) deregulation by different mechanisms in cerebellar granule cells. | 2013 | Biochim. Biophys. Acta | pmid:24035922 |
Saslowsky DE et al. | Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain. | 2013 | J. Biol. Chem. | pmid:23884419 |
Itokazu Y et al. | Effects of amyloid β-peptides and gangliosides on mouse neural stem cells. | 2013 | Neurochem. Res. | pmid:23851714 |
Armendariz KP and Dunn RC | Ganglioside influence on phospholipid films investigated with single molecule fluorescence measurements. | 2013 | J Phys Chem B | pmid:23745772 |
Gustafsson T et al. | Direct interaction between cholera toxin and dendritic cells is required for oral adjuvant activity. | 2013 | Eur. J. Immunol. | pmid:23649516 |
Triantafilou M et al. | Synergic activation of toll-like receptor (TLR) 2/6 and 9 in response to Ureaplasma parvum & urealyticum in human amniotic epithelial cells. | 2013 | PLoS ONE | pmid:23593431 |
Schneider JS et al. | A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson's disease patients. | 2013 | J. Neurol. Sci. | pmid:23199590 |
Li X et al. | TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice. | 2013 | J. Mol. Med. | pmid:23108456 |
Kuwabara S and Yuki N | Axonal Guillain-Barré syndrome: concepts and controversies. | 2013 | Lancet Neurol | pmid:24229616 |
Van Blerkom J and Caltrider K | Sperm attachment and penetration competence in the human oocyte: a possible aetiology of fertilization failure involving the organization of oolemmal lipid raft microdomains influenced by the ΔΨm of subplasmalemmal mitochondria. | 2013 | Reprod. Biomed. Online | pmid:24157131 |
Okawa S et al. | Tolosa-hunt syndrome associated with cytomegalovirus infection. | 2013 | Intern. Med. | pmid:23676602 |
Ogawa G et al. | An antibody to the GM1/GalNAc-GD1a complex correlates with development of pure motor Guillain-Barré syndrome with reversible conduction failure. | 2013 | J. Neuroimmunol. | pmid:23000056 |
Kreutz F et al. | Alterations on Naâº,Kâº-ATPase and acetylcholinesterase activities induced by amyloid-β peptide in rat brain and GM1 ganglioside neuroprotective action. | 2013 | Neurochem. Res. | pmid:24013887 |
Galban-Horcajo F et al. | Antibodies to heteromeric glycolipid complexes in multifocal motor neuropathy. | 2013 | Eur. J. Neurol. | pmid:22727042 |
Mattarella M et al. | Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. | 2013 | Org. Biomol. Chem. | pmid:23736158 |
Garcia-Hartjes J et al. | Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix[5]arene. | 2013 | Org. Biomol. Chem. | pmid:23689250 |
Poggi A et al. | Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells. | 2013 | PLoS ONE | pmid:23667543 |
Matsubara T et al. | Density of GM1 in nanoclusters is a critical factor in the formation of a spherical assembly of amyloid β-protein on synaptic plasma membranes. | 2013 | Langmuir | pmid:23294326 |
Dobos J et al. | Sex-dependent liver colonization of human melanoma in SCID mice--role of host defense mechanisms. | 2013 | Clin. Exp. Metastasis | pmid:23203681 |
Kuwahara M et al. | Clinical features of CIDP with LM1-associated antibodies. | 2013 | J. Neurol. Neurosurg. Psychiatry | pmid:23138763 |
Cheng Q et al. | Fuzheng Huayu inhibits carbon tetrachloride-induced liver fibrosis in mice through activating hepatic NK cells. | 2013 | J Ethnopharmacol | pmid:23127651 |
Hosoya S et al. | Innate immune responses involving natural killer and natural killer T cells promote liver regeneration after partial hepatectomy in mice. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23086918 |
Lammertse DP | Clinical trials in spinal cord injury: lessons learned on the path to translation. The 2011 International Spinal Cord Society Sir Ludwig Guttmann Lecture. | 2013 | Spinal Cord | pmid:23165505 |
Vlam L et al. | Immune pathogenesis and treatment of multifocal motor neuropathy. | 2013 | J. Clin. Immunol. | pmid:22941513 |
Yamaguchi T et al. | Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins. | 2013 | Chem. Commun. (Camb.) | pmid:23296043 |
Buschiazzo J et al. | Cholesterol depletion disorganizes oocyte membrane rafts altering mouse fertilization. | 2013 | PLoS ONE | pmid:23638166 |