| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tuosto L et al. | Organization of plasma membrane functional rafts upon T cell activation. | 2001 | Eur. J. Immunol. | pmid:11180097 |
| Millán J et al. | Segregation of co-stimulatory components into specific T cell surface lipid rafts. | 2001 | Eur. J. Immunol. | pmid:11180111 |
| Metelmann W et al. | Nano-electrospray ionization time-of-flight mass spectrometry of gangliosides from human brain tissue. | 2001 | J Mass Spectrom | pmid:11180643 |
| Fantini J et al. | Glycosphingolipid (GSL) microdomains as attachment platforms for host pathogens and their toxins on intestinal epithelial cells: activation of signal transduction pathways and perturbations of intestinal absorption and secretion. | Glycoconj. J. | pmid:11201788 | |
| Pitto M et al. | Use of a photoactivable GM1 ganglioside analogue to assess lipid distribution in caveolae bilayer. | 2000 Mar-Apr | Glycoconj. J. | pmid:11201793 |
| Mutoh T et al. | Unglycosylated Trk protein does not co-localize nor associate with ganglioside GM1 in stable clone of PC12 cells overexpressing Trk (PCtrk cells). | Glycoconj. J. | pmid:11201795 | |
| Izumi K and Sawada MT | A novel assay method for glycosphingolipid deacylase by enzyme-linked immunochemical detection of lysoglycosphingolipid. | 2001 | Lipids | pmid:11214737 |
| Tsuda H et al. | Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin in animals. | 2000 | Biofactors | pmid:11216510 |
| Dietrich C et al. | Lipid rafts reconstituted in model membranes. | 2001 | Biophys. J. | pmid:11222302 |
| Cohn LA et al. | Pseudomonas aeruginosa infection of respiratory epithelium in a cystic fibrosis xenograft model. | 2001 | J. Infect. Dis. | pmid:11237809 |
| Quattrini A et al. | Human IgM anti-GM1 autoantibodies modulate intracellular calcium homeostasis in neuroblastoma cells. | 2001 | J. Neuroimmunol. | pmid:11240034 |
| Ang CW et al. | Guillain-Barré syndrome- and Miller Fisher syndrome-associated Campylobacter jejuni lipopolysaccharides induce anti-GM1 and anti-GQ1b Antibodies in rabbits. | 2001 | Infect. Immun. | pmid:11254608 |
| Song X et al. | Detection of multivalent interactions through two-tiered energy transfer. | 2001 | Anal. Biochem. | pmid:11262166 |
| Ledesma MD et al. | Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains. | 2000 | EMBO Rep. | pmid:11263499 |
| Hadden RD et al. | Preceding infections, immune factors, and outcome in Guillain-Barré syndrome. | 2001 | Neurology | pmid:11274311 |
| Ratner AJ et al. | Cystic fibrosis pathogens activate Ca2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells. | 2001 | J. Biol. Chem. | pmid:11278360 |
| Thomas C et al. | Influence of gangliosides or LPS-like gangliosides on the tumoricidal activity of adherent leukocytes. | 2001 | C. R. Acad. Sci. III, Sci. Vie | pmid:11280042 |
| Nobile-Orazio E | Multifocal motor neuropathy. | 2001 | J. Neuroimmunol. | pmid:11282149 |
| Nashar TO et al. | Evidence for a role of ganglioside GM1 in antigen presentation: binding enhances presentation of Escherichia coli enterotoxin B subunit (EtxB) to CD4(+) T cells. | 2001 | Int. Immunol. | pmid:11282993 |
| Prendergast MM et al. | Development of an immunoassay for rapid detection of ganglioside GM(1) mimicry in Campylobacter jejuni strains. | 2001 | J. Clin. Microbiol. | pmid:11283076 |
| Alaedini A et al. | Ganglioside agglutination immunoassay for rapid detection of autoantibodies in immune-mediated neuropathy. | 2001 | J. Clin. Lab. Anal. | pmid:11291112 |
| Alaedini A and Latov N | A surface plasmon resonance biosensor assay for measurement of anti-GM(1) antibodies in neuropathy. | 2001 | Neurology | pmid:11294921 |
| Werle E et al. | Antibodies against serotonin have no diagnostic relevance in patients with fibromyalgia syndrome. | 2001 | J. Rheumatol. | pmid:11296965 |
| Beignon AS et al. | Immunization onto bare skin with heat-labile enterotoxin of Escherichia coli enhances immune responses to coadministered protein and peptide antigens and protects mice against lethal toxin challenge. | 2001 | Immunology | pmid:11298834 |
| Suh JY et al. | Backbone dynamics of receptor binding and antigenic regions of a Pseudomonas aeruginosa pilin monomer. | 2001 | Biochemistry | pmid:11300779 |
| Vyas KA et al. | Segregation of gangliosides GM1 and GD3 on cell membranes, isolated membrane rafts, and defined supported lipid monolayers. | 2001 | Biol. Chem. | pmid:11308022 |
| Vukelić Z et al. | Anencephaly: structural characterization of gangliosides in defined brain regions. | 2001 | Biol. Chem. | pmid:11308024 |
| Koga M et al. | Antecedent symptoms in Guillain-Barré syndrome: an important indicator for clinical and serological subgroups. | 2001 | Acta Neurol. Scand. | pmid:11328202 |
| Sherwood AL et al. | An amino acid region at the N-terminus of rat hepatoma alpha1-->2 fucosyltransferase modulates enzyme activity and interaction with lipids: strong preference for glycosphingolipids containing terminal Galbeta1-->3GalNAc-structures. | 2001 | Biochemistry | pmid:11341836 |
| Sarmiento MA et al. | Guillain-Barre syndrome following 2-chlorodeoxyadenosine treatment for Hairy Cell Leukemia. | 2000 | Leuk. Lymphoma | pmid:11342351 |
| Kakio A et al. | Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid. | 2001 | J. Biol. Chem. | pmid:11342534 |
| Sandel PC et al. | Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement. | 2001 | J. Immunol. | pmid:11342608 |
| Nagai M and Masuzawa T | Vaccination with MCP-1 cDNA transfectant on human malignant glioma in nude mice induces migration of monocytes and NK cells to the tumor. | 2001 | Int. Immunopharmacol. | pmid:11357878 |
| Yoshida S et al. | Ganglioside G(D2) in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis. | 2001 | Cancer Res. | pmid:11358851 |
| Kimura M et al. | Engagement of endogenous ganglioside GM1a induces tyrosine phosphorylation involved in neuron-like differentiation of PC12 cells. | 2001 | Glycobiology | pmid:11358882 |
| Nakagawa R et al. | Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice. | 2001 | J. Immunol. | pmid:11359810 |
| Berghs S et al. | Autoimmunity to beta IV spectrin in paraneoplastic lower motor neuron syndrome. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11391009 |
| Sheikh KA and Griffin JW | Variants of the Guillain Barré syndrome: progress toward fulfilling "Koch's postulates". | 2001 | Ann. Neurol. | pmid:11409419 |
| Yuki N et al. | Animal model of axonal Guillain-Barré syndrome induced by sensitization with GM1 ganglioside. | 2001 | Ann. Neurol. | pmid:11409422 |
| Koga M et al. | Range of cross reactivity of anti-GM1 IgG antibody in Guillain-Barré syndrome. | 2001 | J. Neurol. Neurosurg. Psychiatry | pmid:11413278 |
| Goettl VM et al. | Motoric behavior in aged rats treated with GM1. | 2001 | Brain Res. | pmid:11430865 |
| Pickl WF et al. | Lipid rafts and pseudotyping. | 2001 | J. Virol. | pmid:11435598 |
| Valdes-Gonzalez T et al. | Neuropeptides interact with glycolipid receptors: a surface plasmon resonance study. | 2001 | Peptides | pmid:11445240 |
| Aman AT et al. | A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11447291 |
| Yuan C and Johnston LJ | Atomic force microscopy studies of ganglioside GM1 domains in phosphatidylcholine and phosphatidylcholine/cholesterol bilayers. | 2001 | Biophys. J. | pmid:11463647 |
| Zaprianova E et al. | Serum ganglioside patterns in multiple sclerosis. | 2001 | Neurochem. Res. | pmid:11478747 |
| Rodighiero C et al. | A cholera toxin B-subunit variant that binds ganglioside G(M1) but fails to induce toxicity. | 2001 | J. Biol. Chem. | pmid:11479294 |
| Horibata Y et al. | Transglycosylation and reverse hydrolysis reactions of endoglycoceramidase from the jellyfish, Cyanea nozakii. | 2001 | J. Biochem. | pmid:11481044 |
| McNamara N et al. | ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11481474 |
| Sueyoshi N et al. | Apoptosis of Neuro2a cells induced by lysosphingolipids with naturally occurring stereochemical configurations. | 2001 | J. Lipid Res. | pmid:11483620 |