| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zeng Y and Tarbell JM | The adaptive remodeling of endothelial glycocalyx in response to fluid shear stress. | 2014 | PLoS ONE | pmid:24465988 |
| McDonald G et al. | Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients. | 2014 | J. Clin. Invest. | pmid:24463447 |
| Lei L et al. | The role of mechanical tension on lipid raft dependent PDGF-induced TRPC6 activation. | 2014 | Biomaterials | pmid:24397990 |
| Lundius EG et al. | GPR37 protein trafficking to the plasma membrane regulated by prosaposin and GM1 gangliosides promotes cell viability. | 2014 | J. Biol. Chem. | pmid:24371137 |
| te Welscher YM et al. | Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1. | 2014 | J Control Release | pmid:24370893 |
| Andrisani A et al. | Effect of various commercial buffers on sperm viability and capacitation. | 2014 | Syst Biol Reprod Med | pmid:24673547 |
| Kirkeby S | Cholera toxin B subunit-binding and ganglioside GM1 immuno-expression are not necessarily correlated in human salivary glands. | 2014 | Acta Odontol. Scand. | pmid:24655314 |
| Domingue JC and Rao MC | CFTR and GM1 "gangl-ing" up to heal thy wound. Focus on "Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair". | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24627559 |
| Kang S et al. | Altered levels of α-synuclein and sphingolipids in Batten disease lymphoblast cells. | 2014 | Gene | pmid:24534465 |
| Khatun UL and Mukhopadhyay C | Interaction of bee venom toxin melittin with ganglioside GM1 bicelle. | 2013 Oct-Nov | Biophys. Chem. | pmid:23850803 |
| Hirai M et al. | Change of dynamics of raft-model membrane induced by amyloid-β protein binding. | 2013 | Eur Phys J E Soft Matter | pmid:23852578 |
| Rondelli V et al. | Neutrons for rafts, rafts for neutrons. | 2013 | Eur Phys J E Soft Matter | pmid:23852579 |
| Yang R et al. | Monosialoanglioside improves memory deficits and relieves oxidative stress in the hippocampus of rat model of Alzheimer's disease. | 2013 | Neurol. Sci. | pmid:23229411 |
| Nomura M et al. | 13-Cis retinoic acid can enhance the antitumor activity of non-replicating Sendai virus particle against neuroblastoma. | 2013 | Cancer Sci. | pmid:23134437 |
| Kreutz F et al. | Alterations of membrane lipids and in gene expression of ganglioside metabolism in different brain structures in a mouse model of mucopolysaccharidosis type I (MPS I). | 2013 | Gene | pmid:23774686 |
| Konishi M et al. | Extending the glucosyl ceramide cassette approach: application in the total synthesis of ganglioside GalNAc-GM1b. | 2013 | Molecules | pmid:24335571 |
| Bisel B et al. | Decoupling polarization of the Golgi apparatus and GM1 in the plasma membrane. | 2013 | PLoS ONE | pmid:24312472 |
| Manna M and Mukhopadhyay C | Binding, conformational transition and dimerization of amyloid-β peptide on GM1-containing ternary membrane: insights from molecular dynamics simulation. | 2013 | PLoS ONE | pmid:23951128 |
| Zhong L et al. | NSOM/QD-based visualization of GM1 serving as platforms for TCR/CD3 mediated T-cell activation. | 2013 | Biomed Res Int | pmid:24288672 |
| Szklarczyk OM et al. | Receptor concentration and diffusivity control multivalent binding of Sv40 to membrane bilayers. | 2013 | PLoS Comput. Biol. | pmid:24244125 |
| Cox CJ et al. | Brain human monoclonal autoantibody from sydenham chorea targets dopaminergic neurons in transgenic mice and signals dopamine D2 receptor: implications in human disease. | 2013 | J. Immunol. | pmid:24184556 |
| Rios FJ et al. | Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts. | 2013 | PLoS ONE | pmid:24130805 |
| Rong X et al. | Ganglioside GM1 reduces white matter damage in neonatal rats. | 2013 | Acta Neurobiol Exp (Wars) | pmid:24129486 |
| Moeller S et al. | Lack of association between autism and anti-GM1 ganglioside antibody. | 2013 | Neurology | pmid:24068789 |
| Pellistri F et al. | Different ataxin-3 amyloid aggregates induce intracellular Ca(2+) deregulation by different mechanisms in cerebellar granule cells. | 2013 | Biochim. Biophys. Acta | pmid:24035922 |
| Saslowsky DE et al. | Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain. | 2013 | J. Biol. Chem. | pmid:23884419 |
| Itokazu Y et al. | Effects of amyloid β-peptides and gangliosides on mouse neural stem cells. | 2013 | Neurochem. Res. | pmid:23851714 |
| Armendariz KP and Dunn RC | Ganglioside influence on phospholipid films investigated with single molecule fluorescence measurements. | 2013 | J Phys Chem B | pmid:23745772 |
| Gustafsson T et al. | Direct interaction between cholera toxin and dendritic cells is required for oral adjuvant activity. | 2013 | Eur. J. Immunol. | pmid:23649516 |
| Triantafilou M et al. | Synergic activation of toll-like receptor (TLR) 2/6 and 9 in response to Ureaplasma parvum & urealyticum in human amniotic epithelial cells. | 2013 | PLoS ONE | pmid:23593431 |
| Li X et al. | TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice. | 2013 | J. Mol. Med. | pmid:23108456 |
| Kuwabara S and Yuki N | Axonal Guillain-Barré syndrome: concepts and controversies. | 2013 | Lancet Neurol | pmid:24229616 |
| Wakerley BR et al. | Atypical Bickerstaff brainstem encephalitis: ataxic hypersomnolence without ophthalmoplegia. | 2013 | J. Neurol. Neurosurg. Psychiatry | pmid:23564757 |
| Van Blerkom J and Caltrider K | Sperm attachment and penetration competence in the human oocyte: a possible aetiology of fertilization failure involving the organization of oolemmal lipid raft microdomains influenced by the ΔΨm of subplasmalemmal mitochondria. | 2013 | Reprod. Biomed. Online | pmid:24157131 |
| Okawa S et al. | Tolosa-hunt syndrome associated with cytomegalovirus infection. | 2013 | Intern. Med. | pmid:23676602 |
| Ogawa G et al. | An antibody to the GM1/GalNAc-GD1a complex correlates with development of pure motor Guillain-Barré syndrome with reversible conduction failure. | 2013 | J. Neuroimmunol. | pmid:23000056 |
| Kreutz F et al. | Alterations on Naâº,Kâº-ATPase and acetylcholinesterase activities induced by amyloid-β peptide in rat brain and GM1 ganglioside neuroprotective action. | 2013 | Neurochem. Res. | pmid:24013887 |
| Galban-Horcajo F et al. | Antibodies to heteromeric glycolipid complexes in multifocal motor neuropathy. | 2013 | Eur. J. Neurol. | pmid:22727042 |
| Mattarella M et al. | Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. | 2013 | Org. Biomol. Chem. | pmid:23736158 |
| Garcia-Hartjes J et al. | Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix[5]arene. | 2013 | Org. Biomol. Chem. | pmid:23689250 |
| Hoshino T et al. | Binding and aggregation mechanism of amyloid β-peptides onto the GM1 ganglioside-containing lipid membrane. | 2013 | J Phys Chem B | pmid:23688073 |
| Willjes G et al. | Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity. | 2013 | Biochemistry | pmid:23647335 |
| Poggi A et al. | Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells. | 2013 | PLoS ONE | pmid:23667543 |
| Dobos J et al. | Sex-dependent liver colonization of human melanoma in SCID mice--role of host defense mechanisms. | 2013 | Clin. Exp. Metastasis | pmid:23203681 |
| Kuwahara M et al. | Clinical features of CIDP with LM1-associated antibodies. | 2013 | J. Neurol. Neurosurg. Psychiatry | pmid:23138763 |
| Cheng Q et al. | Fuzheng Huayu inhibits carbon tetrachloride-induced liver fibrosis in mice through activating hepatic NK cells. | 2013 | J Ethnopharmacol | pmid:23127651 |
| Hosoya S et al. | Innate immune responses involving natural killer and natural killer T cells promote liver regeneration after partial hepatectomy in mice. | 2013 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:23086918 |
| Lammertse DP | Clinical trials in spinal cord injury: lessons learned on the path to translation. The 2011 International Spinal Cord Society Sir Ludwig Guttmann Lecture. | 2013 | Spinal Cord | pmid:23165505 |
| Vlam L et al. | Immune pathogenesis and treatment of multifocal motor neuropathy. | 2013 | J. Clin. Immunol. | pmid:22941513 |
| Buschiazzo J et al. | Cholesterol depletion disorganizes oocyte membrane rafts altering mouse fertilization. | 2013 | PLoS ONE | pmid:23638166 |