| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Maysinger D et al. | Microencapsulated monosialoganglioside GM1: physical properties and in vivo effects. | J Microencapsul | pmid:2715912 | |
| Yamashita K et al. | Interleukin-18 inhibits lodging and subsequent growth of human multiple myeloma cells in the bone marrow. | Oncol. Rep. | pmid:12375027 | |
| Karpiak SE et al. | Gangliosides (GM1 and AGF2) reduce mortality due to ischemia: protection of membrane function. | Stroke | pmid:3027926 | |
| Tanaka K et al. | Effect of the ganglioside GM1, on cerebral metabolism, microcirculation, recovery kinetics of ECoG and histology, during the recovery period following focal ischemia in cats. | Stroke | pmid:3810717 | |
| pmid:6103241 | ||||
| Touraine JL et al. | Improved engraftment and chimerism by anti-NK cell treatment in allogeneic transplantation of hematopoietic stem cells. | Transplant. Proc. | pmid:9123496 | |
| Mikami M et al. | Characteristic alteration in the concentration of IV 3NeuAc alpha-nLc4Cer in the villi of human placenta during the gestational period. | Placenta | pmid:8248034 | |
| Gavella M et al. | Trisialoganglioside GT1b prevents increase in sperm membrane molecular ordering induced by in vitro lipid peroxidation. | J. Androl. | pmid:16291967 | |
| Basta I et al. | [Antibodies to ganglioside GM1 and Campylobacter jejuni in patients with Guillain-Barré syndrome]. | Srp Arh Celok Lek | pmid:16206698 | |
| Boggs JM et al. | Immune lysis of lipid vesicles containing myelin basic protein or glycolipid antigens by multiple sclerosis and normal sera. | J. Neurol. Sci. | pmid:6085112 | |
| Marushchak D et al. | Self-aggregation--an intrinsic property of G(M1) in lipid bilayers. | Mol. Membr. Biol. | pmid:17453417 | |
| Yanagisawa K and Ihara Y | GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain. | Neurobiol. Aging | pmid:9562471 | |
| Augustinsson LE et al. | Intracerebroventricular administration of GM1 ganglioside to presenile Alzheimer patients. | Dement Geriatr Cogn Disord | pmid:8997549 | |
| Brezicka T and Einbeigi Z | Supra-additive cytotoxic effects of a combination of cytostatic drugs and antibody-induced complement activation on tumor cells in vitro. | Tumour Biol. | pmid:11125282 | |
| Valsecchi M et al. | Rat cerebellar granule cells in culture associate and metabolize differently exogenous GM1 ganglioside molecular species containing a C18 or C20 long chain base. | Chem. Phys. Lipids | pmid:1505063 | |
| Izumi T et al. | Normal developmental profiles of CSF gangliotetraose-series gangliosides from neonatal period to adolescence. | Pediatr. Neurol. | pmid:8216543 | |
| Izumi T et al. | Low levels of CSF gangliotetraose-series gangliosides in West syndrome: implication of brain maturation disturbance. | Pediatr. Neurol. | pmid:8216542 | |
| Richardson JM et al. | Solution dynamics of the oligosaccharide moiety of ganglioside GM1: comparison of solution conformations with the bound state conformation in association with cholera toxin B-pentamer. | J. Mol. Recognit. | pmid:9052976 | |
| Fong TG et al. | GM1 and NGF synergism on choline acetyltransferase and choline uptake in aged brain. | Neurobiol. Aging | pmid:8622782 | |
| Guan C et al. | Expression of cholera toxin B subunit-lumbrokinase in edible sunflower seeds-the use of transmucosal carrier to enhance its fusion protein's effect on protection of rats and mice against thrombosis. | Biotechnol. Prog. | pmid:25080206 | |
| Wallis CJ et al. | GM1 ganglioside reduces ethanol intoxication and the development of ethanol dependence. | Alcohol | pmid:8590622 | |
| Caudie C et al. | [Antiganglioside autoantibody profiles in Guillain-Barré syndrome]. | Ann. Biol. Clin. (Paris) | pmid:12368145 | |
| pmid:7358687 | ||||
| Morrison WJ et al. | Transmembrane signalling associated with ganglioside-induced CD4 modulation. | Immunopharmacology | pmid:2176187 | |
| Izumi T et al. | Abnormality of cerebral gangliosides in Fukuyama type congenital muscular dystrophy. | Brain Dev. | pmid:7762760 | |
| pmid:1680104 | ||||
| Sergeeva SS et al. | Antibodies against gangliosides GM1 of patients with multiple sclerosis alter the response of neurons to synaptic activation. | Dokl. Biol. Sci. | pmid:15717608 | |
| Dawson RM | Characterization of the binding of cholera toxin to ganglioside GM1 immobilized onto microtitre plates. | J Appl Toxicol | pmid:15669043 | |
| Simma B et al. | [GM1 gangliosidosis and dilated cardiomyopathy]. | Klin Padiatr | pmid:2113151 | |
| pmid:11034355 | ||||
| Olivier V et al. | Influence of targeting ligand flexibility on receptor binding of particulate drug delivery systems. | Bioconjug. Chem. | pmid:14624636 |