| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Gaucher Disease | D005776 | 13 associated lipids |
Total
4
Ganglioside GI
Ganglioside GI is a lipid of Sphingolipids (SP) class. Ganglioside gi is associated with abnormalities such as HIV Infections, Amyotrophic Lateral Sclerosis, Neuritis, Motor, Motor Neuron Disease and athymia. The involved functions are known as Gene Expression, antigen binding, Protective Agents, Binding (Molecular Function) and response to hormone stimulus. Ganglioside gi often locates in Membrane, Body tissue, Mucous Membrane, integral to membrane and Virion. The associated genes with Ganglioside GI are Fusion Protein, synthetic peptide, CTBS gene, IL2 gene and CD4 gene. The related lipids are Sphingolipids, sialogangliosides, Membrane Lipids, ganglioside, Gx and polysialoganglioside. The related experimental models are Knock-out, Disease model, Experimental Autoimmune Encephalomyelitis, Rodent Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GI, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GI?
Ganglioside GI is suspected in Neuropathy, Neuritis, Motor, Cholera, Gangliosidosis GM1, Virus Diseases, Neuritis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Ganglioside GI
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GI
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GI?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Ganglioside GI?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GI?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GI?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Ganglioside GI?
Knock-out
Knock-out are used in the study 'GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.' (Tessitore A et al., 2004) and Knock-out are used in the study 'GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.' (Hadaczek P et al., 2015).
Transgenic Model
Transgenic Model are used in the study 'Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.' (Di Pardo A et al., 2012).
Disease model
Disease model are used in the study 'Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action.' (Kreutz F et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Ganglioside GI
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Crain SM and Shen KF | Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions. | 1998 | Trends Pharmacol. Sci. | pmid:9786023 |
| Brezicka T and Einbeigi Z | Supra-additive cytotoxic effects of a combination of cytostatic drugs and antibody-induced complement activation on tumor cells in vitro. | Tumour Biol. | pmid:11125282 | |
| Chen CG et al. | Amplification of immune responses against a DNA-delivered idiotypic lymphoma antigen by fusion to the B subunit of E. coli heat labile toxin. | 2009 | Vaccine | pmid:19450635 |
| Delmas A and Partidos CD | The binding of chimeric peptides to GM1 ganglioside enables induction of antibody responses after intranasal immunization. | 1996 | Vaccine | pmid:8879105 |
| Green EA et al. | Construction, purification and immunogenicity of antigen-antibody-LTB complexes. | 1996 | Vaccine | pmid:8873387 |
| Montaner AD et al. | Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route. | 2006 | Vaccine | pmid:16343699 |
| Lian T et al. | Formulation of HIV-envelope protein with lipid vesicles expressing ganglioside GM1 associated to cholera toxin B enhances mucosal immune responses. | 1999 | Vaccine | pmid:10547418 |
| Suzuki Y et al. | Ganglioside GM1b as an influenza virus receptor. | 1985 | Vaccine | pmid:4060848 |
| Miyata T et al. | Physicochemically stable cholera toxin B subunit pentamer created by peripheral molecular constraints imposed by de novo-introduced intersubunit disulfide crosslinks. | 2012 | Vaccine | pmid:22542816 |
| Majury AL and Shewen PE | Preliminary investigation of the mechanism of inhibition of bovine lymphocyte proliferation by Pasteurella haemolytica A1 leukotoxin. | 1991 | Vet. Immunol. Immunopathol. | pmid:1949583 |
| Ayalew S et al. | Intranasal vaccination of calves with Mannheimia haemolytica chimeric protein containing the major surface epitope of outer membrane lipoprotein PlpE, the neutralizing epitope of leukotoxin, and cholera toxin subunit B. | 2009 | Vet. Immunol. Immunopathol. | pmid:19581005 |
| Zhou J et al. | Evaluation of GM1 ganglioside-mediated apoptosis in feline thymocytes. | 1998 | Vet. Immunol. Immunopathol. | pmid:9847018 |
| Cox NR et al. | Thymic alterations in feline GM1 gangliosidosis. | 1998 | Vet. Immunol. Immunopathol. | pmid:9656423 |
| Verhelst R et al. | E. coli heat labile toxin (LT) inactivation by specific polyphenols is aggregation dependent. | 2013 | Vet. Microbiol. | pmid:23391440 |
| Saunders GK et al. | GM1 gangliosidosis in Portuguese water dogs: pathologic and biochemical findings. | 1988 | Vet. Pathol. | pmid:3136586 |
| Kosanke SD et al. | Clinical and biochemical abnormalities in porcine GM2-gangliosidosis. | 1978 | Vet. Pathol. | pmid:108843 |
| White LL and Smith RA | D variant of encephalomyocarditis virus (EMCV-D)-induced diabetes following natural killer cell depletion in diabetes-resistant male C57BL/6J mice. | 1990 | Viral Immunol. | pmid:2153386 |
| Moore ML et al. | Differential regulation of GM1 and asialo-GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infection. | 2008 | Viral Immunol. | pmid:18788941 |
| Zhao L et al. | Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells. | 2016 | Virology | pmid:26901486 |
| Isa P et al. | Rotavirus RRV associates with lipid membrane microdomains during cell entry. | 2004 | Virology | pmid:15110534 |
| Jeffree CE et al. | Distribution of the attachment (G) glycoprotein and GM1 within the envelope of mature respiratory syncytial virus filaments revealed using field emission scanning electron microscopy. | 2003 | Virology | pmid:12642099 |
| Triantafilou K and Triantafilou M | Lipid-raft-dependent Coxsackievirus B4 internalization and rapid targeting to the Golgi. | 2004 | Virology | pmid:15262490 |
| Isa P et al. | Dissecting the role of integrin subunits alpha 2 and beta 3 in rotavirus cell entry by RNA silencing. | 2009 | Virus Res. | pmid:19635510 |
| Werner PC | New drugs for improving injury outcome in spinal cord injuries. | 1997 | West. J. Med. | pmid:9168687 |
| Zhu Y et al. | Ganglioside-monosialic acid (GM1) prevents oxaliplatin-induced peripheral neurotoxicity in patients with gastrointestinal tumors. | 2013 | World J Surg Oncol | pmid:23351188 |
| Chen D et al. | NK-cell-dependent acute xenograft rejection in the mouse heart-to-rat model. | 2006 | Xenotransplantation | pmid:16925664 |
| Shapiro K et al. | GM1 ganglioside concentration in the cerebrospinal fluid of hydrocephalic infants and children. | 1981 | Z Kinderchir | pmid:7331550 |
| Wang Q et al. | [Effects of ganglioside 1 and nerve growth factor on the proliferation of neural stem cells in vitro]. | 2009 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:19849946 |
| Xiang SL et al. | [Immunopathological evidence of terminal residues containing sialic acid in Campylobacter jejuni lipopolysaccharide as the critical antigen to induce peripheral neuropathy]. | 2005 | Zhonghua Er Ke Za Zhi | pmid:16191299 |
| Shu XM et al. | [Comparative study on the role of parent Campylobacter jejuni and galE mutant in inducing experimental peripheral nerve damage]. | 2005 | Zhonghua Er Ke Za Zhi | pmid:15924714 |
| Zhang D et al. | [Effect of ganglioside GM1 on the metabolism of Alzheimer amyloid beta-protein precursor]. | 1998 | Zhonghua Yi Xue Za Zhi | pmid:10923524 |