Ganglioside GD1

Ganglioside GD1 is a lipid of Sphingolipids (SP) class. Ganglioside gd1 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Neuritis, Motor, Autoimmune Syndrome Type II, Polyglandular and protrusion. The involved functions are known as Drug Interactions, inhibitors, Signal Transduction, Baresthesia and Biological function, NOS. Ganglioside gd1 often locates in Membrane, nucleocapsid location, Cell membrane, Cell surface and Face. The associated genes with Ganglioside GD1 are Polypeptides, N-dodecyl-L-lysine amide, anti-IgM, VIP gene and Homologous Gene. The related lipids are sialogangliosides, ganglioside, GD1b, GT1b-ganglioside, ganglioside, GD1a and IV(4)-galactosyl-N-acetylganglioside GD1a.

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Introduction

To understand associated biological information of Ganglioside GD1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GD1?

Ganglioside GD1 is suspected in Neuropathy, Sensory neuropathy, Acute motor neuropathy, Virus Diseases, Cholera, Little's Disease and other diseases in descending order of the highest number of associated sentences.

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PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GD1

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Ganglioside GD1?

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What functions are associated with Ganglioside GD1?


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What lipids are associated with Ganglioside GD1?

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What genes are associated with Ganglioside GD1?

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What common seen animal models are associated with Ganglioside GD1?

There are no associated biomedical information in the current reference collection.

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All references with Ganglioside GD1

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Authors Title Published Journal PubMed Link
pmid:
Kanda N Gangliosides GD1a and GM3 induce interleukin-10 production by human T cells. 1999 Biochem. Biophys. Res. Commun. pmid:10066419
Maggio B Modulation of phospholipase A2 by electrostatic fields and dipole potential of glycosphingolipids in monolayers. 1999 J. Lipid Res. pmid:10224162
Kozaki S [Studies on the receptor for Clostridium botulinum neurotoxin]. 1999 Nippon Saikingaku Zasshi pmid:10356952
Scorrano L et al. Commitment to apoptosis by GD3 ganglioside depends on opening of the mitochondrial permeability transition pore. 1999 J. Biol. Chem. pmid:10428836
Caudie C et al. [Measurement of antiganglioside autoantibodies by immunodot-blot assay: clinical importance in peripheral neuropathies]. Ann. Biol. Clin. (Paris) pmid:10518060
Hyuga S et al. Suppression by ganglioside GD1A of migration capability, adhesion to vitronectin and metastatic potential of highly metastatic FBJ-LL cells. 1999 Int. J. Cancer pmid:10521808
Yuki N et al. Acute motor axonal neuropathy and acute motor-sensory axonal neuropathy share a common immunological profile. 1999 J. Neurol. Sci. pmid:10526194
Zuberbier T et al. Alterations in ganglioside expression during the differentiation of human mast cells. 1999 Exp. Dermatol. pmid:10536964
Matà S et al. Multiple sclerosis is associated with enhanced B cell responses to the ganglioside GD1a. 1999 Mult. Scler. pmid:10618693
Aydin M et al. Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats. 2000 Cell Biochem. Funct. pmid:10686582
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Lunn MP et al. High-affinity anti-ganglioside IgG antibodies raised in complex ganglioside knockout mice: reexamination of GD1a immunolocalization. 2000 J. Neurochem. pmid:10854286
Kanda N and Watanabe S Ganglioside GD1a enhances immunoglobulin production by human peripheral blood mononuclear cells. 2000 Exp. Hematol. pmid:10880753
Montero EF et al. Kidney and small intestine morphologic aspects following systemic use of gangliosides. 2000 Transplant. Proc. pmid:10995967
Inoki Y et al. Ganglioside GD3 and its mimetics induce cytochrome c release from mitochondria. 2000 Biochem. Biophys. Res. Commun. pmid:11027612
Baumann N Specificity of antiglycolipid antibodies. 2000 Clin Rev Allergy Immunol pmid:11064824
Rocheleau JV and Petersen NO Sendai virus binds to a dispersed population of NBD-GD1a. 2000 Biosci. Rep. pmid:11095114
Metelmann W et al. Nano-electrospray ionization time-of-flight mass spectrometry of gangliosides from human brain tissue. 2001 J Mass Spectrom pmid:11180643
Kopitz J et al. Desialylation of extracellular GD1a-neoganglioprotein suggests cell surface orientation of the plasma membrane-bound ganglioside sialidase activity in human neuroblastoma cells. 2001 FEBS Lett. pmid:11240133
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Tatsumi K et al. Enhanced expression of a-series gangliosides in fibroblasts of patients with peroxisome biogenesis disorders. 2001 Biochim. Biophys. Acta pmid:11278168
Lang Z et al. Ganglioside GD1a enhances VEGF-induced endothelial cell proliferation and migration. 2001 Biochem. Biophys. Res. Commun. pmid:11352656
Saito M and Sugiyama K Gangliosides in rat kidney: composition, distribution, and developmental changes. 2001 Arch. Biochem. Biophys. pmid:11360994
Zaprianova E et al. Serum ganglioside patterns in multiple sclerosis. 2001 Neurochem. Res. pmid:11478747
Mizutani K et al. Sensorimotor demyelinating neuropathy with IgM antibody against gangliosides GD1a, GT1b and GM3. 2001 J. Neurol. Sci. pmid:11489278
Metelmann W et al. Gangliosides from human granulocytes: a nano-ESI QTOF mass spectrometry fucosylation study of low abundance species in complex mixtures. 2001 J. Am. Soc. Mass Spectrom. pmid:11506229
Press R et al. Temporal profile of anti-ganglioside antibodies and their relation to clinical parameters and treatment in Guillain-Barré syndrome. 2001 J. Neurol. Sci. pmid:11574105
De Angelis MV et al. Anti-GD1a antibodies from an acute motor axonal neuropathy patient selectively bind to motor nerve fiber nodes of Ranvier. 2001 J. Neuroimmunol. pmid:11730943
Schnaar RL et al. Immunoglobulin G-class mouse monoclonal antibodies to major brain gangliosides. 2002 Anal. Biochem. pmid:11878808
Mirkin BL et al. Inhibition of human neuroblastoma cell proliferation and EGF receptor phosphorylation by gangliosides GM1, GM3, GD1A and GT1B. 2002 Cell Prolif. pmid:11952645
Alaedini A et al. Detection of anti-ganglioside antibodies in Guillain-Barré syndrome and its variants by the agglutination assay. 2002 J. Neurol. Sci. pmid:11959155
Masserini M et al. Preparation and use of liposomes for the study of sphingolipid segregation in membrane model systems. 2002 Methods Mol. Biol. pmid:12094568
Nachamkin I et al. Campylobacter jejuni from patients with Guillain-Barré syndrome preferentially expresses a GD(1a)-like epitope. 2002 Infect. Immun. pmid:12183587
Tagawa Y et al. Anti-ganglioside antibodies bind with enhanced affinity to gangliosides containing very long chain fatty acids. 2002 Neurochem. Res. pmid:12374222
Gong Y et al. Localization of major gangliosides in the PNS: implications for immune neuropathies. 2002 Brain pmid:12390975
Golovanova NK et al. Sialidase activity in normal and atherosclerotic human aortic intima. 2002 Biochemistry Mosc. pmid:12495418
Rapoport E et al. Ganglioside binding pattern of CD33-related siglecs. 2003 Bioorg. Med. Chem. Lett. pmid:12639556
Shen W and Ladisch S Ganglioside GD1a impedes lipopolysaccharide-induced maturation of human dendritic cells. 2002 Cell. Immunol. pmid:12657247
Hirano M et al. A family with Campylobacter enteritis: anti-GD1a antibody with/without Guillain-Barré syndrome. 2003 Neurology pmid:12771281
Caldwell S et al. Mechanisms of ganglioside inhibition of APC function. 2003 J. Immunol. pmid:12902465
Tsai B et al. Gangliosides are receptors for murine polyoma virus and SV40. 2003 EMBO J. pmid:12941687
Yoshino H et al. Isolated bovine spinal motoneurons have specific ganglioside antigens recognized by sera from patients with motor neuron disease and motor neuropathy. 1992 J. Neurochem. pmid:1383424
Kobayashi T et al. A functional barrier to movement of lipids in polarized neurons. 1992 Nature pmid:1406997
Prabhanjan H et al. Synthesis of disialoganglioside GD1 alpha and its positional isomer. 1992 Carbohydr. Res. pmid:1446313
Odintsova E et al. Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR. 2003 J. Cell. Sci. pmid:14576349
Hasegawa A et al. A facile, systematic synthesis of ganglio-series gangliosides: total synthesis of gangliosides GM1 and GD1a. 1992 Carbohydr. Res. pmid:1473099
Voumvourakis C et al. Serum anti-GM1 and anti-GD1a antibodies in patients with motor neuron disease. 1992 Acta Neurol. Scand. pmid:1481647
Yuki N et al. Severe acute axonal form of Guillain-Barré syndrome associated with IgG anti-GD1a antibodies. 1992 Muscle Nerve pmid:1495505
Papini N et al. The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions. 2004 J. Biol. Chem. pmid:14970224