Ganglioside GD1

Ganglioside GD1 is a lipid of Sphingolipids (SP) class. Ganglioside gd1 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Neuritis, Motor, Autoimmune Syndrome Type II, Polyglandular and protrusion. The involved functions are known as Drug Interactions, inhibitors, Signal Transduction, Baresthesia and Biological function, NOS. Ganglioside gd1 often locates in Membrane, nucleocapsid location, Cell membrane, Cell surface and Face. The associated genes with Ganglioside GD1 are Polypeptides, N-dodecyl-L-lysine amide, anti-IgM, VIP gene and Homologous Gene. The related lipids are sialogangliosides, ganglioside, GD1b, GT1b-ganglioside, ganglioside, GD1a and IV(4)-galactosyl-N-acetylganglioside GD1a.

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Introduction

To understand associated biological information of Ganglioside GD1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GD1?

Ganglioside GD1 is suspected in Neuropathy, Sensory neuropathy, Acute motor neuropathy, Virus Diseases, Cholera, Little's Disease and other diseases in descending order of the highest number of associated sentences.

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PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GD1

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GD1?

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What functions are associated with Ganglioside GD1?


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What lipids are associated with Ganglioside GD1?

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What genes are associated with Ganglioside GD1?

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What common seen animal models are associated with Ganglioside GD1?

There are no associated biomedical information in the current reference collection.

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All references with Ganglioside GD1

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Authors Title Published Journal PubMed Link
Caldwell S et al. Mechanisms of ganglioside inhibition of APC function. 2003 J. Immunol. pmid:12902465
Tsai B et al. Gangliosides are receptors for murine polyoma virus and SV40. 2003 EMBO J. pmid:12941687
Yoshino H et al. Isolated bovine spinal motoneurons have specific ganglioside antigens recognized by sera from patients with motor neuron disease and motor neuropathy. 1992 J. Neurochem. pmid:1383424
Kobayashi T et al. A functional barrier to movement of lipids in polarized neurons. 1992 Nature pmid:1406997
Prabhanjan H et al. Synthesis of disialoganglioside GD1 alpha and its positional isomer. 1992 Carbohydr. Res. pmid:1446313
Odintsova E et al. Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR. 2003 J. Cell. Sci. pmid:14576349
Hasegawa A et al. A facile, systematic synthesis of ganglio-series gangliosides: total synthesis of gangliosides GM1 and GD1a. 1992 Carbohydr. Res. pmid:1473099
Voumvourakis C et al. Serum anti-GM1 and anti-GD1a antibodies in patients with motor neuron disease. 1992 Acta Neurol. Scand. pmid:1481647
Yuki N et al. Severe acute axonal form of Guillain-Barré syndrome associated with IgG anti-GD1a antibodies. 1992 Muscle Nerve pmid:1495505
Papini N et al. The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactions. 2004 J. Biol. Chem. pmid:14970224
Chonn A et al. Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes. 1992 J. Biol. Chem. pmid:1527006
Sheikh KA et al. An anti-ganglioside antibody-secreting hybridoma induces neuropathy in mice. 2004 Ann. Neurol. pmid:15293275
Kaida K et al. Ganglioside complexes as new target antigens in Guillain-Barré syndrome. 2004 Ann. Neurol. pmid:15389898
Gilbert J and Benjamin T Uptake pathway of polyomavirus via ganglioside GD1a. 2004 J. Virol. pmid:15507613
Müthing J et al. Tumor-associated CD75s gangliosides and CD75s-bearing glycoproteins with Neu5Acalpha2-6Galbeta1-4GlcNAc-residues are receptors for the anticancer drug rViscumin. 2005 FASEB J. pmid:15520251
Galassi G et al. Post-infectious acute ataxia and facial diplegia associated with anti-GD1a IgG antibody. 2004 Eur. J. Neurol. pmid:15525304
Gilbert J et al. Ganglioside GD1a restores infectibility to mouse cells lacking functional receptors for polyomavirus. 2005 J. Virol. pmid:15596855
Heffer-Lauc M et al. Membrane redistribution of gangliosides and glycosylphosphatidylinositol-anchored proteins in brain tissue sections under conditions of lipid raft isolation. 2005 Biochim. Biophys. Acta pmid:15629689
Dasgupta S et al. Lack of apparent neurological abnormalities in rabbits sensitized by gangliosides. 2004 Neurochem. Res. pmid:15662849
Goodfellow JA et al. Overexpression of GD1a ganglioside sensitizes motor nerve terminals to anti-GD1a antibody-mediated injury in a model of acute motor axonal neuropathy. 2005 J. Neurosci. pmid:15716397