Ganglioside GD1

Ganglioside GD1 is a lipid of Sphingolipids (SP) class. Ganglioside gd1 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Neuritis, Motor, Autoimmune Syndrome Type II, Polyglandular and protrusion. The involved functions are known as Drug Interactions, inhibitors, Signal Transduction, Baresthesia and Biological function, NOS. Ganglioside gd1 often locates in Membrane, nucleocapsid location, Cell membrane, Cell surface and Face. The associated genes with Ganglioside GD1 are Polypeptides, N-dodecyl-L-lysine amide, anti-IgM, VIP gene and Homologous Gene. The related lipids are sialogangliosides, ganglioside, GD1b, GT1b-ganglioside, ganglioside, GD1a and IV(4)-galactosyl-N-acetylganglioside GD1a.

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Introduction

To understand associated biological information of Ganglioside GD1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GD1?

Ganglioside GD1 is suspected in Neuropathy, Sensory neuropathy, Acute motor neuropathy, Virus Diseases, Cholera, Little's Disease and other diseases in descending order of the highest number of associated sentences.

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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GD1

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GD1?

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What functions are associated with Ganglioside GD1?


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What lipids are associated with Ganglioside GD1?

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What genes are associated with Ganglioside GD1?

Related references are published most in these journals:


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What common seen animal models are associated with Ganglioside GD1?

There are no associated biomedical information in the current reference collection.

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All references with Ganglioside GD1

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Authors Title Published Journal PubMed Link
Kotani M et al. Developmental changes of ganglioside expressions in postnatal rat cerebellar cortex. 1995 Brain Res. pmid:8624728
Sung CC et al. Gangliosides as diagnostic markers of human astrocytomas and primitive neuroectodermal tumors. 1994 Cancer pmid:7954264
Murayama K et al. Qualitative differences in position of sialylation and surface expression of glycolipids between murine lymphomas with low metastatic (Eb) and high metastatic (ESb) potentials and isolation of a novel disialoganglioside (GD1 alpha) from Eb cells. 1986 Cancer Res. pmid:3484680
Taki T et al. Ganglioside GD1alpha functions in the adhesion of metastatic tumor cells to endothelial cells of the target tissue. 1997 Cancer Res. pmid:9157980
Hasegawa A et al. A facile, systematic synthesis of ganglio-series gangliosides: total synthesis of gangliosides GM1 and GD1a. 1992 Carbohydr. Res. pmid:1473099
Prabhanjan H et al. Synthesis of disialoganglioside GD1 alpha and its positional isomer. 1992 Carbohydr. Res. pmid:1446313
Fronza G et al. Synthesis and structural characterization of the dilactone derivative of GD1a ganglioside. 1988 Carbohydr. Res. pmid:3242802
Komori T et al. Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates. 2009 Carbohydr. Res. pmid:19560125
Aydin M et al. Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats. 2000 Cell Biochem. Funct. pmid:10686582
Mirkin BL et al. Inhibition of human neuroblastoma cell proliferation and EGF receptor phosphorylation by gangliosides GM1, GM3, GD1A and GT1B. 2002 Cell Prolif. pmid:11952645
Watanabe Y et al. Effect of gangliosides on murine megakaryocytopoiesis in a liquid culture system. 1988 Cell Struct. Funct. pmid:3180256
Taki T et al. Appearance of a novel type of ganglioside (GD1 alpha) in a differentiation-resistant clone of mouse myeloid leukemia cells, M1-R1. 1988 Cell Struct. Funct. pmid:3163528
Shen W and Ladisch S Ganglioside GD1a impedes lipopolysaccharide-induced maturation of human dendritic cells. 2002 Cell. Immunol. pmid:12657247
Krifuks O et al. The down-modulation of CD4 induced by the GM1 ganglioside is regulated by phosphatases and kinases: evidence from enzyme inhibitors and anti-CD45 antibodies. 1998 Cell. Immunol. pmid:9682003
Brocca P et al. Aggregation properties of semisynthetic GD1a ganglioside (IV3Neu5AcII3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety. 1995 Chem. Phys. Lipids pmid:7586091
van Gorkom LC et al. Ganglioside GD1a generates domains of high curvature in phosphatidylethanolamine liposomes as determined by solid state 31P-NMR spectroscopy. 1995 Chem. Phys. Lipids pmid:7788794
Vachalová I et al. Anti-GM2, -GD1a and -GD1b positive purely isolated facial diplegia. 2014 Clin Neurol Neurosurg pmid:24813327
Baumann N Specificity of antiglycolipid antibodies. 2000 Clin Rev Allergy Immunol pmid:11064824
Zeigler M and Bach G Internalization of exogenous gangliosides in cultured skin fibroblasts for the diagnosis of mucolipidosis IV. 1986 Clin. Chim. Acta pmid:3087662
Davidsson P et al. Determination of gangliosides and sulfatide in human cerebrospinal fluid with a microimmunoaffinity technique. 1991 Clin. Chim. Acta pmid:2049855