Ganglioside GD1

Ganglioside GD1 is a lipid of Sphingolipids (SP) class. Ganglioside gd1 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Neuritis, Motor, Autoimmune Syndrome Type II, Polyglandular and protrusion. The involved functions are known as Drug Interactions, inhibitors, Signal Transduction, Baresthesia and Biological function, NOS. Ganglioside gd1 often locates in Membrane, nucleocapsid location, Cell membrane, Cell surface and Face. The associated genes with Ganglioside GD1 are Polypeptides, N-dodecyl-L-lysine amide, anti-IgM, VIP gene and Homologous Gene. The related lipids are sialogangliosides, ganglioside, GD1b, GT1b-ganglioside, ganglioside, GD1a and IV(4)-galactosyl-N-acetylganglioside GD1a.

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Introduction

To understand associated biological information of Ganglioside GD1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GD1?

Ganglioside GD1 is suspected in Neuropathy, Sensory neuropathy, Acute motor neuropathy, Virus Diseases, Cholera, Little's Disease and other diseases in descending order of the highest number of associated sentences.

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PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GD1

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GD1?

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What functions are associated with Ganglioside GD1?


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What lipids are associated with Ganglioside GD1?

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What genes are associated with Ganglioside GD1?

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What common seen animal models are associated with Ganglioside GD1?

There are no associated biomedical information in the current reference collection.

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All references with Ganglioside GD1

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Authors Title Published Journal PubMed Link
Ogura K et al. Peroxidase-amplified assay of sialidase activity toward gangliosides. 1992 Anal. Biochem. pmid:1595901
Shen W et al. Modulation of CD4 Th cell differentiation by ganglioside GD1a in vitro. 2005 J. Immunol. pmid:16210594
Pandey JP et al. Immunoglobulin KM allotypes are associated with the prevalence of autoantibodies to GD1a ganglioside, but not with susceptibility to the disease, in Japanese patients with Guillain-Barré syndrome. 2005 Neurogenetics pmid:16258760
Gavella M et al. Trisialoganglioside GT1b prevents increase in sperm membrane molecular ordering induced by in vitro lipid peroxidation. J. Androl. pmid:16291967
Caporale CM et al. Experimental axonopathy induced by immunization with Campylobacter jejuni lipopolysaccharide from a patient with Guillain-Barré syndrome. 2006 J. Neuroimmunol. pmid:16516981
Jou I et al. Gangliosides trigger inflammatory responses via TLR4 in brain glia. 2006 Am. J. Pathol. pmid:16651628
Rojas-Garcia R et al. A novel antiganglioside specificity against terminal NeuNAc(alfa 2-3)Gal in acute bulbar palsy. 2006 J. Neuroimmunol. pmid:16707165
Marconi S et al. Anti-GD2-like IgM autoreactivity in multiple sclerosis patients. 2006 Mult. Scler. pmid:16764343
Chung ES and Jin BK Disialogangliosides induce neurodegeneration in rat mesencephalic cultures. 2006 Biochem. Biophys. Res. Commun. pmid:16764823
Date I et al. Stereotaxic injection of GD1a ganglioside induces limited recovery of striatal dopaminergic system in MPTP-treated aging mice. 1991 J. Neurosci. Res. pmid:1678435
Odintsova E et al. Gangliosides play an important role in the organization of CD82-enriched microdomains. 2006 Biochem. J. pmid:16859490
Wang L et al. Ganglioside GD1a regulation of caveolin-1 and Stim1 expression in mouse FBJ cells: augmented expression of caveolin-1 and Stim1 in cells with increased GD1a content. 2006 Glycoconj. J. pmid:16897174
Hu D et al. Apparent suppression of MMP-9 activity by GD1a as determined by gelatin zymography. 2006 Biochem. Biophys. Res. Commun. pmid:16942752
Lehmann HC et al. Passive immunization with anti-ganglioside antibodies directly inhibits axon regeneration in an animal model. 2007 J. Neurosci. pmid:17202469
Liang S et al. Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin. 2007 J. Biol. Chem. pmid:17227759
Connell TD and Holmes RK Molecular genetic analysis of ganglioside GD1b-binding activity of Escherichia coli type IIa heat-labile enterotoxin by use of random and site-directed mutagenesis. 1992 Infect. Immun. pmid:1729197
Heffer-Lauc M et al. Effects of detergents on the redistribution of gangliosides and GPI-anchored proteins in brain tissue sections. 2007 J. Histochem. Cytochem. pmid:17409378
Hamaguchi T et al. Guillain-Barré syndrome with antibodies to GD1a/GD1b complex. 2007 J. Neurol. Neurosurg. Psychiatry pmid:17435195
Fusco C et al. Acute ophthalmoparesis associated with anti-GM1, anti-GD1a, and anti-GD1b antibodies after enterovirus infection in a 6-year-old girl. 2007 J. Child Neurol. pmid:17621523
Hu D et al. Ganglioside GD1a negatively regulates matrix metalloproteinase-9 expression in mouse FBJ cell lines at the transcriptional level. 2007 Connect. Tissue Res. pmid:17653976