| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Watanabe S et al. | Intraplantar injection of sialidase reduces mechanical allodynia during inflammatory pain. | 2017 | J. Pharmacol. Sci. | pmid:28089228 |
| Zhao L et al. | Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells. | 2016 | Virology | pmid:26901486 |
| Hong WS et al. | Development of a Highly Sensitive Cell-Based Assay for Detecting Botulinum Neurotoxin Type A through Neural Culture Media Optimization. | 2016 | J Biomol Screen | pmid:26420788 |
| Wild E et al. | In vitro potency determination of botulinum neurotoxin B based on its receptor-binding and proteolytic characteristics. | 2016 | Toxicol In Vitro | pmid:27032463 |
| Tsukamoto K et al. | CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C. | 2015 | PLoS ONE | pmid:26177297 |
| Xu X et al. | A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis. | 2015 | Dis Model Mech | pmid:26035393 |
| Wang Y et al. | Aβ1-25-Derived Sphingolipid-Domain Tracer Peptide SBD Interacts with Membrane Ganglioside Clusters via a Coil-Helix-Coil Motif. | 2015 | Int J Mol Sci | pmid:26540054 |
| Khalili E et al. | Production of Recombinant Human scFv Against Tetanus Toxin Heavy Chain by Phage Display Technology. | 2015 | Monoclon Antib Immunodiagn Immunother | pmid:26492617 |
| Hwang SU et al. | Effect of ganglioside GT1b on the in vitro maturation of porcine oocytes and embryonic development. | 2015 | J. Reprod. Dev. | pmid:26370787 |
| Zheng Y et al. | Efficient biotransformation of polysialogangliosides for preparation of GM1 by Cellulosimicrobium sp. 21. | 2014 | Molecules | pmid:25299818 |
| Prendergast J et al. | Ganglioside regulation of AMPA receptor trafficking. | 2014 | J. Neurosci. | pmid:25253868 |
| Burns JR and Baldwin MR | Tetanus neurotoxin utilizes two sequential membrane interactions for channel formation. | 2014 | J. Biol. Chem. | pmid:24973217 |
| Yousefi M et al. | Comparative in vitro and in vivo assessment of toxin neutralization by anti-tetanus toxin monoclonal antibodies. | 2014 | Hum Vaccin Immunother | pmid:24126015 |
| Willjes G et al. | Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity. | 2013 | Biochemistry | pmid:23647335 |
| Przedpelski A et al. | Enhancing the protective immune response against botulism. | 2013 | Infect. Immun. | pmid:23670557 |
| Whitemarsh RC et al. | Model for studying Clostridium botulinum neurotoxin using differentiated motor neuron-like NG108-15 cells. | 2012 | Biochem. Biophys. Res. Commun. | pmid:23000406 |
| Zhang Y et al. | Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve. | 2012 | Int J Nanomedicine | pmid:22403485 |
| Viljetić B et al. | Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes. | 2012 | Biochim. Biophys. Acta | pmid:22206893 |
| Venkateshwari S and Veluraja K | Conformational analysis of GT1B ganglioside and its interaction with botulinum neurotoxin type B: a study by molecular modeling and molecular dynamics. | 2012 | J. Biomol. Struct. Dyn. | pmid:22746533 |
| Sun S et al. | Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH. | 2012 | Biochemistry | pmid:22720883 |
| Watanabe S et al. | Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells. | 2012 | Neurosci. Lett. | pmid:22565021 |
| Singh MK et al. | Deletion mutant comprising 198 residues of BoNT/A toxin receptor binding domain retained gt1b binding property but failed to induce protective antibody response in a mouse model. | 2012 | Protein Pept. Lett. | pmid:22486648 |
| Urbina P et al. | Effects of bilayer composition and physical properties on the phospholipase C and sphingomyelinase activities of Clostridium perfringens α-toxin. | 2011 | Biochim. Biophys. Acta | pmid:20727345 |
| Chandrasekaran EV et al. | Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides. | 2011 | Biochemistry | pmid:21913655 |
| Lim ST et al. | Exogenous gangliosides increase the release of brain-derived neurotrophic factor. | 2011 | Neuropharmacology | pmid:20971126 |
| Nishikawa H and Kitani S | Gangliosides inhibit bee venom melittin cytotoxicity but not phospholipase A(2)-induced degranulation in mast cells. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21334356 |
| Sun S et al. | Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly. | 2011 | Cell Host Microbe | pmid:21925111 |
| Dong HJ et al. | Development of a cell immobilization technique for the conversion of polysialogangliosides to monosialotetrahexosylganglioside. | 2011 | Pharm Biol | pmid:21500968 |
| Watanabe S et al. | Intraplantar injection of gangliosides produces nociceptive behavior and hyperalgesia via a glutamate signaling mechanism. | 2011 | Pain | pmid:21134719 |
| Yu R et al. | Enhanced expression of soluble recombinant tetanus neurotoxin Hc in Escherichia coli as a tetanus vaccine candidate. | 2011 | Immunobiology | pmid:20888666 |
| Kook KH et al. | Altered ganglioside expression modulates the pathogenic mechanism of thyroid-associated ophthalmopathy by increase in hyaluronic acid. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:20811057 |
| Qian M and Tsai B | Lipids and proteins act in opposing manners to regulate polyomavirus infection. | 2010 | J. Virol. | pmid:20668088 |
| Cao T et al. | Ganglioside GD1a suppression of NOS2 expression via ERK1 pathway in mouse osteosarcoma FBJ cells. | 2010 | J. Cell. Biochem. | pmid:20589721 |
| Gavella M et al. | Modulation of ROS production in human leukocytes by ganglioside micelles. | 2010 | Braz. J. Med. Biol. Res. | pmid:20878014 |
| Chung ES et al. | GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons. | 2010 | BMC Neurosci | pmid:20540782 |
| de Freitas RM et al. | Neurochemical changes on oxidative stress in rat hippocampus during acute phase of pilocarpine-induced seizures. | 2010 | Pharmacol. Biochem. Behav. | pmid:19800361 |
| Dong Y et al. | GM1 / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line. | 2010 | Cancer Sci. | pmid:20594196 |
| Ebrahimi F et al. | Production and characterization of a recombinant chimeric antigen consisting botulinum neurotoxin serotypes A, B and E binding subdomains. | 2010 | J Toxicol Sci | pmid:20118620 |
| Behrensdorf-Nicol HA et al. | In vitro determination of tetanus toxicity by an endopeptidase assay linked to a ganglioside-binding step. | 2010 | Toxicol In Vitro | pmid:20036726 |
| Gavella M et al. | Ganglioside GT1b protects human spermatozoa from hydrogen peroxide-induced DNA and membrane damage. | 2010 | Int. J. Androl. | pmid:19490186 |
| Komori T et al. | Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates. | 2009 | Carbohydr. Res. | pmid:19560125 |
| Zhang H et al. | Ganglioside GM1 binding the N-terminus of amyloid precursor protein. | 2009 | Neurobiol. Aging | pmid:18077059 |
| Serb A et al. | Top-down glycolipidomics: fragmentation analysis of ganglioside oligosaccharide core and ceramide moiety by chip-nanoelectrospray collision-induced dissociation MS2-MS6. | 2009 | J Mass Spectrom | pmid:19658121 |
| Erickson KD et al. | Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. | 2009 | J. Virol. | pmid:19605473 |
| Liu JX et al. | Immunolocalization of GQ1b and related gangliosides in human extraocular neuromuscular junctions and muscle spindles. | 2009 | Invest. Ophthalmol. Vis. Sci. | pmid:19255160 |
| Miller CE et al. | Integration of ganglioside GT1b receptor into DPPE and DPPC phospholipid monolayers: an X-ray reflectivity and grazing-incidence diffraction study. | 2008 | Biophys. J. | pmid:18599631 |
| Park JY et al. | GM1 induces p38 and microtubule dependent ramification of rat primary microglia in vitro. | 2008 | Brain Res. | pmid:18930716 |
| Stenmark P et al. | Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction. | 2008 | PLoS Pathog. | pmid:18704164 |
| Townson KH et al. | Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury. | 2008 | J. Neuroimmunol. | pmid:18684516 |
| Williams G et al. | Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. | 2008 | J. Biol. Chem. | pmid:18411262 |
| Kim BH et al. | Expression of ganglioside GT1b in mouse embryos at different developmental stages after cryopreservation. | 2008 | Arch. Pharm. Res. | pmid:18277613 |
| Baldwin MR et al. | Subunit vaccine against the seven serotypes of botulism. | 2008 | Infect. Immun. | pmid:18070903 |
| Couesnon A et al. | Receptor-mediated transcytosis of botulinum neurotoxin A through intestinal cell monolayers. | 2008 | Cell. Microbiol. | pmid:17900298 |
| Matusica D et al. | Characterization and use of the NSC-34 cell line for study of neurotrophin receptor trafficking. | 2008 | J. Neurosci. Res. | pmid:17896795 |
| Kaida K et al. | Anti-ganglioside complex antibodies associated with severe disability in GBS. | 2007 | J. Neuroimmunol. | pmid:17113161 |
| Lee DH et al. | Effects of daunorubicin on ganglioside expression and neuronal differentiation of mouse embryonic stem cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17707770 |
| Peng YF et al. | Development of a large scale process for the conversion of polysialogangliosides to monosialotetrahexosylganglioside with a novel strain of Brevibacterium casei producing sialidase. | 2007 | Biotechnol. Lett. | pmid:17415532 |
| Baldwin MR et al. | Botulinum neurotoxin B-host receptor recognition: it takes two receptors to tango. | 2007 | Nat. Struct. Mol. Biol. | pmid:17203068 |
| Samiee KT et al. | Zero mode waveguides for single-molecule spectroscopy on lipid membranes. | 2006 | Biophys. J. | pmid:16461393 |
| Jou I et al. | Gangliosides trigger inflammatory responses via TLR4 in brain glia. | 2006 | Am. J. Pathol. | pmid:16651628 |
| Rojas-Garcia R et al. | A novel antiganglioside specificity against terminal NeuNAc(alfa 2-3)Gal in acute bulbar palsy. | 2006 | J. Neuroimmunol. | pmid:16707165 |
| Slade AL et al. | In situ scanning probe microscopy studies of tetanus toxin-membrane interactions. | 2006 | Biophys. J. | pmid:16997879 |
| Attrill H et al. | Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b. | 2006 | J. Biol. Chem. | pmid:16895906 |
| Wada Y et al. | [A case of acute oropharyngeal palsy with nasal voice as main symptom]. | 2006 | No To Shinkei | pmid:16629449 |
| Low JA et al. | Identification of gangliosides GD1b and GT1b as receptors for BK virus. | 2006 | J. Virol. | pmid:16415013 |
| Murakami N et al. | An adolescent with pharyngeal-cervical-brachial variant of Guillain-Barré syndrome after cytomegalovirus infection. | 2006 | Brain Dev. | pmid:16368212 |
| Wang XQ et al. | Gangliosides inhibit urokinase-type plasminogen activator (uPA)-dependent squamous carcinoma cell migration by preventing uPA receptor/alphabeta integrin/epidermal growth factor receptor interactions. | 2005 | J. Invest. Dermatol. | pmid:15816844 |
| Boffey J et al. | Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire. | 2005 | J. Neuroimmunol. | pmid:15967512 |
| Müthing J et al. | Tumor-associated CD75s gangliosides and CD75s-bearing glycoproteins with Neu5Acalpha2-6Galbeta1-4GlcNAc-residues are receptors for the anticancer drug rViscumin. | 2005 | FASEB J. | pmid:15520251 |
| Jayaraman S et al. | Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin. | 2005 | Proteins | pmid:16104015 |
| Yamaji K et al. | [Internal ophthalmoplegia in acute oropharyngeal palsy with anti-GQ1b and anti-GT1a IgG antibodies]. | 2005 | No To Shinkei | pmid:16026049 |
| Hettmer S et al. | Low complex ganglioside expression characterizes human neuroblastoma cell lines. | 2005 | Cancer Lett. | pmid:15922866 |
| Vukelić Z et al. | Screening and sequencing of complex sialylated and sulfated glycosphingolipid mixtures by negative ion electrospray Fourier transform ion cyclotron resonance mass spectrometry. | 2005 | J. Am. Soc. Mass Spectrom. | pmid:15792727 |
| Higashi H and Chen NH | Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization. | 2004 | Glycoconj. J. | pmid:14973370 |
| Yowler BC and Schengrund CL | Botulinum neurotoxin A changes conformation upon binding to ganglioside GT1b. | 2004 | Biochemistry | pmid:15274627 |
| Baksh MM et al. | Detection of molecular interactions at membrane surfaces through colloid phase transitions. | 2004 | Nature | pmid:14712272 |
| Freire E et al. | Sialic acid residues on astrocytes regulate neuritogenesis by controlling the assembly of laminin matrices. | 2004 | J. Cell. Sci. | pmid:15292398 |
| Mandal PK and Pettegrew JW | Alzheimer's disease: NMR studies of asialo (GM1) and trisialo (GT1b) ganglioside interactions with Abeta(1-40) peptide in a membrane mimic environment. | 2004 | Neurochem. Res. | pmid:15002743 |
| Nagashima T et al. | Clinical correlates of serum anti-GT1a IgG antibodies. | 2004 | J. Neurol. Sci. | pmid:15050449 |
| Yamamoto HA and Mohanan PV | In vivo and in vitro effects of melatonin or ganglioside GT1B on L-cysteine-induced brain mitochondrial DNA damage in mice. | 2003 | Toxicol. Sci. | pmid:12700404 |
| Colarow L et al. | Characterization and biological activity of gangliosides in buffalo milk. | 2003 | Biochim. Biophys. Acta | pmid:12573454 |
| Rapoport E et al. | Ganglioside binding pattern of CD33-related siglecs. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639556 |
| Wang XQ et al. | Ganglioside GM3 inhibits matrix metalloproteinase-9 activation and disrupts its association with integrin. | 2003 | J. Biol. Chem. | pmid:12724312 |
| Osanai T et al. | Immunohistochemical and biochemical analyses of GD3, GT1b, and GQ1b gangliosides during neural differentiation of P19 EC cells. | 2003 | FEBS Lett. | pmid:12606034 |
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Ganglioside GT1
Ganglioside GT1 is a lipid of Sphingolipids (SP) class. Ganglioside gt1 is associated with abnormalities such as Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion and Neuritis. The involved functions are known as Binding (Molecular Function), Adjudication, Process, Drug Interactions and Macromolecular alteration. Ganglioside gt1 often locates in Entire nervous system, nucleocapsid location, Membrane, Face and cell body (neuron). The associated genes with Ganglioside GT1 are Homologous Gene, N-dodecyl-L-lysine amide, G-substrate, synthetic peptide and APP gene. The related lipids are GT1b-ganglioside, trisialaoganglioside GT1a, IV(4)-galactosyl-N-acetylganglioside GD1a, sialogangliosides and polysialoganglioside.
Cross Reference
Introduction
To understand associated biological information of Ganglioside GT1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Ganglioside GT1?
Ganglioside GT1 is suspected in Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion, Neuritis, Gastrointestinal infections and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Ganglioside GT1
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Ganglioside GT1?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Ganglioside GT1?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Ganglioside GT1?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Ganglioside GT1?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Ganglioside GT1?
There are no associated biomedical information in the current reference collection.