Ganglioside GT1

Ganglioside GT1 is a lipid of Sphingolipids (SP) class. Ganglioside gt1 is associated with abnormalities such as Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion and Neuritis. The involved functions are known as Binding (Molecular Function), Adjudication, Process, Drug Interactions and Macromolecular alteration. Ganglioside gt1 often locates in Entire nervous system, nucleocapsid location, Membrane, Face and cell body (neuron). The associated genes with Ganglioside GT1 are Homologous Gene, N-dodecyl-L-lysine amide, G-substrate, synthetic peptide and APP gene. The related lipids are GT1b-ganglioside, trisialaoganglioside GT1a, IV(4)-galactosyl-N-acetylganglioside GD1a, sialogangliosides and polysialoganglioside.

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Introduction

To understand associated biological information of Ganglioside GT1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GT1?

Ganglioside GT1 is suspected in Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion, Neuritis, Gastrointestinal infections and other diseases in descending order of the highest number of associated sentences.

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PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GT1

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Ganglioside GT1?

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What functions are associated with Ganglioside GT1?


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What lipids are associated with Ganglioside GT1?

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What genes are associated with Ganglioside GT1?

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What common seen animal models are associated with Ganglioside GT1?

There are no associated biomedical information in the current reference collection.

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All references with Ganglioside GT1

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Authors Title Published Journal PubMed Link
pmid:
Kanda N and Tamaki K Ganglioside GT1b suppresses immunoglobulin production by human peripheral blood mononuclear cells. 1999 Immunology pmid:10233751
Kozaki S [Studies on the receptor for Clostridium botulinum neurotoxin]. 1999 Nippon Saikingaku Zasshi pmid:10356952
Caudie C et al. [Measurement of antiganglioside autoantibodies by immunodot-blot assay: clinical importance in peripheral neuropathies]. Ann. Biol. Clin. (Paris) pmid:10518060
Morano S et al. Autoimmune markers and neurological complications in non-insulin-dependent diabetes mellitus. 1999 Hum. Immunol. pmid:10527392
Gilbert M et al. Biosynthesis of ganglioside mimics in Campylobacter jejuni OH4384. Identification of the glycosyltransferase genes, enzymatic synthesis of model compounds, and characterization of nanomole amounts by 600-mhz (1)h and (13)c NMR analysis. 2000 J. Biol. Chem. pmid:10660542
Aydin M et al. Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats. 2000 Cell Biochem. Funct. pmid:10686582
Kotani M et al. Ganglioside GT1b in rat brain binds to p58, a brain-specific sodium-dependent inorganic phosphate cotransporter: expression cloning with a specific monoclonal antibody to ganglioside GT1b-binding protein. 2000 J. Biochem. pmid:10731661
Kukimoto M et al. Crystallization and preliminary X-ray diffraction analysis of the extracellular domain of the cell surface antigen CD38 complexed with ganglioside. 2000 J. Biochem. pmid:10731682
Yoshino H et al. IgG antiganglioside antibodies in Guillain-Barré syndrome with bulbar palsy. 2000 J. Neuroimmunol. pmid:10742563
Vautrin J et al. Surface-accessible GABA supports tonic and quantal synaptic transmission. 2000 Synapse pmid:10842350
Fitzsimmons SP et al. Inhibition of tetanus toxin fragment C binding to ganglioside G(T1b) by monoclonal antibodies recognizing different epitopes. 2000 Vaccine pmid:10924793
Sinha K et al. Analysis of mutants of tetanus toxin Hc fragment: ganglioside binding, cell binding and retrograde axonal transport properties. 2000 Mol. Microbiol. pmid:10972823
Bukowski JF et al. T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity. 2000 Eur. J. Immunol. pmid:11093135
Wang X et al. Carbohydrate-carbohydrate binding of ganglioside to integrin alpha(5) modulates alpha(5)beta(1) function. 2001 J. Biol. Chem. pmid:11118433
Kanda N and Watanabe S Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells. 2001 J. Immunol. pmid:11123278
Hara-Yokoyama M et al. Complex gangliosides as cell surface inhibitors for the ecto-NAD+ glycohydrolase of CD38. 2001 Biochemistry pmid:11170409
Metelmann W et al. Nano-electrospray ionization time-of-flight mass spectrometry of gangliosides from human brain tissue. 2001 J Mass Spectrom pmid:11180643
Chung ES et al. GT1b ganglioside induces death of dopaminergic neurons in rat mesencephalic cultures. 2001 Neuroreport pmid:11234774
Vinson M et al. Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition. 2001 J. Biol. Chem. pmid:11279053
Fotinou C et al. The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. 2001 J. Biol. Chem. pmid:11418600
Mizutani K et al. Sensorimotor demyelinating neuropathy with IgM antibody against gangliosides GD1a, GT1b and GM3. 2001 J. Neurol. Sci. pmid:11489278
Zuolo ML et al. Identification of GM3 as a marker of therapy-resistant periradicular lesions. 2001 J Endod pmid:11491632
Kanda N et al. Gangliosides GD1b, GT1b, and GQ1b suppress the growth of human melanoma by inhibiting interleukin-8 production: the inhibition of adenylate cyclase. 2001 J. Invest. Dermatol. pmid:11511306
Bieberich E et al. Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides. 2001 J. Biol. Chem. pmid:11574545
Schnaar RL et al. Immunoglobulin G-class mouse monoclonal antibodies to major brain gangliosides. 2002 Anal. Biochem. pmid:11878808
Mirkin BL et al. Inhibition of human neuroblastoma cell proliferation and EGF receptor phosphorylation by gangliosides GM1, GM3, GD1A and GT1B. 2002 Cell Prolif. pmid:11952645
Alaedini A et al. Detection of anti-ganglioside antibodies in Guillain-Barré syndrome and its variants by the agglutination assay. 2002 J. Neurol. Sci. pmid:11959155
Yamashita T et al. The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. 2002 J. Cell Biol. pmid:12011108
Woolf CJ and Bloechlinger S Neuroscience. It takes more than two to Nogo. 2002 Science pmid:12183616
Irvine AD et al. A colorimetric bead-binding assay for detection of intermolecular interactions. 2002 Exp. Dermatol. pmid:12366700
Caudie C et al. [Antiganglioside autoantibody profiles in Guillain-Barré syndrome]. Ann. Biol. Clin. (Paris) pmid:12368145
Gong Y et al. Localization of major gangliosides in the PNS: implications for immune neuropathies. 2002 Brain pmid:12390975
Onodera M et al. Acute isolated bulbar palsy with anti-GT1a IgG antibody subsequent to Campylobacter jejuni enteritis. 2002 J. Neurol. Sci. pmid:12409189
Orr CF et al. An inflammatory review of Parkinson's disease. 2002 Prog. Neurobiol. pmid:12531233
Colarow L et al. Characterization and biological activity of gangliosides in buffalo milk. 2003 Biochim. Biophys. Acta pmid:12573454
Yamamoto HA and Mohanan PV Ganglioside GT1B and melatonin inhibit brain mitochondrial DNA damage and seizures induced by kainic acid in mice. 2003 Brain Res. pmid:12573517
Osanai T et al. Immunohistochemical and biochemical analyses of GD3, GT1b, and GQ1b gangliosides during neural differentiation of P19 EC cells. 2003 FEBS Lett. pmid:12606034
Rapoport E et al. Ganglioside binding pattern of CD33-related siglecs. 2003 Bioorg. Med. Chem. Lett. pmid:12639556
Yamamoto HA and Mohanan PV In vivo and in vitro effects of melatonin or ganglioside GT1B on L-cysteine-induced brain mitochondrial DNA damage in mice. 2003 Toxicol. Sci. pmid:12700404
Wang XQ et al. Ganglioside GM3 inhibits matrix metalloproteinase-9 activation and disrupts its association with integrin. 2003 J. Biol. Chem. pmid:12724312
Sugiyama N et al. [High-dose intravenous immunoglobulin therapy in a child case of Bickerstaff's brainstem encephalitis]. 2003 No To Hattatsu pmid:12875210
Velly LJ et al. Neuroprotective effects of propofol in a model of ischemic cortical cell cultures: role of glutamate and its transporters. 2003 Anesthesiology pmid:12883409
Yoshino H et al. Isolated bovine spinal motoneurons have specific ganglioside antigens recognized by sera from patients with motor neuron disease and motor neuropathy. 1992 J. Neurochem. pmid:1383424
Colville CA et al. The interaction of tetanus toxin with intact bovine adrenal chromaffin cells: binding of toxin and subsequent inhibition of catecholamine release. 1992 Biochim. Biophys. Acta pmid:1445928
Hettmer S et al. Biological stratification of human neuroblastoma by complex "B" pathway ganglioside expression. 2003 Cancer Res. pmid:14612523
Baksh MM et al. Detection of molecular interactions at membrane surfaces through colloid phase transitions. 2004 Nature pmid:14712272
Higashi H and Chen NH Ganglioside/protein kinase signals triggering cytoskeletal actin reorganization. 2004 Glycoconj. J. pmid:14973370
Mandal PK and Pettegrew JW Alzheimer's disease: NMR studies of asialo (GM1) and trisialo (GT1b) ganglioside interactions with Abeta(1-40) peptide in a membrane mimic environment. 2004 Neurochem. Res. pmid:15002743
Nagashima T et al. Clinical correlates of serum anti-GT1a IgG antibodies. 2004 J. Neurol. Sci. pmid:15050449