Ganglioside GT1

Ganglioside GT1 is a lipid of Sphingolipids (SP) class. Ganglioside gt1 is associated with abnormalities such as Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion and Neuritis. The involved functions are known as Binding (Molecular Function), Adjudication, Process, Drug Interactions and Macromolecular alteration. Ganglioside gt1 often locates in Entire nervous system, nucleocapsid location, Membrane, Face and cell body (neuron). The associated genes with Ganglioside GT1 are Homologous Gene, N-dodecyl-L-lysine amide, G-substrate, synthetic peptide and APP gene. The related lipids are GT1b-ganglioside, trisialaoganglioside GT1a, IV(4)-galactosyl-N-acetylganglioside GD1a, sialogangliosides and polysialoganglioside.

Cross Reference

Introduction

To understand associated biological information of Ganglioside GT1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GT1?

Ganglioside GT1 is suspected in Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion, Neuritis, Gastrointestinal infections and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GT1

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GT1?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Ganglioside GT1?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Ganglioside GT1?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Ganglioside GT1?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ganglioside GT1?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Ganglioside GT1

Download all related citations
Per page 10 20 50 100 | Total 210
Authors Title Published Journal PubMed Link
Agui T et al. The structural relation between the antigenic determinants to monoclonal antibodies and binding sites to rat brain synaptosomes and GT1b ganglioside in Clostridium botulinum type C neurotoxin. 1985 J. Biochem. pmid:2581939
Fidelio GD et al. Molecular parameters of gangliosides in monolayers: comparative evaluation of suitable purification procedures. 1991 J. Biochem. pmid:1939017
Nishikawa H and Kitani S Inhibitory effect of ganglioside on mastoparan-induced cytotoxicity and degranulation in lipid raft of connective tissue type mast cell. J. Biochem. Mol. Toxicol. pmid:21671308
Fotinou C et al. The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. 2001 J. Biol. Chem. pmid:11418600
Vinson M et al. Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition. 2001 J. Biol. Chem. pmid:11279053
Chan KF Ganglioside-modulated protein phosphorylation in muscle. Activation of phosphorylase b kinase by gangliosides. 1989 J. Biol. Chem. pmid:2509465
Gilbert M et al. Biosynthesis of ganglioside mimics in Campylobacter jejuni OH4384. Identification of the glycosyltransferase genes, enzymatic synthesis of model compounds, and characterization of nanomole amounts by 600-mhz (1)h and (13)c NMR analysis. 2000 J. Biol. Chem. pmid:10660542
Wang X et al. Carbohydrate-carbohydrate binding of ganglioside to integrin alpha(5) modulates alpha(5)beta(1) function. 2001 J. Biol. Chem. pmid:11118433
Wang XQ et al. Ganglioside GM3 inhibits matrix metalloproteinase-9 activation and disrupts its association with integrin. 2003 J. Biol. Chem. pmid:12724312
Basu A and Glew RH Characterization of the activation of rat liver beta-glucosidase by sialosylgangliotetraosylceramide. 1985 J. Biol. Chem. pmid:3932339
Bieberich E et al. Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides. 2001 J. Biol. Chem. pmid:11574545
Burns JR and Baldwin MR Tetanus neurotoxin utilizes two sequential membrane interactions for channel formation. 2014 J. Biol. Chem. pmid:24973217
Williams G et al. Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. 2008 J. Biol. Chem. pmid:18411262
Attrill H et al. Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b. 2006 J. Biol. Chem. pmid:16895906
Venkateshwari S and Veluraja K Conformational analysis of GT1B ganglioside and its interaction with botulinum neurotoxin type B: a study by molecular modeling and molecular dynamics. 2012 J. Biomol. Struct. Dyn. pmid:22746533
Yamashita T et al. The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. 2002 J. Cell Biol. pmid:12011108
Rauvala H et al. Studies on cell adhesion and recognition. I. Extent and specificity of cell adhesion triggered by carbohydrate-reactive proteins (glycosidases and lectins) and by fibronectin. 1981 J. Cell Biol. pmid:6782107
Cao T et al. Ganglioside GD1a suppression of NOS2 expression via ERK1 pathway in mouse osteosarcoma FBJ cells. 2010 J. Cell. Biochem. pmid:20589721
Freire E et al. Sialic acid residues on astrocytes regulate neuritogenesis by controlling the assembly of laminin matrices. 2004 J. Cell. Sci. pmid:15292398
Katoh N et al. Protein kinase C substrates and ganglioside inhibitors in bovine mammary nuclei. 1993 J. Dairy Sci. pmid:8270682
Hamanaka S et al. Polysialogangliosides expressed by amelanotic melanoma: a possible explanation for the poor response to anti-monosialoganglioside antibody 202 in a patient with melanoma. 1995 J. Dermatol. pmid:7722094
Mariano A et al. Gangliosides and phospholipids in human thyroids responsive and unresponsive to thyrotropin. 1990 J. Endocrinol. Invest. pmid:2096158
Bukrinskaya AG et al. Gangliosides influence experimental influenza virus infection in mice. 1989 J. Gen. Virol. pmid:2778439
Kanda N and Watanabe S Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells. 2001 J. Immunol. pmid:11123278
Kanda N et al. Gangliosides GD1b, GT1b, and GQ1b suppress the growth of human melanoma by inhibiting interleukin-8 production: the inhibition of adenylate cyclase. 2001 J. Invest. Dermatol. pmid:11511306
Paller AS et al. Ganglioside GT1b inhibits keratinocyte adhesion and migration on a fibronectin matrix. 1995 J. Invest. Dermatol. pmid:7636307
Wang XQ et al. Gangliosides inhibit urokinase-type plasminogen activator (uPA)-dependent squamous carcinoma cell migration by preventing uPA receptor/alphabeta integrin/epidermal growth factor receptor interactions. 2005 J. Invest. Dermatol. pmid:15816844
Seyfried TN et al. Ganglioside biosynthesis in mouse embryos: sialyltransferase IV and the asialo pathway. 1994 J. Lipid Res. pmid:8077855
Yoshino H et al. Isolated bovine spinal motoneurons have specific ganglioside antigens recognized by sera from patients with motor neuron disease and motor neuropathy. 1992 J. Neurochem. pmid:1383424
Davidsson P et al. Ganglioside composition in human meningiomas. 1989 J. Neurochem. pmid:2760617
Seyfried TN et al. Cellular distribution of gangliosides in the developing mouse cerebellum: analysis using the staggerer mutant. 1984 J. Neurochem. pmid:6470710
Massa PT and Wu C Modulation of major histocompatibility complex class I genes by interferon-gamma and ganglioside GT 1b in astrocytes: involvement of protein tyrosine phosphatases. 1996 J. Neurochem. pmid:8863487
Schengrund CL et al. Ganglioside-induced adherence of botulinum and tetanus neurotoxins to adducin. 1996 J. Neurochem. pmid:8632182
Yavin E et al. Nerve growth factor and gangliosides stimulate the release of glycoproteins from PC12 pheochromocytoma cells. 1986 J. Neurochem. pmid:3950609
Yu RK et al. Developmental changes in ganglioside composition and synthesis in embryonic rat brain. 1988 J. Neurochem. pmid:3131485
Freischütz B et al. Characterization of sialyltransferase-IV activity and its involvement in the c-pathway of brain ganglioside metabolism. 1995 J. Neurochem. pmid:7798936
Schengrund CL et al. Binding of botulinum and tetanus neurotoxins to ganglioside GT1b and derivatives thereof. 1991 J. Neurochem. pmid:1861141
Seyfried TN et al. Cellular localization of gangliosides in the developing mouse cerebellum: analysis using the weaver mutant. 1983 J. Neurochem. pmid:6875549
Aguilera J et al. GT1b ganglioside prevents tetanus toxin-induced protein kinase C activation and down-regulation in the neonatal brain in vivo. 1993 J. Neurochem. pmid:8419545
Magal E et al. Gangliosides prevent ischemia-induced down-regulation of protein kinase C in fetal rat brain. 1990 J. Neurochem. pmid:2230813
Goldenring JR et al. Calcium/ganglioside-dependent protein kinase activity in rat brain membrane. 1985 J. Neurochem. pmid:2579206
Riboni L et al. Formation of ganglioside GD1b-lactone in rat brain from intracisternally administered GD1b. 1989 J. Neurochem. pmid:2709011
Koga M et al. Is IgG anti-GT1a antibody associated with pharyngeal-cervical-brachial weakness or oropharyngeal palsy in Guillain-Barré syndrome? 1998 J. Neuroimmunol. pmid:9655474
Ilyas AA et al. Antibodies to GT1a ganglioside in patients with Guillain-Barré syndrome. 1998 J. Neuroimmunol. pmid:9585812
Kaida K et al. Anti-ganglioside complex antibodies associated with severe disability in GBS. 2007 J. Neuroimmunol. pmid:17113161
Boffey J et al. Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire. 2005 J. Neuroimmunol. pmid:15967512
Spirman N et al. Regenerative capacity of the goldfish visual system is affected by antibodies specific to gangliosides injected intraocularly. 1984 J. Neuroimmunol. pmid:6725551
Rojas-Garcia R et al. A novel antiganglioside specificity against terminal NeuNAc(alfa 2-3)Gal in acute bulbar palsy. 2006 J. Neuroimmunol. pmid:16707165
Yoshino H et al. IgG antiganglioside antibodies in Guillain-Barré syndrome with bulbar palsy. 2000 J. Neuroimmunol. pmid:10742563
Townson KH et al. Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury. 2008 J. Neuroimmunol. pmid:18684516
Mizoguchi K et al. Anti-GQ1b and anti-GT1a IgG antibodies in a patient with acute demyelinating polyradiculoneuropathy without ophthalmoplegia. 1997 J. Neurol. Neurosurg. Psychiatry pmid:9328270
Onodera M et al. Acute isolated bulbar palsy with anti-GT1a IgG antibody subsequent to Campylobacter jejuni enteritis. 2002 J. Neurol. Sci. pmid:12409189
Alaedini A et al. Detection of anti-ganglioside antibodies in Guillain-Barré syndrome and its variants by the agglutination assay. 2002 J. Neurol. Sci. pmid:11959155
Mizutani K et al. Sensorimotor demyelinating neuropathy with IgM antibody against gangliosides GD1a, GT1b and GM3. 2001 J. Neurol. Sci. pmid:11489278
Nagashima T et al. Clinical correlates of serum anti-GT1a IgG antibodies. 2004 J. Neurol. Sci. pmid:15050449
Prendergast J et al. Ganglioside regulation of AMPA receptor trafficking. 2014 J. Neurosci. pmid:25253868
Velasco I and Tapia R Ruthenium red neurotoxicity and interaction with gangliosides in primary cortical cultures. 1997 J. Neurosci. Res. pmid:9211991
Leskawa KC and Hogan EL Quantitation of the in vitro neuroblastoma response to exogenous, purified gangliosides. 1985 J. Neurosci. Res. pmid:4009744
Mestrallet MG et al. Tryptophan fluorescence properties of cholera toxin upon interacting with ganglioside GD1b. 1984 J. Neurosci. Res. pmid:6502757
Hynds DL et al. Gangliosides inhibit growth factor-stimulated neurite outgrowth in SH-SY5Y human neuroblastoma cells. 1997 J. Neurosci. Res. pmid:9089210
Matusica D et al. Characterization and use of the NSC-34 cell line for study of neurotrophin receptor trafficking. 2008 J. Neurosci. Res. pmid:17896795
Watanabe S et al. Intraplantar injection of sialidase reduces mechanical allodynia during inflammatory pain. 2017 J. Pharmacol. Sci. pmid:28089228
Hwang SU et al. Effect of ganglioside GT1b on the in vitro maturation of porcine oocytes and embryonic development. 2015 J. Reprod. Dev. pmid:26370787
Qian M and Tsai B Lipids and proteins act in opposing manners to regulate polyomavirus infection. 2010 J. Virol. pmid:20668088
Erickson KD et al. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. 2009 J. Virol. pmid:19605473
Low JA et al. Identification of gangliosides GD1b and GT1b as receptors for BK virus. 2006 J. Virol. pmid:16415013
Ladisch S and Wu ZL Detection of a tumour-associated ganglioside in plasma of patients with neuroblastoma. 1985 Lancet pmid:2857215
Whalen MM and Wild GC The major gangliosides of the bovine pineal body. 1987 Lipids pmid:3821397
Hann RM et al. Gangliosides in membranes from Torpedo electric organ. 1996 Lipids pmid:8784743
Katoh N and Miyamoto T Enhancement by ganglioside GT1b of annexin I phosphorylation in bovine mammary gland in the presence of phosphatidylserine and Ca2+. 1996 Lipids pmid:8882979
Kozaki S et al. Ganglioside GT1b as a complementary receptor component for Clostridium botulinum neurotoxins. 1998 Microb. Pathog. pmid:9712688
Kohda T et al. Differential contribution of the residues in C-terminal half of the heavy chain of botulinum neurotoxin type B to its binding to the ganglioside GT1b and the synaptotagmin 2/GT1b complex. Microb. Pathog. pmid:17188834
Sinha K et al. Analysis of mutants of tetanus toxin Hc fragment: ganglioside binding, cell binding and retrograde axonal transport properties. 2000 Mol. Microbiol. pmid:10972823
Zheng Y et al. Efficient biotransformation of polysialogangliosides for preparation of GM1 by Cellulosimicrobium sp. 21. 2014 Molecules pmid:25299818
Khalili E et al. Production of Recombinant Human scFv Against Tetanus Toxin Heavy Chain by Phage Display Technology. 2015 Monoclon Antib Immunodiagn Immunother pmid:26492617
Baldwin MR et al. Botulinum neurotoxin B-host receptor recognition: it takes two receptors to tango. 2007 Nat. Struct. Mol. Biol. pmid:17203068
Baksh MM et al. Detection of molecular interactions at membrane surfaces through colloid phase transitions. 2004 Nature pmid:14712272
Zhang H et al. Ganglioside GM1 binding the N-terminus of amyloid precursor protein. 2009 Neurobiol. Aging pmid:18077059
Zaprianova E et al. Ganglioside spinal cord changes in chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rats. 1997 Neurochem. Res. pmid:9016843
Mandal PK and Pettegrew JW Alzheimer's disease: NMR studies of asialo (GM1) and trisialo (GT1b) ganglioside interactions with Abeta(1-40) peptide in a membrane mimic environment. 2004 Neurochem. Res. pmid:15002743
Yuki N et al. Acute relapsing sensory neuropathy associated with IgM antibody against B-series gangliosides containing a GalNAc beta 1-4(Gal3-2 alpha NeuAc8-2 alpha NeuAc)beta 1 configuration. 1992 Neurology pmid:1549241
Lim ST et al. Exogenous gangliosides increase the release of brain-derived neurotrophic factor. 2011 Neuropharmacology pmid:20971126
Chung ES et al. GT1b ganglioside induces death of dopaminergic neurons in rat mesencephalic cultures. 2001 Neuroreport pmid:11234774
Popoli M and Paterno R Properties of a synaptic vesicle protein binding plasma membranes. 1991 Neuroreport pmid:1883990
Watanabe S et al. Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells. 2012 Neurosci. Lett. pmid:22565021
Letinić K et al. C-pathway polysialogangliosides are transiently expressed in the human cerebrum during fetal development. 1998 Neuroscience pmid:9692737
Kozaki S [Studies on the receptor for Clostridium botulinum neurotoxin]. 1999 Nippon Saikingaku Zasshi pmid:10356952
Sugiyama N et al. [High-dose intravenous immunoglobulin therapy in a child case of Bickerstaff's brainstem encephalitis]. 2003 No To Hattatsu pmid:12875210
Wada Y et al. [A case of acute oropharyngeal palsy with nasal voice as main symptom]. 2006 No To Shinkei pmid:16629449
Yamaji K et al. [Internal ophthalmoplegia in acute oropharyngeal palsy with anti-GQ1b and anti-GT1a IgG antibodies]. 2005 No To Shinkei pmid:16026049
Watanabe S et al. Intraplantar injection of gangliosides produces nociceptive behavior and hyperalgesia via a glutamate signaling mechanism. 2011 Pain pmid:21134719
Izumi T et al. Normal developmental profiles of CSF gangliotetraose-series gangliosides from neonatal period to adolescence. Pediatr. Neurol. pmid:8216543
Izumi T et al. Low levels of CSF gangliotetraose-series gangliosides in West syndrome: implication of brain maturation disturbance. Pediatr. Neurol. pmid:8216542
Dong HJ et al. Development of a cell immobilization technique for the conversion of polysialogangliosides to monosialotetrahexosylganglioside. 2011 Pharm Biol pmid:21500968
de Freitas RM et al. Neurochemical changes on oxidative stress in rat hippocampus during acute phase of pilocarpine-induced seizures. 2010 Pharmacol. Biochem. Behav. pmid:19800361
Tsukamoto K et al. CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C. 2015 PLoS ONE pmid:26177297
Stenmark P et al. Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction. 2008 PLoS Pathog. pmid:18704164
Yang LJ et al. Gangliosides are neuronal ligands for myelin-associated glycoprotein. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8570640
Pohlentz G et al. Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3140234
Orr CF et al. An inflammatory review of Parkinson's disease. 2002 Prog. Neurobiol. pmid:12531233