Ganglioside GT1

Ganglioside GT1 is a lipid of Sphingolipids (SP) class. Ganglioside gt1 is associated with abnormalities such as Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion and Neuritis. The involved functions are known as Binding (Molecular Function), Adjudication, Process, Drug Interactions and Macromolecular alteration. Ganglioside gt1 often locates in Entire nervous system, nucleocapsid location, Membrane, Face and cell body (neuron). The associated genes with Ganglioside GT1 are Homologous Gene, N-dodecyl-L-lysine amide, G-substrate, synthetic peptide and APP gene. The related lipids are GT1b-ganglioside, trisialaoganglioside GT1a, IV(4)-galactosyl-N-acetylganglioside GD1a, sialogangliosides and polysialoganglioside.

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Introduction

To understand associated biological information of Ganglioside GT1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GT1?

Ganglioside GT1 is suspected in Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion, Neuritis, Gastrointestinal infections and other diseases in descending order of the highest number of associated sentences.

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PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GT1

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Ganglioside GT1?

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What functions are associated with Ganglioside GT1?


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What lipids are associated with Ganglioside GT1?

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What genes are associated with Ganglioside GT1?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Ganglioside GT1?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Ganglioside GT1

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Authors Title Published Journal PubMed Link
Singh MK et al. Deletion mutant comprising 198 residues of BoNT/A toxin receptor binding domain retained gt1b binding property but failed to induce protective antibody response in a mouse model. 2012 Protein Pept. Lett. pmid:22486648
Jayaraman S et al. Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin. 2005 Proteins pmid:16104015
Woolf CJ and Bloechlinger S Neuroscience. It takes more than two to Nogo. 2002 Science pmid:12183616
Vautrin J et al. Surface-accessible GABA supports tonic and quantal synaptic transmission. 2000 Synapse pmid:10842350
Wild E et al. In vitro potency determination of botulinum neurotoxin B based on its receptor-binding and proteolytic characteristics. 2016 Toxicol In Vitro pmid:27032463
Behrensdorf-Nicol HA et al. In vitro determination of tetanus toxicity by an endopeptidase assay linked to a ganglioside-binding step. 2010 Toxicol In Vitro pmid:20036726
Nishikawa H and Kitani S Gangliosides inhibit bee venom melittin cytotoxicity but not phospholipase A(2)-induced degranulation in mast cells. 2011 Toxicol. Appl. Pharmacol. pmid:21334356
Yamamoto HA and Mohanan PV In vivo and in vitro effects of melatonin or ganglioside GT1B on L-cysteine-induced brain mitochondrial DNA damage in mice. 2003 Toxicol. Sci. pmid:12700404
Fitzsimmons SP et al. Inhibition of tetanus toxin fragment C binding to ganglioside G(T1b) by monoclonal antibodies recognizing different epitopes. 2000 Vaccine pmid:10924793
Zhao L et al. Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells. 2016 Virology pmid:26901486