Ganglioside GT1

Ganglioside GT1 is a lipid of Sphingolipids (SP) class. Ganglioside gt1 is associated with abnormalities such as Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion and Neuritis. The involved functions are known as Binding (Molecular Function), Adjudication, Process, Drug Interactions and Macromolecular alteration. Ganglioside gt1 often locates in Entire nervous system, nucleocapsid location, Membrane, Face and cell body (neuron). The associated genes with Ganglioside GT1 are Homologous Gene, N-dodecyl-L-lysine amide, G-substrate, synthetic peptide and APP gene. The related lipids are GT1b-ganglioside, trisialaoganglioside GT1a, IV(4)-galactosyl-N-acetylganglioside GD1a, sialogangliosides and polysialoganglioside.

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Introduction

To understand associated biological information of Ganglioside GT1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GT1?

Ganglioside GT1 is suspected in Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion, Neuritis, Gastrointestinal infections and other diseases in descending order of the highest number of associated sentences.

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PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GT1

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Ganglioside GT1?

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What functions are associated with Ganglioside GT1?


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What lipids are associated with Ganglioside GT1?

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What genes are associated with Ganglioside GT1?

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What common seen animal models are associated with Ganglioside GT1?

There are no associated biomedical information in the current reference collection.

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All references with Ganglioside GT1

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Authors Title Published Journal PubMed Link
Fotinou C et al. The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin. 2001 J. Biol. Chem. pmid:11418600
Vinson M et al. Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition. 2001 J. Biol. Chem. pmid:11279053
Chung ES et al. GT1b ganglioside induces death of dopaminergic neurons in rat mesencephalic cultures. 2001 Neuroreport pmid:11234774
Hara-Yokoyama M et al. Complex gangliosides as cell surface inhibitors for the ecto-NAD+ glycohydrolase of CD38. 2001 Biochemistry pmid:11170409
Kanda N and Watanabe S Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells. 2001 J. Immunol. pmid:11123278
Wang X et al. Carbohydrate-carbohydrate binding of ganglioside to integrin alpha(5) modulates alpha(5)beta(1) function. 2001 J. Biol. Chem. pmid:11118433
Mizutani K et al. Sensorimotor demyelinating neuropathy with IgM antibody against gangliosides GD1a, GT1b and GM3. 2001 J. Neurol. Sci. pmid:11489278
Metelmann W et al. Nano-electrospray ionization time-of-flight mass spectrometry of gangliosides from human brain tissue. 2001 J Mass Spectrom pmid:11180643
Bukowski JF et al. T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity. 2000 Eur. J. Immunol. pmid:11093135
Sinha K et al. Analysis of mutants of tetanus toxin Hc fragment: ganglioside binding, cell binding and retrograde axonal transport properties. 2000 Mol. Microbiol. pmid:10972823
Fitzsimmons SP et al. Inhibition of tetanus toxin fragment C binding to ganglioside G(T1b) by monoclonal antibodies recognizing different epitopes. 2000 Vaccine pmid:10924793
Vautrin J et al. Surface-accessible GABA supports tonic and quantal synaptic transmission. 2000 Synapse pmid:10842350
Kukimoto M et al. Crystallization and preliminary X-ray diffraction analysis of the extracellular domain of the cell surface antigen CD38 complexed with ganglioside. 2000 J. Biochem. pmid:10731682
Kotani M et al. Ganglioside GT1b in rat brain binds to p58, a brain-specific sodium-dependent inorganic phosphate cotransporter: expression cloning with a specific monoclonal antibody to ganglioside GT1b-binding protein. 2000 J. Biochem. pmid:10731661
Gilbert M et al. Biosynthesis of ganglioside mimics in Campylobacter jejuni OH4384. Identification of the glycosyltransferase genes, enzymatic synthesis of model compounds, and characterization of nanomole amounts by 600-mhz (1)h and (13)c NMR analysis. 2000 J. Biol. Chem. pmid:10660542
Yoshino H et al. IgG antiganglioside antibodies in Guillain-Barré syndrome with bulbar palsy. 2000 J. Neuroimmunol. pmid:10742563
Aydin M et al. Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats. 2000 Cell Biochem. Funct. pmid:10686582
Morano S et al. Autoimmune markers and neurological complications in non-insulin-dependent diabetes mellitus. 1999 Hum. Immunol. pmid:10527392
Kanda N and Tamaki K Ganglioside GT1b suppresses immunoglobulin production by human peripheral blood mononuclear cells. 1999 Immunology pmid:10233751
Hamasaki H et al. GT1b in human metastatic brain tumors: GT1b as a brain metastasis-associated ganglioside. 1999 Biochim. Biophys. Acta pmid:9931455
Kozaki S [Studies on the receptor for Clostridium botulinum neurotoxin]. 1999 Nippon Saikingaku Zasshi pmid:10356952
Nordin V et al. Gangliosides in cerebrospinal fluid in children with autism spectrum disorders. 1998 Dev Med Child Neurol pmid:9766735
Kozaki S et al. Ganglioside GT1b as a complementary receptor component for Clostridium botulinum neurotoxins. 1998 Microb. Pathog. pmid:9712688
Letinić K et al. C-pathway polysialogangliosides are transiently expressed in the human cerebrum during fetal development. 1998 Neuroscience pmid:9692737
Koga M et al. Is IgG anti-GT1a antibody associated with pharyngeal-cervical-brachial weakness or oropharyngeal palsy in Guillain-Barré syndrome? 1998 J. Neuroimmunol. pmid:9655474
Heffer-Lauc M et al. C-series polysialogangliosides are expressed on stellate neurons of adult human cerebellum. 1998 Glycoconj. J. pmid:9613831
Hashimoto Y et al. A streptavidin-based neoglycoprotein carrying more than 140 GT1b oligosaccharides: quantitative estimation of the binding specificity of murine sialoadhesin expressed on CHO cells. 1998 J. Biochem. pmid:9538230
Ilyas AA et al. Antibodies to GT1a ganglioside in patients with Guillain-Barré syndrome. 1998 J. Neuroimmunol. pmid:9585812
Sung CC et al. Integrin alpha 5 beta 1 expression is required for inhibition of keratinocyte migration by ganglioside GT1b. 1998 Exp. Cell Res. pmid:9521848
Zhou J et al. Gangliosides enhance apoptosis of thymocytes. 1998 Cell. Immunol. pmid:9606992
Palestini P et al. Change of ganglioside accessibility at the plasma membrane surface of cultured neurons, following protein kinase C activation. 1998 Biochemistry pmid:9485467
Mizoguchi K et al. Anti-GQ1b and anti-GT1a IgG antibodies in a patient with acute demyelinating polyradiculoneuropathy without ophthalmoplegia. 1997 J. Neurol. Neurosurg. Psychiatry pmid:9328270
Fukano Y and Ito M Preparation of GM1 ganglioside with sialidase-producing marine bacteria as a microbial biocatalyst. 1997 Appl. Environ. Microbiol. pmid:9143118
Velasco I and Tapia R Ruthenium red neurotoxicity and interaction with gangliosides in primary cortical cultures. 1997 J. Neurosci. Res. pmid:9211991
Hynds DL et al. Gangliosides inhibit growth factor-stimulated neurite outgrowth in SH-SY5Y human neuroblastoma cells. 1997 J. Neurosci. Res. pmid:9089210
Zaprianova E et al. Ganglioside spinal cord changes in chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rats. 1997 Neurochem. Res. pmid:9016843
Massa PT and Wu C Modulation of major histocompatibility complex class I genes by interferon-gamma and ganglioside GT 1b in astrocytes: involvement of protein tyrosine phosphatases. 1996 J. Neurochem. pmid:8863487
Winter A et al. Gangliosides in phospholipid bilayer membranes: interaction with tetanus toxin. 1996 Chem. Phys. Lipids pmid:9450318
Schengrund CL et al. Ganglioside-induced adherence of botulinum and tetanus neurotoxins to adducin. 1996 J. Neurochem. pmid:8632182
Hicks D et al. Stimulation of endogenous ganglioside metabolism by neurotrophic growth factors in cultured retinal Müller glia. 1996 Glia pmid:8721672
Hann RM et al. Gangliosides in membranes from Torpedo electric organ. 1996 Lipids pmid:8784743
Katoh N and Miyamoto T Enhancement by ganglioside GT1b of annexin I phosphorylation in bovine mammary gland in the presence of phosphatidylserine and Ca2+. 1996 Lipids pmid:8882979
Yang LJ et al. Gangliosides are neuronal ligands for myelin-associated glycoprotein. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8570640
Nishiki T et al. The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a. 1996 FEBS Lett. pmid:8557112
Paller AS et al. Ganglioside GT1b inhibits keratinocyte adhesion and migration on a fibronectin matrix. 1995 J. Invest. Dermatol. pmid:7636307
Raimondi F et al. Calcium-dependent intestinal chloride secretion by Vibrio parahaemolyticus thermostable direct hemolysin in a rabbit model. 1995 Gastroenterology pmid:7615186
Paller AS et al. Ganglioside GT1b induces keratinocyte differentiation without activating protein kinase C. 1995 Exp. Cell Res. pmid:7867710
Sung CC et al. Correlation of ganglioside patterns of primary brain tumors with survival. 1995 Cancer pmid:7828137
Hamanaka S et al. Polysialogangliosides expressed by amelanotic melanoma: a possible explanation for the poor response to anti-monosialoganglioside antibody 202 in a patient with melanoma. 1995 J. Dermatol. pmid:7722094
Freischütz B et al. Characterization of sialyltransferase-IV activity and its involvement in the c-pathway of brain ganglioside metabolism. 1995 J. Neurochem. pmid:7798936