Ganglioside GT1

Ganglioside GT1 is a lipid of Sphingolipids (SP) class. Ganglioside gt1 is associated with abnormalities such as Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion and Neuritis. The involved functions are known as Binding (Molecular Function), Adjudication, Process, Drug Interactions and Macromolecular alteration. Ganglioside gt1 often locates in Entire nervous system, nucleocapsid location, Membrane, Face and cell body (neuron). The associated genes with Ganglioside GT1 are Homologous Gene, N-dodecyl-L-lysine amide, G-substrate, synthetic peptide and APP gene. The related lipids are GT1b-ganglioside, trisialaoganglioside GT1a, IV(4)-galactosyl-N-acetylganglioside GD1a, sialogangliosides and polysialoganglioside.

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Introduction

To understand associated biological information of Ganglioside GT1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GT1?

Ganglioside GT1 is suspected in Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion, Neuritis, Gastrointestinal infections and other diseases in descending order of the highest number of associated sentences.

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PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GT1

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Ganglioside GT1?

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What functions are associated with Ganglioside GT1?


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What lipids are associated with Ganglioside GT1?

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What genes are associated with Ganglioside GT1?

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What common seen animal models are associated with Ganglioside GT1?

There are no associated biomedical information in the current reference collection.

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All references with Ganglioside GT1

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Authors Title Published Journal PubMed Link
Pohlentz G et al. Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3140234
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Slepushkin VA et al. Action of influenza virus neuraminidase on gangliosides. Haemagglutinin inhibits viral neuraminidase. 1985 FEBS Lett. pmid:3979549
Leskawa KC and Hogan EL Quantitation of the in vitro neuroblastoma response to exogenous, purified gangliosides. 1985 J. Neurosci. Res. pmid:4009744
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Sarkar CP and Cenedella RJ Gangliosides in normal and cataractous lenses of several species. 1982 Biochim. Biophys. Acta pmid:7104379
Raimondi F et al. Calcium-dependent intestinal chloride secretion by Vibrio parahaemolyticus thermostable direct hemolysin in a rabbit model. 1995 Gastroenterology pmid:7615186
Paller AS et al. Ganglioside GT1b inhibits keratinocyte adhesion and migration on a fibronectin matrix. 1995 J. Invest. Dermatol. pmid:7636307
Hamanaka S et al. Polysialogangliosides expressed by amelanotic melanoma: a possible explanation for the poor response to anti-monosialoganglioside antibody 202 in a patient with melanoma. 1995 J. Dermatol. pmid:7722094
Freischütz B et al. Characterization of sialyltransferase-IV activity and its involvement in the c-pathway of brain ganglioside metabolism. 1995 J. Neurochem. pmid:7798936
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Paller AS et al. Ganglioside GT1b induces keratinocyte differentiation without activating protein kinase C. 1995 Exp. Cell Res. pmid:7867710
Kato E et al. Interaction between ganglioside-containing liposome and rat T-lymphocyte: confocal fluorescence microscopic study. 1994 Biochem. Biophys. Res. Commun. pmid:7945325
Sung CC et al. Gangliosides as diagnostic markers of human astrocytomas and primitive neuroectodermal tumors. 1994 Cancer pmid:7954264
Seyfried TN et al. Ganglioside biosynthesis in mouse embryos: sialyltransferase IV and the asialo pathway. 1994 J. Lipid Res. pmid:8077855
Irie F et al. Biosynthetic pathway for a new series of gangliosides, GT1a alpha and GQ1b alpha. 1994 FEBS Lett. pmid:8082783
Izumi T et al. Low levels of CSF gangliotetraose-series gangliosides in West syndrome: implication of brain maturation disturbance. Pediatr. Neurol. pmid:8216542
Izumi T et al. Normal developmental profiles of CSF gangliotetraose-series gangliosides from neonatal period to adolescence. Pediatr. Neurol. pmid:8216543
Katoh N et al. Protein kinase C substrates and ganglioside inhibitors in bovine mammary nuclei. 1993 J. Dairy Sci. pmid:8270682
Hwang YH et al. Synthesis of 2-deoxy-D-galactose containing gangliosides in vivo. 1993 FEBS Lett. pmid:8335096
Aguilera J et al. GT1b ganglioside prevents tetanus toxin-induced protein kinase C activation and down-regulation in the neonatal brain in vivo. 1993 J. Neurochem. pmid:8419545
Nishiki T et al. The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a. 1996 FEBS Lett. pmid:8557112
Yang LJ et al. Gangliosides are neuronal ligands for myelin-associated glycoprotein. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8570640
Schengrund CL et al. Ganglioside-induced adherence of botulinum and tetanus neurotoxins to adducin. 1996 J. Neurochem. pmid:8632182
Hicks D et al. Stimulation of endogenous ganglioside metabolism by neurotrophic growth factors in cultured retinal Müller glia. 1996 Glia pmid:8721672
Hann RM et al. Gangliosides in membranes from Torpedo electric organ. 1996 Lipids pmid:8784743
Massa PT and Wu C Modulation of major histocompatibility complex class I genes by interferon-gamma and ganglioside GT 1b in astrocytes: involvement of protein tyrosine phosphatases. 1996 J. Neurochem. pmid:8863487
Katoh N and Miyamoto T Enhancement by ganglioside GT1b of annexin I phosphorylation in bovine mammary gland in the presence of phosphatidylserine and Ca2+. 1996 Lipids pmid:8882979
Zaprianova E et al. Ganglioside spinal cord changes in chronic relapsing experimental allergic encephalomyelitis induced in the Lewis rats. 1997 Neurochem. Res. pmid:9016843
Hynds DL et al. Gangliosides inhibit growth factor-stimulated neurite outgrowth in SH-SY5Y human neuroblastoma cells. 1997 J. Neurosci. Res. pmid:9089210
Fukano Y and Ito M Preparation of GM1 ganglioside with sialidase-producing marine bacteria as a microbial biocatalyst. 1997 Appl. Environ. Microbiol. pmid:9143118
Velasco I and Tapia R Ruthenium red neurotoxicity and interaction with gangliosides in primary cortical cultures. 1997 J. Neurosci. Res. pmid:9211991
Mizoguchi K et al. Anti-GQ1b and anti-GT1a IgG antibodies in a patient with acute demyelinating polyradiculoneuropathy without ophthalmoplegia. 1997 J. Neurol. Neurosurg. Psychiatry pmid:9328270
Winter A et al. Gangliosides in phospholipid bilayer membranes: interaction with tetanus toxin. 1996 Chem. Phys. Lipids pmid:9450318
Palestini P et al. Change of ganglioside accessibility at the plasma membrane surface of cultured neurons, following protein kinase C activation. 1998 Biochemistry pmid:9485467