Ganglioside GT1

Ganglioside GT1 is a lipid of Sphingolipids (SP) class. Ganglioside gt1 is associated with abnormalities such as Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion and Neuritis. The involved functions are known as Binding (Molecular Function), Adjudication, Process, Drug Interactions and Macromolecular alteration. Ganglioside gt1 often locates in Entire nervous system, nucleocapsid location, Membrane, Face and cell body (neuron). The associated genes with Ganglioside GT1 are Homologous Gene, N-dodecyl-L-lysine amide, G-substrate, synthetic peptide and APP gene. The related lipids are GT1b-ganglioside, trisialaoganglioside GT1a, IV(4)-galactosyl-N-acetylganglioside GD1a, sialogangliosides and polysialoganglioside.

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Introduction

To understand associated biological information of Ganglioside GT1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Ganglioside GT1?

Ganglioside GT1 is suspected in Neuropathy, Peripheral Neuropathy, Autoimmune Syndrome Type II, Polyglandular, protrusion, Neuritis, Gastrointestinal infections and other diseases in descending order of the highest number of associated sentences.

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PubChem Associated disorders and diseases

What pathways are associated with Ganglioside GT1

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Ganglioside GT1?

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What functions are associated with Ganglioside GT1?


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What lipids are associated with Ganglioside GT1?

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What genes are associated with Ganglioside GT1?

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What common seen animal models are associated with Ganglioside GT1?

There are no associated biomedical information in the current reference collection.

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All references with Ganglioside GT1

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Authors Title Published Journal PubMed Link
pmid:
Jou I et al. Gangliosides trigger inflammatory responses via TLR4 in brain glia. 2006 Am. J. Pathol. pmid:16651628
Wu GS and Ledeen R Quantification of gangliotetraose gangliosides with cholera toxin. 1988 Anal. Biochem. pmid:3189815
Schnaar RL et al. Immunoglobulin G-class mouse monoclonal antibodies to major brain gangliosides. 2002 Anal. Biochem. pmid:11878808
Velly LJ et al. Neuroprotective effects of propofol in a model of ischemic cortical cell cultures: role of glutamate and its transporters. 2003 Anesthesiology pmid:12883409
Caudie C et al. [Antiganglioside autoantibody profiles in Guillain-Barré syndrome]. Ann. Biol. Clin. (Paris) pmid:12368145
Caudie C et al. [Measurement of antiganglioside autoantibodies by immunodot-blot assay: clinical importance in peripheral neuropathies]. Ann. Biol. Clin. (Paris) pmid:10518060
Fukano Y and Ito M Preparation of GM1 ganglioside with sialidase-producing marine bacteria as a microbial biocatalyst. 1997 Appl. Environ. Microbiol. pmid:9143118
Kim BH et al. Expression of ganglioside GT1b in mouse embryos at different developmental stages after cryopreservation. 2008 Arch. Pharm. Res. pmid:18277613
Kato E et al. Interaction between ganglioside-containing liposome and rat T-lymphocyte: confocal fluorescence microscopic study. 1994 Biochem. Biophys. Res. Commun. pmid:7945325
Chan KF Phosphorylation of myelin basic protein and peptides by ganglioside-stimulated protein kinase. 1989 Biochem. Biophys. Res. Commun. pmid:2480129
Whitemarsh RC et al. Model for studying Clostridium botulinum neurotoxin using differentiated motor neuron-like NG108-15 cells. 2012 Biochem. Biophys. Res. Commun. pmid:23000406
Lee DH et al. Effects of daunorubicin on ganglioside expression and neuronal differentiation of mouse embryonic stem cells. 2007 Biochem. Biophys. Res. Commun. pmid:17707770
Bianco ID et al. Modulation of phospholipase A2 activity by neutral and anionic glycosphingolipids in monolayers. 1989 Biochem. J. pmid:2930519
Hara-Yokoyama M et al. Complex gangliosides as cell surface inhibitors for the ecto-NAD+ glycohydrolase of CD38. 2001 Biochemistry pmid:11170409
Yowler BC and Schengrund CL Botulinum neurotoxin A changes conformation upon binding to ganglioside GT1b. 2004 Biochemistry pmid:15274627
Palestini P et al. Change of ganglioside accessibility at the plasma membrane surface of cultured neurons, following protein kinase C activation. 1998 Biochemistry pmid:9485467
Willjes G et al. Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity. 2013 Biochemistry pmid:23647335
Chandrasekaran EV et al. Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides. 2011 Biochemistry pmid:21913655
Sun S et al. Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH. 2012 Biochemistry pmid:22720883
Colarow L et al. Characterization and biological activity of gangliosides in buffalo milk. 2003 Biochim. Biophys. Acta pmid:12573454
Urbina P et al. Effects of bilayer composition and physical properties on the phospholipase C and sphingomyelinase activities of Clostridium perfringens α-toxin. 2011 Biochim. Biophys. Acta pmid:20727345
Hamasaki H et al. GT1b in human metastatic brain tumors: GT1b as a brain metastasis-associated ganglioside. 1999 Biochim. Biophys. Acta pmid:9931455
Suzuki Y et al. Gangliosides in the blood plasma: levels of ganglio-series gangliosides in the plasma after administration of brain gangliosides. 1988 Biochim. Biophys. Acta pmid:3048415
Fidelio GD et al. Molecular parameters and physical state of neutral glycosphingolipids and gangliosides in monolayers at different temperatures. 1986 Biochim. Biophys. Acta pmid:3942728
Colville CA et al. The interaction of tetanus toxin with intact bovine adrenal chromaffin cells: binding of toxin and subsequent inhibition of catecholamine release. 1992 Biochim. Biophys. Acta pmid:1445928
Sarkar CP and Cenedella RJ Gangliosides in normal and cataractous lenses of several species. 1982 Biochim. Biophys. Acta pmid:7104379
Bertoli E et al. Electron paramagnetic resonance studies on the fluidity and surface dynamics of egg phosphatidylcholine vesicles containing gangliosides. 1981 Biochim. Biophys. Acta pmid:6271209
Guan Z et al. Gangliosides inhibit platelet-derived growth-factor-stimulated increases in intracellular calcium in Swiss 3T3 cells. 1992 Biochim. Biophys. Acta pmid:1520706
Viljetić B et al. Distribution of mono-, di- and trisialo gangliosides in the brain of Actinopterygian fishes. 2012 Biochim. Biophys. Acta pmid:22206893
Zhu ZM et al. Compositional analysis of the three main gangliosides from adult human myometrium by a rapid capillary gas chromatographic method. 1989 Biomed. Chromatogr. pmid:2706362
Rapoport E et al. Ganglioside binding pattern of CD33-related siglecs. 2003 Bioorg. Med. Chem. Lett. pmid:12639556
McDaniel RV et al. Electrokinetic and electrostatic properties of bilayers containing gangliosides GM1, GD1a, or GT1. Comparison with a nonlinear theory. 1986 Biophys. J. pmid:3697476
Miller CE et al. Integration of ganglioside GT1b receptor into DPPE and DPPC phospholipid monolayers: an X-ray reflectivity and grazing-incidence diffraction study. 2008 Biophys. J. pmid:18599631
Samiee KT et al. Zero mode waveguides for single-molecule spectroscopy on lipid membranes. 2006 Biophys. J. pmid:16461393
Slade AL et al. In situ scanning probe microscopy studies of tetanus toxin-membrane interactions. 2006 Biophys. J. pmid:16997879
Peng YF et al. Development of a large scale process for the conversion of polysialogangliosides to monosialotetrahexosylganglioside with a novel strain of Brevibacterium casei producing sialidase. 2007 Biotechnol. Lett. pmid:17415532
Chung ES et al. GT1b-induced neurotoxicity is mediated by the Akt/GSK-3/tau signaling pathway but not caspase-3 in mesencephalic dopaminergic neurons. 2010 BMC Neurosci pmid:20540782
Gong Y et al. Localization of major gangliosides in the PNS: implications for immune neuropathies. 2002 Brain pmid:12390975
Murakami N et al. An adolescent with pharyngeal-cervical-brachial variant of Guillain-Barré syndrome after cytomegalovirus infection. 2006 Brain Dev. pmid:16368212
Park JY et al. GM1 induces p38 and microtubule dependent ramification of rat primary microglia in vitro. 2008 Brain Res. pmid:18930716
Yamamoto HA and Mohanan PV Ganglioside GT1B and melatonin inhibit brain mitochondrial DNA damage and seizures induced by kainic acid in mice. 2003 Brain Res. pmid:12573517
Gavella M et al. Modulation of ROS production in human leukocytes by ganglioside micelles. 2010 Braz. J. Med. Biol. Res. pmid:20878014
Sung CC et al. Correlation of ganglioside patterns of primary brain tumors with survival. 1995 Cancer pmid:7828137
Sung CC et al. Gangliosides as diagnostic markers of human astrocytomas and primitive neuroectodermal tumors. 1994 Cancer pmid:7954264
Hettmer S et al. Low complex ganglioside expression characterizes human neuroblastoma cell lines. 2005 Cancer Lett. pmid:15922866
Hettmer S et al. Biological stratification of human neuroblastoma by complex "B" pathway ganglioside expression. 2003 Cancer Res. pmid:14612523
Dong Y et al. GM1 / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line. 2010 Cancer Sci. pmid:20594196
Komori T et al. Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates. 2009 Carbohydr. Res. pmid:19560125
Aydin M et al. Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats. 2000 Cell Biochem. Funct. pmid:10686582