Arachidic acid is a lipid of Fatty Acyls (FA) class. Arachidic acid is associated with abnormalities such as nervous system disorder, Liver diseases, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and Cardiovascular Diseases. The involved functions are known as Process, Regulation, Saturated, Oxidation and enzyme activity. Arachidic acid often locates in Mitochondria, Brown Fat, Microsomes, Membrane and Muscle. The associated genes with Arachidic acid are ELOVL3 gene, P4HTM gene, CFLAR gene, Homologous Gene and Polypeptides. The related lipids are Fatty Acids, Glycerophospholipids, Palmitates, Stearic acid and hexadecenoic acid.
To understand associated biological information of Arachidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Arachidic acid is suspected in Diabetes, Hypertensive disease, nervous system disorder, Liver diseases, Obesity, Diabetes Mellitus, Non-Insulin-Dependent and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Arachidic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Arnold-Chiari Malformation | D001139 | 1 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Kulacoglu DN et al. | Alterations of fatty acid composition of erythrocyte membrane in type 2 diabetes patients with diabetic retinopathy. | Jpn. J. Ophthalmol. | pmid:14636844 | |
| GOERANSSON G | THE METABOLISM OF FATTY ACIDS IN THE RAT. 3. ARACHIDIC ACID. | 1965 | Acta Physiol. Scand. | pmid:14329153 |
| Kanoh H and Lindsay DB | Synthesis of fatty acids from (1- 14 C)acetyl-coenzyme A in subcellular particles of rat epididymal adipose tissue. | 1972 | Biochem. J. | pmid:4638795 |
| Cronan JE et al. | Regulation of membrane lipid synthesis in Escherichia coli. Accumulation of free fatty acids of abnormal length during inhibition of phospholipid synthesis. | 1975 | J. Biol. Chem. | pmid:1097444 |
| Ito H et al. | [Some observations on prognosis in congenital hydrocephalus (second report) -with reference to the physical handicap in survival cases (author's transl)]. | 1975 | No Shinkei Geka | pmid:1107877 |
| Brophy PJ and Vance DE | The synthesis and hydrolysis of long-chain fatty acyl-coenzyme A thioesters by soluble and microsomal fractions from the brain of the developing rat. | 1976 | Biochem. J. | pmid:1008855 |
| Hauser H et al. | Ion-binding to phospholipids. Interaction of calcium with phosphatidylserine. | 1976 | Eur. J. Biochem. | pmid:3416 |
| Onodera Y and Ito H | Fatty acid in cerebrospinal fluid of congenital hydrocephalus. | 1977 | Childs Brain | pmid:862460 |
| Barnes RB et al. | Quantum yield and image contrast of bacteriochlorophyll monolayers in photoelectron microscopy. | 1978 | Biophys. J. | pmid:630040 |
| Horvat RJ | Identification of some new minor acids from chicken skin lipids. | 1978 | Poult. Sci. | pmid:674060 |
| Rillema JA | Activation of guanylate cyclase by arachidonic acid in mammary gland homogenates from mice. | 1978 | Prostaglandins | pmid:30119 |
| van Joost T et al. | Sensitization to olive oil (olea europeae). | 1981 | Contact Derm. | pmid:7338030 |
| Onodera Y et al. | Fatty acid of cerebrospinal fluid in arrested hydrocephalus. | 1982 | Childs Brain | pmid:7094674 |
| Cook HW et al. | Involvement of triacylglycerol in the metabolism of fatty acids by cultured neuroblastoma and glioma cells. | 1982 | J. Lipid Res. | pmid:7161559 |
| Higuchi M et al. | Gas chromatography-mass spectrometric determination of fatty acids in seed oil of winged bean (Psophocarpus tetragonolobus (L.) DC). | 1982 | J. Nutr. Sci. Vitaminol. | pmid:7161648 |
| Vuori E et al. | Maternal diet and fatty acid pattern of breast milk. | 1982 | Acta Paediatr Scand | pmid:6897601 |
| Dray F | Sensitivity and specificity of eicosanoid radioimmunoassays: new strategy. | 1983 | Br. J. Dermatol. | pmid:6860583 |
| Cook HW et al. | Inability of rabbit peritoneal polymorphonuclear leukocytes to synthesize arachidonic acid from linoleic acid. | 1983 | Prostaglandins Leukot Med | pmid:6402793 |
| Tuyau JE and Sims W | Aspects of the pathogenicity of some oral and other haemophili. | 1983 | J. Med. Microbiol. | pmid:6644787 |
| Kiuchi K and Hager LP | Reconstitution of the lipid-depleted pyruvate oxidase system of Escherichia coli: the palmitic acid effect. | 1984 | Arch. Biochem. Biophys. | pmid:6385860 |
| Crowley PJ et al. | Chemical analyses of membranes isolated from Streptococcus mutans BHT. | 1984 | J. Dent. Res. | pmid:6392377 |
| Mandl J et al. | Uptake of arachidonic acid, arachidic acid, oleic acid and their incorporation into phospholipids and triacylglycerols of isolated murine hepatocytes. Effect of thrombin-antithrombin III complex. | 1984 | Thromb. Res. | pmid:6435278 |
| Kikuchi S and Kusaka T | Purification of NADPH-dependent enoyl-CoA reductase involved in the malonyl-CoA dependent fatty acid elongation system of Mycobacterium smegmatis. | 1984 | J. Biochem. | pmid:6501266 |
| Dennis RD et al. | Glycosphingolipids in insects. Chemical structures of ceramide tetra-, penta-, hexa-, and heptasaccharides from Calliphora vicina pupae (Insecta: Diptera). | 1985 | J. Biol. Chem. | pmid:3988759 |
| Dennis RD et al. | Glycosphingolipids in insects. Chemical structures of ceramide monosaccharide, disaccharide, and trisaccharide from pupae of Calliphora vicina (Insecta: Diptera). | 1985 | Eur. J. Biochem. | pmid:3967656 |
| Kokatnur M et al. | Fatty acids of sphingomyelin from amniotic fluid of normal and diabetic pregnancies. | 1985 | Lipids | pmid:4033364 |
| Jänicke U and Förster W | [Prostaglandins and endogenous psychoses]. | 1986 | Psychiatr Neurol Med Psychol (Leipz) | pmid:3786574 |
| Morand O et al. | Arachidonoyl-coenzyme A synthetase and nonspecific acyl-coenzyme A synthetase activities in purified rat brain microvessels. | 1987 | J. Neurochem. | pmid:3102692 |
| Novo C et al. | Altered fatty acid membrane composition modifies lymphocyte localization in vivo. | 1987 | Cell. Immunol. | pmid:2882861 |
| Chaudhry A et al. | The effects of fatty acids on phosphoinositide synthesis and myo-inositol accumulation in exocrine pancreas. | 1987 | J. Biol. Chem. | pmid:2826420 |
| Pachence JM and Blasie JK | The location of cytochrome c on the surface of ultrathin lipid multilayer films using x-ray diffraction. | 1987 | Biophys. J. | pmid:2827799 |
| Keough KM et al. | The influence of unsaturation on the phase transition temperatures of a series of heteroacid phosphatidylcholines containing twenty-carbon chains. | 1987 | Biochim. Biophys. Acta | pmid:3111533 |
| Beaumier L et al. | Arachidonic acid-induced release of calcium in permeabilized human neutrophils. | 1987 | FEBS Lett. | pmid:3114002 |
| Nishikawa M et al. | Possible involvement of direct stimulation of protein kinase C by unsaturated fatty acids in platelet activation. | 1988 | Biochem. Pharmacol. | pmid:3401239 |
| Redgrave TG et al. | The effect of triacyl-sn-glycerol structure on the metabolism of chylomicrons and triacylglycerol-rich emulsions in the rat. | 1988 | J. Biol. Chem. | pmid:3356683 |
| Marowsky G and Steinhoff R | Hemicyanine monolayer orientation studied by second-harmonic generation. | 1988 | Opt Lett | pmid:19746010 |
| Bedzyk MJ et al. | X-ray standing waves: a molecular yardstick for biological membranes. | 1988 | Science | pmid:3175619 |
| Pachence JM et al. | Location of the heme-Fe atoms within the profile structure of a monolayer of cytochrome c bound to the surface of an ultrathin lipid multilayer film. | 1989 | Biophys. J. | pmid:2550089 |
| Stelzle M and Sackmann E | Sensitive detection of protein adsorption to supported lipid bilayers by frequency-dependent capacitance measurements and microelectrophoresis. | 1989 | Biochim. Biophys. Acta | pmid:2541788 |
| Villarroel M et al. | [Chemical composition and biological quality of defatted hazelnut flour]. | 1989 | Arch Latinoam Nutr | pmid:2487030 |
| Swidzińska K et al. | Effect of fatty acid chain length and saturation on formation of the acylenzyme complex by the isolated aortic enzyme fraction. | 1989 Mar-Apr | Acta Physiol Pol | pmid:2641424 |
| Yoneyama M et al. | Two-dimensional domain shape transitions in photosensitive monolayer assemblies. | 1995 | BioSystems | pmid:7488698 |
| Viswanathan R et al. | Liquid to hexatic to crystalline order in Langmuir-Blodgett films. | 1995 | Science | pmid:7604278 |
| Kankofer M et al. | The analysis of fatty acid content and phospholipase A2 activity in placenta of cows with and without retained fetal membranes. | 1996 | Zentralbl Veterinarmed A | pmid:8940891 |
| Almeida T et al. | Facilitation by arachidonic acid of acetylcholine release from the rat hippocampus. | 1999 | Brain Res. | pmid:10216201 |
| Sato K et al. | Apatite formation on organic monolayers in simulated body environment. | 2000 | J. Biomed. Mater. Res. | pmid:10644958 |
| Gole A et al. | Fabrication, characterization, and enzymatic activity of encapsulated fungal protease--fatty lipid biocomposite films. | 2000 | Anal. Chem. | pmid:11008764 |
| Reason M et al. | Characterisation of fatty acid multilayers using a TSM biosensor. | 2000 | Int J Pharm | pmid:10675678 |
| Cahoon EB et al. | Production of fatty acid components of meadowfoam oil in somatic soybean embryos. | 2000 | Plant Physiol. | pmid:10982439 |
| Hlongwane C et al. | Comparative quantitative fatty acid analysis of triacylglycerols using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and gas chromatography. | 2001 | Rapid Commun. Mass Spectrom. | pmid:11675670 |
| Mancuso P et al. | Evaluation of phagocytosis and arachidonate metabolism by alveolar macrophages and recruited neutrophils from F344xBN rats of different ages. | 2001 | Mech. Ageing Dev. | pmid:11557288 |
| Schewe T et al. | Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase. | 2001 | Biol. Chem. | pmid:11843182 |
| He H et al. | The effect of temperature on the fatty acids and isozymes of a psychrotrophic and two mesophilic species of Xenorhabdus, a bacterial symbiont of entomopathogenic nematodes. | 2001 | Can. J. Microbiol. | pmid:11400727 |
| Constantino C et al. | Surface enhanced resonance Raman scattering imaging of Langmuir-Blodgett monolayers of bis (benzimidazo) thioperylene. | 2001 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:11419467 |
| Ballistreri A et al. | Biosynthesis and structural characterization of medium-chain-length poly(3-hydroxyalkanoates) produced by Pseudomonas aeruginosa from fatty acids. | 2001 | Int. J. Biol. Macromol. | pmid:11518582 |
| Takamoto DY et al. | Stable ordering in Langmuir-Blodgett films. | 2001 | Science | pmid:11509723 |
| Sakata T et al. | Structural elucidation of twelve novel esters composed of five fatty acids and three new branched alcohols together with four monoterpenoids from Sancassania shanghaiensis (Acari: Acaridae). | 2001 | Biosci. Biotechnol. Biochem. | pmid:11388473 |
| Li D | Relationship between the concentrations of plasma phospholipid stearic acid and plasma lipoprotein lipids in healthy men. | 2001 | Clin. Sci. | pmid:11115414 |
| Egea PF et al. | Molecular recognition of agonist ligands by RXRs. | 2002 | Mol. Endocrinol. | pmid:11981034 |
| Wanten GJ et al. | Saturated triglycerides and fatty acids activate neutrophils depending on carbon chain-length. | 2002 | Eur. J. Clin. Invest. | pmid:11952815 |
| Chen N et al. | Inhibition by arachidonic acid and other fatty acids of dopamine uptake at the human dopamine transporter. | 2003 | Eur. J. Pharmacol. | pmid:14575792 |
| Fernández-Moya V et al. | Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. | 2003 | Planta | pmid:12624771 |
| Pozzi R et al. | Inflammatory mediators induced by coarse (PM2.5-10) and fine (PM2.5) urban air particles in RAW 264.7 cells. | 2003 | Toxicology | pmid:12504355 |
| Constantino CJ et al. | Surface-enhanced resonance raman scattering: single-molecule detection in a Langmuir-Blodgett monolayer. | 2003 | Appl Spectrosc | pmid:14658697 |
| Volkmer D et al. | Morphosynthesis of star-shaped titania-silica shells. | 2003 | Angew. Chem. Int. Ed. Engl. | pmid:19757590 |
| Riebeling C et al. | Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. | 2003 | J. Biol. Chem. | pmid:12912983 |
| Zou G et al. | Study of molecular interaction in the mixed film of arachidic acid and metal beta-diketonate complexes by the "surface ions" method. | 2003 | J Colloid Interface Sci | pmid:16256550 |
| Anwar F and Bhanger MI | Analytical characterization of Moringa oleifera seed oil grown in temperate regions of Pakistan. | 2003 | J. Agric. Food Chem. | pmid:14558778 |
| Buckner JS and Hagen MM | Triacylglycerol and phospholipid fatty acids of the silverleaf whitefly: composition and biosynthesis. | 2003 | Arch. Insect Biochem. Physiol. | pmid:12761874 |
| Yao K et al. | Expression of the Arabidopsis ADS1 gene in Brassica juncea results in a decreased level of total saturated fatty acids. | 2003 | Plant Biotechnol. J. | pmid:17156034 |
| Chavez JA and Summers SA | Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. | 2003 | Arch. Biochem. Biophys. | pmid:14592453 |
| Sun GY et al. | Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases. | 2004 | J. Lipid Res. | pmid:14657205 |
| Barbarich NC et al. | Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa. | 2004 | Int J Eat Disord | pmid:14705152 |
| O'Dowd YM et al. | Inhibition of formyl-methionyl-leucyl-phenylalanine-stimulated respiratory burst in human neutrophils by adrenaline: inhibition of Phospholipase A2 activity but not p47phox phosphorylation and translocation. | 2004 | Biochem. Pharmacol. | pmid:14667941 |
| Rupp H et al. | Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids. | 2004 | Herz | pmid:15580322 |
| Chen D et al. | Particle-rod hybrids: growth of arachidic acid molecular rods from capped cadmium selenide nanoparticles. | 2004 | J. Am. Chem. Soc. | pmid:15600308 |
| Hunt AN et al. | Acyl chain-based molecular selectivity for HL60 cellular phosphatidylinositol and of phosphatidylcholine by phosphatidylinositol transfer protein alpha. | 2004 | Biochim. Biophys. Acta | pmid:15522822 |
| Bhaumik A et al. | Formation of a DNA layer on Langmuir-Blodgett films and its enzymatic digestion. | 2004 | Langmuir | pmid:16459606 |
| Kuroda S | J-aggregation and its characterization in Langmuir-Blodgett films of merocyanine dyes. | 2004 | Adv Colloid Interface Sci | pmid:15589808 |
| Costa AS and Imae T | Morphological investigation of hybrid Langmuir-Blodgett films of arachidic acid with a hydrotalcite/dendrimer nanocomposite. | 2004 | Langmuir | pmid:15379519 |
| de Jong AE et al. | Behavior of Clostridium perfringens at low temperatures. | 2004 | Int. J. Food Microbiol. | pmid:15527920 |
| Salas JJ et al. | Very long chain fatty acid synthesis in sunflower kernels. | 2005 | J. Agric. Food Chem. | pmid:15796615 |
| Ghosh D et al. | Transcription of T7 DNA immobilised on latex beads and Langmuir-Blodgett film. | 2005 | J. Biochem. Biophys. Methods | pmid:15656943 |
| Perona JS and Ruiz-Gutierrez V | Triacylglycerol molecular species are depleted to different extents in the myocardium of spontaneously hypertensive rats fed two oleic acid-rich oils. | 2005 | Am. J. Hypertens. | pmid:15691620 |
| Holman J et al. | Sum frequency generation from Langmuir-Blodgett multilayer films on metal and dielectric substrates. | 2005 | J Phys Chem B | pmid:16853409 |
| Fernández-Real JM et al. | Circulating adiponectin and plasma fatty acid profile. | 2005 | Clin. Chem. | pmid:15637134 |
| Erriquez J et al. | Calcium signals activated by arachidonic acid in embryonic chick ciliary ganglion neurons. | 2005 | Neurosignals | pmid:16301839 |
| Brar LK et al. | Langmuir monolayer as a tool toward visualization of a specific DNA-protein complex. | 2005 | Langmuir | pmid:16262335 |
| Vitta S | Metal-substituted organic Cd-arachidate multilayers as soft-x-ray mirrors. | 2005 | Appl Opt | pmid:15943259 |
| Shchipunov YA et al. | Polysaccharides as a template for silicate generated by sol-gel processes. | 2005 | J Colloid Interface Sci | pmid:15837474 |
| Diaz ME et al. | Infrared spectroscopy analysis of the structure of multilayer Langmuir-Blodgett films: effect of deposition velocity and pH. | 2005 | Langmuir | pmid:15641830 |
| Hagfors L et al. | Fat intake and composition of fatty acids in serum phospholipids in a randomized, controlled, Mediterranean dietary intervention study on patients with rheumatoid arthritis. | 2005 | Nutr Metab (Lond) | pmid:16216119 |
| Westerberg R et al. | ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue. | 2006 | J. Biol. Chem. | pmid:16326704 |
| Duan W and Zhang L | Cyclooxygenase inhibitors not inhibit resting lung cancer A549 cell proliferation. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16618538 |
| Salles HC et al. | The venomous secrets of the web droplets from the viscid spiral of the orb-weaver spider Nephila clavipes (Araneae, Tetragnatidae). | 2006 | Chem. Biodivers. | pmid:17193305 |
| Sawant SN et al. | Polymer-surfactant layered heterostructures by electropolymerization of phenosafranine in Langmuir-Blodgett films. | 2006 | J Phys Chem B | pmid:17134212 |
| Valli L et al. | Ethane-bridged zinc porphyrin dimers in Langmuir-Shäfer thin films: structural and spectroscopic properties. | 2006 | J Phys Chem B | pmid:16526704 |
| Eto K et al. | Modulation of ATP-induced inward currents by docosahexaenoic acid and other fatty acids in rat nodose ganglion neurons. | 2006 | J. Pharmacol. Sci. | pmid:17099292 |
| Botto L et al. | Biochemical and morphological changes in endothelial cells in response to hypoxic interstitial edema. | 2006 | Respir. Res. | pmid:16412226 |